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    Chemistry

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    Also known as: Chlorpheniramine mixture with hydrocodone, 131219-97-1, Vituz, Tuzistra xr, Tussionex pennkinetic, S-t forte 2
    Molecular Formula
    C34H40ClN3O3
    Molecular Weight
    574.1  g/mol
    InChI Key
    UUEZOEBHFHYMGR-RNWHKREASA-N
    Tussionex
    1 2D Structure

    Tussionex

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
    2.1.2 InChI
    InChI=1S/C18H21NO3.C16H19ClN2/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3,6,11-12,17H,4-5,7-9H2,1-2H3;3-9,11,15H,10,12H2,1-2H3/t11-,12+,17-,18-;/m0./s1
    2.1.3 InChI Key
    UUEZOEBHFHYMGR-RNWHKREASA-N
    2.1.4 Canonical SMILES
    CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4.CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
    2.1.5 Isomeric SMILES
    CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3C(=O)CC4.CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
    2.2 Synonyms
    2.2.1 Depositor-Supplied Synonyms

    1. Chlorpheniramine Mixture With Hydrocodone

    2. 131219-97-1

    3. Vituz

    4. Tuzistra Xr

    5. Tussionex Pennkinetic

    6. S-t Forte 2

    7. Tussicaps Extended-release

    8. Tussionex

    9. Chlorpheniramine / Hydrocodone

    10. Chlorpheniramine Polistirex / Hydrocodone Polistirex

    11. Chlorpheniramine Polistirex And Hydrocodone Polistirex

    12. Hydrocodone Polistirex And Chlorpheniramine Polistirex

    13. Schembl2522788

    14. Dtxsid50156960

    15. Hydrocodone Conbination Product 15 Mg/du

    2.3 Create Date
    2009-08-20
    3 Chemical and Physical Properties
    Molecular Weight 574.1 g/mol
    Molecular Formula C34H40ClN3O3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count6
    Exact Mass573.2758198 g/mol
    Monoisotopic Mass573.2758198 g/mol
    Topological Polar Surface Area54.9 Ų
    Heavy Atom Count41
    Formal Charge0
    Complexity758
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameHydrocodone polistirex and chlorpheniramine polistirex
    Active IngredientChlorpheniramine polistirex; hydrocodone polistirex
    Dosage FormSuspension, extended release
    RouteOral
    Strengtheq 10mg bitartrate/5ml; eq 8mg maleate/5ml
    Market StatusPrescription
    CompanyTris Pharma

    2 of 6  
    Drug NameTussicaps
    Active IngredientChlorpheniramine polistirex; hydrocodone polistirex
    Dosage FormCapsule, extended release
    RouteOral
    Strengtheq 10mg bitartrate; eq 5mg bitartrate; eq 4mg maleate; eq 8mg maleate
    Market StatusPrescription
    CompanyEcr Pharma

    3 of 6  
    Drug NameTussionex pennkinetic
    PubMed HealthHydrocodone and Chlorpheniramine Polistirex (Oral route)
    Drug ClassesAntitussive, Opioid/Antihistamine Combination, Chlorpheniramine
    Active IngredientChlorpheniramine polistirex; hydrocodone polistirex
    Dosage FormSuspension, extended release
    RouteOral
    Strengtheq 10mg bitartrate/5ml; eq 8mg maleate/5ml
    Market StatusPrescription
    CompanyUcb

    4 of 6  
    Drug NameHydrocodone polistirex and chlorpheniramine polistirex
    Active IngredientChlorpheniramine polistirex; hydrocodone polistirex
    Dosage FormSuspension, extended release
    RouteOral
    Strengtheq 10mg bitartrate/5ml; eq 8mg maleate/5ml
    Market StatusPrescription
    CompanyTris Pharma

    5 of 6  
    Drug NameTussicaps
    Active IngredientChlorpheniramine polistirex; hydrocodone polistirex
    Dosage FormCapsule, extended release
    RouteOral
    Strengtheq 10mg bitartrate; eq 5mg bitartrate; eq 4mg maleate; eq 8mg maleate
    Market StatusPrescription
    CompanyEcr Pharma

    6 of 6  
    Drug NameTussionex pennkinetic
    PubMed HealthHydrocodone and Chlorpheniramine Polistirex (Oral route)
    Drug ClassesAntitussive, Opioid/Antihistamine Combination, Chlorpheniramine
    Active IngredientChlorpheniramine polistirex; hydrocodone polistirex
    Dosage FormSuspension, extended release
    RouteOral
    Strengtheq 10mg bitartrate/5ml; eq 8mg maleate/5ml
    Market StatusPrescription
    CompanyUcb

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    Histamine-1 Receptor Antagonist [EPC]; Opioid Agonist [EPC]; Opioid Agonists [MoA]; Histamine H1 Receptor Antagonists [MoA]

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