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Also known as: Hydroxycobalamin, Hydroxocobalamin, Hydroxycob(lll)alamin, 13422-51-0, C08230

Molecular Formula

C₆₂H₉₀CoN₁₃O₁₅P

Molecular Weight

1347.4 g/mol

InChI Key

DQOCFCZRZOAIBN-UVKKECPRSA-L

Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY.

1 2D Structure

Hydroxocobalamin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

cobalt(2+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate;hydrate

2.1.2 InChI

InChI=1S/C62H90N13O14P.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;1H2/q;+2;/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56?,57+,59-,60+,61+,62+;;/m1../s1

2.1.3 InChI Key

DQOCFCZRZOAIBN-UVKKECPRSA-L

2.1.4 Canonical SMILES

CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=N7)C=C8C(C(C(=N8)C(=C4[N-]5)C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.O.[Co+2]

2.1.5 Isomeric SMILES

CC1=CC2=C(C=C1C)N(C=N2)[C@@H]3[C@@H]([C@@H]([C@H](O3)CO)OP(=O)([O-])O[C@H](C)CNC(=O)CC[C@@]\4([C@H](C5[C@]6([C@@]([C@@H](C(=N6)/C(=C\7/[C@@]([C@@H](C(=N7)/C=C\8/C([C@@H](C(=N8)/C(=C4\[N-]5)/C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)/C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.O.[Co+2]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Hydroxo-cobalamin

2. Hydroxocobalamin

3. Hydroxycobalamin

2.2.2 Depositor-Supplied Synonyms

1. Hydroxycobalamin

2. Hydroxocobalamin

3. Hydroxycob(lll)alamin

4. 13422-51-0

5. C08230

2.3 Create Date

2008-09-10

3 Chemical and Physical Properties

Molecular Formula	C₆₂H₉₀CoN₁₃O₁₅P
Molecular Weight	1347.4 g/mol
Hydrogen Bond Donor Count	10
Hydrogen Bond Acceptor Count	20
Rotatable Bond Count	26
Exact Mass	1346.574890 g/mol
Monoisotopic Mass	1346.574890 g/mol
Topological Polar Surface Area	453 Å²
Heavy Atom Count	92
Formal Charge	0
Complexity	3150
Isotope Atom Count	0
Defined Atom Stereocenter Count	13
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	3
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Cyanokit
PubMed Health	Hydroxocobalamin (Injection)
Drug Classes	Cyanide Antidote
Drug Label	Hydroxocobalamin, the active ingredient in Cyanokit, is cobinamide dihydroxide dihydrogen phosphate (ester), mono (inner salt), 3'-ester with 5,6-dimethyl-1--D-ribofuranosyl-1H-benzimidazole. The drug substance is the hydroxylated active form of vi..
Active Ingredient	Hydroxocobalamin
Dosage Form	Injectable
Route	Injection
Strength	5gm/vial (5gm/kit)
Market Status	Prescription
Company	Merck Sante Sas

2 of 4
Drug Name	Hydroxocobalamin
PubMed Health	Hydroxocobalamin (Injection)
Drug Classes	Cyanide Antidote
Drug Label	Hydroxocobalamin, the active ingredient in Cyanokit, is cobinamide dihydroxide dihydrogen phosphate (ester), mono (inner salt), 3'-ester with 5,6-dimethyl-1--D-ribofuranosyl-1H-benzimidazole. The drug substance is the hydroxylated active form of vi..
Active Ingredient	Hydroxocobalamin
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml
Market Status	Prescription
Company	Watson Labs

3 of 4
Drug Name	Cyanokit
PubMed Health	Hydroxocobalamin (Injection)
Drug Classes	Cyanide Antidote
Drug Label	Hydroxocobalamin, the active ingredient in Cyanokit, is cobinamide dihydroxide dihydrogen phosphate (ester), mono (inner salt), 3'-ester with 5,6-dimethyl-1--D-ribofuranosyl-1H-benzimidazole. The drug substance is the hydroxylated active form of vi..
Active Ingredient	Hydroxocobalamin
Dosage Form	Injectable
Route	Injection
Strength	5gm/vial (5gm/kit)
Market Status	Prescription
Company	Merck Sante Sas

4 of 4
Drug Name	Hydroxocobalamin
PubMed Health	Hydroxocobalamin (Injection)
Drug Classes	Cyanide Antidote
Drug Label	Hydroxocobalamin, the active ingredient in Cyanokit, is cobinamide dihydroxide dihydrogen phosphate (ester), mono (inner salt), 3'-ester with 5,6-dimethyl-1--D-ribofuranosyl-1H-benzimidazole. The drug substance is the hydroxylated active form of vi..
Active Ingredient	Hydroxocobalamin
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml
Market Status	Prescription
Company	Watson Labs

4.2 Therapeutic Uses

Hematinics

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

Cyanokit is indicated for the treatment of known or suspected cyanide poisoning.

Thomson Health Care Inc.; Physicians' Desk Reference 62 ed., Montvale, NJ 2008, p. 1032

Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.

US Natl Inst Health; DailyMed. Current Medication Information for Hydroxocobalamin (February 2006). Available from, as of October 3, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6636

The US government considers cyanide to be among the most likely agents of chemical terrorism. Cyanide differs from many other biological or chemical agents for which little or no defense is available because its individual and public health effects are largely remediable through appropriate preparedness and response. Because the toxicity of the cyanide antidote currently available in the United States renders it ill-suited for use in terrorist incidents and other situations requiring rapid out-of-hospital treatment, hydroxocobalamin--an effective and safe cyanide antidote being used in other countries--has been introduced in the United States. Unlike the other available cyanide antidote, hydroxocobalamin can be administered at the scene of a cyanide disaster, and it need not be reserved for cases of confirmed cyanide poisoning but can be administered in cases of suspected poisoning. Both of these attributes facilitate the rapid intervention necessary for saving lives. To realize the potential benefits of hydroxocobalamin, progress also needs to be realized in other aspects of readiness, including but not limited to developing plans for ensuring local and regional availability of antidote, educating emergency responders and health care professionals in the recognition and management of cyanide poisoning, and raising public awareness of the potential for a chemical weapons attack and of how to respond.

PMID:17976798 Eckstein M; J Emerg Med. 2008 Jul;35(1):59-65 (2008)

For more Therapeutic Uses (Complete) data for HYDROXOCOBALAMIN (10 total), please visit the HSDB record page.

4.3 Drug Warning

Caution should be exercised when administering other cyanide antidotes simultaneously with Cyanokit, as the safety of coadministration has not been established. If a decision is made to administer another cyanide antidote with Cyanokit, these drugs should not be administered concurrently in the same IV line.

Thomson Health Care Inc.; Physicians' Desk Reference 62 ed., Montvale, NJ 2008, p. 1033

Use caution in the management of patients with known anaphylactic reactions to hydroxocobalamin or cyanocobalamin. Consideration should be given to use of alternative therapies, if available. Allergic reactions may include: anaphylaxis, chest tightness, edema, urticaria, pruritus, dyspnea, and rash. Allergic reactions including angioneurotic edema have also been reported in postmarketing experience.

Thomson Health Care Inc.; Physicians' Desk Reference 62 ed., Montvale, NJ 2008, p. 1033

Maternal Medication usually Compatible with Breast-Feeding: B12: Reported Sign or Symptom in Infant or Effect on Lactation: None. /from Table 6/

Report of the American Academy of Pediatrics Committee on Drugs in Pediatrics 93 (1): 140 (1994)

While determination of blood cyanide concentration is not required for management of cyanide poisoning and should not delay treatment with Cyanokit, collecting a pretreatment blood sample may be useful for documenting cyanide poisoning as sampling post- Cyanokit use may be inaccurate.

Thomson Health Care Inc.; Physicians' Desk Reference 62 ed., Montvale, NJ 2008, p. 1033

For more Drug Warnings (Complete) data for HYDROXOCOBALAMIN (19 total), please visit the HSDB record page.

4.4 Drug Indication

Treatment of known or suspected cyanide poisoning.

Cyanokit is to be administered together with appropriate decontamination and supportive measures.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Hematinics

Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias. (See all compounds classified as Hematinics.)

Vitamin B Complex

A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Antidote [EPC]

5.3 ATC Code

V03AB33

B - Blood and blood forming organs

B03 - Antianemic preparations

B03B - Vitamin b12 and folic acid

B03BA - Vitamin b12 (cyanocobalamin and analogues)

B03BA03 - Hydroxocobalamin

V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AB - Antidotes

V03AB33 - Hydroxocobalamin

5.4 Absorption, Distribution and Excretion

The possibility of direct transport of hydroxocobalamin from the nasal cavity into the cerebrospinal fluid after nasal administration in rats was investigated and the results were compared with a human study. Hydroxocobalamin was given to rats (n=8) both intranasally (214 ug/rat) and intravenously (49.5 ug/rat) into the jugular vein using a Vascular Access Port (VAP). Prior to and after drug administration, blood and cerebrospinal fluid samples were taken and analysed by radioimmunoassay. The AUCcerebrospinal fluid/AUCplasma ratio after nasal delivery does not differ from the ratio after intravenous infusion, indicating that hydroxocobalamin enters the cerebrospinal fluid via the blood circulation across the blood-brain barrier (BBB). This same transport route is confirmed by the cumulative AUC-time profiles in cerebrospinal fluid and plasma, demonstrating a 30 min delay between plasma absorption and cerebrospinal fluid uptake of hydroxocobalamin in rats and in a comparative human study. The present results in rats show that there is no additional uptake of hydroxocobalamin in the cerebrospinal fluid after nasal delivery compared to intravenous administration, which is in accordance with the results found in humans.

PMID:14668053 Van den Berg MP et al; J Drug Target 11 (6): 325-31 (2003)

Fifty percent of the administered dose of hydroxocobalamin disappears from the injection site in 2.5 hours. Hydroxocobalamin is bound to plasma proteins and stored in the liver. It is excreted in the bile and undergoes some enterohepatic recycling. Within 72 hours after injection of 500 to 1000 mcg of hydroxocobalamin, 16 to 66 percent of the injected dose may appear in the urine. The major portion is excreted within the first 24 hours.

US Natl Inst Health; DailyMed. Current Medication Information for Hydroxocobalamin (February 2006). Available from, as of October 3, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6636

Hydroxocobalamin is absorbed more slowly from the site of injection than is cyanocobalamin and there is some evidence that liver uptake of hydroxocobalamin may be greater than that of cyanocobalamin. It is believed that the increased retention of hydroxocobalamin compared with that of cyanocobalamin results from the greater affinity of hydroxocobalamin for both specific and nonspecific binding proteins in blood and tissues, as well as to its slower absorption from the injection site.

American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008

In the presence of gastric acid and pancreatic proteases, dietary vitamin B12 is released from food and salivary binding protein and bound to gastric intrinsic factor. When the vitamin B12-intrinsic factor complex reaches the ileum, it interacts with a receptor on the mucosal cell surface and is actively transported into circulation. Adequate intrinsic factor, bile, and sodium bicarbonate (to provide a suitable pH) all are required for ileal transport of vitamin B12. Vitamin B12 deficiency in adults is rarely the result of a deficient diet per se; rather, it usually reflects a defect in one or another aspect of this complex sequence of absorption. Achlorhydria and decreased secretion of intrinsic factor by parietal cells secondary to gastric atrophy or gastric surgery is a common cause of vitamin B12 deficiency in adults. Antibodies to parietal cells or intrinsic factor complex also can play a prominent role in producing a deficiency. A number of intestinal diseases can interfere with absorption, including pancreatic disorders (loss of pancreatic protease secretion), bacterial overgrowth, intestinal parasites, sprue, and localized damage to ileal mucosal cells by disease or as a result of surgery. /Vitamin B-12/

Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006., p. 1454-5

For more Absorption, Distribution and Excretion (Complete) data for HYDROXOCOBALAMIN (9 total), please visit the HSDB record page.

5.5 Metabolism/Metabolites

Toxicokinetics of hydroxocobalamin were studied in rats and in dogs after single administration. In dogs, the AUCs of free cobalamins-(III) and total cobalamins-(III) increased proportionally to the dose. Mean Cmax measured for free- and total cobalamins-(III) were 1 to 5 fold higher than those measured in humans treated with 5.0 and 10.0 g hydroxocobalamin. Terminal half-lives reached approximately 6 and 8 hours for free and total cobalamins-(III), respectively in dogs. Corresponding figures in rats amounted to 3 and 5 hours. In dogs, the clearance of total cobalamins-(III) (0.064 to 0.083 L/h/kg) was 6-7 fold lower than clearance of free cobalamins-(III).

European Medicines Agency (EMEA), The European Agency for the Evaluation of Medicinal Products, European Public Assessment Report (EPAR) for Authorized Medicinal Products for Human Use; Cyanokit, Scientific Discussion (2007). Available from, as of November 24, 2008: https://www.emea.europa.eu/humandocs/Humans/EPAR/cyanokit/cyanokit.htm

The binding of hydroxocobalamin to proteins may be regarded as reversible metabolism. Hydroxocobalamin also reacts with cyanide thereby forming cyanocobalamin. This complex is highly stable and is therefore regarded as a physiological end product of hydroxocobalamin especially during cyanide intoxication.

5.6 Biological Half-Life

In normal individuals, hydroxocobalamin has a plasma half life of 3-20 hours. In patients with cyanide poisoning, the half life is 14-24 hours.

Olson, K.R. (Ed.); Poisoning & Drug Overdose. 5th ed. Lange Medical Books/McGraw-Hill. New York, N.Y. 2007., p. 459

5.7 Mechanism of Action

Hydroxocobalamin is a complexation agent that acts by direct binding of the cyanide ions, resulting in cyanocobalamin which is a highly stable, nontoxic compound that is excreted in the urine. In addition, increased blood pressure observed in some healthy subjects of the phase I clinical study and results of a non-clinical study performed in anesthetized rabbits suggest an interference of hydroxocobalamin with the NO system.

VITAMIN B12 IS IMPLICATED IN PROTEIN SYNTH THROUGH ITS ROLE IN SYNTH OF AMINE ACID METHIONINE... /COBALAMINS/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1329

COENZYME B12 IS REQUIRED FOR HYDROGEN TRANSFER & ISOMERIZATION WHEREBY METHYLMALONATE IS CONVERTED TO SUCCINATE, THUS INVOLVING COBALAMIN IN BOTH FAT & CARBOHYDRATE METABOLISM. ... METHYLCOBALAMIN IS REQUIRED FOR CONVERSION OF HOMOCYSTEINE TO METHIONINE IN MAMMALS. /COBALAMINS/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1329

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Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

Contact Supplier

India

Virtual Booth

Digital Content

HYDROXOCOBALAMIN

NDC Package Code : 58159-027

Start Marketing Date : 2019-10-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (5kg/5kg)

Marketing Category : BULK INGREDIENT

Product Web Link

05

Supriya Lifescience Limited

India

Medlab Asia & Asia Health

Not Confirmed

Supriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

Contact Supplier

India

Virtual Booth

Digital Content

HYDROXOCOBALAMIN

NDC Package Code : 61281-9600

Start Marketing Date : 2017-02-24

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

06

Professional Compounding Centers of...

United Kingdom

Medlab Asia & Asia Health

Not Confirmed

07

Spectrum Laboratory Products, Inc.

U.S.A

Medlab Asia & Asia Health

Not Confirmed

08

Spectrum Laboratory Products, Inc.

U.S.A

Medlab Asia & Asia Health

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

01

HealthTech BioActives

Spain

Medlab Asia & Asia Health

Not Confirmed

HealthTech BioActives, leading globally in Flavonoids and Vitamin B12 Derivatives.

Contact Supplier

Spain

Virtual Booth

Digital Content

Hydroxocobalamin

About the Company : HTBA (HealthTech BioActives) is a leading global company highly specialized in flavonoids and vitamin B12 derivatives After 40 years in the pharmaceutical world of ingredients of ...

HTBA (HealthTech BioActives) is a leading global company highly specialized in flavonoids and vitamin B12 derivatives After 40 years in the pharmaceutical world of ingredients of natural origin, HTBA is determined to formulate today the new methods of tomorrow. HTBA covers the entire value chain, from raw materials to merchandise, with global reach in pharmaceuticals, dietary supplements, human and animal nutrition, and in cosmetics. In HTBA we know that our ingredients have a direct impact, not only in our clients activity but also in the well-being of the consumers of their products.

02

Deccan Nutraceuticals Pvt. Ltd

India

Medlab Asia & Asia Health

Not Confirmed

Deccan Nutraceuticals: A global leader in the integrated development, manufacturing, and marketing of pharmaceutical products.

Contact Supplier

India

Virtual Booth

Digital Content

Hydroxocobalamin

About the Company : Deccan Nutraceuticals Pvt. Ltd. (DNPL) is a group company of Alkaloids Corporation (India), was founded in 2001 and operates from a 22,000 sq. m. facility in Pune (India). Their co...

Deccan Nutraceuticals Pvt. Ltd. (DNPL) is a group company of Alkaloids Corporation (India), was founded in 2001 and operates from a 22,000 sq. m. facility in Pune (India). Their commitment to quality and adherence to Current Good Manufacturing Practices (CGMP) are integral to their operations. The company has been successfully audited by USFDA (5 times) and EDQM (2 times). The company manufactures high quality phytochemicals, semi-synthetic and synthetic APIs. DNPL stands as a responsible pharmaceutical manufacturer, devoted to delivering premium products across all the regions we serve.

Corporate PDF

03

EUROAPI

France

DDL Conference

Attending

EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

Contact Supplier

France

Virtual Booth

Digital Content

Hydroxocobalamin

About the Company : EUROAPI is the market leader in small molecule APIs with projected sales of about €1 billion in 2022. With around 200 APIs, it has one of the largest portfolios in the market. Th...

EUROAPI is the market leader in small molecule APIs with projected sales of about €1 billion in 2022. With around 200 APIs, it has one of the largest portfolios in the market. Thanks to its excellent R&D skills and six manufacturing facilities across Europe, EUROAPI guarantees API manufacturing of the highest quality to its clients in over 80 countries. Its strong innovation and R&D skills helps it to speed the development of more complex molecule segments through CDMO operations. It also offers experience in supply, regulation and quality. EUROAPI employs 3,350 people and is listed on Euronext.

04

Supriya Lifescience

India

Medlab Asia & Asia Health

Not Confirmed

Supriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

Contact Supplier

India

Virtual Booth

Digital Content

Hydroxocobalamin

About the Company : Supriya Lifescience Ltd. specializes in API manufacturing, focusing on therapeutic segments like antihistamines, anti-allergic drugs, vitamins, anaesthetics and anti-asthmatics. Su...

Supriya Lifescience Ltd. specializes in API manufacturing, focusing on therapeutic segments like antihistamines, anti-allergic drugs, vitamins, anaesthetics and anti-asthmatics. Supriya follows industry standards and constantly improves to deliver quality products. Its facility is 47,000 square meters with dedicated areas for warehouse, QA, QC, R&D, production and finished products. The current capacity is 550 KL, with plans to expand to over 1000 KL by 2024. Supriya has 14 active USDMFs, 8 active CEPs, strong R&D and compliant facilities worldwide. Supriya works with innovators, generic companies, and as a CMO.

Portfolio PDF

Product Web Link

Virtual Booth

India

Medlab Asia & Asia Health

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

API Reference Price

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SOCIETY ROAD,JOGESHWARI (E), MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1647282600,"product":"HYDROXOCOBALAMIN BASE USP","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD, GOREGAON EAST Contact No: 919869435","city":"MUMBAI","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"HOUSTON, TX","customer":"CONSIGNEE","customerCountry":"UNITED STATES","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"12500","totalValueFC":"5956.5","currency":"USD","unitRateINR":908000,"date":"15-Mar-2022","totalValueINR":"454000","totalValueInUsd":"5956.5","indian_port":"BOMBAY AIR","hs_no":"29362690","bill_no":"8945275","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD, GOREGAON EAST Contact No: 919869435, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1660156200,"product":"HYDROXOCOBALAMIN ACETATE EP","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD, GOREGAON EAST Contact No: 919869435","city":"MUMBAI","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"CONSIGNEE","customerCountry":"KOREA, REPUBLIC OF","quantity":"0.25","actualQuantity":"0.25","unit":"KGS","unitRateFc":"16000","totalValueFC":"3808.1","currency":"USD","unitRateINR":1212000,"date":"11-Aug-2022","totalValueINR":"303000","totalValueInUsd":"3808.1","indian_port":"BOMBAY AIR","hs_no":"29362690","bill_no":"3436345","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD, GOREGAON EAST Contact No: 919869435, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1672770600,"product":"HYDROXOCOBALAMIN HYDROCHLORIDE BP\/EP","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD, GOREGAON EAST Contact No: 919869435","city":"MUMBAI","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"AUCKLAND","customer":"CONSIGNEE","customerCountry":"NEW ZEALAND","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"9000","totalValueFC":"44594.2","currency":"USD","unitRateINR":729200,"date":"04-Jan-2023","totalValueINR":"3646000","totalValueInUsd":"44594.2","indian_port":"BOMBAY AIR","hs_no":"29362690","bill_no":"6689196","productDescription":"API","marketType":"REGULATED MARKET","country":"NEW ZEALAND","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD, GOREGAON EAST Contact No: 919869435, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1674498600,"product":"HYDROXOCOBALAMIN ACETATE EP","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD, GOREGAON EAST Contact No: 919869435","city":"MUMBAI","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"CONSIGNEE","customerCountry":"GERMANY","quantity":"0.04","actualQuantity":"0.039","unit":"KGS","unitRateFc":"41025.6","totalValueFC":"1455.5","currency":"USD","unitRateINR":3051282.0512820515,"date":"24-Jan-2023","totalValueINR":"119000","totalValueInUsd":"1455.5","indian_port":"BOMBAY AIR","hs_no":"29362690","bill_no":"7219939","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD, GOREGAON EAST Contact No: 919869435, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693593000,"product":"ACTIVE PHARMACEUTICAL INGREDIENT - HYDROXOCOBALAMIN ACETATE EP10","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"CONSIGNEE","customerCountry":"PAKISTAN","quantity":"0.05","actualQuantity":"0.05","unit":"KGS","unitRateFc":"20000","totalValueFC":"927.6","currency":"USD","unitRateINR":1540000,"date":"02-Sep-2023","totalValueINR":"77000","totalValueInUsd":"927.6","indian_port":"Bombay Air","hs_no":"29362690","bill_no":"3662554","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703701800,"product":"ACTIVE PHARMACEUTICAL INGREDIENT - HYDROXOCOBALAMIN BASE","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"HOUSTON, TX","customer":"CONSIGNEE","customerCountry":"UNITED STATES","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"10000","totalValueFC":"9802.6","currency":"USD","unitRateINR":816000,"date":"28-Dec-2023","totalValueINR":"816000","totalValueInUsd":"9802.6","indian_port":"Bombay Air","hs_no":"29362690","bill_no":"6360163","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709749800,"product":"ACTIVE PHARMACEUTICAL INGREDIENT - HYDROXOCOBALAMIN CHLORIDE EP","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"WARSAW","customer":"CONSIGNEE","customerCountry":"POLAND","quantity":"1.06","actualQuantity":"1.06","unit":"KGS","unitRateFc":"13500","totalValueFC":"14049.3","currency":"USD","unitRateINR":1100564.1509433961,"date":"07-Mar-2024","totalValueINR":"1166598","totalValueInUsd":"14049.3","indian_port":"Bombay Air","hs_no":"29362690","bill_no":"8117041","productDescription":"API","marketType":"REGULATED MARKET","country":"POLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721241000,"product":"PHARMACEUTICAL ALLOPATHIC RAW MATERIAL : HYDROXOCOBALAMIN SULPHATE BP","address":"66\/70;PRINCESS STREET","city":"MUMBAI, ,MAHARASHTRA","supplier":"MICRO ORGO CHEM","supplierCountry":"INDIA","foreign_port":"BUENOS AIRES","customer":"GEMINIS FARMACEUTICA S.A.","customerCountry":"ARGENTINA","quantity":"1.50","actualQuantity":"1.5","unit":"KGS","unitRateFc":"8400","totalValueFC":"12316.1","currency":"USD","unitRateINR":686346.66666666663,"date":"18-Jul-2024","totalValueINR":"1029520","totalValueInUsd":"12316.1","indian_port":"Bombay Air","hs_no":"29362690","bill_no":"2506371","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ARGENTINA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"66\/70;PRINCESS STREET, MUMBAI, ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729708200,"product":"HYDROXOCOBALAMIN CHLORIDE (QTY: 6 X 3 X 150MG, VALUE: USD 296\/EACH) (FOC)","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"USP","supplierCountry":"HUNGARY","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0027","unit":"KGS","unitRateFc":"657777.8","totalValueFC":"1828.6","currency":"USD","unitRateINR":"56908488.9","date":"24-Oct-2024","totalValueINR":"153652.92","totalValueInUsd":"1828.6","indian_port":"Hyderabad Air","hs_no":"29362690","bill_no":"6307574","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,M D 21704 USA Frederick, , United Sta tes United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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FDF Dossiers

01

Aspen Pharmacare Holdings

South Africa

Medlab Asia & Asia Health

Not Confirmed

Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

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South Africa

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Regulatory Info :

Registration Country : Australia

hydroxocobalamin

Brand Name : Hydroxo-B12

Dosage Form : injection

Dosage Strength : 1 mg/mL

Packaging : 3

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

Portfolio PDF

Product Web Link

Virtual Booth

Digital Content

Website

Corporate PDF

02

Actavis Inc

Ireland

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FDA Orange Book

01

ABRAXIS PHARM

U.S.A

U.S.A

Medlab Asia & Asia Health

Not Confirmed

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Europe

01

PFIZER ITALIA Srl

U.S.A

DDL Conference

Not Confirmed

02

Takeda AS

Japan

DDL Conference

Not Confirmed

03

World Medicine Ilac San ve tic LTD STl

Turkey

Country

DDL Conference

Not Confirmed

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Canada

01

SERB S.A.

Belgium

Medlab Asia & Asia Health

Not Confirmed

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Australia

01

Aspen Pharmacare Australia Pty Limited

South Africa

Medlab Asia & Asia Health

Not Confirmed

Contact Supplier

South Africa

Virtual Booth

Digital Content

Regulatory Info :

Registration Country : Australia

hydroxocobalamin

Brand Name : Hydroxo-B12

Dosage Form : injection

Dosage Strength : 1 mg/mL

Packaging : 3

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

Portfolio PDF

Product Web Link

Virtual Booth

Digital Content

Website

Corporate PDF

02

Amdipharm Mercury (Australia) Pty Limite...

United Kingdom

Medlab Asia & Asia Health

Not Confirmed

03

Amdipharm Mercury (Australia) Pty Limite...

United Kingdom

Medlab Asia & Asia Health

Not Confirmed

04

Juno Pharmaceuticals Pty Ltd

Australia

Medlab Asia & Asia Health

Not Confirmed

05

Pfizer Australia Pty Ltd

Canada

Medlab Asia & Asia Health

Not Confirmed

06

Pfizer Australia Pty Ltd

Canada

Medlab Asia & Asia Health

Not Confirmed

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Co-Processed Excipients

Granulation

Topical

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

11 API Suppliers

3 USDMF

1 JDMF

1 EU WC

2 KDMF

8 NDC API

10 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

23 FDF Dossiers

7 FDA Orange Book

9 Europe

1 Canada

6 Australia

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EXCIPIENTS BY APPLICATIONS

52 Coating Systems & Additives

47 Fillers, Diluents & Binders

29 Controlled & Modified Release

23 Direct Compression

20 Disintegrants & Superdisintegrants

18 Thickeners and Stabilizers

16 Lubricants & Glidants

16 Taste Masking

14 Film Formers & Plasticizers

13 Co-Processed Excipients

12 Granulation

10 Topical

9 Chewable & Orodispersible Aids

9 Parenteral

5 Empty Capsules

5 API Stability Enhancers

5 Solubilizers

4 Emulsifying Agents

4 Vegetarian Capsules