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    Chemistry

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    Also known as: Mls002637530, Hydrocortisoni acetas, Ncgc00183367-01, Chembl1715636, Schembl13026148, Hms2232p13
    Molecular Formula
    C23H32O6
    Molecular Weight
    404.5  g/mol
    InChI Key
    ALEXXDVDDISNDU-UHFFFAOYSA-N
    Hydrocortisone Acetate
    1 2D Structure

    Hydrocortisone Acetate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] acetate
    2.1.2 InChI
    InChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3
    2.1.3 InChI Key
    ALEXXDVDDISNDU-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)O
    2.2 Synonyms
    2.2.1 Depositor-Supplied Synonyms

    1. Mls002637530

    2. Hydrocortisoni Acetas

    3. Ncgc00183367-01

    4. Chembl1715636

    5. Schembl13026148

    6. Hms2232p13

    7. Hms3373l06

    8. Bbl033683

    9. Stl301800

    10. Akos001582713

    11. Akos021734921

    12. [2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] Acetate

    13. Ac-12502

    14. Smr001317857

    15. Vs-12217

    16. Ft-0627126

    17. Ft-0667894

    18. Ah-034/06873032

    19. Pregn-4-ene-3,20-dione,11beta,17alpha,21-trihydroxy-,21 Acetate

    20. 2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate

    21. 2-{1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1h,2h,3h,3ah,3bh,4h,5h,7h,8h,9h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-1-yl}-2-oxoethyl Acetate

    2.3 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 404.5 g/mol
    Molecular Formula C23H32O6
    XLogP32.2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count4
    Exact Mass404.21988874 g/mol
    Monoisotopic Mass404.21988874 g/mol
    Topological Polar Surface Area101 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity786
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count7
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameHydrocortisone acetate
    Drug LabelEpifoam (hydrocortisone acetate 1% and pramoxine hydrochloride 1%) is a topical aerosol foam containing: hydrocortisone acetate 1% and pramoxine hydrochloride 1% in a base containing: propylene glycol, cetyl alcohol, glyceryl monostearate and PEG 1...
    Active IngredientHydrocortisone acetate
    Dosage FormCream; Powder
    RouteFor rx compounding; Topical
    Strength100%; 2.5%
    Market StatusPrescription
    CompanyX Gen Pharms; Ferndale Labs

    2 of 2  
    Drug NameHydrocortisone acetate
    Drug LabelEpifoam (hydrocortisone acetate 1% and pramoxine hydrochloride 1%) is a topical aerosol foam containing: hydrocortisone acetate 1% and pramoxine hydrochloride 1% in a base containing: propylene glycol, cetyl alcohol, glyceryl monostearate and PEG 1...
    Active IngredientHydrocortisone acetate
    Dosage FormCream; Powder
    RouteFor rx compounding; Topical
    Strength100%; 2.5%
    Market StatusPrescription
    CompanyX Gen Pharms; Ferndale Labs

    API Reference Price

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NO.19, XINY CHINA","customerAddress":"218\/219, 2ND FLOOR,KAILASH PLAZA,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697653800,"product":"HYDROCORTISONE ACETATE EP\/USP","address":"110-B,ANDHERI INDUSTRIAL ESTATE","city":"ANDHERI(W),MUMBAI, MAHARASHTRA","supplier":"TIANJIN TIANFA PHARMACEUTICALS","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"ADD BIOTEC","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"365","totalValueFC":"18451.9","currency":"USD","unitRateINR":"30714.8","date":"19-Oct-2023","totalValueINR":"1535737.5","totalValueInUsd":"18451.9","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"8365361","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"109 BA WEI ROAD, HEDONG DISTRICT TIANJIN Tianjin - 300171, , CHINASDNF CHINA","customerAddress":"110-B,ANDHERI INDUSTRIAL ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698604200,"product":"HYDROCORTISONE ACETATE IP\/EP","address":"110-B,ANDHERI INDUSTRIAL ESTATE","city":"ANDHERI(W),MUMBAI, MAHARASHTRA","supplier":"TIANJIN JINJIN PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"ADD BIOTEC","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"370","totalValueFC":"18715.8","currency":"USD","unitRateINR":"31154","date":"30-Oct-2023","totalValueINR":"1557700","totalValueInUsd":"18715.8","indian_port":"Delhi Air","hs_no":"29372900","bill_no":"8537045","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"110-B,ANDHERI INDUSTRIAL ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716748200,"product":"HYDROCORTISONE ACETATE EP\/USP","address":"110-B,ANDHERI INDUSTRIAL ESTATE","city":"ANDHERI(W),MUMBAI, MAHARASHTRA","supplier":"TIANJIN TIANFA PHARMACEUTICALS","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"ADD BIOTEC","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"300","totalValueFC":"9107.5","currency":"USD","unitRateINR":"25305","date":"27-May-2024","totalValueINR":"759150","totalValueInUsd":"9107.5","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"3677875","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"109 BA WEI ROAD, HEDONG DISTRICT TIANJIN Tianjin - 300171, , CHINASDNF CHINA","customerAddress":"110-B,ANDHERI INDUSTRIAL ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719426600,"product":"HYDROCORTISONE ACETATE USP","address":"L-4, PHASE-III,","city":"AKOLA. 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MAHARASHTRA,? 400020","city":"","supplier":"HENAN LIHUA PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"ZHENGZHOU","customer":"B M CHEMIE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"338","totalValueFC":"17066.1","currency":"USD","unitRateINR":"28493.4","date":"28-Jun-2024","totalValueINR":"1424670","totalValueInUsd":"17066.1","indian_port":"Bombay Air","hs_no":"29372100","bill_no":"4230819","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"ZHENGZHOU","supplierAddress":"MIDDLE OF HUANGHE STREET, ANYANG HIAN, , , CHINA CHINA","customerAddress":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722882600,"product":"HYDROCORTISONE ACETATE IP\/EP\/USP","address":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020","city":"","supplier":"HENAN LIHUA PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"B M CHEMIE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"338","totalValueFC":"17045.4","currency":"USD","unitRateINR":"28594.8","date":"06-Aug-2024","totalValueINR":"1429740","totalValueInUsd":"17045.4","indian_port":"Bombay Air","hs_no":"29372100","bill_no":"4907007","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"MIDDLE OF HUANGHE STREET, ANYANG HI- TECH INDUSTRY DEVELOPMENT ZONE,HENAN CHINA","customerAddress":"502 FLOOR 5 PLOT 7 2 JOLLY BHAWAN ,? NEW MARINE LINES CHURCHGATE MUMBAI CITY ,? MUMBAI , ?MUMBAI ,? MAHARASHTRA,? 400020"}]
    09-Jan-2021
    21-Oct-2024
    KGS
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    Average Price (USD/KGS)

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - AEROSOL, METERED;RECTAL - 10%

    USFDA APPLICATION NUMBER - 17351

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    DOSAGE - CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/G...DOSAGE - CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 50218

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    DOSAGE - SUSPENSION/DROPS;OTIC - EQ 3MG BASE/...DOSAGE - SUSPENSION/DROPS;OTIC - EQ 3MG BASE/ML;10MG/ML;EQ 3.3MG BASE/ML;0.5MG/ML

    USFDA APPLICATION NUMBER - 50356

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    DOSAGE - AEROSOL, METERED;TOPICAL - 1%;1%

    USFDA APPLICATION NUMBER - 86195

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