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Chemistry

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Also known as: 467459-31-0, Lu ae58054, Lu-ae58054, 2-(6-fluoro-1h-indol-3-yl)-n-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]ethanamine, Lu ae 58054, 1h-indole-3-ethanamine, 6-fluoro-n-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-
Molecular Formula
C20H19F5N2O
Molecular Weight
398.4  g/mol
InChI Key
YBAWYTYNMZWMMJ-UHFFFAOYSA-N
FDA UNII
59WCJ0YNWM

Idalopirdine
Idalopirdine has been used in trials studying the treatment of Cognition, Schizophrenia, and Alzheimer's Disease.
1 2D Structure

Idalopirdine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]ethanamine
2.1.2 InChI
InChI=1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2
2.1.3 InChI Key
YBAWYTYNMZWMMJ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=CC(=C1)OCC(C(F)F)(F)F)CNCCC2=CNC3=C2C=CC(=C3)F
2.2 Other Identifiers
2.2.1 UNII
59WCJ0YNWM
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (2-(6-fluoro-1h-indol-3-yl)-ethyl)-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)amine

2. Lu Ae58054

3. Lu-ae58054

4. Luae58054

2.3.2 Depositor-Supplied Synonyms

1. 467459-31-0

2. Lu Ae58054

3. Lu-ae58054

4. 2-(6-fluoro-1h-indol-3-yl)-n-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]ethanamine

5. Lu Ae 58054

6. 1h-indole-3-ethanamine, 6-fluoro-n-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-

7. 59wcj0ynwm

8. Sgs518

9. Lu Ae-58054

10. Lu-ae-58054

11. Ly483518

12. Ly-483518

13. 2-(6-fluoro-1h-indol-3-yl)-n-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)ethan-1-amine

14. N-(2-(6-fluoro-1h-indol-3-yl)ethyl)-3-(2,2,3,3-tetrafluoropropoxy)benzylamine

15. Unii-59wcj0ynwm

16. Idalopirdine [usan:inn]

17. Idlopirdine

18. 1h-indole-3-ethanamine, 6-fluoro-n-((3-(2,2,3,3-tetrafluoropropoxy)phenyl)methyl)-

19. Idalopirdine [usan]

20. Idalopirdine (usan/inn)

21. Idalopirdine [inn]

22. Lu Ae58054;idalopirdine

23. Idalopirdine [who-dd]

24. Schembl762762

25. Gtpl8689

26. Idalopirdine(lu-ae-58054)

27. Chembl3286580

28. Ex-a844

29. Dtxsid201026015

30. Bcp08339

31. Bdbm50019754

32. Mfcd18633269

33. Zinc95936819

34. Akos028114439

35. Cs-1347

36. Db11957

37. Sb16535

38. Ncgc00378842-04

39. Ac-30941

40. Da-21188

41. Hy-14338

42. Ft-0700312

43. D10710

44. Q855545

45. N-[3-(2,2,3,3-tetrafluoropropoxy)benzyl]-6-fluoro-1h-indole-3-ethanamine

46. 1h-indole-3-ethanamine,6-fluoro-n-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-

2.4 Create Date
2007-12-05
3 Chemical and Physical Properties
Molecular Weight 398.4 g/mol
Molecular Formula C20H19F5N2O
XLogP35
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Exact Mass398.14175404 g/mol
Monoisotopic Mass398.14175404 g/mol
Topological Polar Surface Area37 Ų
Heavy Atom Count28
Formal Charge0
Complexity482
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in neurologic disorders and schizophrenia and schizoaffective disorders.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Serotonin Antagonists

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)


5.2 Mechanism of Action

SGS518 is a selective antagonist of the 5-Hydroxytryptamine-6 (5-HT6) serotonin receptor believed to act by enhancing transmission of chemicals in the brain.


ABOUT THIS PAGE

Idalopirdine Manufacturers

A Idalopirdine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Idalopirdine, including repackagers and relabelers. The FDA regulates Idalopirdine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Idalopirdine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Idalopirdine Suppliers

A Idalopirdine supplier is an individual or a company that provides Idalopirdine active pharmaceutical ingredient (API) or Idalopirdine finished formulations upon request. The Idalopirdine suppliers may include Idalopirdine API manufacturers, exporters, distributors and traders.

Idalopirdine GMP

Idalopirdine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Idalopirdine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Idalopirdine GMP manufacturer or Idalopirdine GMP API supplier for your needs.

Idalopirdine CoA

A Idalopirdine CoA (Certificate of Analysis) is a formal document that attests to Idalopirdine's compliance with Idalopirdine specifications and serves as a tool for batch-level quality control.

Idalopirdine CoA mostly includes findings from lab analyses of a specific batch. For each Idalopirdine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Idalopirdine may be tested according to a variety of international standards, such as European Pharmacopoeia (Idalopirdine EP), Idalopirdine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Idalopirdine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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