menu
    • menu

    Find Hydrogen Peroxide manufacturers, exporters & distributors on PharmaCompass

    Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

    Virtual Booth

    Contact Supplier

    Jai Radhe Sales is your partner for all your sourcing needs.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

    Virtual Booth

    Contact Supplier

    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

    MARKET PLACE

    PATENTS & EXCLUSIVITIES

    PharmaCompass

    Synopsis

    Related ProductsRelated Products

    Synopsis

    ACTIVE PHARMA INGREDIENTS

    9

    API Suppliers

    API Suppliers

    4

    USDMF

    US DMFs Filed

    3

    CEP/COS

    CEP/COS Certifications

    0

    JDMF

    JDMFs Filed

    0

    EU WC

    EU WC

    0

    KDMF

    KDMF

    0

    NDC API

    NDC API

    0

    VMF

    NDC API

    2

    Listed Suppliers

    Other Suppliers

    API REF. PRICE (USD/KG)

    $
    $ 7

    MARKET PLACE

    5

    API

    0

    FDF

    1INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    125

    FDF Dossiers

    FDF Dossiers

    1

    FDA Orange Book

    FDA (Orange Book)

    2

    Europe

    Europe

    116

    Canada

    Canada

    0

    Australia

    Australia

    0

    South Africa

    South Africa

    6

    Listed Dossiers

    Listed Dossiers

    2DRUGS IN DEVELOPMENT

    FDF Dossiers

    DRUG PRODUCT COMPOSITIONS

    REF. STANDARDS OR IMPURITIES

    0

    EDQM

    0

    USP

    0

    JP

    0

    Others

    PATENTS & EXCLUSIVITIES

    5

    US Patents

    0

    US Exclusivities

    2

    Health Canada Patents

    DIGITAL CONTENT

    1

    Data Compilation #PharmaFlow

    0

    Stock Recap #PipelineProspector

    0

    Weekly News Recap #Phispers

    13

    News #PharmaBuzz

    GLOBAL SALES INFORMATION

    US Medicaid

    NA

    Annual Reports

    NA

    Finished Drug Prices

    Listed Dossiers

    115 RELATED EXCIPIENT COMPANIES

    225EXCIPIENTS BY APPLICATIONS

    Chemistry

    Click the arrow to open the dropdown
    read-moreClick the button for full data set
    read-moreClick the button for full data set
    Also known as: 7722-84-1, Oxydol, Perhydrol, Superoxol, Interox, Hydrogen dioxide
    Molecular Formula
    H2O2
    Molecular Weight
    34.015  g/mol
    InChI Key
    MHAJPDPJQMAIIY-UHFFFAOYSA-N
    FDA UNII
    BBX060AN9V
    Hydrogen Peroxide
    A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
    1 2D Structure

    Hydrogen Peroxide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    hydrogen peroxide
    2.1.2 InChI
    InChI=1S/H2O2/c1-2/h1-2H
    2.1.3 InChI Key
    MHAJPDPJQMAIIY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    OO
    2.2 Other Identifiers
    2.2.1 UNII
    BBX060AN9V
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hydrogen Peroxide (h2o2)

    2. Hydroperoxide

    3. Oxydol

    4. Perhydrol

    5. Peroxide, Hydrogen

    6. Superoxol

    2.3.2 Depositor-Supplied Synonyms

    1. 7722-84-1

    2. Oxydol

    3. Perhydrol

    4. Superoxol

    5. Interox

    6. Hydrogen Dioxide

    7. Hydroperoxide

    8. Inhibine

    9. Peroxaan

    10. Albone

    11. Hioxyl

    12. Kastone

    13. Albone 35

    14. Albone Ds

    15. Dihydrogen Dioxide

    16. Hydrogen Peroxide Solution

    17. T-stuff

    18. Lensept

    19. Peroxide

    20. Elawox

    21. H2o2

    22. Perone

    23. Albone 50

    24. Albone 70

    25. Perone 50

    26. Albone 35cg

    27. Albone 50cg

    28. Albone 70cg

    29. Hydrogen Peroxide (h2o2)

    30. Peroxan

    31. Hydrogen Peroxide, 30%

    32. Hydrogen Dioxide Solution

    33. Hydrogen Peroxide, 90%

    34. Perone 30

    35. Perone 35

    36. Hydrogen Peroxide, Solution

    37. Waterstofperoxyde

    38. Hydrogen Peroxide, 3%

    39. Wasserstoffperoxid

    40. Caswell No. 486aaa

    41. Peroxyde D'hydrogene

    42. Perossido Di Idrogeno

    43. Asepticper

    44. Baquashock

    45. Crystacide

    46. Peroxclean

    47. Ccris 1060

    48. Dentasept

    49. Hsdb 547

    50. Hybrite

    51. Metrokur

    52. Mirasept

    53. Oxigenal

    54. Oxyfull

    55. Oxysept

    56. Pegasyl

    57. Eskata

    58. Hipox

    59. Hyrogen Peroxide

    60. Select Bleach

    61. Hydrogen Peroxide, Solution, 3%

    62. Hydrogen Peroxide Solution (dot)

    63. Xtra White

    64. Hydrogen Peroxide (conc > 52%)

    65. Oxysept I

    66. Hydrogen Peroxide Solutions

    67. Hydrogen Peroxide, Solution, 30%

    68. Hydrogen Peroxide, Solution, 35%

    69. Lensan A

    70. Odosat D

    71. Adeka Super El

    72. Crestal Whitestrips

    73. Un2014

    74. Un2015

    75. Un2984

    76. Epa Pesticide Chemical Code 000595

    77. Anti-keim 50

    78. Hydrogen Peroxide, 8% To 20%

    79. Hydrogen Peroxide, 20% To 60%

    80. Hydrogen Peroxide (> 52% Conc.)

    81. Hydrogen Peroxide [usp]

    82. Mfcd00011333

    83. Nsc-19892

    84. Un 2015 (>52%)

    85. Bbx060an9v

    86. Un 2984 (8%-20%)

    87. Un 2014 (20%-52%)

    88. Chebi:16240

    89. Hydrogen Peroxide Solutions (over 8% But Not Over 60%)

    90. Hydrogen Peroxide Solutions (over 60% But Not Over 70%)

    91. Hydrogen Peroxide (usp)

    92. Peo

    93. Dioxidane

    94. Peroxides

    95. Puresept

    96. Hydrogenperoxide

    97. Waterstofperoxyde [dutch]

    98. Accel Concentrate

    99. Wasserstoffperoxid [german]

    100. Astri-uc

    101. Htp [peroxide]

    102. High Test Peroxide

    103. Cix

    104. Peroxyde D'hydrogene [french]

    105. Teat Dip Hp 5

    106. Perossido Di Idrogeno [italian]

    107. Pre Milk Hp 0.5

    108. Pre Milk Hp 1.0

    109. Hydrogen Peroxide 35%

    110. Einecs 231-765-0

    111. Nsc 19892

    112. Unii-bbx060an9v

    113. Pre Milk Hp 0.5 10

    114. Whitespeed

    115. A Peroxide

    116. Magic Bleaching

    117. Clarigel Gold

    118. Lase Peroxide

    119. Quasar Brite

    120. Opalescence Xtra

    121. Whiteness Hp

    122. Deslime Lp

    123. Hydrogen Peroxide (conc >52%)

    124. Hydrogen Per Oxide

    125. Dihydrogen Peroxide

    126. Dihydrogen(peroxide)

    127. Oxyfull (tn)

    128. Hooh

    129. Hydrogen Hydroperoxide

    130. Nite White Excel 2

    131. Oxydol (jp17)

    132. Hydrogen Peroxide 50%

    133. Hydrogen-peroxide

    134. Oxydol [jan]

    135. Hydrogen Peroxide, 50%

    136. Hydrogen Peroxide (8ci)

    137. Molmap_000025

    138. Bis(hydridooxygen)(o--o)

    139. Ec 231-765-0

    140. 30 %hydrogen Peroxide(aq)

    141. 8007-30-5

    142. Chembl71595

    143. Hydrogen Peroxide 32 Wt. %

    144. Oxteril? 350 Spray

    145. Hydrogen Peroxide [ii]

    146. Hydrogen Peroxide [mi]

    147. [oh(oh)]

    148. Hydrogen Peroxide [fcc]

    149. Dtxsid2020715

    150. Hydrogen Peroxide [hsdb]

    151. Hydrogen Peroxide [iarc]

    152. Hydrogen Peroxide [inci]

    153. Chebi:25940

    154. Hydrogen Peroxide [vandf]

    155. Hydrogen Peroxide [mart.]

    156. Hydrogen Peroxide [who-dd]

    157. Hydrogen Peroxide (h2o2) (9ci)

    158. Nsc19892

    159. Wln: H2 O2 90%

    160. Hydrogen Peroxide [topical Solution]

    161. Akos015856794

    162. Hydrogen Peroxide [green Book]

    163. Db11091

    164. Hydrogen Peroxide [orange Book]

    165. Hydrogen Peroxide [usp Impurity]

    166. Qtl1_000041

    167. Hydrogen Peroxide, Aqueous Solutions With >40% But Not >60% Hydrogen Peroxide (stabilized As Necessary) [un2014] [oxidizer]

    168. Hydrogen Peroxide, Aqueous Solutions With Not <20% But Not >40% Hydrogen Peroxide (stabilized As Necessary) [un2014] [oxidizer]

    169. Hydrogen Peroxide, Aqueous Solutions With Not <8% But <20% Hydrogen Peroxide (stabilized As Necessary) [un2984] [oxidizer]

    170. Hydrogen Peroxide, Stabilized Or Hydrogen Peroxide Aqueous Solutions, Stabilized With >60% Hydrogen Peroxide [un2015] [oxidizer]

    171. Ft-0627133

    172. H1222

    173. Hydrogen Peroxide In Aqueous Solution

    174. C00027

    175. D00008

    176. Hydrogen Peroxide Solution, 3%, For Microbiology

    177. Hydrogen Peroxide Solution, For Ultratrace Analysis

    178. Q171877

    179. Q1088474

    180. Hydrogen Peroxide Solution, Extra Pure, 30.0-32.0%

    181. Hydrogen Peroxide Solution, Purum P.a., >=30% (rt)

    182. Hydrogen Peroxide Solution, Purum P.a., >=35% (rt)

    183. Hydrogen Peroxide Solution, >=30%, For Trace Analysis

    184. Hydrogen Peroxide Solution, Saj First Grade, >=30.0%

    185. Hydrogen Peroxide Solution, Tested According To Ph.eur.

    186. Hydrogen Peroxide Solution, 50 Wt. % In H2o, Stabilized

    187. Hydrogen Peroxide Solution, Jis Special Grade, 30.0-35.5%

    188. Hydrogen Peroxide Solution, 30 % (w/w) In H2o, Contains Stabilizer

    189. Hydrogen Peroxide Solution, Contains Inhibitor, 35 Wt. % In H2o

    190. Hydrogen Peroxide Solution, P.a., Acs Reagent, Reag. Iso, 30.0%

    191. Hydrogen Peroxide 30%, Meets The Analytical Specifications Of Ph. Eur., Stabilized

    192. Hydrogen Peroxide Solution, 30% (w/w), Puriss. P.a., Reag. Iso, Reag. Ph. Eur.

    193. Hydrogen Peroxide Solution, Ar, Contains Sodium Pyrophosphate As Stabilizer, >=30 % (w/v)

    194. Hydrogen Peroxide Solution, Contains ~200 Ppm Acetanilide As Stabilizer, 3 Wt. % In H2o

    195. Hydrogen Peroxide Solution, Contains Inhibitor, 30 Wt. % In H2o, Acs Reagent

    196. Hydrogen Peroxide Solution, Lr, Contains Sodium Pyrophosphate As Stabilizer, >=30 % (w/v)

    197. Hydrogen Peroxide Solution, Lr, Contains Sodium Pyrophosphate As Stabilizer, >=50 % (w/v)

    198. Hydrogen Peroxide Solution, Meets Analytical Specification Of Ph. Nord., 34.5-36.5%

    199. Hydrogen Peroxide Solution, Puriss. P.a., Acs Reagent, Not Stabilized, >=30% (rt)

    200. Hydrogen Peroxide Solution, Semiconductor Grade Mos Puranal(tm) (honeywell 17937), >=30%

    201. Hydrogen Peroxide Solution, Semiconductor Grade Puranal(tm) (honeywell 17948), >=30%

    202. Hydrogen Peroxide Solution, Semiconductor Grade Ulsi Puranal(tm) (honeywell 17024), >=30%

    203. Hydrogen Peroxide Solution, Semiconductor Grade Vlsi Puranal(tm) (honeywell 17606), >=30%

    204. Hydrogen Peroxide Solution, Contains Inhibitor, 30 Wt. % In H2o, Meets Usp Testing Specifications

    205. Hydrogen Peroxide Solution, Contains Potassium Stannate As Inhibitor, 30-32 Wt. % In Water, Semiconductor Grade, 99.999% Trace Metals Basis

    206. Hydrogen Peroxide, Aqueous Solutions With >40% But Not >60% Hydrogen Peroxide (stabilized As Necessary)

    207. Hydrogen Peroxide, Aqueous Solutions With >40% But Not >60% Hydrogen Peroxide (stabilized As Necessary) [un2014] [oxidizer]

    208. Hydrogen Peroxide, Aqueous Solutions With Not <20% But Not >40% Hydrogen Peroxide (stabilized As Necessary)

    209. Hydrogen Peroxide, Aqueous Solutions With Not <20% But Not >40% Hydrogen Peroxide (stabilized As Necessary) [un2014] [oxidizer]

    210. Hydrogen Peroxide, Aqueous Solutions With Not <8% But <20% Hydrogen Peroxide (stabilized As Necessary)

    211. Hydrogen Peroxide, Aqueous Solutions With Not <8% But <20% Hydrogen Peroxide (stabilized As Necessary) [un2984] [oxidizer]

    212. Hydrogen Peroxide, Stabilized Or Hydrogen Peroxide Aqueous Solutions, Stabilized With >60% Hydrogen Peroxide

    213. Hydrogen Peroxide, Stabilized Or Hydrogen Peroxide Aqueous Solutions, Stabilized With >60% Hydrogen Peroxide [un2015] [oxidizer]

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 34.015 g/mol
    Molecular Formula H2O2
    XLogP3-0.9
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass34.005479302 g/mol
    Monoisotopic Mass34.005479302 g/mol
    Topological Polar Surface Area40.5 Ų
    Heavy Atom Count2
    Formal Charge0
    Complexity0
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Anti-Infective Agents, Local; Oxidants

    National Library of Medicine's Medical Subject Headings. Hydrogen peroxide. Online file (MeSH, 2017). Available from, as of October 2, 2017: https://www.nlm.nih.gov/mesh/2017/mesh_browser/MBrowser.html

    /CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Hydrogen peroxide is included in the database.

    NIH/NLM; ClinicalTrials.Gov. Available from, as of October 2, 2017: https://clinicaltrials.gov/

    Antiseptic; disinfectant.

    O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 889

    Hydrogen peroxide 3% topical solution is used to cleanse minor cuts or skin abrasions. More potent solutions (e.g., 20-30%) have been used as a hair bleach.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017

    For more Therapeutic Uses (Complete) data for Hydrogen peroxide (14 total), please visit the HSDB record page.

    4.2 Drug Warning

    The US Food and Drug Administration (FDA) has alerted consumers that high strength hydrogen peroxide preparations (e.g., 35% food grade hydrogen peroxide) should not be used for any medicinal purpose. These preparations are being promoted on websites illegally for various medicinal purposes (e.g., AIDS, cancer, emphysema, other life-threatening conditions) without any proven clinical value, and such uses are dangerous. Hydrogen peroxide 35% is not approved by the FDA for any purpose. Ingestion of such preparations can cause serious harm or death. Oral ingestion of hydrogen peroxide can result in GI irritation and ulceration. IV administration of hydrogen peroxide can result in inflammation at the injection site, gas embolism, and life-threatening allergic reactions.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017

    Concentrated solutions (20-30% or more) of hydrogen peroxide are strongly irritating to skin or mucous membranes and should be handled cautiously.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017

    4.3 Drug Indication

    Indicated to be used as a disinfectant and sterilizer.

    Treatment of seborrhoeic keratosis

    Treatment of common warts (verrucae vulgaris)

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Hydrogen peroxide exhibits antimicrobial properties against most forms of microorganisms, including dormant forms with known high resistance profiles, such as bacterial spores and protozoal cysts. It acts as an oxidative biocide to generate free radical species to induce DNA, protein and membrane lipid damage via oxidation.

    5.2 MeSH Pharmacological Classification

    Anti-Infective Agents, Local

    Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

    Oxidants

    Electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION). (See all compounds classified as Oxidants.)

    5.3 ATC Code

    A - Alimentary tract and metabolism

    A01 - Stomatological preparations

    A01A - Stomatological preparations

    A01AB - Antiinfectives and antiseptics for local oral treatment

    A01AB02 - Hydrogen peroxide

    D - Dermatologicals

    D08 - Antiseptics and disinfectants

    D08A - Antiseptics and disinfectants

    D08AX - Other antiseptics and disinfectants

    D08AX01 - Hydrogen peroxide

    D - Dermatologicals

    D11 - Other dermatological preparations

    D11A - Other dermatological preparations

    D11AX - Other dermatologicals

    D11AX25 - Hydrogen peroxide

    S - Sensory organs

    S02 - Otologicals

    S02A - Antiinfectives

    S02AA - Antiinfectives

    S02AA06 - Hydrogen peroxide

    5.4 Absorption, Distribution and Excretion

    Absorption

    It is reported that hydrogen peroxide is decomposed before absorption in the intestine. Solutions of hydrogen peroxide displays poor penetration when applied to tissue.

    Volume of Distribution

    Target organs affected by hydrogen peroxide include the lungs, intestine, thymus, liver, and kidney.

    This in vivo study determined the kinetics of 3% hydrogen peroxide in a bleaching gel within the first hour. The material used in this study was 3% hydrogen peroxide gel and the study involved 10 subjects who met the inclusion and exclusion criteria. Each subject wore the tray with gel six different times on separate days. Evaluation of the remaining amount of hydrogen peroxide was calculated by the method stated in US Pharmacopoeia. The study results indicate that the mean percentage of hydrogen peroxide recovered for 5, 10, 20, 30, 45 and 60 minutes was 61, 56, 49, 44, 38 and 32, respectively. The amount of hydrogen peroxide in the saliva sample after one hour was 0.42 mg. Excluding the first 10 minutes, the kinetics of hydrogen peroxide in the tray and teeth sample was exponential.

    PMID:12760694 Al-Qunaian TA et al; Oper Dent 28 (3): 236-41 (2003)

    5.5 Metabolism/Metabolites

    Hydrogen peroxide is reduced by glutathione peroxidase, which is an endogenous enzyme in human tissue. It is rapidly decomposed to oxygen and water when in contact with catalase, an enzyme found in blood and most tissues.

    5.6 Mechanism of Action

    The production of free hydroxyl radicals in the Fenton reaction is thought to be the basis of biocidal actions of hydrogen peroxide. Free radicals eventually lead to oxidative damage proteins and membrane lipids _in vivo_. The oxidizing radical as the ferryl radical induces DNA oxidation.

    Hydrogen peroxide topical solution is a weak antibacterial agent, a wound cleanser, and a deodorant. The pharmacologic activity of the drug depends on the release of nascent oxygen which has a powerful oxidizing effect that destroys some microorganisms and chemically alters many organic substances. When hydrogen peroxide topical solution comes in contact with tissues that contain the enzyme catalase, the solution releases oxygen which exerts antibacterial action; the mechanical effect of effervescence loosens tissue debris and pus. The release of nascent oxygen and effervescence is more rapid on wounds, denuded areas, and mucous membranes than on unbroken skin. The presence of reactive organic material such as pus and blood diminishes the efficiency of hydrogen peroxide. The antibacterial activity of hydrogen peroxide is relatively weak and slow and the drug exhibits poor tissue and wound penetration. Hydrogen peroxide's mechanical effect of effervescence and resultant removal of tissue debris is probably a more effective means of reducing the bacterial content of wounds, denuded areas, and mucous membranes than actual antibacterial activity. The drug also appears to have a styptic effect when applied topically to minor wounds. Concentrated solutions of hydrogen peroxide have a bleaching effect on hair and may injure tissue.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017

    Increases in the levels of reactive oxygen species (ROS) are correlated with a decrease in calcineurin (CN) activity under oxidative or neuropathological conditions. However, the molecular mechanism underlying this ROS-mediated CN inactivation remains unclear. Here, we describe a mechanism for the inactivation of CN by hydrogen peroxide. The treatment of mouse primary cortical neuron cells with Abeta(1-42) peptide and hydrogen peroxide triggered the proteolytic cleavage of CN and decreased its enzymatic activity. In addition, hydrogen peroxide was found to cleave CN in different types of cells. Calcium influx was not involved in CN inactivation during hydrogen peroxide-mediated cleavage, but CN cleavage was partially blocked by chloroquine, indicating that an unidentified lysosomal protease is probably involved in its hydrogen peroxide-mediated cleavage. Treatment with hydrogen peroxide triggered CN cleavage at a specific sequence within its catalytic domain, and the cleaved form of CN had no enzymatic ability to dephosphorylate nuclear factor in activated T cells. Thus, our findings suggest a molecular mechanism by which hydrogen peroxide inactivates CN by proteolysis in ROS-related diseases.

    PMID:17217415 Lee JE et al; J Neurochem 100 (6): 1703-12 (2007)

    Matrix metalloproteinase-2 (MMP-2) is well known to proteolyse both extracellular and intracellular proteins. Reactive oxygen species activate MMP-2 at both transcriptional and post-translational levels, thus MMP-2 activation is considered an early event in oxidative stress injury. Although hydrogen peroxide is widely used to trigger oxidative stress-induced cell death, the type of cell death (apoptosis vs. necrosis) in cardiomyocytes is still controversial depending on the concentration used and the exposure time. We ... investigated the mode of cell death in neonatal rat cardiomyocytes induced by different concentrations (50-500 uM) of hydrogen peroxide at various time intervals after exposure and determined whether MMP-2 is implicated in hydrogen peroxide-induced cardiomyocyte death. Treating cardiomyocytes with hydrogen peroxide led to elevated MMP-2 level/activity with maximal effects seen at 200 uM. Hydrogen peroxide caused necrotic cell death by disrupting the plasmalemma as evidenced by the release of lactate dehydrogenase in a concentration- and time-dependent manner as well as the necrotic cleavage of PARP-1. The absence of both caspase-3 cleavage/activation and apoptotic cleavage of PARP-1 illustrated the weak contribution of apoptosis. Pre-treatment with selective MMP inhibitors did not protect against hydrogen peroxide-induced necrosis. In conclusion hydrogen peroxide increases MMP-2 level/activity in cardiomyocytes and induces necrotic cell death, however, the later effect is MMP-2 independent.

    PMID:23665313 Ali MA et al; Toxicol In Vitro 27 (6): 1686-92 (2013)

    API SUPPLIERS

    read-more
    read-more
    Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

    API Reference Price

    read-more
    read-more
    [{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1669401000,"product":"2-ETHYL ANTHRA QUINONE (USED AS A MAIN CONSTITUENT OF WORKING SOLUTION IN OUR HYDROGEN PEROXIDE PLANT)","address":"P.O. RASAYANI RAIGAD.","city":"DIST.RAIGAD MAHARASHTRA","supplier":"NAMBI GENERAL TRADING (FZC}","supplierCountry":"CHINA","foreign_port":"NA","customer":"HINDUSTAN ORGANIC CHEMICALS LIMITED","customerCountry":"INDIA","quantity":"3000.00","actualQuantity":"3000","unit":"KGS","unitRateFc":"15.5","totalValueFC":"46910.7","currency":"USD","unitRateINR":"1276.2","date":"26-Nov-2022","totalValueINR":"3828510","totalValueInUsd":"46910.7","indian_port":"COCHIN SEA","hs_no":"29146100","bill_no":"3479234","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.O. RASAYANI RAIGAD."},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1669919400,"product":"2-ETHYL ANTHRAQUINONE (2-EAQ) (FOR USE IN MANUFACTURING OF HYDROGEN PEROXIDE)","address":"CH\/1, CH\/2, GIDC INDL ESTATE,DAHEJ , TAL. VAGHRA","city":"BHARUCH,GUJARAT","supplier":"WEIFANG MENJIE CHEMICAL CO. LTD","supplierCountry":"CHINA","foreign_port":"NA","customer":"MEGHMANI FINECHEM LIMITED","customerCountry":"INDIA","quantity":"15000.00","actualQuantity":"15000","unit":"KGS","unitRateFc":"9.3","totalValueFC":"138812.3","currency":"USD","unitRateINR":"762.6","date":"02-Dec-2022","totalValueINR":"11439000","totalValueInUsd":"138812.3","indian_port":"JNPT","hs_no":"29146100","bill_no":"3567085","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"CH\/1, CH\/2, GIDC INDL ESTATE,DAHEJ , TAL. VAGHRA"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1683311400,"product":"EAQ 2 ETHYL ANTHRAQUINONE FOR USE IN MANUFACTURE OF HYDROGEN PEROXIDE","address":"1ST FLOOR, KANCHENJUNGA BUILDING,1 8, BARAKHAMBA ROAD DELHI,","city":"NEW DELHI","supplier":"SHANDONG YUBIN CHEMICAL CO LTD","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"DCM SHRIRAM LIMITED","customerCountry":"INDIA","quantity":"60000.00","actualQuantity":"60000","unit":"KGS","unitRateFc":"7.7","totalValueFC":"463773.1","currency":"USD","unitRateINR":"636","date":"06-May-2023","totalValueINR":"38161200","totalValueInUsd":"463773.1","indian_port":"JNPT","hs_no":"29146990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"China","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"","customerAddress":"1ST FLOOR, KANCHENJUNGA BUILDING,1 8, BARAKHAMBA ROAD DELHI,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1687545000,"product":"2-ETHYL ANTHRA QUINONE (USED AS A MAIN CONSTITUENT OF WORKING SOLUTION IN OUR HYDROGEN PEROXIDE PLANT)","address":"P.O. RASAYANI RAIGAD.","city":"DIST.RAIGAD MAHARASHTRA","supplier":"NAMBI GENERAL TRADING (FZC}","supplierCountry":"CHINA","foreign_port":"NA","customer":"HINDUSTAN ORGANIC CHEMICALS LIMITED","customerCountry":"INDIA","quantity":"3000.00","actualQuantity":"3000","unit":"KGS","unitRateFc":"14.5","totalValueFC":"43800.2","currency":"USD","unitRateINR":"1200.4","date":"24-Jun-2023","totalValueINR":"3600217.67","totalValueInUsd":"43800.2","indian_port":"COCHIN SEA","hs_no":"29146100","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.O. RASAYANI RAIGAD."},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704393000,"product":"2-ETHYL ANTHRA QUINONE LOT NO E2311009 (USED AS A MAIN CONSTITUENT OF WORKING SOLUTION IN OUR HYDROGEN PEROXIDE PLANT)","address":"P.O. RASAYANI","city":"DIST.RAIGAD MAHARASHTRA","supplier":"NAMBI GENERAL TRADING (FZC}","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"HINDUSTAN ORGANIC CHEMICALS LIMITED","customerCountry":"INDIA","quantity":"600.00","actualQuantity":"600","unit":"KGS","unitRateFc":"12.8","totalValueFC":"7785.2","currency":"USD","unitRateINR":"1078.4","date":"05-Jan-2024","totalValueINR":"647040","totalValueInUsd":"7785.2","indian_port":"Cochin Air","hs_no":"29146100","bill_no":"9543718","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"2ND FLOOR , ROOM NO 205, AJMAN FREEZONE P.O.BOX NO. 21076., AJMAN ,UNITED ARAB EMIRATES United Arab Emirates","customerAddress":"P.O. RASAYANI"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711045800,"product":"TETRA-N-BUTYLUREA MIN 99.5% (USED IN PROCESS FOR MANUFACTURING OF HYDROGEN PEROXIDE)","address":"5TH FLOOR KANCHENJUNGA BUILDING","city":"NEW DELHI","supplier":"JIANGSU HOLLY UWILL INTERNATIONAL CO., LTD.","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"DCM SHRIRAM LIMITED","customerCountry":"INDIA","quantity":"27200.00","actualQuantity":"27200","unit":"KGS","unitRateFc":"4.6","totalValueFC":"124824.5","currency":"USD","unitRateINR":"381.1","date":"22-Mar-2024","totalValueINR":"10364900","totalValueInUsd":"124824.5","indian_port":"JNPT","hs_no":"29242190","bill_no":"2694493","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"3\/F, BUILDING B, SOHO INTL PLAZA,48 SOFTWARE AVENUE,NANJING 210012, CHINA","customerAddress":"5TH FLOOR KANCHENJUNGA BUILDING"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711737000,"product":"2-ETHYL ANTHRAQUINONE (2-EAQ) (FOR USE IN MANUFACTURING OF HYDROGEN PEROXIDE)(HAZARDUS GOODS CLASS: 9)","address":"CH\/1, CH\/2, GIDC INDL ESTATE","city":"","supplier":"SHANDONG YUBIN CHEMICAL CO.,LTD","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"EPIGRAL LIMITED","customerCountry":"INDIA","quantity":"15000.00","actualQuantity":"15000","unit":"KGS","unitRateFc":"6.3","totalValueFC":"94838.6","currency":"USD","unitRateINR":"525","date":"30-Mar-2024","totalValueINR":"7875000","totalValueInUsd":"94838.6","indian_port":"JNPT","hs_no":"29146100","bill_no":"2812747","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"BINHAI ECONOMIC DEVELOPMENT ZONE WEIFANG 262737, CHINASDNF CHINA","customerAddress":"CH\/1, CH\/2, GIDC INDL ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720031400,"product":"2-ETHYL ANTHRAQUINONE (2-EAQ) (FOR USE IN MANUFACTURING OF HYDROGEN PEROXIDE)(HAZARDUS GOODS CLASS: 9)","address":"CH\/1, CH\/2, GIDC INDL ESTATE","city":"","supplier":"SHANDONG YUBIN CHEMICAL CO.,LTD","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"EPIGRAL LIMITED","customerCountry":"INDIA","quantity":"20000.00","actualQuantity":"20000","unit":"KGS","unitRateFc":"6.2","totalValueFC":"125253.3","currency":"USD","unitRateINR":"523.5","date":"04-Jul-2024","totalValueINR":"10470060","totalValueInUsd":"125253.3","indian_port":"JNPT","hs_no":"29146100","bill_no":"4323930","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"BINHAI ECONOMIC DEVELOPMENT ZONE WEIFANG 262737, CHINASDNF CHINA","customerAddress":"CH\/1, CH\/2, GIDC INDL ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727029800,"product":"2-ETHYL ANTHRA QUINONE (USED AS A MAIN CONSTITUENT OF WORKING SOLUTION IN HYDROGEN PEROXIDE PLANT)","address":"P.O. RASAYANI","city":"DIST.RAIGAD MAHARASHTRA","supplier":"NAMBI GENERAL TRADING (F.Z.C)","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"HINDUSTAN ORGANIC CHEMICALS LIMITED","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"8.1","totalValueFC":"65417.7","currency":"USD","unitRateINR":"685.3","date":"23-Sep-2024","totalValueINR":"5482080","totalValueInUsd":"65417.7","indian_port":"Cochin Sea","hs_no":"29146100","bill_no":"5744403","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"B\/1 OFFICE BLDG, 2ND FLOOR, ROOM NO.205, AJMAN FREE ZONE PO BOX 21076 AJMAN AE","customerAddress":"P.O. RASAYANI"}]
    26-Nov-2022
    23-Sep-2024
    KGS
    overview
    Loading...

    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

    Upgrade, download data, analyse, strategize, subscribe with us contact

    Related Excipient Companies

    Upload your portfolio for free, ask us

    Excipients by Applications

    Click here to find the perfect excipient manufacturers by their capabilities

    Solubilizers

    read-more
    read-more

    Coating Systems & Additives

    read-more
    read-more

    Fillers, Diluents & Binders

    read-more
    read-more

    Topical

    read-more
    read-more

    Parenteral

    read-more
    read-more

    Film Formers & Plasticizers

    read-more
    read-more

    Thickeners and Stabilizers

    read-more
    read-more

    Taste Masking

    read-more
    read-more

    Direct Compression

    read-more
    read-more

    Controlled & Modified Release

    read-more
    read-more

    Granulation

    read-more
    read-more

    Emulsifying Agents

    read-more
    read-more

    Chewable & Orodispersible Aids

    read-more
    read-more

    Surfactant & Foaming Agents

    read-more
    read-more

    Lubricants & Glidants

    read-more
    read-more

    Co-Processed Excipients

    read-more
    read-more

    Disintegrants & Superdisintegrants

    read-more
    read-more

    API Stability Enhancers

    read-more
    read-more

    Coloring Agents

    read-more
    read-more

    Rheology Modifiers

    read-more
    read-more

    Soft Gelatin

    read-more
    read-more

    Digital Content read-more

    Create Content with PharmaCompass, ask us

    DATA COMPILATION #PharmaFlow

    read-more
    read-more

    NEWS #PharmaBuzz

    read-more
    read-more

    Global Sales Information

    Do you need Business Intel? Ask us

    Market Place

    Do you need sourcing support? Ask us

    Patents & EXCLUSIVITIES

    Check the patents & exclusivity for this product

    ABOUT THIS PAGE

    Ask Us for Pharmaceutical Supplier and Partner
    Ask Us, Find A Supplier / Partner
    No Commissions, No Strings Attached, Get Connected for FREE

    What are you looking for?

    How can we help you?

    The request can't be empty

    Please read our Privacy Policy carefully

    You must agree to the privacy policy

    The name can't be empty
    The company can't be empty.
    The email can't be empty Please enter a valid email.
    The mobile can't be empty

    Market Place

    Market Place

    PharmaCompass

    Home

    Market Place

    Menu

    Post Enquiry

    Post Enquiry

    Market Place

    Market Place

    Search