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Chemistry

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Also known as: Cortisol, 50-23-7, Acticort, Cetacort, Cortef, Hydrasson
Molecular Formula
C21H30O5
Molecular Weight
362.5  g/mol
InChI Key
JYGXADMDTFJGBT-VWUMJDOOSA-N
FDA UNII
WI4X0X7BPJ

Hydrocortisone
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Hydrocortisone is a Corticosteroid. The mechanism of action of hydrocortisone is as a Corticosteroid Hormone Receptor Agonist.
1 2D Structure

Hydrocortisone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
2.1.2 InChI
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
2.1.3 InChI Key
JYGXADMDTFJGBT-VWUMJDOOSA-N
2.1.4 Canonical SMILES
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
2.1.5 Isomeric SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
2.2 Other Identifiers
2.2.1 UNII
WI4X0X7BPJ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 11 Epicortisol

2. 11-epicortisol

3. Cortef

4. Cortifair

5. Cortisol

6. Cortril

7. Epicortisol

8. Hydrocortisone, (11 Alpha)-isomer

9. Hydrocortisone, (9 Beta,10 Alpha,11 Alpha)-isomer

10. Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-

2.3.2 Depositor-Supplied Synonyms

1. Cortisol

2. 50-23-7

3. Acticort

4. Cetacort

5. Cortef

6. Hydrasson

7. Hydrocortisyl

8. Hydrocortone

9. Cobadex

10. Hytone

11. Cortenema

12. Cortril

13. Dermacort

14. Proctocort

15. Hycort

16. Signef

17. 17-hydroxycorticosterone

18. Optef

19. Kendall's Compound F

20. Cort-dome

21. Cortanal

22. Corticreme

23. Cortifan

24. Cortiment

25. Cortispray

26. Cortonema

27. Dermolate

28. Efcorbin

29. Efcortelan

30. Eldecort

31. Ficortril

32. Genacort

33. Hycortol

34. Hycortole

35. Penecort

36. Permicort

37. Tarcortin

38. Traumaide

39. Alacort

40. Cleiton

41. Epicort

42. Dihydrocostisone

43. Hytone Lotion

44. Hidro-colisona

45. Hydro-adreson

46. Scheroson F

47. Incortin-h

48. Reichstein's Substance M

49. Ala-scalp

50. Domolene-hc

51. Epiderm H

52. Esiderm H

53. Otosone-f

54. Polcort H

55. Aeroseb-hc

56. Cortolotion

57. Cortoxide

58. Cremesone

59. Eldercort

60. Heb-cort

61. Maintasone

62. Nutracort

63. Delacort

64. Dioderm

65. Mildison

66. Rectoid

67. Synacort

68. Anflam

69. Hydrocorticosterone

70. Hydroxycortisone

71. H-cort

72. Hydro-colisona

73. Cortisol Alcohol

74. Incortin-hydrogen

75. Ala-cort

76. Barseb Hc

77. Dermocortal

78. Flexicort

79. Texacort

80. Timocort

81. Evacort

82. Komed Hc

83. Hydrocortisone Base

84. Lacticare-hc

85. Texacort Lotion 25

86. Anti-inflammatory Hormone

87. Hydrocortisone Alcohol

88. Algicirtis

89. Aquacort

90. Colocort

91. Cortesal

92. Cortisolonum

93. Hidalone

94. Hytisone

95. Kyypakkaus

96. Lactisona

97. Lubricort

98. Meusicort

99. Milliderm

100. Sanatison

101. Schericur

102. Sigmacort

103. Stiefcorcil

104. Amberin

105. Cutisol

106. Dermil

107. Glycort

108. Uniderm

109. Foille Insetti

110. Gyno-cortisone

111. Balneol-hc

112. Transderma H

113. Basan-corti

114. Clear Aid

115. Cremicort-h

116. Dome-cort

117. Stie-cort

118. Beta-hc

119. Neosporin-h Ear

120. Remederm Hc

121. Aquanil Hc

122. Cortisporin Otico

123. Derm-aid

124. Heb Cort

125. Nogenic Hc

126. Scalpicin Capilar

127. Systral Hydrocort

128. Prevex Hc

129. Cortisporin

130. Efcortelin

131. Fiocortril

132. Hidrocortisona

133. Hydrocortisone Free Alcohol

134. Hydrocortisonum

135. Proctofoam

136. Alphaderm

137. Hydracort

138. Medicort

139. Otocort

140. Zenoxone

141. Drotic

142. Vytone

143. 11beta-hydroxycortisone

144. Nystaform-hc

145. Aeroseb Hc

146. Caldecort Spray

147. Anusol Hc

148. Pediotic Suspension

149. Vosol Hc

150. Idrocortisone

151. 17alpha-hydroxycorticosterone

152. Hydrocortal

153. Hydroskin

154. Otalgine

155. Otobiotic

156. Plenadren

157. Protocort

158. Hysone

159. Racet

160. Ef Corlin

161. 11beta-hydrocortisone

162. Compound F

163. Lacticare Hc

164. Compound F (kendall)

165. 11-beta-hydrocortisone

166. 11-beta-hydroxycortisone

167. Hydrocortisone (cortisol)

168. Chronocort

169. Hydrocort

170. Preparation H Hydrocortisone Cream

171. Neo-cort-dome

172. 11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione

173. Otic-neo-cort-dome

174. 11beta,17,21-trihydroxypregn-4-ene-3,20-dione

175. Nsc 10483

176. Hc

177. [3h]cortisol

178. Nsc-10483

179. (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

180. Prestwick_265

181. (8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one

182. 4-pregnene-11beta,17alpha,21-triol-3,20-dione

183. Chebi:17650

184. 11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione

185. Nsc10483

186. 11.beta.-hydrocortisone

187. Dermaspray

188. Wi4x0x7bpj

189. 11beta,17,21-trihydroxyprogesterone

190. 11.beta.-hydroxycortisone

191. Ophthocort

192. Terra-cortril

193. Mls000069609

194. 17.alpha.-hydroxycorticosterone

195. Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-

196. Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-

197. 4-pregnen-11beta,17alpha,21-triol-3,20-dione

198. Idrocortisone [dcit]

199. Genacort (lotion)

200. Anucort

201. Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11b)-

202. Prepcort

203. Smr000059022

204. Dsstox_cid_714

205. Hydrocortisonum [inn-latin]

206. Proctozone Hc

207. Scalp-cort

208. Hidrocortisona [inn-spanish]

209. Rectasol-hc

210. Anucort-hc

211. Hydro-rx

212. Dsstox_rid_75753

213. Dsstox_gsid_20714

214. (8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3(2h)-one

215. Hc (hydrocortisone)

216. 11.beta.,17,21-trihydroxypregn-4-ene-3,20-dione

217. Corhydron

218. (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

219. Duocort

220. Hydrocortisone In Absorbase

221. Proctosol-hc

222. Hc #1

223. Hc #4

224. Acticort (tn)

225. Colocort (tn)

226. (1s,2r,10s,11s,14r,15s,17s)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

227. Smr000653523

228. Cortef (tn)

229. Hytone (tn)

230. Ccris 5854

231. Component Of Otalgine

232. Anusol Hc (tn)

233. Component Of Lubricort

234. Cor-oticin

235. Hsdb 3339

236. Einecs 200-020-1

237. Unii-wi4x0x7bpj

238. Mfcd00011654

239. Component Of Neo-cort-dome

240. Cortizol

241. Efmody

242. Ai3-25006

243. 3h-cortisol

244. 11beta-cortisol

245. Cas-50-23-7

246. 11-hydrocortisone

247. Plenadren (tn)

248. Ncgc00022848-06

249. 11b-hydrocortisone

250. Hydrocortisone [usp:inn:ban:jan]

251. Drotic (salt/mix)

252. 11b-hydroxycortisone

253. Otocort (salt/mix)

254. Pregn-4-ene-3,20-dione, 11beta,17,21-trihydroxy-

255. Otalgine (salt/mix)

256. Hydrocortisone, 98%

257. 11,17,21-trihydroxypregn-4-ene-3,20-dione

258. Alkindi Sprinkle

259. Alphaderm (salt/mix)

260. Hydrocortisone, Topical

261. Otobiotic (salt/mix)

262. 4p6x

263. Cort-quin (salt/mix)

264. Cortisporin (salt/mix)

265. Vosol Hc (salt/mix)

266. 11a-hydroxycorticosterone

267. 17a-hydroxycorticosterone

268. Opera_id_1292

269. Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11-beta)-

270. Prestwick0_000447

271. Prestwick1_000447

272. Prestwick2_000447

273. Prestwick3_000447

274. Epitope Id:174851

275. Upcmld-dp133

276. Ec 200-020-1

277. H 4001

278. Hydrocortisone [ii]

279. Hydrocortisone [mi]

280. Schembl4148

281. Neo-cort-dome (salt/mix)

282. Hydrocortisone [inn]

283. Hydrocortisone [jan]

284. Lopac0_000594

285. 11alpha-hydroxycorticosterone

286. Bspbio_000494

287. Hydrocortisone [hsdb]

288. Mls001148103

289. Mls002207135

290. Mls002222189

291. Mls002548868

292. Hydrocortisone [vandf]

293. Spbio_002433

294. Hydrocortisone [mart.]

295. Bpbio1_000544

296. Chembl389621

297. Gtpl2868

298. Hydrocortisone [usp-rs]

299. Hydrocortisone [who-dd]

300. Hydrocortisone [who-ip]

301. Pediotic Suspension (salt/mix)

302. Dtxsid7020714

303. Upcmld-dp133:001

304. Bdbm13775

305. Otic-neo-cort-dome (salt/mix)

306. 2v95

307. Hydrocortisone (jp17/usp/inn)

308. Hms1569i16

309. Hms2090m04

310. Hms2096i16

311. Hms2230b18

312. Hms2235f17

313. Hms3259c05

314. Hms3261h10

315. Hms3713i16

316. Hydrocortisone, >=98% (hplc)

317. Vioform-hydrocortisone (salt/mix)

318. 11b,17,21-trihydroxyprogesterone

319. Hydrocortisone [green Book]

320. Bcp09054

321. Hy-n0583

322. Hydrocortisone [orange Book]

323. Tox21_110883

324. Tox21_200815

325. Tox21_500594

326. Hydrocortisone [ep Monograph]

327. Lmst02030001

328. S1696

329. Zinc13540519

330. Hydrocortisone [usp Monograph]

331. Akos001582651

332. Hydrocortisonum [who-ip Latin]

333. Oticair Component Hydrocortisone

334. Otocort Component Hydrocortisone

335. Tox21_110883_1

336. Ccg-204683

337. Db00741

338. Lp00594

339. Nc00456

340. Sdccgsbi-0050576.p003

341. 11.beta.,17,21-trihydroxyprogesterone

342. Cipro Hc Component Hydrocortisone

343. Orlex Hc Component Hydrocortisone

344. Otobione Component Hydrocortisone

345. Pediotic Component Hydrocortisone

346. Pyocidin Component Hydrocortisone

347. Smp1_000156

348. Vosol Hc Component Hydrocortisone

349. Alphaderm Component Hydrocortisone

350. Ncgc00022848-07

351. Ncgc00022848-09

352. Ncgc00022848-10

353. Ncgc00022848-11

354. Ncgc00022848-12

355. Ncgc00022848-13

356. Ncgc00022848-14

357. Ncgc00022848-15

358. Ncgc00022848-17

359. Ncgc00022848-26

360. Ncgc00258369-01

361. Ncgc00261279-01

362. Otobiotic Component Hydrocortisone

363. (1s,10s,11s,15s,17s,2r,14r)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyl Tetracyclo[8.7.0.0<2,7>.0<11,15>]heptadec-6-en-5-one

364. (8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3h-cyclopenta[a]phenanthren-3-one

365. Ac-12902

366. As-11651

367. Bp-20390

368. Hydrocortisone 100 Microg/ml In Methanol

369. Hydrocortisone Component Of Oticair

370. Hydrocortisone Component Of Otocort

371. Nci60_000118

372. Acetasol Hc Component Hydrocortisone

373. Calmurid Hc Component Hydrocortisone

374. Hydrocortisone Component Of Otobione

375. Hydrocortisone Component Of Pediotic

376. Hydrocortisone Component Of Pyocidin

377. 4-pregnene-11alpha,21-triol 3,20-dione

378. Hydrocortisone Component Of Alphaderm

379. Hydrocortisone Component Of Cipro Hc

380. Hydrocortisone Component Of Orlex Hc

381. Hydrocortisone Component Of Otobiotic

382. Hydrocortisone Component Of Vosol Hc

383. B1951

384. Eu-0100594

385. Prednisolone Impurity A [ep Impurity]

386. 4-pregnene-11b,17a,21-triol-3,20-dione

387. Hydrocortisone 100 Microg/ml In Acetonitrile

388. Hydrocortisone Component Of Acetasol Hc

389. Hydrocortisone Component Of Calmurid Hc

390. 50h237

391. C00735

392. D00088

393. U 1851

394. Hydrocortisone, Meets Usp Testing Specifications

395. Pregn-4-ene-3, 11.beta.,17,21-trihydroxy-

396. 11?,17?,21-trihydroxypregn-4-ene-3,20-dione

397. A929789

398. Hydrocortisone, Vetranal(tm), Analytical Standard

399. Q190875

400. Sr-01000000139

401. Q-201211

402. Sr-01000000139-3

403. Brd-k93568044-001-03-1

404. Brd-k93568044-001-11-4

405. Brd-k93568044-001-32-0

406. Hydrocortisone Acetate Impurity A [ep Impurity]

407. Hydrocortisone, Bioreagent, Suitable For Cell Culture

408. 4-pregnen-11.beta.,17.alpha.,21-triol-3,20-dione

409. 4-pregnene-11.beta.,17.alpha.,21-triol-3,20-dione

410. Pregn-4-ene-3,20-dione, 11.beta.,17,21-trihydroxy-

411. Z2786051549

412. (11beta)-11,17,21-trihydroxy-pregn-4-ene-3,20-dione

413. 11.beta.,17.alpha.,21-trihydroxy-4-pregnene-3,20-dione

414. 11.beta.,17.alpha.,21-trihydroxypregn-4-ene-3,20-dione

415. B48448a1-24ba-47ca-8d9e-43e5bc949386

416. Hydrocortisone, British Pharmacopoeia (bp) Assay Standard

417. Pregn-4-ene-3, 11,17,21-trihydroxy-, (11.beta.)-

418. 11,17,21-trihydroxypregn-4-ene-3,20-dione, (11.beta.)-

419. Hydrocortisone Sodium Succinate Impurity A [ep Impurity]

420. Hydrocortisone, European Pharmacopoeia (ep) Reference Standard

421. Hydrocortisone Hydrogen Succinate Impurity A [ep Impurity]

422. Hydrocortisone, United States Pharmacopeia (usp) Reference Standard

423. Hydrocortisone-water Soluble, Bioreagent, Suitable For Cell Culture

424. Hydrocortisone, Gamma-irradiated, Powder, Bioxtra, Suitable For Cell Culture

425. 4-(6-chloro-4-oxoquinazolin-3(4h)-yl)-n-(3-methoxyphenyl)piperidine-1-carboxamide

426. Cortisol Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

427. Hydrocortisone For Peak Identification, European Pharmacopoeia (ep) Reference Standard

428. Hydrocortisone Solution, 50 Mum, Sterile-filtered, Bioxtra, Suitable For Cell Culture

429. Hydrocortisone, Pharmaceutical Secondary Standard; Certified Reference Material

430. (10r,13s,17r)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one

2.3.3 Other Synonyms

1. Efficort

2. Retef

3. Hydrocortisone Aceponate

4. Cortef Fluid

5. Hydrocortisone Cypionate

6. Hidroaltesona

7. Hydrocortone Phosphate

8. Hydrocortisone Phosphate

9. Hydrocortisone Sodium Phosphate

10. Aacicortisol

11. Hydrocortisone Hydrogen Succinate

12. Hydrocortisone Hemisuccinate Hydrate

13. Hydrocortisone Hemisuccinate

14. Hydrocortisone 21-hemisuccinate

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 362.5 g/mol
Molecular Formula C21H30O5
XLogP31.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass362.20932405 g/mol
Monoisotopic Mass362.20932405 g/mol
Topological Polar Surface Area94.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity684
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 36  
Drug NameAcetasol hc
PubMed HealthAcetic Acid/Hydrocortisone (Into the ear)
Drug ClassesAnti-Infective/Anti-Inflammatory Combination
Active IngredientAcetic acid, glacial; hydrocortisone
Dosage FormSolution/drops
RouteOtic
Strength1%; 2%
Market StatusPrescription
CompanyActavis Mid Atlantic

2 of 36  
Drug NameAla-cort
PubMed HealthHydrocortisone
Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
Active IngredientHydrocortisone
Dosage FormCream
RouteTopical
Strength1%
Market StatusPrescription
CompanyCrown Labs

3 of 36  
Drug NameAla-scalp
PubMed HealthHydrocortisone (On the skin)
Drug ClassesCorticosteroid, Intermediate, Corticosteroid, Weak
Active IngredientHydrocortisone
Dosage FormLotion
RouteTopical
Strength2%
Market StatusPrescription
CompanyCrown Labs

4 of 36  
Drug NameAnusol hc
PubMed HealthHydrocortisone (By mouth)
Drug ClassesAnti-Inflammatory, Endocrine-Metabolic Agent, Immune Suppressant
Active IngredientHydrocortisone
Dosage FormCream
RouteTopical
Strength2.5%
Market StatusPrescription
CompanySalix Pharms

5 of 36  
Drug NameColocort
PubMed HealthHydrocortisone Enema (Rectal)
Drug ClassesAnti-Inflammatory, Gastrointestinal Agent
Drug LabelHydrocortisone is a white to practically white, odorless, crystalline powder, very slightly soluble in water. It has the chemical name Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-,(11)- and the following structural formula:Colocort is a convenien...
Active IngredientHydrocortisone
Dosage FormEnema
RouteRectal
Strength100mg/60ml
Market StatusPrescription
CompanyPaddock

6 of 36  
Drug NameCortef
PubMed HealthHydrocortisone (Rectal)
Drug ClassesAnti-Inflammatory, Hemorrhoidal Anti-Inflammatory
Drug LabelCORTEF Tablets contain hydrocortisone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Hydrocortisone USP is white to practical...
Active IngredientHydrocortisone
Dosage FormTablet
RouteOral
Strength5mg; 10mg; 20mg
Market StatusPrescription
CompanyPharmacia And Upjohn

7 of 36  
Drug NameCortenema
PubMed HealthNeomycin, Polymyxin B, and Hydrocortisone
Drug ClassesAdrenal Glucocorticoid, Aminoglycoside/Corticosteroid Combination, Anti-Infective/Anti-Inflammatory Combination, Neomycin
Drug LabelHydrocortisone is a white to practically white, odorless, crystalline powder, very slightly soluble in water. It has the chemical name Pregn-4-ene-3,20-dione,11,17,21-trihydroxy,(11)-and the following structural formula: CORTENEMA is a convenient...
Active IngredientHydrocortisone
Dosage FormEnema
RouteRectal
Strength100mg/60ml
Market StatusPrescription
CompanyAni Pharms

8 of 36  
Drug NameCortifoam
PubMed HealthHydrocortisone
Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
Active IngredientHydrocortisone acetate
Dosage FormAerosol, metered
RouteRectal
Strength10%
Market StatusPrescription
CompanyMeda Pharms

9 of 36  
Drug NameCortisporin
PubMed HealthHydrocortisone
Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
Active IngredientHydrocortisone acetate; polymyxin b sulfate; Hydrocortisone; Bacitracin zinc; hydrocortisone; neomycin sulfate
Dosage FormSolution/drops; Suspension/drops; Ointment; Cream
RouteTopical; Otic
Strength400 units/gm; 10,000 units/gm; 0.5%; 10,000 units/ml; 1%; eq 3.5mg base/ml; eq 3.5mg base/gm; 5,000 units/gm
Market StatusPrescription
CompanyMonarch Pharms; Citron Pharma

10 of 36  
Drug NameHydrocortisone
Active IngredientHydrocortisone
Dosage FormOintment; Enema; Tablet; Cream; Lotion
RouteRectal; Oral; Topical
Strength1%; 5mg; 10mg; 2.5%; 100mg/60ml; 20mg
Market StatusPrescription
CompanyVintage Pharms; Amedra Pharms; Taro; Fougera; Lyne; Fougera Pharms; Teva Pharms; Actavis Mid Atlantic; Vintage; Perrigo New York

11 of 36  
Drug NameHydrocortisone and acetic acid
Drug LabelTopical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Texacort Topical Solution contains hydrocortisone as the active corticosteroid, having the chemical formula of Pregn-4-ene-3...
Active IngredientAcetic acid, glacial; hydrocortisone
Dosage FormSolution/drops
RouteOtic
Strength1%; 2%
Market StatusPrescription
CompanyTaro; Vintage

12 of 36  
Drug NameHydrocortisone in absorbase
Active IngredientHydrocortisone
Dosage FormOintment
RouteTopical
Strength1%
Market StatusPrescription
CompanyCarolina Medcl

13 of 36  
Drug NameHydro-rx
PubMed HealthAcetic Acid/Hydrocortisone (Into the ear)
Drug ClassesAnti-Infective/Anti-Inflammatory Combination
Drug LabelGlucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.Hydrocortisone is a white to practically white, odorless, crystalline powder, very slightly soluble in wat...
Active IngredientHydrocortisone
Dosage FormPowder
RouteFor rx compounding
Strength100%
Market StatusPrescription
CompanyX Gen Pharms

14 of 36  
Drug NameNutracort
Active IngredientHydrocortisone
Dosage FormLotion
RouteTopical
Strength2.5%
Market StatusPrescription
CompanyDow Pharm

15 of 36  
Drug NameStie-cort
Active IngredientHydrocortisone
Dosage FormLotion
RouteTopical
Strength2.5%
Market StatusPrescription
CompanyPerrigo

16 of 36  
Drug NameSynacort
Active IngredientHydrocortisone
Dosage FormCream
RouteTopical
Strength1%; 2.5%
Market StatusPrescription
CompanyMedicis

17 of 36  
Drug NameTexacort
Active IngredientHydrocortisone
Dosage FormSolution
RouteTopical
Strength2.5%
Market StatusPrescription
CompanyMission Pharma

18 of 36  
Drug NameVosol hc
Active IngredientAcetic acid, glacial; hydrocortisone
Dosage FormSolution/drops
RouteOtic
Strength1%; 2%
Market StatusPrescription
CompanyHi Tech Pharma

19 of 36  
Drug NameAcetasol hc
PubMed HealthAcetic Acid/Hydrocortisone (Into the ear)
Drug ClassesAnti-Infective/Anti-Inflammatory Combination
Active IngredientAcetic acid, glacial; hydrocortisone
Dosage FormSolution/drops
RouteOtic
Strength1%; 2%
Market StatusPrescription
CompanyActavis Mid Atlantic

20 of 36  
Drug NameAla-cort
PubMed HealthHydrocortisone
Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
Active IngredientHydrocortisone
Dosage FormCream
RouteTopical
Strength1%
Market StatusPrescription
CompanyCrown Labs

21 of 36  
Drug NameAla-scalp
PubMed HealthHydrocortisone (On the skin)
Drug ClassesCorticosteroid, Intermediate, Corticosteroid, Weak
Active IngredientHydrocortisone
Dosage FormLotion
RouteTopical
Strength2%
Market StatusPrescription
CompanyCrown Labs

22 of 36  
Drug NameAnusol hc
PubMed HealthHydrocortisone (By mouth)
Drug ClassesAnti-Inflammatory, Endocrine-Metabolic Agent, Immune Suppressant
Active IngredientHydrocortisone
Dosage FormCream
RouteTopical
Strength2.5%
Market StatusPrescription
CompanySalix Pharms

23 of 36  
Drug NameColocort
PubMed HealthHydrocortisone Enema (Rectal)
Drug ClassesAnti-Inflammatory, Gastrointestinal Agent
Drug LabelHydrocortisone is a white to practically white, odorless, crystalline powder, very slightly soluble in water. It has the chemical name Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-,(11)- and the following structural formula:Colocort is a convenien...
Active IngredientHydrocortisone
Dosage FormEnema
RouteRectal
Strength100mg/60ml
Market StatusPrescription
CompanyPaddock

24 of 36  
Drug NameCortef
PubMed HealthHydrocortisone (Rectal)
Drug ClassesAnti-Inflammatory, Hemorrhoidal Anti-Inflammatory
Drug LabelCORTEF Tablets contain hydrocortisone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Hydrocortisone USP is white to practical...
Active IngredientHydrocortisone
Dosage FormTablet
RouteOral
Strength5mg; 10mg; 20mg
Market StatusPrescription
CompanyPharmacia And Upjohn

25 of 36  
Drug NameCortenema
PubMed HealthNeomycin, Polymyxin B, and Hydrocortisone
Drug ClassesAdrenal Glucocorticoid, Aminoglycoside/Corticosteroid Combination, Anti-Infective/Anti-Inflammatory Combination, Neomycin
Drug LabelHydrocortisone is a white to practically white, odorless, crystalline powder, very slightly soluble in water. It has the chemical name Pregn-4-ene-3,20-dione,11,17,21-trihydroxy,(11)-and the following structural formula: CORTENEMA is a convenient...
Active IngredientHydrocortisone
Dosage FormEnema
RouteRectal
Strength100mg/60ml
Market StatusPrescription
CompanyAni Pharms

26 of 36  
Drug NameCortifoam
PubMed HealthHydrocortisone
Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
Active IngredientHydrocortisone acetate
Dosage FormAerosol, metered
RouteRectal
Strength10%
Market StatusPrescription
CompanyMeda Pharms

27 of 36  
Drug NameCortisporin
PubMed HealthHydrocortisone
Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
Active IngredientHydrocortisone acetate; polymyxin b sulfate; Hydrocortisone; Bacitracin zinc; hydrocortisone; neomycin sulfate
Dosage FormSolution/drops; Suspension/drops; Ointment; Cream
RouteTopical; Otic
Strength400 units/gm; 10,000 units/gm; 0.5%; 10,000 units/ml; 1%; eq 3.5mg base/ml; eq 3.5mg base/gm; 5,000 units/gm
Market StatusPrescription
CompanyMonarch Pharms; Citron Pharma

28 of 36  
Drug NameHydrocortisone
Active IngredientHydrocortisone
Dosage FormOintment; Enema; Tablet; Cream; Lotion
RouteRectal; Oral; Topical
Strength1%; 5mg; 10mg; 2.5%; 100mg/60ml; 20mg
Market StatusPrescription
CompanyVintage Pharms; Amedra Pharms; Taro; Fougera; Lyne; Fougera Pharms; Teva Pharms; Actavis Mid Atlantic; Vintage; Perrigo New York

29 of 36  
Drug NameHydrocortisone and acetic acid
Drug LabelTopical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Texacort Topical Solution contains hydrocortisone as the active corticosteroid, having the chemical formula of Pregn-4-ene-3...
Active IngredientAcetic acid, glacial; hydrocortisone
Dosage FormSolution/drops
RouteOtic
Strength1%; 2%
Market StatusPrescription
CompanyTaro; Vintage

30 of 36  
Drug NameHydrocortisone in absorbase
Active IngredientHydrocortisone
Dosage FormOintment
RouteTopical
Strength1%
Market StatusPrescription
CompanyCarolina Medcl

31 of 36  
Drug NameHydro-rx
PubMed HealthAcetic Acid/Hydrocortisone (Into the ear)
Drug ClassesAnti-Infective/Anti-Inflammatory Combination
Drug LabelGlucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.Hydrocortisone is a white to practically white, odorless, crystalline powder, very slightly soluble in wat...
Active IngredientHydrocortisone
Dosage FormPowder
RouteFor rx compounding
Strength100%
Market StatusPrescription
CompanyX Gen Pharms

32 of 36  
Drug NameNutracort
Active IngredientHydrocortisone
Dosage FormLotion
RouteTopical
Strength2.5%
Market StatusPrescription
CompanyDow Pharm

33 of 36  
Drug NameStie-cort
Active IngredientHydrocortisone
Dosage FormLotion
RouteTopical
Strength2.5%
Market StatusPrescription
CompanyPerrigo

34 of 36  
Drug NameSynacort
Active IngredientHydrocortisone
Dosage FormCream
RouteTopical
Strength1%; 2.5%
Market StatusPrescription
CompanyMedicis

35 of 36  
Drug NameTexacort
Active IngredientHydrocortisone
Dosage FormSolution
RouteTopical
Strength2.5%
Market StatusPrescription
CompanyMission Pharma

36 of 36  
Drug NameVosol hc
Active IngredientAcetic acid, glacial; hydrocortisone
Dosage FormSolution/drops
RouteOtic
Strength1%; 2%
Market StatusPrescription
CompanyHi Tech Pharma

4.2 Therapeutic Uses

Anti-Inflammatory Agents, Steroidal

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


MEDICATION (VET): Acute urticaria /can be treated by/ rapid-acting adrenocorticosteroids, eg, hydrocortisone ... .

Kahn, C.M. (Ed.); The Merck Veterinary Manual 9th ed. Merck & Co. Whitehouse Station, NJ. 2005, p. 690


MEDICATION (VET): /USED/ IV, IN PREVENTING OR TREATING ADRENAL FAILURE & SHOCK-LIKE CONDITIONS IN SURGICAL CASES WHICH HAVE BEEN ON CORTICOSTEROIDS, IN ACUTE ALLERGIC REACTIONS...IN POOR SURGICAL RISKS, & IN CASES WHICH HAVE HAD OVERWHELMING SYSTEMIC INFECTIONS...IN DOGS OR CATTLE...

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 266


MEDICATION (VET) /EXPL:/: 5 Standardbreds and 4 Dutch Warmblood horses /were/ used to examine sensitivity of peripheral tissues to exogenous insulin 24 hours after administration of a single dose of hydrocortisone (0.06 mg/kg), eGH (20 ug/kg), or saline (0.9% NaCl) solution and after long-term administration (11 to 15 days) of eGH to horses. The amounts of metabolized glucose (M) and plasma insulin concentration (I) were determined. Values for M and the M-to-I ratio were significantly higher 24 hours after administration of a single dose of hydrocortisone than after single-dose administration of eGH or saline solution. After long-term administration of eGH, basal I concentration was increased and the mean M-to-I ratio was 22% lower, compared with values for horses treated with saline solution. Increases in M and the M-to-I ratio after a single dose of hydrocortisone imply that short-term hydrocortisone treatment increases glucose use by, and insulin sensitivity of, peripheral tissues. Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.

PMID:6334949 de Graaf-Roelfsema E et al; Am J Vet Res 66 (11): 1907-13 (2005)


For more Therapeutic Uses (Complete) data for HYDROCORTISONE (23 total), please visit the HSDB record page.


4.3 Drug Warning

It is not known whether rectal corticosteroids are distributed into breast milk. Systemic corticosteroids are distributed into breast milk and may cause unwanted effects, such as growth suppression, in the infant. Rectal corticosteroids are not recommended for use by breast-feeding mothers. /Corticosteroids, rectal/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 913


The results of a prospective randomized controlled trial, which looked at the incidence of postoperative diabetes insipidus following the use of three different hydrocortisone protocols, and the results of a study, on the incidence of diabetes insipidus and cortisol response in patients not given hydrocortisone /was reported/. In study 1, 114 patients with pituitary macroadenoma were randomized into three groups: conventional dose (injected hydrocortisone 100 mg IV 6-hourly for 3 days); intermediate dose (injected hydrocortisone 100 mg IV 6-hourly on day 1, 100 mg IV 8-hourly on day 2, and 100 mg IV 12-hourly on day 3); low dose protocol (injected hydrocortisone 25 mg IV 6-hourly on day 1, 25 mg IV 8-hourly on day 2 and 25 mg IV 12-hourly on day 3). Radical excision was achieved in 92 patients. The incidence of diabetes insipidus with the conventional dose was 52%, intermediate dose, 36% and low dose, 24% (p = 0.025). Study 2 included 16 consecutive patients with Hardy's grade A & B pituitary adenoma. These patients were randomized to receive (Group I) or not receive (Group II) hydrocortisone. Patients in Group II demonstrated normal cortisol response intraoperatively and no patient developed features of hypocortisolism; the incidence of diabetes insipidus in this group was 14%. The low dose hydrocortisone protocol reduced the incidence of diabetes insipidus by 46% when compared with the conventional dose hydrocortisone protocol. In patients with grade A and B tumor with normal preoperative cortisol levels, the use of perioperative hydrocortisone can be avoided.

PMID:14635749 Rajaratnam S et al; Br J Neurosurg 17 (5): 437-42 (2003)


ACUTE ADRENAL INSUFFICIENCY RESULTS FROM TOO RAPID WITHDRAWAL OF CORTICOSTEROID THERAPY. /CORTICOSTEROIDS/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1496


POTENTIAL ADVERSE EFFECTS ON FETUS: Cleft palate, spontaneous abortions, and intrauterine growth retardation in animals. Potential for cleft palate formation and adrenal suppression in humans, although teratogenic effects have not been confirmed. POTENTIAL SIDE EFFECTS ON BREAST-FED INFANT: Passes into breast milk in small amounts. Administration of physiologic doses unlikely to adversely affect infant. FDA Category: C (C = Studies in laboratory animals have revealed adverse effects on the fetus (teratogenic, embryocidal, etc.) but there are no controlled studies in pregnant women. The benefits from use of the drug in pregnant women may be acceptable despite its potential risks, or there are no laboratory animal studies or adequate studies in pregnant women.) /Adrenocorticosteroids/ /from table II/

PMID:2195076 Stockton DL, Palle AS; J Am Acad Dermatol 23 (1): 87-103 (1990)


For more Drug Warnings (Complete) data for HYDROCORTISONE (31 total), please visit the HSDB record page.


4.4 Drug Indication

Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated for ulcerative colitis, a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections, and a topical cream with [acyclovir] is indicated to treat cold sores. Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.


FDA Label


Replacement therapy of adrenal insufficiency in infants, children and adolescents (from birth to < 18 years old).


Treatment of adrenal insufficiency in adults.


Treatment of adrenocortical insufficiency


Treatment of congenital adrenal hyperplasia (CAH) in adolescents aged 12 years and over and adults.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Hydrocortisone binds to the glucocorticoid receptor leading to downstream effects such as inhibition of phospholipase A2, NF-kappa B, other inflammatory transcription factors, and the promotion of anti-inflammatory genes. Hydrocortisone has a wide therapeutic index and a moderate duration of action. Patients should stop taking the medication if irritation or sensitization occurs.


5.2 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
HYDROCORTISONE
5.3.2 FDA UNII
WI4X0X7BPJ
5.3.3 Pharmacological Classes
Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]
5.4 ATC Code

H02AB09


H02AB09


H02AB09


D07AA02

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


A - Alimentary tract and metabolism

A01 - Stomatological preparations

A01A - Stomatological preparations

A01AC - Corticosteroids for local oral treatment

A01AC03 - Hydrocortisone


A - Alimentary tract and metabolism

A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents

A07E - Intestinal antiinflammatory agents

A07EA - Corticosteroids acting locally

A07EA02 - Hydrocortisone


C - Cardiovascular system

C05 - Vasoprotectives

C05A - Agents for treatment of hemorrhoids and anal fissures for topical use

C05AA - Corticosteroids

C05AA01 - Hydrocortisone


D - Dermatologicals

D07 - Corticosteroids, dermatological preparations

D07A - Corticosteroids, plain

D07AA - Corticosteroids, weak (group i)

D07AA02 - Hydrocortisone


D - Dermatologicals

D07 - Corticosteroids, dermatological preparations

D07X - Corticosteroids, other combinations

D07XA - Corticosteroids, weak, other combinations

D07XA01 - Hydrocortisone


H - Systemic hormonal preparations, excl. sex hormones and insulins

H02 - Corticosteroids for systemic use

H02A - Corticosteroids for systemic use, plain

H02AB - Glucocorticoids

H02AB09 - Hydrocortisone


S - Sensory organs

S01 - Ophthalmologicals

S01B - Antiinflammatory agents

S01BA - Corticosteroids, plain

S01BA02 - Hydrocortisone


S - Sensory organs

S01 - Ophthalmologicals

S01C - Antiinflammatory agents and antiinfectives in combination

S01CB - Corticosteroids/antiinfectives/mydriatics in combination

S01CB03 - Hydrocortisone


S - Sensory organs

S02 - Otologicals

S02B - Corticosteroids

S02BA - Corticosteroids

S02BA01 - Hydrocortisone


5.5 Absorption, Distribution and Excretion

Absorption

Oral hydrocortisone at a dose of 0.2-0.3mg/kg/day reached a mean Cmax of 32.69nmol/L with a mean AUC of 90.63h\*nmol/L A 0.4-0.6mg/kg/day dose reached a mean Cmax of 70.81nmol/L with a mean AUC of 199.11h\*nmol/L. However, the pharmacokinetics of hydrocortisone can vary by 10 times from patient to patient. Topical hydrocortisone cream is 4-19% bioavailable[8546995] with a Tmax of 24h. Hydrocortisone retention enemas are have a bioavailability of 0.810 for slow absorbers and 0.502 in rapid absorbers. Slow absorbers take up hydrocortisone at a rate of 0.3610.255/h while fast absorbers take up hydrocortisone at a rate of 1.050.255/h. A 20mg IV dose of hydrocortisone has an AUC of 1163277ng\*h/mL.


Route of Elimination

Corticosteroids are eliminated predominantly in the urine. However, data regarding the exact proportion is not readily available.


Volume of Distribution

Total hydrocortisone has a volume of distribution of 39.82L, while the free fraction has a volume of distribution of 474.38L.


Clearance

Total hydrocortisone by the oral route has a mean clearance of 12.85L/h, while the free fraction has a mean clearance of 235.78L/h. A 20mg IV dose of hydrocortisone has a clearance of 18.24.2L/h.


Following percutaneous penetration of a topical corticosteroid, the drug that is systemically absorbed probably follows the metabolic pathways of systemically administered corticosteroids. Corticosteroids usually are metabolized in the liver and excreted by the kidneys. Some topical corticosteroids and their metabolites are excreted in bile. /Topical corticosteroids/

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 3525


Topical application of corticosteroids to the mucosa of the genitourinary or lower intestinal tract may result in substantial systemic absorption of the drugs. In healthy individuals, as much as 30-90% of rectally administered hydrocortisone as a retention enema may be absorbed. Greater amounts of hydrocortisone may be absorbed rectally if the intestinal mucosa is inflamed.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 3525


Following topical application of a corticosteroid to most areas of normal skin, only minimal amounts of the drug reach the dermis and subsequently the systemic circulation; however, absorption is markedly increased when the skin has lost its keratin layer and can be increased by inflammation and/or diseases of the epidermal barrier (e.g., psoriasis, eczema). The drugs are absorbed to a greater degree from the scrotum, axilla, eyelid, face, and scalp than from the forearm, knee, elbow, palm, and sole. Even after washing the area being treated, prolonged absorption of the corticosteroid occurs, possibly because the drug is retained in the stratum corneum. /Topical corticosteroids/

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 3525


Percutaneous penetration of corticosteroids varies among individual patients and can be increased by the use of occlusive dressings, by increasing the concentration of the corticosteroid, and by using different vehicles. The use of an occlusive dressing with hydrocortisone for 96 hours substantially enhances percutaneous penetration of the drug; however, such use for up to 24 hours does not appear to alter penetration of topically applied hydrocortisone.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 3525


For more Absorption, Distribution and Excretion (Complete) data for HYDROCORTISONE (15 total), please visit the HSDB record page.


5.6 Metabolism/Metabolites

Hydrocortisone is metabolised to 6-beta hydrocortisol via CYP3A, 5-beta tetrahydrocortisol via 3-oxo-5-beta-steroid 4-dehydrogenase, 5-alpha tetrahydrocortisol via 3-oxo-5-alpha-steroid 4-dehydrogenase 2, cortisone via Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticosteroid 11-beta-dehydrogenase isozyme 2, and glucuronide products. Cortisone is further metabolized to tetrahydrocortisone and dihydrocortisol.


A study was made of the absorption of exogenous hydrocortisone and formation of its metabolites in isolated liver of intact and exposed rats in conditions of recirculating perfusion. It was shown that the absorption of the hormone by the liver of irradiated rats was greatly lowered but the content of most metabolites found in the perfused medium of irradiated liver increased as compared to the control. It is suggested that irradiation inhibits subsequent transformations of the hydrocortisone metabolism products.

PMID:4001319 Litskevich LA, Dokshina GA; Radiobiologiia 25 (2): 200-3 (1985)


Subcellular distribution of (3)H-hydrocortisone and its metabolites in the liver and kidney of intact and alloxan diabetic rats was investigated. Ten minutes after the administration of this hormone several metabolites (mostly tetrahydrocortisol) and the native hormone were found in liver cytosol, microsomes, mitochondria and nuclei, the relative content of individual compounds in various subcellular fractions being different. In liver mitochondria, microsomes and nuclei of alloxan diabetic rats the concentration of tetrahydrocortisol was decreased, while that of native hormone was increased as compared to normal animals. It was suggested that such changes found in diabetic animals may be one of the causes of increased sensitivity of transcription and translation processes to glucocorticoids. In kidney cytosol and microsomes of intact rats cortisone and tetrahydrocortisol were found. In diabetic animals, however, the concentration of tetrahydrocortisol increased, while that of cortisone was undetectable.

PMID:3259502 Minchenko AG, Tronjko ND; Endocrinol Exp 22 (1): 19-28 (1988)


5.7 Biological Half-Life

Total hydrocortisone via the oral route has a half life of 2.15h while the free fraction has a half life of 1.39h. A 20mg IV dose of hydrocortisone has a terminal half life of 1.90.4h.


... After IV administration, hydrocortisone was eliminated with a total body clearance of 18 L/hr and a half-life of 1.7 hr.

PMID:2050835 Derendorf H et al; J Clin Pharmacol 31 (5): 473-6 (1991)


5.8 Mechanism of Action

The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days. Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.


Following topical application, corticosteroids produce anti-inflammatory, antipruritic, and vasoconstrictor actions. The activity of the drugs is thought to result at least in part from binding with a steroid receptor. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation; and possibly by other mechanisms as yet unknown. Corticosteroids, especially the fluorinated corticosteroids, have antimitotic activity on cutaneous fibroblasts and the epidermis. /Corticosteroids/

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 3525


Reactive oxygen species (ROS) generation by polymorphonuclear leukocytes (PMNL) and mononuclear cells (MNC) is inhibited following the intravenous administration of hydrocortisone. This is associated with a parallel decrease in intranuclear NFkappaB, known to modulate inflammatory responses including ROS generation. Plasma levels of interleukin-10 (IL-10), an anti-inflammatory and immunosuppressive cytokine produced by TH2 cells, are also increased after hydrocortisone administration. In this study, we have investigated the effect of hydrocortisone on p47(phox) subunit, a key component of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, in MNC and the pharmacodynamics of this effect with ROS generation and plasma IL-10 levels /were investigated/. p47(phox) subunit protein levels in MNC showed a progressive decrease after hydrocortisone administration. It reached a nadir at 4 hours and increased thereafter to a baseline level at 24 hours. ROS generation also decreased, reached a nadir between 2 and 4 hours, and returned to a baseline level at 24 hours. IL-10 concentrations increased, peaked at 4 hours, and reverted to the baseline levels at 24 hours. In conclusion, p47(phox) subunit suppression may contribute to the inhibition of ROS generation in MNC after hydrocortisone administration. This suppression occurs in parallel with the suppression of NFkappaB and an increase in IL-10 plasma levels. Therefore, it would appear that the decrease in intranuclear NFkappaB and an increase in IL-10 may cause the inhibitory modulation on p47(phox) subunit and ROS generation by MNC following hydrocortisone and other glucocorticoids.

PMID:11319715 Dandona P et al; Metabolism 50 (5): 548-52 (2001)


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EUROAPI

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
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  • WHO-GMP

Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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USDMF CEP/COS arrow-down JDMF arrow-down EU-WC NDC arrow-down KDMF arrow-down VMF ROW arrow-down AUDIT
EUROAPI Compnay Banner

02

Pfizer CentreOne

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPfizer CentreOne is a global CDMO and a leading supplier of Specialty APIs.

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Digital Content Digital Content
USDMF arrow-down CEP/COS arrow-down JDMF arrow-down EU-WC NDC KDMF VMF Others AUDIT
Pfizer centreOne

03

Symbiotec Pharmalab

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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Digital Content Digital Content
USDMF CEP/COS JDMF EU-WCarrow-down NDC arrow-down KDMF VMF Others AUDIT
Symbiotec Pharmalab

04

Axplora

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAxplora- The partner of choice for complex APIs.

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Digital Content Digital Content
USDMF arrow-down CEP/COS JDMF EU-WC NDC KDMF VMF EU arrow-down AUDIT
Axplora CB

05

Sanofi

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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euroPLX 86 Munich
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Digital Content Digital Content
USDMF Inactive-api CEP/COS JDMF EU-WC NDC arrow-down KDMF VMF Others AUDIT
Sanofi Company Banner

06

Rochem International Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Suppliers Night Expo
Not Confirmed
  • fda
  • EDQM
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Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Rochem

07

Gonane Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothGonane has API manufacturing expertise in new-age Corticosteroids, Hormones and other pharma raw materials.

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Digital Content Digital Content
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Gonane Pharma

08

Pharm-RX Chemical

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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euroPLX 86 Munich
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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Digital Content Digital Content
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Pharm RX

09

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothHRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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Digital Content Digital Content
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF AU arrow-down AUDIT
HRV Global Life Sciences

10

Bioquim

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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euroPLX 86 Munich
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothBioquim: An European GMP-certified company manufacturing bulk APIs, specializing in sterile lyophilization and chemical synthesis.

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Digital Content Digital Content
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Bioquim
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USDMF

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Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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GDUFA

DMF Review : Complete

Rev. Date : 2016-08-04

Pay. Date : 2016-04-08

DMF Number : 30373

Submission : 2016-03-03

Status : Active

Type : II

EUROAPI Compnay Banner

02

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Digital Content Digital Content

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 2789

Submission : 1976-11-11

Status : Active

Type : II

EUROAPI Compnay Banner

03

  • fda
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Virtual BoothPfizer CentreOne is a global CDMO and a leading supplier of Specialty APIs.

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Digital Content Digital Content

GDUFA

DMF Review : Complete

Rev. Date : 2013-02-26

Pay. Date : 2013-02-13

DMF Number : 1413

Submission : 1969-09-02

Status : Active

Type : II

Pfizer centreOne

04

  • fda
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  • WHO-GMP

Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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Digital Content Digital Content

GDUFA

DMF Review : Complete

Rev. Date : 2016-02-09

Pay. Date : 2015-06-09

DMF Number : 29221

Submission : 2015-03-30

Status : Active

Type : II

Symbiotec Pharmalab

05

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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Digital Content Digital Content

GDUFA

DMF Review : Complete

Rev. Date : 2019-12-27

Pay. Date : 2019-12-03

DMF Number : 31349

Submission : 2017-01-12

Status : Active

Type : II

Symbiotec Pharmalab

06

Farmabios Spa

Germany
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Virtual BoothAxplora- The partner of choice for complex APIs.

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 37639

Submission : 2023-01-24

Status : Active

Type : II

Axplora CB

07

Compamed
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 7416

Submission : 1988-04-04

Status : Inactive

Type : II

Sanofi Company Banner

08

Diosynth Inc

United Kingdom

USDMF

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Compamed
Not Confirmed

08

Diosynth Inc

United Kingdom
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Compamed
Not Confirmed

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 3917

Submission : 1980-07-17

Status : Inactive

Type : II

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CEP/COS

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Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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R0-CEP 2019-166 - Rev 01
Valid
Chemical
2021-12-16
335
EUROAPI Compnay Banner

01

  • fda
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  • WHO-GMP

Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Digital Content Digital Content

Certificate Number : R0-CEP 2019-166 - Rev 01

Status : Valid

Issue Date : 2021-12-16

Type : Chemical

Substance Number : 335

EUROAPI Compnay Banner
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Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Digital Content Digital Content
R1-CEP 1996-052 - Rev 07
Valid
Chemical
2021-12-16
335
EUROAPI Compnay Banner

02

  • fda
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  • WHO-GMP

Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Digital Content Digital Content

Certificate Number : R1-CEP 1996-052 - Rev 07

Status : Valid

Issue Date : 2021-12-16

Type : Chemical

Substance Number : 335

EUROAPI Compnay Banner
  • fda
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  • WHO-GMP

Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Digital Content Digital Content
R1-CEP 2012-163 - Rev 01
Valid
Chemical
2021-12-16
335
EUROAPI Compnay Banner

03

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Digital Content Digital Content

Certificate Number : R1-CEP 2012-163 - Rev 01

Status : Valid

Issue Date : 2021-12-16

Type : Chemical

Substance Number : 335

EUROAPI Compnay Banner
  • fda
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Virtual BoothPfizer CentreOne is a global CDMO and a leading supplier of Specialty APIs.

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Digital Content Digital Content
R1-CEP 2002-220 - Rev 02
Valid
Chemical
2023-03-23
335
Pfizer centreOne

04

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Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPfizer CentreOne is a global CDMO and a leading supplier of Specialty APIs.

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Digital Content Digital Content

Certificate Number : R1-CEP 2002-220 - Rev 02

Status : Valid

Issue Date : 2023-03-23

Type : Chemical

Substance Number : 335

Pfizer centreOne
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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Digital Content Digital Content
CEP 2018-054 - Rev 02
Valid
Chemical
2024-04-15
335
Symbiotec Pharmalab

05

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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Digital Content Digital Content

Certificate Number : CEP 2018-054 - Rev 02

Status : Valid

Issue Date : 2024-04-15

Type : Chemical

Substance Number : 335

Symbiotec Pharmalab

06

BioFlorida Conference
Not Confirmed
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BioFlorida Conference
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Certificate Number : R1-CEP 2000-099 - Rev 02

Status : Valid

Issue Date : 2017-03-01

Type : Chemical

Substance Number : 335

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07

BioFlorida Conference
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BioFlorida Conference
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Certificate Number : R0-CEP 2022-264 - Rev 00

Status : Valid

Issue Date : 2023-08-22

Type : Chemical

Substance Number : 335

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08

BioFlorida Conference
Not Confirmed
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BioFlorida Conference
Not Confirmed

Certificate Number : R0-CEP 2000-354 - Rev 00

Status : Withdrawn by Holder

Issue Date : 2001-10-24

Type : TSE

Substance Number : 335

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09

BioFlorida Conference
Not Confirmed
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BioFlorida Conference
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Certificate Number : R0-CEP 2019-176 - Rev 00

Status : Valid

Issue Date : 2021-10-06

Type : Chemical

Substance Number : 335

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10

BioFlorida Conference
Not Confirmed
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JDMF

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01

  • fda
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Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Hydrocortisone sodium phosphate

Registration Number : 220MF10093

Registrant's Address : 15 rue Traversie(')re 75012 Paris France

Initial Date of Registration : 2008-03-28

Latest Date of Registration : 2022-06-22

EUROAPI Compnay Banner

02

  • fda
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Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Digital Content Digital Content

Hydrocortisone

Registration Number : 218MF10377

Registrant's Address : 15 rue Traversie(')re 75012 Paris France

Initial Date of Registration : 2006-03-20

Latest Date of Registration : 2019-11-27

EUROAPI Compnay Banner

03

  • fda
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  • WHO-GMP

Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Hydrocortisone

Registration Number : 228MF10090

Registrant's Address : 15 rue Traversie(')re 75012 Paris France

Initial Date of Registration : 2016-04-15

Latest Date of Registration : 2021-03-05

EUROAPI Compnay Banner

04

Pfizer Inc.

U.S.A
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Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPfizer CentreOne is a global CDMO and a leading supplier of Specialty APIs.

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Digital Content Digital Content

Hydrocortisone

Registration Number : 222MF10138

Registrant's Address : 235 East 42nd Street, New York, NY 10017

Initial Date of Registration : 2010-04-14

Latest Date of Registration : 2023-03-23

Pfizer centreOne

05

BioFlorida Conference
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Hydrocortisone Sodium Phosphate

Registration Number : 217MF10680

Registrant's Address : Parque Tecnologico-Parcela 105 Boecillo (Valladolid) Spain

Initial Date of Registration : 2005-10-07

Latest Date of Registration : 2015-09-03

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06

BioFlorida Conference
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BioFlorida Conference
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Hydrocortisone

Registration Number : 226MF10036

Registrant's Address : Middle of Huanghe Street, Anyang Hi-Tech Industry Development Zone, Henan, China

Initial Date of Registration : 2014-02-05

Latest Date of Registration : 2017-08-08

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EU WC

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01

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Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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Digital Content Digital Content

Hydrocortisone Hydrogen Succinate EP

Date of Issue : 2022-09-30

Valid Till : 2025-07-02

Written Confirmation Number : WC-0161

Address of the Firm : 385/2, Pigdamber, Rau, Indore-453 331, MP, India

Symbiotec Pharmalab

02

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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Digital Content Digital Content

Hydrocortisone Hemisuccinate BP/USP

Date of Issue : 2022-07-05

Valid Till : 2025-07-02

Written Confirmation Number : WC-0161A2

Address of the Firm : 385/2, Pigdamber, Rau, Indore-453 331, MP, India

Symbiotec Pharmalab

03

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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Digital Content Digital Content

Hydrocortisone BP/EP/USP

Date of Issue : 2022-07-05

Valid Till : 2025-07-02

Written Confirmation Number : WC-0161A2

Address of the Firm : 385/2, Pigdamber, Rau, Indore-453 331, MP, India

Symbiotec Pharmalab

04

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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Digital Content Digital Content

Hydrocortisone USP/EP/BP

Date of Issue : 2022-08-31

Valid Till : 2025-07-02

Written Confirmation Number : WC-0162

Address of the Firm : Plot No. 5, 6, 7 & 8 Special Economic Zone, Phase II, Pithampur, Dist: Dhar, MP-...

Symbiotec Pharmalab

05

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Hydrocortisone Acetate USP/BP

Date of Issue : 2021-08-13

Valid Till : 2023-09-24

Written Confirmation Number : WC-0485A3

Address of the Firm : Block No 203, Vaso-Alindra Road, PO Alindra-387510, Tal-Matar Dist. Kheda, Gujar...

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KDMF

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EUROAPI

France
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Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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hydrocortisone

Registrant Name : Novartis Korea Ltd.

Registration Date : 2023-07-25

Registration Number : 20230725-209-J-1524

Manufacturer Name : EUROAPI France

Manufacturer Address : 4 Lieu Dit La Paterie, Vertolaye, 63480, France

EUROAPI Compnay Banner

02

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hydrocortisone

Registrant Name : Toru Corporation

Registration Date : 2021-09-14

Registration Number : 20210711-209-J-980(2)

Manufacturer Name : Henan Lihua Pharmaceutical C...

Manufacturer Address : Middle of Huanghe Street, Anyang Hi-Tech Industry Development Zone, China

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03

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hydrocortisone

Registrant Name : Daeshin Pharmaceutical Co., Ltd.

Registration Date : 2021-08-12

Registration Number : 20210711-209-J-980(1)

Manufacturer Name : Henan Lihua Pharmaceutical C...

Manufacturer Address : Middle of Huanghe Street, Anyang Hi-Tech Industry Development Zone, China

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04

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hydrocortisone

Registrant Name : Donggu Biopharmaceutical Co., Ltd.

Registration Date : 2021-11-15

Registration Number : 20210711-209-J-980(3)

Manufacturer Name : Henan Lihua Pharmaceutical C...

Manufacturer Address : Middle of Huanghe Street, Anyang Hi-Tech Industry Development Zone, China

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05

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hydrocortisone

Registrant Name : Hiple Co., Ltd.

Registration Date : 2022-02-24

Registration Number : 20210711-209-J-980(4)

Manufacturer Name : Henan Lihua Pharmaceutical C...

Manufacturer Address : Middle of Huanghe Street, Anyang Hi-Tech Industry Development Zone, China

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06

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hydrocortisone

Registrant Name : Insung Trading Co., Ltd.

Registration Date : 2021-07-11

Registration Number : 20210711-209-J-980

Manufacturer Name : Henan Lihua Pharmaceutical C...

Manufacturer Address : Middle of Huanghe Street, Anyang Hi-Tech Industry Development Zone, China

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07

Pfizer Inc

U.S.A
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Pfizer Inc

U.S.A
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hydrocortisone

Registrant Name : Bansen Co., Ltd.

Registration Date : 2022-03-10

Registration Number : 20220310-209-J-1237

Manufacturer Name : Pharmacia & Upjohn Company L...

Manufacturer Address : 7000 Portage Road, Kalamazoo, Michigan 49001 USA

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hydrocortisone

Registrant Name : Ace Biopharm Co., Ltd.

Registration Date : 2020-12-17

Registration Number : 20201217-209-J-539

Manufacturer Name : Shandong Xinhua Pharmaceutic...

Manufacturer Address : Hutian Chemical Industrial Zone, Zibo, Shandong, PR China

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09

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hydrocortisone

Registrant Name : Sanil Pharma Co., Ltd.

Registration Date : 2021-07-05

Registration Number : 20210705-209-J-740

Manufacturer Name : Tianjin Jinjin Pharmaceutica...

Manufacturer Address : Industrial Zone of Zhangjiawo Town, Xiqing District Tianjin, China@Industrial Zone of...

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hydrocortisone

Registrant Name : Kukjeon Pharmaceutical Co., Ltd.

Registration Date : 2018-02-05

Registration Number : 20180205-209-J-16

Manufacturer Name : Zhejiang Xianju Pharmaceutic...

Manufacturer Address : No.3 Donghai 4th Avenue, Zhejiang Toumen Port Economic Development Zone, Linhai, Zhej...

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NDC API

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HYDROCORTISONE

NDC Package Code : 82298-101

Start Marketing Date : 2011-02-07

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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HYDROCORTISONE

NDC Package Code : 22552-0037

Start Marketing Date : 2013-06-04

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

Symbiotec Pharmalab

03

Sanofi chimie

France
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Not Confirmed
  • fda
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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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HYDROCORTISONE

NDC Package Code : 50396-7004

Start Marketing Date : 2011-02-07

End Marketing Date : 2026-07-26

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

Sanofi Company Banner

04

Valdepharm

Luxembourg
  • fda
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Virtual BoothFareva is a one-stop-shop for API/HPAPI, OSD & Sterile products, is USFDA, EMA and PMDA-inspected and has multiple NDA & ANDA filings.

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HYDROCORTISONE HEMISUCCINATE

NDC Package Code : 24823-907

Start Marketing Date : 2010-08-30

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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05

Fagron Inc

Netherlands
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Fagron Inc

Netherlands
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HYDROCORTISONE

NDC Package Code : 51552-0020

Start Marketing Date : 2004-09-01

End Marketing Date : 2025-06-13

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT FOR HUMAN P...

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HYDROCORTISONE

NDC Package Code : 64958-0062

Start Marketing Date : 2003-01-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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HYDROCORTISONE

NDC Package Code : 81918-001

Start Marketing Date : 2023-03-17

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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HYDROCORTISONE

NDC Package Code : 60592-310

Start Marketing Date : 2019-12-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT FOR HUMAN P...

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HYDROCORTISONE

NDC Package Code : 86014-200

Start Marketing Date : 2019-06-07

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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10

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Not Confirmed
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HYDROCORTISONE HEMISUCCINATE

NDC Package Code : 0009-5086

Start Marketing Date : 2014-07-03

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Listed Suppliers

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01

EUROAPI

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Hydrocortisone

About the Company : EUROAPI is the market leader in small molecule APIs with projected sales of about €1 billion in 2022. With around 200 APIs, it has one of the largest portfolios in the market. Th...

EUROAPI is the market leader in small molecule APIs with projected sales of about €1 billion in 2022. With around 200 APIs, it has one of the largest portfolios in the market. Thanks to its excellent R&D skills and six manufacturing facilities across Europe, EUROAPI guarantees API manufacturing of the highest quality to its clients in over 80 countries. Its strong innovation and R&D skills helps it to speed the development of more complex molecule segments through CDMO operations. It also offers experience in supply, regulation and quality. EUROAPI employs 3,350 people and is listed on Euronext.
EUROAPI Compnay Banner

02

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BioFlorida Conference
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPfizer CentreOne is a global CDMO and a leading supplier of Specialty APIs.

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Hydrocortisone

About the Company : Pfizer CentreOne® is an altogether different global contract development and manufacturing organization (CDMO), and a leading supplier of specialty APIs and intermediates.
...

Pfizer CentreOne® is an altogether different global contract development and manufacturing organization (CDMO), and a leading supplier of specialty APIs and intermediates. Backed by Pfizer resources, we’ve been delivering technical expertise, regulatory support and long-term supply for over 40 years. With 35+ sites across six continents, our expansive network allows us to securely and efficiently guide complex compounds from development through commercial manufacture. For more information, visit http://www.pfizercentreone.com
Pfizer centreOne

03

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSymbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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Hydrocortisone

About the Company : Symbiotec, a leading API manufacturing company based in Indore, Central India, specializes in Cortico-Steroids and Steroid-Hormone APIs. Since 1995, their focus on R&D, sustainable...

Symbiotec, a leading API manufacturing company based in Indore, Central India, specializes in Cortico-Steroids and Steroid-Hormone APIs. Since 1995, their focus on R&D, sustainable operations, and innovation has driven their commitment to improving global healthcare access. With a state-of-the-art manufacturing facility inaugurated in 2004, Symbiotec has become a trusted provider in the industry. Their certifications including WHO-GMP, ISO, US FDA, and EU GMP showcase their dedication to quality and excellence. Over two decades, they've maintained their position through adaptability, efficiency, and competitive pricing.
Symbiotec Pharmalab

04

Axplora

Germany
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAxplora- The partner of choice for complex APIs.

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Hydrocortisone Hemisuccinate Hydrate

About the Company : Axplora, created from the merger of Farmabios, Novasep & PharmaZell, is a leading API manufacturing partner to the world’s leading pharma & biotech companies, delivering top-qual...

Axplora, created from the merger of Farmabios, Novasep & PharmaZell, is a leading API manufacturing partner to the world’s leading pharma & biotech companies, delivering top-quality APIs on time & at scale, to the highest industry standards. It is dedicated to helping pharma companies make critical medicines safely to benefit patients. Leveraging our combined expertise & manufacturing capabilities across 9 industrial sites in the EU & India & an R&D facility in the USA, it offers CDMO services for small molecule APIs & biopharmaceuticals to innovators as well as APIs that address lifestyle-induced respiratory, inflammatory & liver diseases.
Axplora CB

05

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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Hydrocortisone

About the Company : Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quali...

Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quality ingredients manufactured in China. Headquartered in the Hauppauge, New York, Rochem has 16 offices spread across the globe to cater to the needs of its customers. Rochem’s operations are fully cGMP compliant and has been audited by the USFDA as well as several multinational organizations. It also trains and audits its partners to ensure all of their technologies and systems are FDA-compliant.
Rochem

06

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothGonane has API manufacturing expertise in new-age Corticosteroids, Hormones and other pharma raw materials.

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Hydrocortisone Aceponate

About the Company : Gonane Pharma, is a contract pharmaceutical company located in Gujarat, India, specializing in the manufacturing and marketing of Corticosteroids, Hormones, Antivirals, and Oncolog...

Gonane Pharma, is a contract pharmaceutical company located in Gujarat, India, specializing in the manufacturing and marketing of Corticosteroids, Hormones, Antivirals, and Oncology products. The company's core strength lies in its dedicated team, and its promoters bring over 25 years of experience in manufacturing, promoting products, and managing audits for regulated markets such as the EU, Mexico, China, Korea, and Russia. GONANE PHARMA is actively engaged in discussions with Japanese customers and anticipates further expansion into additional markets.
Gonane Pharma

07

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BioFlorida Conference
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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Hydrocortisone

About the Company : Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritio...

Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritional supplement, and food industries. The company maintains an exceptionally selective approach to its suppliers, personally visiting manufacturers overseas to ensure the highest standards. The sustained growth of Pharm-Rx can be attributed to its steadfast commitment to three core values: quality ingredients, competitive pricing, and unparalleled customer service.
Pharm RX

08

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothHRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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Hydrocortisone

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
HRV Global Life Sciences

09

Bioquim

Spain
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BioFlorida Conference
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothBioquim: An European GMP-certified company manufacturing bulk APIs, specializing in sterile lyophilization and chemical synthesis.

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Hydrocortisone Sodium Phosphate

About the Company : Bioquim is a European company specializing in bulk oral & sterile APIs for the pharmaceutical industry. With over 40 years of experience, we offer high-quality corticosteroids, pep...

Bioquim is a European company specializing in bulk oral & sterile APIs for the pharmaceutical industry. With over 40 years of experience, we offer high-quality corticosteroids, peptides, amino acids, penicillin derivatives, non-penicillin antibiotics, and HPAPIs for human & veterinary markets. We adhere to stringent GMP and operate state-of-the-art facilities with advanced technology. Bioquim also provides Custom Synthesis & Contract Manufacturing services, delivering tailored solutions backed by our expertise in chemical synthesis & lyophilization of sterile APIs. Trust Bioquim for your API needs & experience our commitment to quality.
Bioquim

10

Curia

U.S.A
BioFlorida Conference
Not Confirmed
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Curia

U.S.A
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BioFlorida Conference
Not Confirmed

Hydrocortisone Sodium Phosphate

About the Company : Curia is a global contract research, development and manufacturing organization (CDMO), offering products and services across the drug development spectrum to help our partners tur...

Curia is a global contract research, development and manufacturing organization (CDMO), offering products and services across the drug development spectrum to help our partners turn their ideas into real-world impact. We partner closely with pharmaceutical and biotechnology companies to boost business performance and improve patients’ lives. From early discovery and development through manufacturing and commercialization, our suite of custom solutions allows us to tailor every engagement to your precise needs, whether that’s an independent project or an opportunity that cuts across the drug continuum.
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API Reference Price

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MAHARASHTRA,MAHARASHTR","supplier":"CURIA","supplierCountry":"SPAIN","foreign_port":"#N\/A","customer":"CIPLA","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"5000","totalValueFC":"5178.3","currency":"USD","unitRateINR":"385750","date":"03-Jan-2022","totalValueINR":"385750","totalValueInUsd":"5178.3","indian_port":"BOMBAY AIR","hs_no":"29372100","bill_no":"6935943","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"#N\/A","supplierAddress":"","customerAddress":"CIPLA HOUSE, PENINSULA BUSINESS,PA RK,GANPATRAO KADAM MARG,LOWER"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1646159400,"product":"HYDROCORTISONE SODIUM PHOSPHATE","address":"CIPLA HOUSE, PENINSULA BUSINESS,PA RK,GANPATRAO KADAM MARG,LOWER","city":"PAREL MUMBAI MAHARASHTRA,MAHARASHTR","supplier":"CURIA","supplierCountry":"SPAIN","foreign_port":"NA","customer":"CIPLA","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"5000","totalValueFC":"24944.4","currency":"USD","unitRateINR":"380250","date":"02-Mar-2022","totalValueINR":"1901250","totalValueInUsd":"24944.4","indian_port":"BOMBAY AIR","hs_no":"29372100","bill_no":"7702494","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"CIPLA HOUSE, PENINSULA BUSINESS,PA RK,GANPATRAO KADAM MARG,LOWER"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1675621800,"product":"HYDROCORTISONE SODIUM PHOSPHATE","address":"688, Ground Floor, 6th Main, III Block, Bel lay, Vidyaranyapura","city":"BANGALORE","supplier":"CURIA","supplierCountry":"SPAIN","foreign_port":"NA","customer":"MAIVA PHARMA PRIVATE 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","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"255","totalValueFC":"25762.5","currency":"USD","unitRateINR":"21445.5","date":"05-Dec-2023","totalValueINR":"2144550","totalValueInUsd":"25762.5","indian_port":"Ahmedabad Air","hs_no":"29372100","bill_no":"9072239","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"BEIJING","supplierAddress":"HENGSHENG BUILDING, NO. 6 LIUJIANGROAD, HEXI DIST. 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01-Feb-2021
29-Oct-2024
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DOSAGE - SUSPENSION/DROPS;OTIC - EQ 0.2% BASE...DOSAGE - SUSPENSION/DROPS;OTIC - EQ 0.2% BASE;1%

USFDA APPLICATION NUMBER - 20805

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DOSAGE - CREAM;TOPICAL - 5%;1%

USFDA APPLICATION NUMBER - 22436

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DOSAGE - OINTMENT;TOPICAL - 400 UNITS/GM;1%;E...DOSAGE - OINTMENT;TOPICAL - 400 UNITS/GM;1%;EQ 3.5MG BASE/GM;5,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50168

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DOSAGE - CREAM;TOPICAL - 1%

USFDA APPLICATION NUMBER - 80693

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DOSAGE - TABLET;ORAL - 10MG

USFDA APPLICATION NUMBER - 8697

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DOSAGE - TABLET;ORAL - 20MG

USFDA APPLICATION NUMBER - 8697

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DOSAGE - TABLET;ORAL - 5MG

USFDA APPLICATION NUMBER - 8697

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DATA COMPILATION #PharmaFlow

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FDA’s June 2024 list of off-patent, off-exclusivity drugs sees rise in cancer, HIV treatments
This week PharmaCompass brings to you key highlights of the US Food and Drug Administration’s recently released June 2024 list of Off-Patent, Off-Exclusivity Drugs without an Approved Generic (OPOE list). The list is a crucial resource for promoting competition and affordability in the pharmaceutical industry. Updated biannually in December and June, the OPOE list serves as a transparent guide for drug manufacturers. Since December 2021, the FDA has enhanced its transparency efforts by providing separate lists for prescription (Rx) and over-the-counter (OTC) drugs approved under a New Drug Application (NDA). This initiative is a significant cog in the FDA’s broader strategy to encourage the development and submission of Abbreviated New Drug Applications (ANDAs). ANDAs are a streamlined pathway for generic drug development, offering a more cost-effective alternative to brand-name drugs. By highlighting drugs that lack generic competition on the OPOE list, FDA aims to incentivize manufacturers to develop generics, ultimately leading to greater affordability and access for patients. Access the Interactive Dashboard on FDA's June 2024 List of Off-Patent Drugs (Free Excel) ALS drugs, cancer, asthma, HIV treatments among new drugs added to OPOE list The December 2023 OPOE list had 23 new applications of branded drugs eligible for but without generic competition. The June list further added 21 new applications of drugs that had never appeared before. These include bendamustine hydrochloride (to treat chronic lymphocytic leukemia), fluticasone propionate (to treat asthma), maraviroc (to treat HIV-1 infection in patients two years of age and older weighing at least 10 kilograms), carbamazepine (to treat epilepsy and bipolar I disorder), and posaconazole (an antifungal agent indicated for Aspergillus and Candida infections). There are two other drugs on the list – edaravone and riluzole – to treat amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease (a neurological disorder).  Much like the June 2023 OPOE list, nearly one-third of the prescription drugs listed are injectables – 170 out of 499. There are 74 prescription entries for oral solid dosage forms (such as tablets, capsules and modified release forms). The June 2024 OPOE list has 57 OTC drugs, a tad shy of the 60 drugs in last year’s list. Among them are antihistamine drugs (used to treat allergies), cetirizine hydrochloride, nizatidine, famotidine, loratadine and anti-obesity medication orlistat. The list also had a newly listed drug, which is a combination of chlorpheniramine maleate, ibuprofen and pseudoephedrine hydrochloride for treating allergic sinusitis. Out of the 57 OTC drug products on the list, 18 are delivered as oral solid dosage forms. Access the Interactive Dashboard on FDA's June 2024 List of Off-Patent Drugs (Free Excel)  Novartis blockbusters lose exclusivity, Lupin wins FDA nod for copycat of Neurocrine’s bestseller This year, several large-selling drugs from drugmakers like Eisai, AbbVie, Gilead, Sanofi, Fresenius Kabi and others are due to face their first generic or biosimilar challengers in the US market. “First generics” are given for a first-to-file ANDA, for which there is no previously-approved ANDA by the FDA for the drug product. The agency considers first generics to be important to public health and prioritizes review of these submissions. First generics are eligible for a 180-day exclusivity period.  Three of Novartis’ drugs have lost exclusivity so far, this year. These include Promacta/Revolade (eltrombopag) used to treat thrombocytopenia (low platelet count). Promacta was approved in 2015 and saw sales of US$ 2.27 billion last year. Annora Pharma scored an FDA approval for eltrombopag’s first generic in April. Tasigna (nilotinib), the Swiss drugmaker’s oral treatment for Philadelphia chromosome-positive chronic myeloid leukemia (a kind of leukemia where patients have an abnormal chromosome in their blood cells called the Philadelphia chromosome), got its first generic in January, which was introduced by Apotex. Tasigna brought in sales of US$ 1.85 billion in 2023 and its sales are projected to plummet to US$ 79 million by 2029. Novartis’ Rydapt (midostaurin) for treating adult patients with newly diagnosed acute myeloid leukemia (AML) also lost exclusivity in April. Neurocrine Biosciences’ top-selling drug Ingrezza (valbenazine) was the first FDA-approved drug to treat tardive dyskinesia, a disorder that involves involuntary movements. It raked in US$ 1.84 billion in 2023, registering a year-on-year growth of 29 percent. In April, Lupin won FDA’s approval for the first generic of valbenazine capsules. Access the Interactive Dashboard on FDA's June 2024 List of Off-Patent Drugs (Free Excel)  Our view The Biden administration has been pushing hard to lower the price of prescription drugs. It is one of President Joe Biden’s central campaign promises this year. However, lowering drug prices is a bipartisan issue in the US. So whether a republican or a democrat takes over the US administration, making medicines affordable should remain a priority. In 2023, generic drugs accounted for US$ 424 billion of the US$ 1.6 trillion global pharmaceutical market. A determined FDA that is proactively looking to approve generic drugs will no doubt help this segment grow even further.  

Impressions: 2971

https://www.pharmacompass.com/radio-compass-blog/fda-s-june-2024-list-of-off-patent-off-exclusivity-drugs-sees-rise-in-cancer-hiv-treatments

#PharmaFlow by PHARMACOMPASS
11 Jul 2024

NEWS #PharmaBuzz

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Eton Pharma's ET-400 NDA Accepted By FDA
Eton Pharma's ET-400 NDA Accepted By FDA

15 Jul 2024

// GLOBENEWSWIRE

https://www.globenewswire.com/news-release/2024/07/15/2913383/0/en/Eton-Pharmaceuticals-Announces-FDA-Acceptance-of-New-Drug-Application-for-ET-400-Hydrocortisone-Oral-Solution.html

GLOBENEWSWIRE
15 Jul 2024

https://www.prnewswire.com/news-releases/neurocrine-biosciences-to-present-new-phase-3-cahtalyst-data-in-adult-and-pediatric-patients-with-cah-and-study-data-for-modified-release-hydrocortisone-in-primary-adrenal-insufficiency-and-cah-at-endo-2024-302155663.html

PR NEWSWIRE
28 May 2024

https://www.prnewswire.com/news-releases/neurocrine-biosciences-presented-baseline-data-from-the-cahtalyst-program-in-cah-and-study-data-for-modified-release-hydrocortisone-in-primary-adrenal-insufficiency-and-cah-at-ece-2024-302144009.html

PR NEWSWIRE
14 May 2024

https://www.prnewswire.com/news-releases/neurocrine-biosciences-to-present-phase-3-baseline-characteristics-data-from-the-cahtalyst-program-of-crinecerfont-in-cah-and-data-for-modified-release-hydrocortisone-in-primary-adrenal-insufficiency-and-cah-studies-at-ece-2024-302137447.html

PR NEWSWIRE
07 May 2024

https://www.globenewswire.com/news-release/2024/04/30/2872041/0/en/Eton-Pharmaceuticals-Announces-Submission-to-FDA-of-New-Drug-Application-for-ET-400-Hydrocortisone-Oral-Solution.html

GLOBENEWSWIRE
30 Apr 2024

https://www.globenewswire.com//news-release/2024/02/21/2832591/0/en/Eton-Pharmaceuticals-Awarded-U-S-Patent-for-Proprietary-Hydrocortisone-Oral-Liquid-Formulation.html

GLOBENEWSWIRE
21 Feb 2024

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