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1. Acid, Fluohydric
2. Acid, Fluorhydric
3. Acid, Hydrofluoric
4. Fluohydric Acid
5. Fluorhydric Acid
6. Fluoride, Hydrogen
7. Hydrogen Fluoride
1. Hydrogen Fluoride
2. 7664-39-3
3. Fluorane
4. Hydrofluoride
5. Fluorwasserstoff
6. Hydrogen-fluoride
7. Hydrofluoricum Acidum
8. Chebi:29228
9. Rgl5ye86cz
10. Hydrogen Fluoride, Anhydrous
11. Nsc-750679
12. Rubigine
13. Fluorine, Isotope Ofmass 18, At.
14. Antisal 2b
15. Fluorowodor [polish]
16. Caswell No. 484
17. Hydrogenfluorid
18. Fluorowodor
19. Fluorwaterstof
20. Fluorwaterstof [dutch]
21. Hydrogenfluoride
22. Hydrogen Fluoride (hf)
23. Fluorwasserstoff [german]
24. Mfcd00011346
25. Acido Fluoridrico
26. Un 1790 (solution)
27. Hydrofluoric Acid, Acs Reagent, 48%
28. Un 1052 (anhydrous)
29. Acido Fluorhidrico
30. Rcra Waste Number U134
31. Acide Fluorhydrique
32. Acido Fluoridrico [italian]
33. Acide Fluorhydrique [french]
34. Acido Fluorhidrico [spanish]
35. Hsdb 546
36. Einecs 231-634-8
37. Unii-rgl5ye86cz
38. Un1052
39. Un1790
40. Rcra Waste No. U134
41. Fluorure D'hydrogene Anhydre [french]
42. Epa Pesticide Chemical Code 045601
43. Fluorure D'hydrogene Anhydre
44. Fluoroorganics
45. Fluorum
46. Fluoruro De Hidrogeno Anhidro [spanish]
47. Fluoruro De Hidrogeno Anhidro
48. Hydridofluorine
49. Fluoridohydrogen
50. Fluoro Radical
51. Hyrofluoric Acid
52. Fluorohydric Acid
53. Fluorure D'hydrogene
54. Fluoroorganic Compound
55. Fluoroorganic Compounds
56. Organofluorine Compound
57. Organofluorine Compounds
58. Hydrofluoric Acid 70% By Weight Or More Hf
59. Fluororganische Verbindungen
60. Ec 231-634-8
61. 32057-09-3
62. Hydrofluoric Acid, 55%, Cp
63. Hydrofluoric Acid [mi]
64. Hydrogen Fluoride [mi]
65. [hf]
66. 60% Hf/dmf
67. Chembl1232767
68. Dtxsid1049641
69. Hydrofluoric Acid [hsdb]
70. Chebi:24061
71. Chebi:37143
72. Hydrofluoric Acid [vandf]
73. Hydrogen Fluoride/hydrofluoric Acid (conc 50% Or Greater)
74. Hydrofluoric Acid [mart.]
75. Hydrofluoric Acid, Ar, >=40%
76. Hydrofluoric Acid [who-dd]
77. Hydrofluoric Acid, Lr, 39-43%
78. Hydrofluoric Acid, Saj First Grade
79. Hydrofluoricum Acidum [hpus]
80. Bdbm50499187
81. Hydrofluoric Acid, 48% Acs Reagent
82. Hydrofluoric Acid, Jis Special Grade
83. Nsc750679
84. Akos024438092
85. Db11072
86. Nsc 750679
87. Hydrofluoric Acid, Technical, 40-45%
88. 37249-79-9
89. Hydrofluoric Acid, Technical Grade, 68.0%
90. Ft-0627129
91. Q2468
92. Hydrofluoric Acid, With More Than 60% Strength
93. Hydrofluoric Acid, With Not More Than 60% Strength
94. Hydrogen Fluoride, Anhydrous [un1052] [corrosive]
95. Hydrofluoric Acid, For Ultratrace Analysis, 47-51% (t)
96. Hydrofluoric Acid, Environmental Grade, (47-51 Wt% In Water)
97. Hydrofluoric Acid, 48 Wt. % In H2o, >=99.99% Trace Metals Basis
98. Hydrofluoric Acid, Environmental Grade Plus, (47-51wt % In Water)
99. Hydrofluoric Acid, Electronic Grade,49wt. % In H2o,99.99998%metals Basis
100. Hydrofluoric Acid, Puriss. P.a., Reag. Iso, Reag. Ph. Eur., >=40%
101. Hydrofluoric Acid, Semiconductor Grade Vlsi Puranal(tm) (honeywell 17601)
102. Hydrofluoric Acid, With More Than 60% Strength [un1790] [corrosive]
103. Hydrofluoric Acid, With Not More Than 60% Strength [un1790] [corrosive]
104. Hydrofluoric Acid, P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., 48.0-51.0%
105. Hydrofluoric Acid, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., >=48%
106. Hydrofluoric Acid, Semiconductor Grade Mos Puranal(tm) (honeywell 17928), 49.5-50.5%
107. Hydrofluoric Acid, Semiconductor Grade Puranal(tm) (honeywell 17735), 40-41%
108. Hydrofluoric Acid, Semiconductor Grade Puranal(tm) (honeywell 17736), 49.5-50.5%
109. 12381-92-9
110. Cytoreg (r) Is Pharmacologically Active Solution Composed By 6 Acids In An Aqueous Medium. The Active Ingredient Is Hydrofluoric Acid.
| Molecular Weight | 20.0064 g/mol |
|---|---|
| Molecular Formula | FH |
| XLogP3 | 0.6 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 20.006228194 g/mol |
| Monoisotopic Mass | 20.006228194 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 1 |
| Formal Charge | 0 |
| Complexity | 0 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
/EXPL THER/ Our aim was to evaluate the effects of hydrofluoric acid and anodised micro and micro/nano surface implants on bony ingrowth in the earliest stage of implantation in rats. Sixty cylindrical screwed titanium alloy implants with machined, micro, and hierarchical hybrid micro/nano surfaces (n=20 in each group) were inserted into the distal femurs of 30 female Sprague-Dawley rats. In vivo microcomputed tomography (micro CT) was used to assess microarchitectural changes in the bone around the implants 2 weeks after implantation. All the animals were then killed and the femurs with implants harvested for histological analysis and pull-out testing. Micro CT analysis showed that the trabecular thickness and the bone:volume ratio (bone volume:total volume) (BV:TV) increased significantly in the micro/nano group compared with the other two groups, while the trabecular separation decreased significantly in the micro/nano group compared with the machined group. The mean (SD) bone-implant contacts (%) were 38.94 (9.48), 41.67 (8.71), and 51.49 (12.49) in the machined, micro, and micro/nano groups, respectively. The maximum pull-out forces (N) were 64.95 (6.11), 71.45 (7.15), and 81.90 (13.1), respectively. Both bone-implant contacts and maximum pull-out forces were significantly higher in the micro/nano group, but there was no significant difference between the micro group and the machined group. These data indicate that the hierarchical hybrid micro/nano surface of the implant can promote osseointegration in the earliest stage of implantation, and may be a promising option for further clinical use.
PMID:22257706 Li Y et al; Br J Oral Maxillofac Surg 50 (8): 779-83 (2012)
Hydrofluoric acid can be used for intra-oral repair of restorations. Contamination of tooth substrate with hydrofluoric acid cannot always be avoided. /The study objective was/ to investigate the bonding effectiveness to hydrofluoric acid contaminated dentin by, micro-tensile bond strength testing, SEM and TEM. For this study, 15 molar teeth were used of which dentin surfaces were subjected to five, different etching procedures. Group A, 37.5% phosphoric acid (Kerr Gel) (control group); group B, 37.5% phosphoric acid followed by 3% hydrofluoric acid (DenMat); group C, 37.5% phosphoric acid, followed by 9.6% hydrofluoric acid (Pulpdent); group D, 3% hydrofluoric acid followed by 37.5%, phosphoric acid; group E, 9.6% hydrofluoric acid followed by 37.5% phosphoric acid. After the bonding procedure (OptiBond FL, Kerr) a composite resin build-up (Clearfil AP-X, Kuraray), was made. After 1 week storage, specimens were prepared for micro-tensile bond testing, SEM- and, TEM-analysis. Data were analyzed using ANOVA and post hoc Tukey's HSD (p<0.05). In the control group (solely phosphoric acid), the mean microTBS was 53.4+/-10.6 MPa, which was, significantly higher than any hydrofluoric acid prepared group (group A versus groups B-E, p<0.001). No, significant differences in microTBS were found between the 3% and 9.6% hydrofluoric acid groups: group B versus group C (13.5+/-5.5 MPa and 18.7+/-4.3 MPa, respectively) or group D versus group E (19.9+/-6.8 MPa and 20.3+/-4.1 MPa, respectively). Due to its adverse effect on the bond strength of composite to dentin, contact of hydrofluoric acid to dentin should be avoided.
PMID:20359738 Loomans BA et al; Dent Mater 26 (7): 643-9 (2010)
Food and Environmental Agents: Effect on Breast-Feeding: Reported Sign or Symptom in Infant or Effect on Lactation: Fluorides: None. /From Table 7/
Report of the American Academy of Pediatrics Committee on Drugs in Pediatrics 93 (1): 142 (1994)
Increases in plasma fluoride levels were observed in humans inhaling 0.8-2.8 or 2.9-6.0 ppm fluoride as hydrogen fluoride of 60 minutes; maximum plasma concentrations were observed 60-90 minutes after exposure initiation.
DHHS/ATSDR; Toxicological Profile for Fluorides, Hydrogen Fluoride, and Fluorine p.136 (September 2003)
A study in rats suggests that hydrogen fluoride is absorbed primarily by the upper respiratory tract, and that removal of hydrogen fluoride from inhaled air by the upper respiratory tract approaches 100% for exposures that range from 30 to 176 mg fluoride/cu m. Furthermore, it is apparent that distribution to the blood is rapid. Immediately following 40 minutes of intermittent exposure, plasma fluoride concentrations correlated closely (correlation coefficient = 0.98; p<0.01) with the concentration of hydrogen fluoride in the air passed through the surgically isolated upper respiratory tract. Plasma levels were not measured at time points <40 minutes.
DHHS/ATSDR; Toxicological Profile for Fluorides, Hydrogen Fluoride, and Fluorine p.136 (September 2003)
To define the relationship between ionic fluoride concentration in the serum of workers and the amount of hydrofluoric acid (HF) in the work environment, pre-and postshift serum and urine samples of 142 HF workers and 270 unexposed workers were examined. The maximum and minimum concentrations of HF in the air in each workshop varied from the mean by less than 30%. The preexposure levels of serum and urinary fluoride in HF workers were higher (P < 0.001) than the control values. This suggests that fluoride excretion from the body continues for at least 12 hr. The postshift serum and urinary fluoride concentrations of these workers were significantly higher (P < 0.001) than the preshift concentrations. A good correlation (r = 0.64) was obtained between postshift serum fluoride and postshift urine fluoride. There was a linear relationship between mean serum fluoride concentration and HF concentration in the workshop. A mean fluoride concentration of 82.3 ug/L with a lower fiducial limit (95%, P = 0.05) of 57.9 ug/L was estimated to correspond to an atmospheric HF concentration of 3 ppm. ...
PMID:1487331 Kono K et al; Int Arch Occup Environ Health. 1992;64(5):343-6 (1992)
A study /was conducted/ to determine the absorption of inhaled hydrofluoric acid. Two human subjects were exposed for an 8 hour period in an industrial environment to fluorides consisting primarily of hydrogen fluoride and silicon tetrafluoride at an average airborne concentration of 3.8 mg F/cu m. Urine specimens were collected at 2 hour intervals during exposure and or approximately 2 days afterwards. There was a rapid rise in urinary fluoride excretion during exposure, and a peak output was reached in 2-4 hours after cessation of exposure. Within 24 hours, the urinary fluoride levels returned practically to base levels, although a slight elevation persisted into the following day. The total amounts of fluoride excreted daily by the two subjects were as follows: day of exposure, 9.64 and 8.56 mg fluoride; first day after exposure, 1.67 and 2.49; second day, 0.99 and 1.31; and third day, 0.89 and 1.34. The baseline daily urinary fluoride excretions before exposure were 0.9 and 1.2 mg fluoride, respectively.
Collings GH et al; Arch Ind Hyg Occup Med 4: 585-90 (1951) as cited in NIOSH; Criteria Document: Hydrogen Flouride p.48 (1976) DHEW Pub. NIOSH 76-143
For more Absorption, Distribution and Excretion (Complete) data for Hydrogen fluoride (18 total), please visit the HSDB record page.
About 12-24 hr
IPCS; Poisons Information Monograph 268: Hydrogen Fluoride. (Date of last update: April 1990). Available from, as of July 20, 2017: https://www.inchem.org/documents/pims/chemical/hydfluor.htm
Concentrated solutions (>40%) and anhydrous hydrogen fluoride are sufficiently acidic to cause immediate injury due to the activity of the hydrogen ion. However, the more significant injury to the tissues and systemic toxicity are mediated by the cellular toxicity and chemical activity of the fluoride ion. Fluoride binds irreversibly to calcium and magnesium resulting in precipitation and much of the cellular and systemic toxicity is mediated via this action. The fluoride ion is the most electronegative element in the periodic table; it is a relatively small ion and therefore diffuses readily; and, because hydrogen fluoride is a weak acid, there are sufficiently uncharged species to allow tissue penetration. The fluoride ion is an inhibitor of glycolysis (Embden-Meyerhoff pathway) and it attacks many different cellular constituents including cell membranes and lipids, destroying cell membranes and producing cell necrosis. Severe hypocalcemia and hypomagnesemia are produced by hydrogen fluoride absorption causing tetany and disturbances of cardiac rhythm.
IPCS; Poisons Information Monograph 268: Hydrogen Fluoride. (Date of last update: April 1990). Available from, as of July 20, 2017: https://www.inchem.org/documents/pims/chemical/hydfluor.htm
The toxic effects of hydrogen fluoride are due primarily to the fluoride ion, which is able to penetrate tissues and bind intracellular calcium and magnesium. This results in cell destruction and local bone demineralization. Systemic deficiency of calcium and magnesium and excess of potassium can occur. Hypocalcemia can cause tetany, decreased myocardial contractility, and possible cardiovascular collapse, while hyperkalemia has been suggested to cause ventricular fibrillation leading to death. The adverse action of the fluoride ion may progress for several days before symptoms appear.
ATSDR; Medical Management Guidelines for Hydrogen Fluoride (HF) CAS 7664-39-3; UN 1052 (anhydrous), UN 1790 (solution). Available from, as of June 20, 20017: https://www.atsdr.cdc.gov/MHMI/mmg11.pdf
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