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    Also known as: 125-04-2, A-hydrocort, Hydrocortisone 21-hemisuccinate sodium salt, Cortop, Solu-cortef, Arcocort
    Molecular Formula
    C25H33NaO8
    Molecular Weight
    484.5  g/mol
    InChI Key
    HHZQLQREDATOBM-CODXZCKSSA-M
    FDA UNII
    50LQB69S1Z
    Hydrocortisone Sodium Succinate
    Hydrocortisone Sodium Succinate is the sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation.
    1 2D Structure

    Hydrocortisone Sodium Succinate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate
    2.1.2 InChI
    InChI=1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
    2.1.3 InChI Key
    HHZQLQREDATOBM-CODXZCKSSA-M
    2.1.4 Canonical SMILES
    CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
    2.1.5 Isomeric SMILES
    C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    50LQB69S1Z
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. A-hyrocort

    2. Cortisol Hemisuccinate

    3. Cortisol Succinate

    4. Cortisol Succinate, Sodium Salt

    5. Cortisol-21-(hydrogen Succinate)

    6. Hydrocortisone 21-sodium Succinate

    7. Hydrocortisone Hemisuccinate

    8. Hydrocortisone Hemisuccinate Anhydrous

    9. Hydrocortisone Succinate

    10. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11beta)-

    11. Solu-cortef

    12. Sopolcort H

    13. Sopolkort

    2.3.2 Depositor-Supplied Synonyms

    1. 125-04-2

    2. A-hydrocort

    3. Hydrocortisone 21-hemisuccinate Sodium Salt

    4. Cortop

    5. Solu-cortef

    6. Arcocort

    7. Buccalsone

    8. Corlan

    9. Emi-corlin

    10. Cortisol 21-(sodium Succinate)

    11. Flebocortid

    12. Hycorace

    13. Intracort

    14. Nordicort

    15. Oralsone

    16. Solu-hizon

    17. Solu-glyc

    18. Hydrocortisone 21-sodium Succinate

    19. Ef-cortelan Soluble

    20. 50lqb69s1z

    21. Chebi:5782

    22. Cortisol Sodium Succinate

    23. Hydrocortisone Hemisuccinate

    24. Cortisol Sodium Hemisuccinate

    25. Sodium Hydrocortisone Succinate

    26. Cortisol Hemisuccinate Sodium Salt

    27. Hydrocortisone Sodium Hemisuccinate

    28. Hydrocortisone 21-sodium Succinide

    29. Sodium Hydrocortisone 21-succinate

    30. Nsc-9152

    31. Hydrocortisone 21-hemisuccinate Sodium

    32. Hydrocortisone Sodium 21-hemisuccinate

    33. Sodium Hydrocortisone 21-hemisuccinate

    34. Hydrocortisone Hemisuccinate Sodium Salt

    35. Dsstox_cid_28932

    36. Dsstox_rid_83198

    37. Dsstox_gsid_49006

    38. Hydrocortisone 21-succinate Sodium Salt

    39. Sodium 17-hydroxycorticosterone 21-succinate

    40. Hidrokortizon

    41. U 4905

    42. Nositrol

    43. Rapicort

    44. Lycortin-s

    45. Cas-125-04-2

    46. Sodium;4-[2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate

    47. Flebocortid [inj.]

    48. Hydro-adreson Aquosum

    49. Ncgc00022248-03

    50. Idrocortisone B. I. L.

    51. Unii-50lqb69s1z

    52. Hydrocortisone Succinate,sodium Salt

    53. Einecs 204-725-5

    54. A-hydrocort (tn)

    55. Solu-cortef (tn)

    56. Hydrocortisone 21-(sodium Succinate)

    57. Mfcd00069472

    58. Hydrocortisone-21-hemisuccinate Sodium

    59. Hydrocortisone-21-hemisuccinate Sodium Salt

    60. Cortisol 21-hemisuccinate Sodium Salt

    61. Hydrocortisone Sodium Succinate [usp:ban:jan]

    62. Schembl93508

    63. Hydrocortisoni Natrii Succinas

    64. Mls000069545

    65. Chembl1200495

    66. Dtxsid2049006

    67. Cortisol 21-hemisuccinate Sodium

    68. Hms2234h22

    69. Succinic Acid Hydrocortisone Sodium

    70. Tox21_113501

    71. Akos024386298

    72. Tox21_113501_1

    73. Cortisol, Succinate, Sodium Salt

    74. Ncgc00022248-04

    75. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, Monosodium Salt, (11.beta.)-

    76. Smr000058768

    77. Eu-0100623

    78. Hydrocortisone Sodium Succinate (jp17/usp)

    79. Hydrocortisone Sodium Succinate [jan]

    80. U4905

    81. C08178

    82. D00978

    83. F20569

    84. H 2270

    85. Hydrocortisone Sodium Succinate [mart.]

    86. Hydrocortisone Sodium Succinate [vandf]

    87. Hydrocortisone 21-sodium Succinate [mi]

    88. Hydrocortisone Sodium Succinate [who-dd]

    89. Hydrocortisone Sodium Succinate [who-ip]

    90. Cortisol, 21-(hydrogen Succinate), Monosodium Salt

    91. Hydrocortisone Sodium Succinate [orange Book]

    92. Hydrocortisone Sodium Succinate [usp Monograph]

    93. Hydrocortisoni Natrii Succinas [who-ip Latin]

    94. Q27106890

    95. Hydrocortisone 21-hemisuccinate Sodium Salt, >=90% (hplc)

    96. Hydrocortisone 21-hemisuccinate Sodium Salt, Powder, Bioreagent, Suitable For Cell Culture

    97. (11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxypregn-14-ene-3,20-dione, Monosodium Salt

    98. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, Monosodium Salt, (11beta)-

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 484.5 g/mol
    Molecular Formula C25H33NaO8
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count7
    Exact Mass484.20731229 g/mol
    Monoisotopic Mass484.20731229 g/mol
    Topological Polar Surface Area141 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity915
    Isotope Atom Count0
    Defined Atom Stereocenter Count7
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameA-hydrocort
    PubMed HealthHydrocortisone (Injection)
    Drug ClassesEndocrine-Metabolic Agent, Immune Suppressant
    Active IngredientHydrocortisone sodium succinate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 100mg base/vial
    Market StatusPrescription
    CompanyHospira

    2 of 4  
    Drug NameSolu-cortef
    PubMed HealthHydrocortisone
    Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
    Drug LabelSOLU-CORTEF Sterile Powder is an anti-inflammatory glucocorticoid that contains hydrocortisone sodium succinate as the active ingredient. SOLU-CORTEF Sterile Powder is available in several packages for intravenous or intramuscular administration.100...
    Active IngredientHydrocortisone sodium succinate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 500mg base/vial; eq 250mg base/vial; eq 1gm base/vial; eq 100mg base/vial
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    3 of 4  
    Drug NameA-hydrocort
    PubMed HealthHydrocortisone (Injection)
    Drug ClassesEndocrine-Metabolic Agent, Immune Suppressant
    Active IngredientHydrocortisone sodium succinate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 100mg base/vial
    Market StatusPrescription
    CompanyHospira

    4 of 4  
    Drug NameSolu-cortef
    PubMed HealthHydrocortisone
    Drug ClassesAnti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Weak, Endocrine-Metabolic Agent, Gastrointestinal Agent, Hemorrhoidal Anti-Inflammatory, Hydrocortisone, Immune Suppressant
    Drug LabelSOLU-CORTEF Sterile Powder is an anti-inflammatory glucocorticoid that contains hydrocortisone sodium succinate as the active ingredient. SOLU-CORTEF Sterile Powder is available in several packages for intravenous or intramuscular administration.100...
    Active IngredientHydrocortisone sodium succinate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 500mg base/vial; eq 250mg base/vial; eq 1gm base/vial; eq 100mg base/vial
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]

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    17-Feb-2021
    13-Dec-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    Hydrocortisone Sodium Succinate Manufacturers

    A Hydrocortisone Sodium Succinate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hydrocortisone Sodium Succinate, including repackagers and relabelers. The FDA regulates Hydrocortisone Sodium Succinate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hydrocortisone Sodium Succinate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Hydrocortisone Sodium Succinate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Hydrocortisone Sodium Succinate Suppliers

    A Hydrocortisone Sodium Succinate supplier is an individual or a company that provides Hydrocortisone Sodium Succinate active pharmaceutical ingredient (API) or Hydrocortisone Sodium Succinate finished formulations upon request. The Hydrocortisone Sodium Succinate suppliers may include Hydrocortisone Sodium Succinate API manufacturers, exporters, distributors and traders.

    click here to find a list of Hydrocortisone Sodium Succinate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Hydrocortisone Sodium Succinate USDMF

    A Hydrocortisone Sodium Succinate DMF (Drug Master File) is a document detailing the whole manufacturing process of Hydrocortisone Sodium Succinate active pharmaceutical ingredient (API) in detail. Different forms of Hydrocortisone Sodium Succinate DMFs exist exist since differing nations have different regulations, such as Hydrocortisone Sodium Succinate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Hydrocortisone Sodium Succinate DMF submitted to regulatory agencies in the US is known as a USDMF. Hydrocortisone Sodium Succinate USDMF includes data on Hydrocortisone Sodium Succinate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hydrocortisone Sodium Succinate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Hydrocortisone Sodium Succinate suppliers with USDMF on PharmaCompass.

    Hydrocortisone Sodium Succinate JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Hydrocortisone Sodium Succinate Drug Master File in Japan (Hydrocortisone Sodium Succinate JDMF) empowers Hydrocortisone Sodium Succinate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Hydrocortisone Sodium Succinate JDMF during the approval evaluation for pharmaceutical products. At the time of Hydrocortisone Sodium Succinate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Hydrocortisone Sodium Succinate suppliers with JDMF on PharmaCompass.

    Hydrocortisone Sodium Succinate CEP

    A Hydrocortisone Sodium Succinate CEP of the European Pharmacopoeia monograph is often referred to as a Hydrocortisone Sodium Succinate Certificate of Suitability (COS). The purpose of a Hydrocortisone Sodium Succinate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Hydrocortisone Sodium Succinate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Hydrocortisone Sodium Succinate to their clients by showing that a Hydrocortisone Sodium Succinate CEP has been issued for it. The manufacturer submits a Hydrocortisone Sodium Succinate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Hydrocortisone Sodium Succinate CEP holder for the record. Additionally, the data presented in the Hydrocortisone Sodium Succinate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Hydrocortisone Sodium Succinate DMF.

    A Hydrocortisone Sodium Succinate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Hydrocortisone Sodium Succinate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Hydrocortisone Sodium Succinate suppliers with CEP (COS) on PharmaCompass.

    Hydrocortisone Sodium Succinate WC

    A Hydrocortisone Sodium Succinate written confirmation (Hydrocortisone Sodium Succinate WC) is an official document issued by a regulatory agency to a Hydrocortisone Sodium Succinate manufacturer, verifying that the manufacturing facility of a Hydrocortisone Sodium Succinate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Hydrocortisone Sodium Succinate APIs or Hydrocortisone Sodium Succinate finished pharmaceutical products to another nation, regulatory agencies frequently require a Hydrocortisone Sodium Succinate WC (written confirmation) as part of the regulatory process.

    click here to find a list of Hydrocortisone Sodium Succinate suppliers with Written Confirmation (WC) on PharmaCompass.

    Hydrocortisone Sodium Succinate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Hydrocortisone Sodium Succinate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Hydrocortisone Sodium Succinate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Hydrocortisone Sodium Succinate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Hydrocortisone Sodium Succinate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Hydrocortisone Sodium Succinate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Hydrocortisone Sodium Succinate suppliers with NDC on PharmaCompass.

    Hydrocortisone Sodium Succinate GMP

    Hydrocortisone Sodium Succinate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Hydrocortisone Sodium Succinate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hydrocortisone Sodium Succinate GMP manufacturer or Hydrocortisone Sodium Succinate GMP API supplier for your needs.

    Hydrocortisone Sodium Succinate CoA

    A Hydrocortisone Sodium Succinate CoA (Certificate of Analysis) is a formal document that attests to Hydrocortisone Sodium Succinate's compliance with Hydrocortisone Sodium Succinate specifications and serves as a tool for batch-level quality control.

    Hydrocortisone Sodium Succinate CoA mostly includes findings from lab analyses of a specific batch. For each Hydrocortisone Sodium Succinate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Hydrocortisone Sodium Succinate may be tested according to a variety of international standards, such as European Pharmacopoeia (Hydrocortisone Sodium Succinate EP), Hydrocortisone Sodium Succinate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hydrocortisone Sodium Succinate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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