Find Idronoxil manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Phenoxodiol, Dehydroequol, 81267-65-4, Haginin e, 3-(4-hydroxyphenyl)-2h-chromen-7-ol, 3-(4-hydroxyphenyl)-2h-1-benzopyran-7-ol
Molecular Formula
C15H12O3
Molecular Weight
240.25  g/mol
InChI Key
ZZUBHVMHNVYXRR-UHFFFAOYSA-N
FDA UNII
995FT1W541

Idronoxil
Idronoxil is a synthetic flavonoid derivative. Idronoxil activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.
1 2D Structure

Idronoxil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(4-hydroxyphenyl)-2H-chromen-7-ol
2.1.2 InChI
InChI=1S/C15H12O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-8,16-17H,9H2
2.1.3 InChI Key
ZZUBHVMHNVYXRR-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1C(=CC2=C(O1)C=C(C=C2)O)C3=CC=C(C=C3)O
2.2 Other Identifiers
2.2.1 UNII
995FT1W541
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 7-hydroxy-3-hydroxyphenyl-1h-benzopyran

2. Phenoxodiol

2.3.2 Depositor-Supplied Synonyms

1. Phenoxodiol

2. Dehydroequol

3. 81267-65-4

4. Haginin E

5. 3-(4-hydroxyphenyl)-2h-chromen-7-ol

6. 3-(4-hydroxyphenyl)-2h-1-benzopyran-7-ol

7. Nv-06

8. 7,4'-dihydroxyisoflav-3-ene

9. 2h-1-benzopyran-7-ol, 3-(4-hydroxyphenyl)-

10. Idronoxil;dehydroequol;haginin E

11. 995ft1w541

12. Nv 06

13. Idronoxil [usan]

14. Ccris 8949

15. Idronoxil (usan/inn)

16. Idronoxil [usan:inn]

17. 7-hydroxy-3-hydroxyphenyl-1h-benzopyran

18. Haganin E

19. Unii-995ft1w541

20. Idronoxil [inn]

21. Phenoxodiol (haginin E)

22. Dehydroequol [mi]

23. Isoflav-3-ene4',7-diol

24. Idronoxil [who-dd]

25. Isoflav-3-ene-4',7-diol

26. Mls006010720

27. Schembl149612

28. 4',7-dihydroxyisoflav-3-ene

29. Chembl1957038

30. Phenoxodiol, >=98% (hplc)

31. Dtxsid50231029

32. ...7,4?-dihydroxyisoflav-3-ene

33. Nox-66 Component Idronoxil

34. Zinc1491943

35. Bdbm50419932

36. S9634

37. Akos015918005

38. Db04915

39. 3-(4-hydroxy-phenyl)-2h-chromen-7-ol

40. Ncgc00346822-01

41. Ncgc00346822-02

42. Hy-13721

43. Smr004701684

44. Xd161580

45. Xd161694

46. Db-012327

47. Cs-0007751

48. Ft-0602222

49. Nox66 Suppository Component Idronoxil

50. D04498

51. Idronoxil Component Of Nox66 Suppository

52. 267p654

53. A853212

54. Q27095562

55. (+/-)-cis-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2h-cromen-7-ol

2.4 Create Date
2005-07-19
3 Chemical and Physical Properties
Molecular Weight 240.25 g/mol
Molecular Formula C15H12O3
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass240.078644241 g/mol
Monoisotopic Mass240.078644241 g/mol
Topological Polar Surface Area49.7 Ų
Heavy Atom Count18
Formal Charge0
Complexity318
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Intended for the treatment of various forms of cancer.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Phenoxodiol inhibits proliferation of many cancer cell lines and induces apoptosis by disrupting FLICE-inhibitory protein, FLIP, expression and by caspase-dependent and -independent degradation of the X-linked inhibitor of apoptosis, XIAP. In addition, phenoxodiol sensitizes drug-resistant tumour cells to anticancer drugs including paclitaxel, carboplatin and gemcitabine.


5.2 Mechanism of Action

The antiproliferative effects of phenoxodiol are associated with inhibition of plasma membrane electron transport in tumour cell lines and primary immune cells. Results from one study (PMID: 17904534) indicate that plasma membrane electron transport (PMET) may be a primary target for phenoxodiol in tumour cells and in activated T cells.


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Looking for 81267-65-4 / Idronoxil API manufacturers, exporters & distributors?

Idronoxil manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Idronoxil API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Idronoxil manufacturer or Idronoxil supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Idronoxil manufacturer or Idronoxil supplier.

PharmaCompass also assists you with knowing the Idronoxil API Price utilized in the formulation of products. Idronoxil API Price is not always fixed or binding as the Idronoxil Price is obtained through a variety of data sources. The Idronoxil Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Idronoxil

Synonyms

Phenoxodiol, Dehydroequol, 81267-65-4, Haginin e, 3-(4-hydroxyphenyl)-2h-chromen-7-ol, 3-(4-hydroxyphenyl)-2h-1-benzopyran-7-ol

Cas Number

81267-65-4

Unique Ingredient Identifier (UNII)

995FT1W541

About Idronoxil

Idronoxil is a synthetic flavonoid derivative. Idronoxil activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.

Idronoxil Manufacturers

A Idronoxil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Idronoxil, including repackagers and relabelers. The FDA regulates Idronoxil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Idronoxil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Idronoxil Suppliers

A Idronoxil supplier is an individual or a company that provides Idronoxil active pharmaceutical ingredient (API) or Idronoxil finished formulations upon request. The Idronoxil suppliers may include Idronoxil API manufacturers, exporters, distributors and traders.

Idronoxil GMP

Idronoxil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Idronoxil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Idronoxil GMP manufacturer or Idronoxil GMP API supplier for your needs.

Idronoxil CoA

A Idronoxil CoA (Certificate of Analysis) is a formal document that attests to Idronoxil's compliance with Idronoxil specifications and serves as a tool for batch-level quality control.

Idronoxil CoA mostly includes findings from lab analyses of a specific batch. For each Idronoxil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Idronoxil may be tested according to a variety of international standards, such as European Pharmacopoeia (Idronoxil EP), Idronoxil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Idronoxil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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