Finished Dosage Form (FDF) export of Iguratimod obtained from Indian Custom Trade Statistics

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

EU WC

EU WC

0

KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

API REF. PRICE (USD/KG)

MARKET PLACE

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FDF

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

0

Canada

Canada

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Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

DIGITAL CONTENT

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Data Compilation #PharmaFlow

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Stock Recap #PipelineProspector

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Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

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Finished Drug Prices

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0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 123663-49-0, N-(7-(methylsulfonamido)-4-oxo-6-phenoxy-4h-chromen-3-yl)formamide, Careram, Kolbet, T-614, Iguratimod [inn]
Molecular Formula
C17H14N2O6S
Molecular Weight
374.4  g/mol
InChI Key
ANMATWQYLIFGOK-UHFFFAOYSA-N
FDA UNII
4IHY34Y2NV

Iguratimod
Iguratimod is under investigation in Rheumatoid Arthritis.
1 2D Structure

Iguratimod

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[7-(methanesulfonamido)-4-oxo-6-phenoxychromen-3-yl]formamide
2.1.2 InChI
InChI=1S/C17H14N2O6S/c1-26(22,23)19-13-8-15-12(17(21)14(9-24-15)18-10-20)7-16(13)25-11-5-3-2-4-6-11/h2-10,19H,1H3,(H,18,20)
2.1.3 InChI Key
ANMATWQYLIFGOK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)NC1=C(C=C2C(=C1)OC=C(C2=O)NC=O)OC3=CC=CC=C3
2.2 Other Identifiers
2.2.1 UNII
4IHY34Y2NV
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-formylamino-7-methylsulfonylamino-6-phenoxy-4h-1-benzopyran-4-one

2. T 614

3. T-614

2.3.2 Depositor-Supplied Synonyms

1. 123663-49-0

2. N-(7-(methylsulfonamido)-4-oxo-6-phenoxy-4h-chromen-3-yl)formamide

3. Careram

4. Kolbet

5. T-614

6. Iguratimod [inn]

7. Iremod

8. 4ihy34y2nv

9. 3-formylamino-7-methylsulfonylamino-6-phenoxy-4h-1-benzopyran-4-one

10. Ncgc00181783-02

11. T614

12. N-[7-(methanesulfonamido)-4-oxo-6-phenoxychromen-3-yl]formamide

13. N-[7-methanesulfonamido-4-oxo-6-(phenoxy)chromen-3-yl]formamide

14. N-(7-((methylsulfonyl)amino)-4-oxo-6-phenoxy-4h-1-benzopyran-3-yl)formamide

15. Unii-4ihy34y2nv

16. Colvet

17. T 614

18. Iguratimod- Bio-x

19. Iguratimod [mi]

20. Iguratimod (jan/inn)

21. Iguratimod [jan]

22. Dsstox_cid_28897

23. Dsstox_rid_83165

24. Iguratimod [who-dd]

25. Dsstox_gsid_48971

26. Schembl26326

27. Gtpl9736

28. Chembl2107455

29. Dtxsid0048971

30. Iguratimod, >=98% (hplc)

31. Chebi:31689

32. Bcp04206

33. Tox21_113422

34. Bdbm50458537

35. Mfcd00882374

36. S5648

37. Akos015888743

38. Zinc100018451

39. Ccg-268349

40. Cs-0617

41. Db12233

42. Sb16814

43. Ncgc00181783-01

44. Ncgc00181783-03

45. As-12959

46. Bi164569

47. Hy-17009

48. A3484

49. Cas-123663-49-0

50. Ft-0654508

51. I0945

52. C71931

53. D01146

54. 663i490

55. A805134

56. Sr-01000945251

57. J-521483

58. Sr-01000945251-1

59. Q13575264

60. N-(3-formamido-4-oxo-6-phenoxy-4h-chromen-7-yl)methanesulfonamide

61. N-[7-(methanesulfonamido)-4-oxo-6-phenoxy-4h-chromen-3-yl]formamide

62. N-[7-(methanesulfonamido)-4-oxo-6-phenoxy-chromen-3-yl]formamide;iguratimod

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 374.4 g/mol
Molecular Formula C17H14N2O6S
XLogP31.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass374.05725734 g/mol
Monoisotopic Mass374.05725734 g/mol
Topological Polar Surface Area119 Ų
Heavy Atom Count26
Formal Charge0
Complexity665
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API SUPPLIERS

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01

Zhejiang Hengkang Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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  • WHO-GMP

Virtual BoothZhejiang Hengkang Pharm Group is a dynamic pharmaceutical entity, spanning drug research, large-scale production, and global marketing.

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Zhejiang Hengkang Pharmaceutical

02

Yangtze River Pharmaceutical Group

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target
Not Confirmed
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03

Medilux Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target
Not Confirmed
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Medilux Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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04

Guangzhou Topwork Chemical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target
Not Confirmed
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05

Lewens Labs

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target
Not Confirmed
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06

Allastir

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target
Not Confirmed
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07

Jiangsu Simcere Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target
Not Confirmed
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Jiangsu Simcere Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Discovery on Target
Not Confirmed
USDMF CEP/COS JDMF arrow-down EU-WC NDC KDMF VMF Others AUDIT
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08

Tianjin Hankang Pharmaceutical Bio...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target
Not Confirmed
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09

Jiangsu Chiatai Qingjiang Pharmace...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target
Not Confirmed
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Jiangsu Chiatai Qingjiang Pharmace...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Discovery on Target
Not Confirmed
USDMF CEP/COS JDMF arrow-down EU-WC NDC KDMF VMF Others AUDIT
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10

Maiden Group

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target
Not Confirmed
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JDMF

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01

Formnext Forum
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Iguratimod

Registration Number : 305MF10057

Registrant's Address : No. 9 Hantai North Road, Qinghe District, Huai'an City, Jiangsu Province, P. R. China

Initial Date of Registration : 2023-05-10

Latest Date of Registration : 2024-07-24

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02

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Igurachimod

Registration Number : 302MF10085

Registrant's Address : No. 9 Hantai North Road, Qinghe District, Huai'an City, Jiangsu Province, P. R. China

Initial Date of Registration : 2020-07-22

Latest Date of Registration : 2023-08-02

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03

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Igurachimod

Registration Number : 302MF10127

Registrant's Address : No. 2, Yaogu 3rd Road, Pharma Valley, Xiuying District, Haikou City, Hainan Province,...

Initial Date of Registration : 2020-10-14

Latest Date of Registration : 2020-10-14

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Listed Suppliers

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01

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothZhejiang Hengkang Pharm Group is a dynamic pharmaceutical entity, spanning drug research, large-scale production, and global marketing.

Flag China
Digital Content Digital Content

Iguratimod

About the Company : Established in 2004 and headquartered in Hangzhou, Hengkang established multiple factories, research and sales centers in Zhejiang, Shandong, and Henan. With facilities conforming ...

Established in 2004 and headquartered in Hangzhou, Hengkang established multiple factories, research and sales centers in Zhejiang, Shandong, and Henan. With facilities conforming to global API standards, along with professional R&D and marketing teams, Hengkang’s operations span major pharmaceutical markets such as China, Europe, the CIS region, Japan, and South Korea. Hengkang has established long-term and stable relationships with nearly 70 countries overseas and hundreds of domestic enterprises.
Zhejiang Hengkang Pharmaceutical

02

Allastir

India
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Allastir

India
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Iguratimod

About the Company : Allastir instituted the services in 2010 with a motive to cater the pharmaceutical industry with niche API's. In Allastir we strongly believe in team work and customer satisfaction...

Allastir instituted the services in 2010 with a motive to cater the pharmaceutical industry with niche API's. In Allastir we strongly believe in team work and customer satisfaction. Allastir is backed by the strong R&D team who are passionate about what they do. We manufacture niche API's with high quality which are suitable for formulations like tablets, capsules, soft gelatins and oral liquids.To be the larder to develop innovative niche molecule to the health care industry for the betterment of human life.Our Vision is to be the Number ONE company in Health care Industry in the World.
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03

Formnext Forum
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Iguratimod

About the Company : Guangzhou Topwork Chemical Co., Ltd. Specializes in manufacturing corticosteroid and relative intermediates. We provide high quality products and excellent service to our clients a...

Guangzhou Topwork Chemical Co., Ltd. Specializes in manufacturing corticosteroid and relative intermediates. We provide high quality products and excellent service to our clients and have gained a high business reputation in the world market. Topwork gathers a group of energetic, hardworking and much experienced experts. They dedicate their entire efforts to research and development of new products. To guarantee the quality of our products, we have established an international standard quality control system. All of our products conform the latest standard of USP, EP, BP and CP.
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04

Lewens Labs

India
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Lewens Labs

India
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Iguratimod

About the Company : Lewens Labs finds its roots in 4 years of engineering during which we saw a dream to carve out a niche for ourselves in Pharmaceutical Industry. As a part of the final year project...

Lewens Labs finds its roots in 4 years of engineering during which we saw a dream to carve out a niche for ourselves in Pharmaceutical Industry. As a part of the final year project, We worked on cost reduction of “Aceclofenac” which fetched us four national awards including one from Consultancy Development Center, Government of India. At Lewens, We aim to develop and provide quality,cost effective and sustainable solutions to our Customers by empowering people to think beyond the traditional norms of Chemistry and Engineering to come up with different and innovative solutions to the problems.
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Maiden Group

India
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Maiden Group

India
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Iguratimod

About the Company : We are Maiden, a rapidly growing Indian pharma company committed to developing, manufacturing and marketing diverse portfolio of products. Our core strength lies in development, up...

We are Maiden, a rapidly growing Indian pharma company committed to developing, manufacturing and marketing diverse portfolio of products. Our core strength lies in development, up scaling and manufacturing differentiated formulations. Various national and multi-national pharmaceutical companies across geographies rely on our expertises to deliver world class quality products. Maiden complies with various National / International regulatory norms and standards. We strive hard to make a difference in people lives, through our innovative healthcare solutions.
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06

Formnext Forum
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Iguratimod

About the Company : Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry since our inception in 1988. Our resources are dedicated to promoting better health ...

Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry since our inception in 1988. Our resources are dedicated to promoting better health through products that offer superior value. Located in Pithampur, Madhya Pradesh, Medilux Laboratories is committed to strategic research, delivering a complex range of globally benchmarked chemistries. Our products and services are rapidly making strides in the global pharmaceutical space, giving us the impetus to constantly strive for excellence and provide quality customer service.
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07

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Iguratimod

About the Company : Established in 1999, Hankang Pharmaceutical Group stands as a prominent CRO-CDMO integrated service enterprise in China. Focused on generic drugs while venturing into innovative on...

Established in 1999, Hankang Pharmaceutical Group stands as a prominent CRO-CDMO integrated service enterprise in China. Focused on generic drugs while venturing into innovative ones, the group is dedicated to offering comprehensive solutions to the industry. Presently, Hankang has crafted over 200 varieties for 600+ domestic and international companies, serving 10+ innovative drugs. It has successfully developed more than 10 initial generic drugs, with over 20 varieties endorsed by the top three domestic companies and 30 exceeding a 100 million output value.
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08

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Iguratimod

About the Company : Yangtze River Pharmaceutical Group (hereinafter refers to YRPG) was founded in 1971, with over 9000 employees. Comprehensive competitiveness of YRPG has been ranked in the top five...

Yangtze River Pharmaceutical Group (hereinafter refers to YRPG) was founded in 1971, with over 9000 employees. Comprehensive competitiveness of YRPG has been ranked in the top five of national pharmaceutical industry for over 10 years. YRPG was ranked top in China Pharmaceutical Industry Top 100 in 2009 and 2010.Major products of YRPG include Chinese and Western medicines, covering antibiotics, digestive system, circulatory system, anti-neoplastic, antipyretic-analgesic and other areas, owning nearly 20 dosage forms and around 200 varieties.
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API Reference Price

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[{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1626460200,"product":"IGURATIMOD API","address":"PLOT?NO.88\/A,?FLAT?NO.401,SARALANIVAS APTS?ROAD?NO.2,?BANJARA?HILLS","city":"HYDERABAD,?A.P","supplier":"SMILAX LABORATORIES LIMITED","supplierCountry":"INDIA","foreign_port":"TOKYO - NARITA","customer":"TOKUYAMA CORPORATION","customerCountry":"JAPAN","quantity":"360.72","actualQuantity":"360.72","unit":"KGS","unitRateFc":"2028.2","totalValueFC":"707279.8","currency":"USD","unitRateINR":146127.94133954312,"date":"17-Jul-2021","totalValueINR":"52711271","totalValueInUsd":"707279.8","indian_port":"HYDERABAD AIR","hs_no":"29420090","bill_no":"3201960","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"PLOT?NO.88\/A,?FLAT?NO.401,SARALANIVAS APTS?ROAD?NO.2,?BANJARA?HILLS, HYDERABAD,?A.P","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698258600,"product":"IGURATIMOD PHARMA PRODUCT SMILAX LABORATORIES LIMITED","address":"PLOT NO.12\/A, IDA, PHASE-III,","city":"","supplier":"SMILAX LABORATORIES LIMITED","supplierCountry":"INDIA","foreign_port":"TOKYO - NARITA","customer":"TO THE ORDER OF ., ,. ,,, .. ,,","customerCountry":"JAPAN","quantity":"281.50","actualQuantity":"281.5","unit":"KGS","unitRateFc":"1910.7","totalValueFC":"530498.3","currency":"USD","unitRateINR":156849.02309058615,"date":"26-Oct-2023","totalValueINR":"44153000","totalValueInUsd":"530498.3","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"4902506","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO.12\/A, IDA, PHASE-III,, ","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702924200,"product":"IGURATIMOD PHARMA PRODUCT SMILAX LABORATORIES LIMITED (RE-IMPORT BE NUMBER 7758335 DT:09.09.2023)","address":"PLOT NO.12\/A, IDA, PHASE-III,","city":"","supplier":"SMILAX LABORATORIES LIMITED","supplierCountry":"INDIA","foreign_port":"TOKYO - NARITA","customer":"TOKUYAMA CORPORATION","customerCountry":"JAPAN","quantity":"72.20","actualQuantity":"72.2","unit":"KGS","unitRateFc":"2960.9","totalValueFC":"211464.8","currency":"USD","unitRateINR":243808.86426592796,"date":"19-Dec-2023","totalValueINR":"17603000","totalValueInUsd":"211464.8","indian_port":"Hyderabad Air","hs_no":"29329990","bill_no":"6139353","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO.12\/A, IDA, PHASE-III,, ","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704911400,"product":"IGURATIMOD PHARMA PRODUCT SMILAX LABORATORIES LIMITED","address":"PLOT NO.12\/A, IDA, PHASE-III,","city":"","supplier":"SMILAX LABORATORIES LIMITED","supplierCountry":"INDIA","foreign_port":"TOKYO - NARITA","customer":"TOKUYAMA CORPORATION","customerCountry":"JAPAN","quantity":"188.90","actualQuantity":"188.9","unit":"KGS","unitRateFc":"1910.7","totalValueFC":"357003.4","currency":"USD","unitRateINR":157073.35722604551,"date":"11-Jan-2024","totalValueINR":"29671157.18","totalValueInUsd":"357003.4","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"6677470","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO.12\/A, IDA, PHASE-III,, ","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707676200,"product":"IGURATIMOD (BATCH NO: 1723123020)","address":"P NO12,SHED NO.9A,SIDCO INDUSTRIAL","city":"CHENNAI,TAMIL NADU","supplier":"ALLASTIR PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"AGP LIMITED","customerCountry":"PAKISTAN","quantity":"0.60","actualQuantity":"0.6","unit":"KGS","unitRateFc":"3016","totalValueFC":"1774.7","currency":"USD","unitRateINR":245415.70000000004,"date":"12-Feb-2024","totalValueINR":"147249.42","totalValueInUsd":"1774.7","indian_port":"Madras Air","hs_no":"29359090","bill_no":"7463572","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"P NO12,SHED NO.9A,SIDCO INDUSTRIAL, CHENNAI,TAMIL NADU","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708626600,"product":"IGURATIMOD (IH GRADE) PHARMACEUTICAL RAWMATERIAL (BATCH NO:LFP0060123006)","address":"PNO 67 68 1STFLR RAMAKRISHNA","city":"KORATTUR NORTH CHENNAI","supplier":"PHARMARULE","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"NABIQASIM INDUSTRIES PVT ","customerCountry":"PAKISTAN","quantity":"0.30","actualQuantity":"0.3","unit":"KGS","unitRateFc":"3160","totalValueFC":"921.1","currency":"USD","unitRateINR":254752.00000000003,"date":"23-Feb-2024","totalValueINR":"76425.6","totalValueInUsd":"921.1","indian_port":"Madras Air","hs_no":"29339990","bill_no":"7774032","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"PNO 67 68 1STFLR RAMAKRISHNA, KORATTUR NORTH CHENNAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1719772200,"product":"IGURATIMOD PHARMA PRODUCT SMILAX LABORATORIES LIMITED","address":"PLOT NO.12\/A, IDA, PHASE-III,","city":"N\/A","supplier":"SMILAX LABORATORIES LIMITED","supplierCountry":"INDIA","foreign_port":"TOKYO - NARITA","customer":"TOKUYAMA CORPORATION","customerCountry":"JAPAN","quantity":"189.00","actualQuantity":"189","unit":"KGS","unitRateFc":"1910.7","totalValueFC":"355435","currency":"USD","unitRateINR":157202.09756613759,"date":"01-Jul-2024","totalValueINR":"29711196.44","totalValueInUsd":"355435","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"2095768","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO.12\/A, IDA, PHASE-III,, N\/A","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722364200,"product":"IGURATIMOD PHARMA PRODUCT SMILAX LABORATORIES LIMITED","address":"PLOT NO.12\/A, IDA, PHASE-III,","city":"N\/A","supplier":"SMILAX LABORATORIES LIMITED","supplierCountry":"INDIA","foreign_port":"TOKYO - NARITA","customer":"TOKUYAMA CORPORATION","customerCountry":"JAPAN","quantity":"187.80","actualQuantity":"187.8","unit":"KGS","unitRateFc":"1910.7","totalValueFC":"353351.9","currency":"USD","unitRateINR":157279.34036208733,"date":"31-Jul-2024","totalValueINR":"29537060.12","totalValueInUsd":"353351.9","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"2863274","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO.12\/A, IDA, PHASE-III,, N\/A","customerAddress":""}]
17-Jul-2021
31-Jul-2024
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INTERMEDIATES SUPPLIERS

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01

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CAS Number : 149436-41-9

End Use API : Iguratimod

About The Company : Hiray Pharma Solutions is an international end-to-end CDMO, facilitating the development and manufacturing of important drug products and key intermediates arou...

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