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Strides Pharma Hydrocortisone Sodium Succinate

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ACTIVE PHARMA INGREDIENTS

25 API Suppliers, 7 USDMF, 7 CEP/COS, 1 JDMF, 3 EU WC, 2 NDC API, 13 Listed Suppliers, $ API Reference Price

25 API Suppliers
7 USDMF
7 CEP/COS
1 JDMF
3 EU WC
2 NDC API
13 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

63 FDF Dossiers, 30 FDA Orange Book, 2 Europe, 4 Canada, 8 Australia, 1 South Africa, 18 Listed Dossiers

63 FDF Dossiers
30 FDA Orange Book
2 Europe
4 Canada
8 Australia
1 South Africa
18 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - EQ 100MG BASE/VIAL, INJECTABLE;INJECTION - EQ 1GM BASE/VIAL, INJECTABLE;INJECTION - EQ 250MG BASE/VIAL, INJECTABLE;INJECTION - EQ 500MG BASE/VIAL

drugProductComposition
INJECTABLE;INJECTION - EQ 100MG BASE/VIAL
INJECTABLE;INJECTION - EQ 1GM BASE/VIAL
INJECTABLE;INJECTION - EQ 250MG BASE/VIAL
INJECTABLE;INJECTION - EQ 500MG BASE/VIAL

RELATED EXCIPIENT COMPANIES

1 Nanjing Well Pharmaceutical, 1 Actylis, 1 Finar

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1 Nanjing Well Pharmaceutical
1 Actylis
1 Finar

EXCIPIENTS BY APPLICATIONS

2 Topical, 1 Parenteral, 1 Solubilizers

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2 Topical
1 Parenteral
1 Solubilizers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 1 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 2 Finished Drug Prices

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2 US Medicaid Prescriptions
2 Finished Drug Prices

MARKET PLACE

12 APIs, 6 FDF Dossiers

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12 APIs
6 FDF Dossiers

PATENTS & EXCLUSIVITIES

1 US Exclusivities

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1 US Exclusivities

REF. STANDARDS & IMPURITIES

2 JP

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2 JP

Hydrocortisone Sodium Succinate

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

850,712

Annual Reports (USD Million)

Finished Drug Prices

4EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 125-04-2, A-hydrocort, Hydrocortisone 21-hemisuccinate sodium salt, Cortop, Solu-cortef, Arcocort

Molecular Formula

C₂₅H₃₃NaO₈

Molecular Weight

484.5 g/mol

InChI Key

HHZQLQREDATOBM-CODXZCKSSA-M

FDA UNII

50LQB69S1Z

Hydrocortisone Sodium Succinate is the sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation.

1 2D Structure

Hydrocortisone Sodium Succinate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate

2.1.2 InChI

InChI=1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1

2.1.3 InChI Key

HHZQLQREDATOBM-CODXZCKSSA-M

2.1.4 Canonical SMILES

CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]

2.1.5 Isomeric SMILES

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]

2.2 Other Identifiers

2.2.1 UNII

50LQB69S1Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. A-hyrocort

2. Cortisol Hemisuccinate

3. Cortisol Succinate

4. Cortisol Succinate, Sodium Salt

5. Cortisol-21-(hydrogen Succinate)

6. Hydrocortisone 21-sodium Succinate

7. Hydrocortisone Hemisuccinate

8. Hydrocortisone Hemisuccinate Anhydrous

9. Hydrocortisone Succinate

10. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11beta)-

11. Solu-cortef

12. Sopolcort H

13. Sopolkort

2.3.2 Depositor-Supplied Synonyms

1. 125-04-2

2. A-hydrocort

3. Hydrocortisone 21-hemisuccinate Sodium Salt

4. Cortop

5. Solu-cortef

6. Arcocort

7. Buccalsone

8. Corlan

9. Emi-corlin

10. Cortisol 21-(sodium Succinate)

11. Flebocortid

12. Hycorace

13. Intracort

14. Nordicort

15. Oralsone

16. Solu-hizon

17. Solu-glyc

18. Hydrocortisone 21-sodium Succinate

19. Ef-cortelan Soluble

20. 50lqb69s1z

21. Chebi:5782

22. Cortisol Sodium Succinate

23. Hydrocortisone Hemisuccinate

24. Cortisol Sodium Hemisuccinate

25. Sodium Hydrocortisone Succinate

26. Cortisol Hemisuccinate Sodium Salt

27. Hydrocortisone Sodium Hemisuccinate

28. Hydrocortisone 21-sodium Succinide

29. Sodium Hydrocortisone 21-succinate

30. Nsc-9152

31. Hydrocortisone 21-hemisuccinate Sodium

32. Hydrocortisone Sodium 21-hemisuccinate

33. Sodium Hydrocortisone 21-hemisuccinate

34. Hydrocortisone Hemisuccinate Sodium Salt

35. Dsstox_cid_28932

36. Dsstox_rid_83198

37. Dsstox_gsid_49006

38. Hydrocortisone 21-succinate Sodium Salt

39. Sodium 17-hydroxycorticosterone 21-succinate

40. Hidrokortizon

41. U 4905

42. Nositrol

43. Rapicort

44. Lycortin-s

45. Cas-125-04-2

46. Sodium;4-[2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate

47. Flebocortid [inj.]

48. Hydro-adreson Aquosum

49. Ncgc00022248-03

50. Idrocortisone B. I. L.

51. Unii-50lqb69s1z

52. Hydrocortisone Succinate,sodium Salt

53. Einecs 204-725-5

54. A-hydrocort (tn)

55. Solu-cortef (tn)

56. Hydrocortisone 21-(sodium Succinate)

57. Mfcd00069472

58. Hydrocortisone-21-hemisuccinate Sodium

59. Hydrocortisone-21-hemisuccinate Sodium Salt

60. Cortisol 21-hemisuccinate Sodium Salt

61. Hydrocortisone Sodium Succinate [usp:ban:jan]

62. Schembl93508

63. Hydrocortisoni Natrii Succinas

64. Mls000069545

65. Chembl1200495

66. Dtxsid2049006

67. Cortisol 21-hemisuccinate Sodium

68. Hms2234h22

69. Succinic Acid Hydrocortisone Sodium

70. Tox21_113501

71. Akos024386298

72. Tox21_113501_1

73. Cortisol, Succinate, Sodium Salt

74. Ncgc00022248-04

75. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, Monosodium Salt, (11.beta.)-

76. Smr000058768

77. Eu-0100623

78. Hydrocortisone Sodium Succinate (jp17/usp)

79. Hydrocortisone Sodium Succinate [jan]

80. U4905

81. C08178

82. D00978

83. F20569

84. H 2270

85. Hydrocortisone Sodium Succinate [mart.]

86. Hydrocortisone Sodium Succinate [vandf]

87. Hydrocortisone 21-sodium Succinate [mi]

88. Hydrocortisone Sodium Succinate [who-dd]

89. Hydrocortisone Sodium Succinate [who-ip]

90. Cortisol, 21-(hydrogen Succinate), Monosodium Salt

91. Hydrocortisone Sodium Succinate [orange Book]

92. Hydrocortisone Sodium Succinate [usp Monograph]

93. Hydrocortisoni Natrii Succinas [who-ip Latin]

94. Q27106890

95. Hydrocortisone 21-hemisuccinate Sodium Salt, >=90% (hplc)

96. Hydrocortisone 21-hemisuccinate Sodium Salt, Powder, Bioreagent, Suitable For Cell Culture

97. (11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxypregn-14-ene-3,20-dione, Monosodium Salt

98. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, Monosodium Salt, (11beta)-

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₂₅H₃₃NaO₈
Molecular Weight	484.5 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Exact Mass	484.20731229 g/mol
Monoisotopic Mass	484.20731229 g/mol
Topological Polar Surface Area	141 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	915
Isotope Atom Count	0
Defined Atom Stereocenter Count	7
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	A-hydrocort
PubMed Health	Hydrocortisone (Injection)
Drug Classes	Endocrine-Metabolic Agent, Immune Suppressant
Active Ingredient	Hydrocortisone sodium succinate
Dosage Form	Injectable
Route	Injection
Strength	eq 100mg base/vial
Market Status	Prescription
Company	Hospira

2 of 4
Drug Name	Solu-cortef
PubMed Health	Hydrocortisone
Drug Classes	Anti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
Drug Label	SOLU-CORTEF Sterile Powder is an anti-inflammatory glucocorticoid that contains hydrocortisone sodium succinate as the active ingredient. SOLU-CORTEF Sterile Powder is available in several packages for intravenous or intramuscular administration.100...
Active Ingredient	Hydrocortisone sodium succinate
Dosage Form	Injectable
Route	Injection
Strength	eq 500mg base/vial; eq 250mg base/vial; eq 1gm base/vial; eq 100mg base/vial
Market Status	Prescription
Company	Pharmacia And Upjohn

3 of 4
Drug Name	A-hydrocort
PubMed Health	Hydrocortisone (Injection)
Drug Classes	Endocrine-Metabolic Agent, Immune Suppressant
Active Ingredient	Hydrocortisone sodium succinate
Dosage Form	Injectable
Route	Injection
Strength	eq 100mg base/vial
Market Status	Prescription
Company	Hospira

4 of 4
Drug Name	Solu-cortef
PubMed Health	Hydrocortisone
Drug Classes	Anti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
Drug Label	SOLU-CORTEF Sterile Powder is an anti-inflammatory glucocorticoid that contains hydrocortisone sodium succinate as the active ingredient. SOLU-CORTEF Sterile Powder is available in several packages for intravenous or intramuscular administration.100...
Active Ingredient	Hydrocortisone sodium succinate
Dosage Form	Injectable
Route	Injection
Strength	eq 500mg base/vial; eq 250mg base/vial; eq 1gm base/vial; eq 100mg base/vial
Market Status	Prescription
Company	Pharmacia And Upjohn

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]

API SUPPLIERS

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USDMF

01

Antibioticos Spa

Italy

American Pharma Summit

Not Confirmed

02

Schering Ag

Germany

American Pharma Summit

Not Confirmed

03

Quatrum

Country

American Pharma Summit

Not Confirmed

04

Diosynth Bv

United Kingdom

American Pharma Summit

Not Confirmed

05

Diosynth Bv

United Kingdom

American Pharma Summit

Not Confirmed

06

Compania Espanola De Sintesis Quimic...

Spain

American Pharma Summit

Not Confirmed

07

Societa Italiana Corticosteroidi Spa

Italy

American Pharma Summit

Not Confirmed

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CEP/COS

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JDMF

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API Reference Price

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