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Chemistry

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Also known as: 87-28-5, Glycol salicylate, 2-hydroxyethyl 2-hydroxybenzoate, Ethylene glycol monosalicylate, Espirosal, Glycol monosalicylate
Molecular Formula
C9H10O4
Molecular Weight
182.17  g/mol
InChI Key
LVYLCBNXHHHPSB-UHFFFAOYSA-N
FDA UNII
3I1VBB7AXH

Hydroxyethyl Salicylate
Glycol salicylate, also known as 2-hydroxyethyl salicylate, is a benzoate ester formed from the condensation of the carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol. It is found as an active ingredient and topical analgesic in patches used to provide relief for mild to moderate muscle and joint pain. This drug belongs to the salicylate group of drugs, which are used as analgesic agents for the treatment of mild to moderate pain. Glycol salicylate (GS), composed of salicylic acid (SA) and ethylene glycol, is a non-steroidal anti-inflammatory drug. This ingredient is an important component of many topical creams and sprays for the relief of aches, pains, and stiffness of the muscles, joints, and tendons.
1 2D Structure

Hydroxyethyl Salicylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-hydroxyethyl 2-hydroxybenzoate
2.1.2 InChI
InChI=1S/C9H10O4/c10-5-6-13-9(12)7-3-1-2-4-8(7)11/h1-4,10-11H,5-6H2
2.1.3 InChI Key
LVYLCBNXHHHPSB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C(=C1)C(=O)OCCO)O
2.2 Other Identifiers
2.2.1 UNII
3I1VBB7AXH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ethyleneglycolmonosalicylic Acid Ester

2. Glycol Monosalicylate

3. Glycol Salicylate

4. Hydroxyethyl Salicylate

5. Menthoneurin

2.3.2 Depositor-Supplied Synonyms

1. 87-28-5

2. Glycol Salicylate

3. 2-hydroxyethyl 2-hydroxybenzoate

4. Ethylene Glycol Monosalicylate

5. Espirosal

6. Glycol Monosalicylate

7. Rheumacyl

8. Sarocol

9. Spirosal

10. Glysal

11. Ethylene Glycol Salicylate

12. Phlogont

13. Monoglycol Salicylate

14. Gl 7

15. Benzoic Acid, 2-hydroxy-, 2-hydroxyethyl Ester

16. Glykolsalicylat

17. Traumasenex

18. Ethylene Glycol, Salicylate

19. Kytta-gel

20. Ethylene Glycol, Monosalicylate

21. 1,2-ethylene Glycol Monosalicylate

22. Aethylenglykolsalicylat

23. Hydroxyethyl Salicylate

24. 2-hydroxybenzoic Acid 2-hydroxyethyl Ester

25. Salicylic Acid, 2-hydroxyethyl Ester

26. Ethylenglycol-monosalicylsaeureester

27. Nsc-72097

28. 3i1vbb7axh

29. .beta.-hydroxyethyl Salicylate

30. Chebi:86541

31. 2-hydroxyethyl 2-oxidanylbenzoate

32. Mfcd00002862

33. Ncgc00159379-03

34. 2-hydroxybenzoic Acid, 2-hydroxyethyl Ester

35. Glycol Salicylate (jan)

36. Glycol Salicylate [jan]

37. Unii-3i1vbb7axh

38. Norgesic (tn)

39. Phlogont (tn)

40. Einecs 201-737-2

41. Nsc 72097

42. Ai3-05033

43. 2-hydroxyethyl-salicylate

44. Bmse000750

45. Dsstox_cid_28913

46. Dsstox_rid_83181

47. Dsstox_gsid_48987

48. Schembl15402

49. Salicylic Acid Ethylene Glycol

50. Glycol Salicylate [mi]

51. Chembl173562

52. Dtxsid4048987

53. Glycol Salicylate [inci]

54. Lvylcbnxhhhpsb-uhfffaoysa-

55. Glycol Salicylate [mart.]

56. Glycol Salicylate [who-dd]

57. Cs-b1707

58. Hy-b2208

59. Nsc72097

60. Zinc1698306

61. Salicylic Acid 2-hydroxyethyl Ester

62. Tox21_113462

63. Akos009075810

64. Db11323

65. Cas-87-28-5

66. Ncgc00159379-02

67. Ncgc00159379-04

68. 2-hydroxy-benzoicacid2-hydroxyethyl Ester

69. Sy032913

70. E0113

71. Ft-0626298

72. Salicylic Acid, 2-hydroxyethyl Ester (8ci)

73. Hydroxyethyl Salicylate [ep Monograph]

74. D01557

75. E78954

76. Ethylene Glycol Monosalicylate, >=98.0% (gc)

77. A842078

78. Q117422

79. Sr-01000944719

80. Sr-01000944719-1

81. W-104034

82. Hydroxyethyl Salicylate, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 182.17 g/mol
Molecular Formula C9H10O4
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass182.05790880 g/mol
Monoisotopic Mass182.05790880 g/mol
Topological Polar Surface Area66.8 Ų
Heavy Atom Count13
Formal Charge0
Complexity169
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

This drug is only recommended for topical usages for the relief of muscular and rheumatic pain in human and animals.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Temporarily relieves minor to moderate aches and pains. Works with ingredients such as menthol, which has counter-irritant properties. Counter-irritants are externally applied, and lead to irritation or mild inflammation of the skin to relieve pain in muscles or joints by reducing inflammation in deeper adjacent structures. Counter-irritants relieve pain by disrupting the brain from receiving pain signals resulting from conditions such as osteoarthritis (OA) or injuries such as sprains or strains. These agents may cause vasodilatation or skin irritation, leading to a false sensation of heat or warmth.


5.2 Absorption, Distribution and Excretion

Absorption

Salicylate absorption follows first-order kinetics with an absorption half-life ranging from 5 to 16 minutes.


Route of Elimination

Salicylates are generally excreted.


5.3 Metabolism/Metabolites

The metabolism of glycol salicylate is similar to that of [DB00945] at other salicylates. Metabolism of salicylic acid occurs through glucuronide formation (to produce salicyl acyl glucuronide and salicyl phenolic glucuronide), conjugation with glycine (to produce salicyluric acid), and oxidation to gentisic acid. The rate of formation of salicyl phenolic glucuronide and salicyluric acid are readily saturated at low salicylic acid concentrations and their formation is described by Michaelis-Menten kinetics. The larger the dose administered, the longer it will take to reach steady-state concentrations of salicylates. There is also evidence that enzyme induction of salicyluric acid formation occurs during the metabolism of salicylates.


5.4 Biological Half-Life

The serum half-life of [DB00945], a similar salicylate, is 20 min.


5.5 Mechanism of Action

Similar to other salicylates. Salicylates and other analgesics and anti-inflammatory drugs, particularly the non-steroidal anti-inflammatory drugs (NSAID) mainly used in rheumatology, inhibit cyclooxygenase, therefore reducing prostaglandin synthesis.


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ABOUT THIS PAGE

Hydroxyethyl Salicylate Manufacturers

A Hydroxyethyl Salicylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hydroxyethyl Salicylate, including repackagers and relabelers. The FDA regulates Hydroxyethyl Salicylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hydroxyethyl Salicylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Hydroxyethyl Salicylate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Hydroxyethyl Salicylate Suppliers

A Hydroxyethyl Salicylate supplier is an individual or a company that provides Hydroxyethyl Salicylate active pharmaceutical ingredient (API) or Hydroxyethyl Salicylate finished formulations upon request. The Hydroxyethyl Salicylate suppliers may include Hydroxyethyl Salicylate API manufacturers, exporters, distributors and traders.

click here to find a list of Hydroxyethyl Salicylate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Hydroxyethyl Salicylate CEP

A Hydroxyethyl Salicylate CEP of the European Pharmacopoeia monograph is often referred to as a Hydroxyethyl Salicylate Certificate of Suitability (COS). The purpose of a Hydroxyethyl Salicylate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Hydroxyethyl Salicylate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Hydroxyethyl Salicylate to their clients by showing that a Hydroxyethyl Salicylate CEP has been issued for it. The manufacturer submits a Hydroxyethyl Salicylate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Hydroxyethyl Salicylate CEP holder for the record. Additionally, the data presented in the Hydroxyethyl Salicylate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Hydroxyethyl Salicylate DMF.

A Hydroxyethyl Salicylate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Hydroxyethyl Salicylate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Hydroxyethyl Salicylate suppliers with CEP (COS) on PharmaCompass.

Hydroxyethyl Salicylate GMP

Hydroxyethyl Salicylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Hydroxyethyl Salicylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hydroxyethyl Salicylate GMP manufacturer or Hydroxyethyl Salicylate GMP API supplier for your needs.

Hydroxyethyl Salicylate CoA

A Hydroxyethyl Salicylate CoA (Certificate of Analysis) is a formal document that attests to Hydroxyethyl Salicylate's compliance with Hydroxyethyl Salicylate specifications and serves as a tool for batch-level quality control.

Hydroxyethyl Salicylate CoA mostly includes findings from lab analyses of a specific batch. For each Hydroxyethyl Salicylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Hydroxyethyl Salicylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Hydroxyethyl Salicylate EP), Hydroxyethyl Salicylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hydroxyethyl Salicylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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