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Chemistry

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Also known as: Ory-1001 free base, Iadademstat [inn], 1431304-21-0, Chembl3781751, 1431304-21-0 (free base), 54t74394f8
Molecular Formula
C15H22N2
Molecular Weight
230.35  g/mol
InChI Key
ALHBJBCQLJZYON-PFSRBDOWSA-N
FDA UNII
54T74394F8

Iadademstat
Iadademstat is an orally available inhibitor of lysine specific histone demethylase 1 (KDM1A; LSD1), with potential antineoplastic activity. Upon administration, iadademstat binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. In addition, LSD1 demethylates mono- or di-methylated H3K9, which increases gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family, is overexpressed in certain tumor cells and plays a key role in in the regulation of gene expression, tumor cell growth and survival.
1 2D Structure

Iadademstat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-N-[(1R,2S)-2-phenylcyclopropyl]cyclohexane-1,4-diamine
2.1.2 InChI
InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15+/m0/s1
2.1.3 InChI Key
ALHBJBCQLJZYON-PFSRBDOWSA-N
2.1.4 Canonical SMILES
C1CC(CCC1N)NC2CC2C3=CC=CC=C3
2.1.5 Isomeric SMILES
C1CC(CCC1N)N[C@@H]2C[C@H]2C3=CC=CC=C3
2.2 Other Identifiers
2.2.1 UNII
54T74394F8
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Ory-1001 Free Base

2. Iadademstat [inn]

3. 1431304-21-0

4. Chembl3781751

5. 1431304-21-0 (free Base)

6. 54t74394f8

7. Rg-6016

8. N-[(1r,2s)-2-phenylcyclopropyl]-1,4-cyclohexanediamine

9. 4-n-[(1r,2s)-2-phenylcyclopropyl]cyclohexane-1,4-diamine

10. Trans-n1-((1r,2s)-2-phenylcyclopropyl)-1,4-cyclohexanediamine

11. Trans-n1-((1r,2s)-2-phenylcyclopropyl)cyclohexane-1,4-diamine

12. 1,4-cyclohexanediamine, N1-((1r,2s)-2-phenylcyclopropyl)-, Trans-

13. Ory1001

14. Starbld0049467

15. Iadademstat [who-dd]

16. Gtpl8390

17. Chembl3906257

18. Chembl5028924

19. Schembl14880401

20. Schembl14880402

21. Schembl14880654

22. Bdbm254603

23. Unii-54t74394f8

24. Bdbm50155773

25. Nsc806812

26. Rg6016

27. Zinc94088493

28. Nsc-806812

29. Ncgc00480828-02

30. Ncgc00480828-04

31. Us9469597, 4

2.4 Create Date
2013-06-11
3 Chemical and Physical Properties
Molecular Weight 230.35 g/mol
Molecular Formula C15H22N2
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass230.178298710 g/mol
Monoisotopic Mass230.178298710 g/mol
Topological Polar Surface Area38 Ų
Heavy Atom Count17
Formal Charge0
Complexity239
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Iadademstat Manufacturers

A Iadademstat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Iadademstat, including repackagers and relabelers. The FDA regulates Iadademstat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Iadademstat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Iadademstat Suppliers

A Iadademstat supplier is an individual or a company that provides Iadademstat active pharmaceutical ingredient (API) or Iadademstat finished formulations upon request. The Iadademstat suppliers may include Iadademstat API manufacturers, exporters, distributors and traders.

Iadademstat GMP

Iadademstat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Iadademstat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Iadademstat GMP manufacturer or Iadademstat GMP API supplier for your needs.

Iadademstat CoA

A Iadademstat CoA (Certificate of Analysis) is a formal document that attests to Iadademstat's compliance with Iadademstat specifications and serves as a tool for batch-level quality control.

Iadademstat CoA mostly includes findings from lab analyses of a specific batch. For each Iadademstat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Iadademstat may be tested according to a variety of international standards, such as European Pharmacopoeia (Iadademstat EP), Iadademstat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Iadademstat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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