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Hyoscine Butyl Bromide

Alchem Hyoscine Butyl Bromide

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Sarv BioLabs Hyoscine Butyl Bromide

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Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

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ACTIVE PHARMA INGREDIENTS

20 API Suppliers, 2 USDMF, 5 CEP/COS, 2 JDMF, 5 EU WC, 2 KDMF, 2 NDC API, 13 Listed Suppliers, $ API Reference Price

20 API Suppliers
2 USDMF
5 CEP/COS
2 JDMF
5 EU WC
2 KDMF
2 NDC API
13 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

63 FDF Dossiers, 4 Europe, 6 Canada, 12 Australia, 11 South Africa, 30 Listed Dossiers

63 FDF Dossiers
4 Europe
6 Canada
12 Australia
11 South Africa
30 Listed Dossiers

RELATED EXCIPIENT COMPANIES

2 Actylis

relatedExcipients
2 Actylis

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 3 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 Finished Drug Prices, 5 Annual Reports

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2 Finished Drug Prices
5 Annual Reports

MARKET PLACE

24 APIs, 10 FDF Dossiers

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24 APIs
10 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 1 Others

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2 EDQM
1 Others

Hyoscine Butyl Bromide

Synopsis

ACTIVE PHARMA INGREDIENTS

20

API Suppliers

2

USDMF

5

CEP/COS

CEP/COS Certifications

2

JDMF

5

EU WC

2

KDMF

2

NDC API

0

VMF

13

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 1,346

MARKET PLACE

24

API

10

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

63

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

4

Europe

6

Canada

12

Australia

11

South Africa

30

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

2

EDQM

0

USP

0

JP

1

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

1

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

3

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

897

Finished Drug Prices

2 RELATED EXCIPIENT COMPANIES

2EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 149-64-4, N-butylscopolammonium bromide, Hyoscine butylbromide, Buscopan, Scopolan, Buscapine

Molecular Formula

C₂₁H₃₀BrNO₄

Molecular Weight

440.4 g/mol

InChI Key

HOZOZZFCZRXYEK-HNHWXVNLSA-M

FDA UNII

0GH9JX37C8

Hyoscine Butyl Bromide

Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.

1 2D Structure

Hyoscine Butyl Bromide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(1S,2S,4R,5R)-9-butyl-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate;bromide

2.1.2 InChI

InChI=1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15?,16-,17-,18+,19-,20+,22?;/m1./s1

2.1.3 InChI Key

HOZOZZFCZRXYEK-HNHWXVNLSA-M

2.1.4 Canonical SMILES

CCCC[N+]1(C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4)C.[Br-]

2.1.5 Isomeric SMILES

CCCC[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4)C.[Br-]

2.2 Other Identifiers

2.2.1 UNII

0GH9JX37C8

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bromide, Butylscopolammonium

2. Bromide, N-butylscopolammonium

3. Buscapine

4. Buscolysin

5. Buscopan

6. Butylscopolamine

7. Butylscopolammonium Bromide

8. Hyoscinbutylbromide

9. Hyoscine N Butylbromide

10. Hyoscine N-butylbromide

11. N Butylscopolammonium Bromide

12. N-butylbromide, Hyoscine

13. N-butylscopolammonium Bromide

14. Scopolaminebutylbromide

15. Scopolan

2.3.2 Depositor-Supplied Synonyms

1. 149-64-4

2. N-butylscopolammonium Bromide

3. Hyoscine Butylbromide

4. Buscopan

5. Scopolan

6. Buscapine

7. Buscolysin

8. Scobutil

9. Sporamin

10. Amisepan

11. Buscapina

12. Butylmin

13. Donopon

14. Joscine

15. Monospan

16. Scobron

17. Scobutyl

18. Sparicon

19. Tirantil

20. Buscol

21. Scobro

22. Buscolamin

23. Butylscopolammonium Bromide

24. Butylscopolamine Bromide

25. Scopolamine Bromobutylate

26. Hyoscine-n-butyl Bromide

27. Buscolysine

28. Stilbron

29. Hyoscine Butyl Bromide

30. N-butylhyoscinium Bromide

31. Butylhyoscine

32. Scopolamine Butobromide

33. N-butylhyoscine Bromide

34. Scoburen

35. Stibron

36. Hyoscin-n-butyl Bromide

37. Scopolamine Butyl Bromide

38. Scopolamine N-butylbromide

39. N-butylscopolamine Bromide

40. Scopolamine N-butyl Bromide

41. N-butylscopolaminium Bromide

42. (-)-n-butylscopolamine Bromide

43. (-)-scopolamine Butylbromide

44. Mls000069755

45. 0gh9jx37c8

46. (-)-scopolamine N-butyl Bromide

47. Smr000058795

48. Dsstox_cid_2718

49. Dsstox_rid_76697

50. Dsstox_gsid_22718

51. Cas-149-64-4

52. Hyoscine Butobromide

53. Hyoscin-n-butylbromid

54. Butylscopolamin

55. Unii-0gh9jx37c8

56. Buskolamin

57. Antipan

58. Buscogast

59. Hyocimax

60. Scopinal

61. Spasmin

62. Hybrocare

63. Butylscopolamine Bromide [jan]

64. Sr-01000759230

65. Hyoscin-n-butylbromid [german]

66. Spasler-p

67. Hyoscin Butobromide

68. (1?,2?,4?,5?,7?)-9-butyl-7-[(2s)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide

69. Einecs 205-744-1

70. Mfcd00078561

71. Opera_id_556

72. Ncgc00163224-01

73. Scopolamine (butylbromide)

74. Scopolamine N-n-butylbromide

75. Hyoscine-n-butyl Bromide Bp

76. Schembl25291

77. Mls002153372

78. Mls006013629

79. Chembl1256901

80. Dtxsid1022718

81. Chebi:32123

82. Hms2235k20

83. Hms3714i19

84. Hms3884j15

85. Hy-n0340

86. Tox21_112031

87. Hyoscine Butylbromide [mart.]

88. Scopolamine Butylbromide [jan]

89. Akos016009548

90. Akos037515799

91. Hyoscine Butylbromide [who-dd]

92. Tox21_112031_1

93. Ccg-208412

94. Cs-3142

95. Ncgc00186628-02

96. 3-oxa-9-azoniatricyclo(3.3.1.02,4)nonane, 9-butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, Bromide, (7(s)-(1alpha,2beta,4beta,5alpha,7beta))-

97. Ac-34139

98. As-78017

99. N-butylscopolammonium Bromide [mi]

100. Smr004705104

101. Hyoscine Butylbromide [ep Monograph]

102. Butylscopolamine Bromide [green Book]

103. F17660

104. A884250

105. J-008603

106. Sr-01000759230-3

107. N-butyl Scopolamine Bromide (n-butyl Hyoscine Bromide)

108. (-)-scopolamine N-butyl Bromide, >=98% (tlc), Powder

109. Hyoscine Butylbromide, British Pharmacopoeia (bp) Reference Standard

110. Hyoscine Butylbromide, European Pharmacopoeia (ep) Reference Standard

111. (1r,2r,4s,5s,7s)-9-butyl-7-{[(2s)-3-hydroxy-2-phenylpropanoyl]oxy}-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane Bromide

112. (2r,4s,5s,7s)-9-butyl-7-{[(2s)-3-hydroxy-2-phenylpropanoyl]oxy}-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonane Bromide

113. [(1s,2s,4r,5r)-9-butyl-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonan-7-yl] (2s)-3-hydroxy-2-phenylpropanoate;bromide

114. 1-alpha-h,5-alpha-h-tropanium, 8-butyl-6-beta,7-beta-epoxy-3-alpha-hydroxy-, Bromide, (-)-tropate

115. 3-oxa-9-azoniatricyclo(3.3.1.0 Sup(2,4))nonane, 9-butyl-7-((2s)-3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, Bromide (1:1),(1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-

2.4 Create Date

2006-06-15

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₃₀BrNO₄
Molecular Weight	440.4 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Exact Mass	439.13582 g/mol
Monoisotopic Mass	439.13582 g/mol
Topological Polar Surface Area	59.1 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	500
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

API SUPPLIERS

01

Alchem International Private Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Alchem offers Phytochemical APIs for Pharmaceuticals, Cosmetics and Nutraceuticals// FDA-inspected and EU-GMP certified.

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Sarv Biolabs Pvt Ltd

India

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Sarv BioLabs manufactures high-quality Phytochemicals & Active Pharmaceutical Ingredients.

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LGM Pharma

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LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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Transo-Pharm Handels GmbH

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Transo-Pharm GmbH works globally to supply Active Pharmaceutical Ingredients adhering to the highest quality & GMP standards.

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Transo Pharm Handels GmbH

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Aspen API

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Aspen API. More than just an API.

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Jai Radhe Sales

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Atman Pharmaceuticals

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08

Vital Laboratories Private Limited

India

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09

Boehringer Ingelheim GmbH

Germany

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10

Alkaloids of Australia

Australia

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Boehringer Ingelheim Pharma Kg

Germany

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Vital Laboratories Pvt Ltd

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CEP/COS

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ALCHEM INTERNATIONAL PRIVATE LIMITE...

India

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Hyoscine butylbromide

Certificate Number : CEP 2017-085 - Rev 03

Status : Valid

Issue Date : 2023-10-06

Type : Chemical

Substance Number : 737

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ALKALOIDS PRIVATE LIMITED Secundera...

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Scopolamine Butyl Bromide

Registration Number : 229MF10013

Registrant's Address : 201,Empire Plaza,Mehrauli-Gurgaon Road Sultanpur,New Delhi-110 030,INDIA

Initial Date of Registration : 2017-01-23

Latest Date of Registration : 2018-10-26

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Alps Pharmaceutical Co., Ltd.

Japan

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EU WC

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Alchem International Private Ltd

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Hyoscine Butylbromide EP

Date of Issue : 2022-05-27

Valid Till : 2025-05-26

Written Confirmation Number : WC-0006

Address of the Firm : 25/2, Main Mathura Road, Village Kalli, Ballabgarh, Faridabad-121 004, Haryana, ...

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Alkaloids Corporation

India

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Alkaloids Corporation

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Prism Industries

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Butyl scopolamine bromide

Registrant Name : Ace Biopharm Co., Ltd.

Registration Date : 2021-10-07

Registration Number : 20211007-210-J-649

Manufacturer Name : Alchem International P...

Manufacturer Address : SP 2-5, RIICO Industrial Area, Neemrana, Alwar-301705, Rajasthan, India

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Butylscopolamine bromide

Registrant Name : Inseong Trading Co., Ltd.

Registration Date : 2021-11-30

Registration Number : 20211130-210-J-1101

Manufacturer Name : Alchem International P...

Manufacturer Address : 25/2,Main Mathura Road,Village-Kaili,Ballabgarh,District-Faridabad-121004,Haryana

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API Reference Price

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LTD","supplierCountry":"INDIA","foreign_port":"BIRGUNJ","customer":"S.R.DRUG LABORATORIES PVT ","customerCountry":"NEPAL","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1391","totalValueFC":"7041.6","currency":"USD","unitRateINR":103000,"date":"10-Jan-2021","totalValueINR":"515000","totalValueInUsd":"7041.6","indian_port":"RAXAUL","hs_no":"29391900","bill_no":"7807172","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"NEPAL","selfForZScoreResived":"Pharma Grade","supplierPort":"RAXAUL","supplierAddress":"VENKATESH,MAHANT ROAD EXTN,UTTKARSH,MANDAL CIRCLE,, VILE PARLE[E],MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"HYOSCINE BUTYL BROMIDE","year":"2021","qtr":"Q1","strtotime":1611253800,"product":"HYOSCINE BUTYL BROMIDE EP\/BP","address":"VENKATESH,MAHANT ROAD EXTN,UTTKARSH,MANDAL CIRCLE,","city":"VILE PARLE[E],MUMBAI, MAHARASHTRA.","supplier":"VITAL HEALTH CARE PVT. 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NATUBHAI ,CIRCLE, RACE COURSE,","city":"VADODARA","supplier":"MEDBRIDGE PHARMACEUTICAL LIMITED","supplierCountry":"HONG KONG","foreign_port":"XIAMEN","customer":"PRISM INDUSTRIES","customerCountry":"INDIA","quantity":"7.50","actualQuantity":"7.5","unit":"KGS","unitRateFc":"1150","totalValueFC":"9186.9","currency":"USD","unitRateINR":"100792","date":"18-May-2023","totalValueINR":"755939.78","totalValueInUsd":"9186.9","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"Hong Kong","selfForZScoreResived":"Pharma Grade","supplierPort":"XIAMEN","supplierAddress":"","customerAddress":"214A, TRIVIA COMPLEX, NR. NATUBHAI ,CIRCLE, RACE COURSE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709836200,"product":"HYOSCINE N-BUTYLBROMIDE EP (CAS NO.149-64-4) IUPAC NAME (7(S)-(LA,2P,4P,SA,7P)-9-BUTYL-7-(3-HYDROXY-1-OXO-2-PHENYLPROPOX","address":"301 CEEJAY HOUSE LEVEL 3 SHIVSAGAR","city":"MUMBAI,MAHARASHTRA","supplier":"XXSTRXXIANXXLKAXXIDSXXRADXXG PXX LTX","supplierCountry":"AUSTRALIA","foreign_port":"BRISBANE","customer":"ARSHIYA LOGISTICS SERVICES LTD","customerCountry":"INDIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"2554.6","totalValueFC":"515303.6","currency":"USD","unitRateINR":"213943.2","date":"08-Mar-2024","totalValueINR":"42788640","totalValueInUsd":"515303.6","indian_port":"ARSHIYA-SEZ\/PANVEL","hs_no":"29398000","bill_no":"1003515","productDescription":"API","marketType":"REGULATED MARKET","country":"AUSTRALIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BRISBANE","supplierAddress":"N\/A","customerAddress":"301 CEEJAY HOUSE LEVEL 3 SHIVSAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715193000,"product":"HYOSCINE N-BUTYLBROMIDE EP (CAS NO.149-64-4) IUPAC NAME (7(S)-(LA,2P,4P,SA,7P)-9-BUTYL-7-(3-HYDROXY-1-OXO-2-PHENYLPROPOX","address":"301 CEEJAY HOUSE LEVEL 3 SHIVSAGAR","city":"MUMBAI,MAHARASHTRA","supplier":"XXSTRXXIANXXLKAXXIDSXXADIXX PTXXLTD","supplierCountry":"AUSTRALIA","foreign_port":"BRISBANE","customer":"ARSHIYA LOGISTICS SERVICES LTD","customerCountry":"INDIA","quantity":"260.00","actualQuantity":"260","unit":"KGS","unitRateFc":"2511.5","totalValueFC":"660800.5","currency":"USD","unitRateINR":"211848","date":"09-May-2024","totalValueINR":"55080480","totalValueInUsd":"660800.5","indian_port":"ARSHIYA-SEZ\/PANVEL","hs_no":"29398000","bill_no":"1006624","productDescription":"API","marketType":"REGULATED MARKET","country":"AUSTRALIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BRISBANE","supplierAddress":"N\/A","customerAddress":"301 CEEJAY HOUSE LEVEL 3 SHIVSAGAR"}]

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Quantity (KGS) & Unit rate (USD/KGS) over time

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Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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