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Chemistry

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Also known as: Hydroxyethylcellulose, Cellulose hydroxyethyl ether, 2-hydroxyethyl cellulose ether, Db11602
Molecular Formula
C36H70O19
Molecular Weight
806.9  g/mol
InChI Key
DFJVHKAPIXJTSC-UHFFFAOYSA-N

Hydroxyethyl Cellulose
Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic character.
1 2D Structure

Hydroxyethyl Cellulose

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[[3,4,5-tris(2-hydroxypropoxy)-6-[4,5,6-tris(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]propan-2-ol
2.1.2 InChI
InChI=1S/C36H70O19/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41/h19-44H,9-18H2,1-8H3
2.1.3 InChI Key
DFJVHKAPIXJTSC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(COCC1C(C(C(C(O1)OC2C(OC(C(C2OCC(C)O)OCC(C)O)OCC(C)O)COCC(C)O)OCC(C)O)OCC(C)O)OCC(C)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Aldiamed

2. Hydroxyethylcellulose

3. Hydroxyethylcellulose, Sodium Salt

4. Hydroxyl Ethyl Cellulose

5. Lacrigel

6. Minims Artificial Tears

7. Natrosol 250

2.2.2 Depositor-Supplied Synonyms

1. Hydroxyethylcellulose

2. Cellulose Hydroxyethyl Ether

3. 2-hydroxyethyl Cellulose Ether

4. Db11602

2.3 Create Date
2005-09-14
3 Chemical and Physical Properties
Molecular Weight 806.9 g/mol
Molecular Formula C36H70O19
XLogP3-3
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count19
Rotatable Bond Count28
Exact Mass806.45113000 g/mol
Monoisotopic Mass806.45113000 g/mol
Topological Polar Surface Area263 Ų
Heavy Atom Count55
Formal Charge0
Complexity986
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count18
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For alleviating surface irritation in topical ocular administrations, such as artificial tear solutions. Hydroxyethyl cellulose is also found in topical formulations to aid in more efficient drug diffusion across the membranes.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Hydroxyethyl cellulose acts as a demulcent by relieving inflammation or irritation and dryness of eyes. It acts as one of the key ingredient and viscosity-enhancing agent to prolong corneal contact time and increase intraocular drug levels.


5.2 Mechanism of Action

Interacts with the solid surface through hydrogen bonding to thicken and prolong the formation time of a water-retaining film. Hydroxyethyl cellulose acts as a drug carrier or microsphere to entrap other drug molecules and form a viscous gel-like dispersion, enabling drug diffusion across biological membranes.


API Reference Price

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[{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702837800,"product":"LIDOCAINE HCL (HYDROXYETHYL CELLULOSE (HEC) POLYMER)","address":"Plot No. G1,B-11A, Ved Villa Colony","city":"Jaipur","supplier":"TYN BIOTECH","supplierCountry":"INDIA","foreign_port":"ALGER","customer":"SARL LABORATOIRE PRODUCTION","customerCountry":"ALGERIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"9.4","totalValueFC":"913","currency":"USD","unitRateINR":760,"date":"18-Dec-2023","totalValueINR":"76000","totalValueInUsd":"913","indian_port":"JNPT","hs_no":"29420090","bill_no":"6121554","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ALGERIA","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"Plot No. G1,B-11A, Ved Villa Colony, Jaipur","customerAddress":""}]
18-Dec-2023
18-Dec-2023
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