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Also known as: 172152-36-2, Iy-81149, Noltec, Iy 81149, Ilaprazole [inn], Iy81149
Molecular Formula
C19H18N4O2S
Molecular Weight
366.4  g/mol
InChI Key
HRRXCXABAPSOCP-UHFFFAOYSA-N
FDA UNII
776Q6XX45J

Ilaprazole
Ilaprazole is a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. A weak base, ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.
1 2D Structure

Ilaprazole

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1H-benzimidazole
2.1.2 InChI
InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)
2.1.3 InChI Key
HRRXCXABAPSOCP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C=CN=C1CS(=O)C2=NC3=C(N2)C=C(C=C3)N4C=CC=C4)OC
2.2 Other Identifiers
2.2.1 UNII
776Q6XX45J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Iy 81149

2. Iy-81149

3. Iy81149

2.3.2 Depositor-Supplied Synonyms

1. 172152-36-2

2. Iy-81149

3. Noltec

4. Iy 81149

5. Ilaprazole [inn]

6. Iy81149

7. 2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1h-benzimidazole

8. 2-(((4-methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-6-(1h-pyrrol-1-yl)-1h-benzo[d]imidazole

9. 776q6xx45j

10. 2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-5-pyrrol-1-yl-3h-benzoimidazole

11. Aldenon

12. 1h-benzimidazole,2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-5-(1h-pyrrol-1-yl)- (9ci)

13. 2-((rs)-((4-methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-5-(1h-pyrrol-1-yl)-1h-benzimidazole

14. Unii-776q6xx45j

15. Ilaprazole [mart.]

16. Ilaprazole [who-dd]

17. Schembl1179039

18. Chembl2106370

19. Gtpl10512

20. Dtxsid10870115

21. Chebi:135544

22. Amy42072

23. Bcp08220

24. Xga15236

25. Iy81149;iy 81149;ilaprazole

26. S3666

27. Akos025401705

28. Ccg-268243

29. Cs-6444

30. Db11964

31. 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1h-pyrrol-1-yl)-1h-benzimidazole

32. Iy 81149iy81149

33. Ac-24701

34. Bs-15650

35. Db-064841

36. Hy-101664

37. Ft-0704889

38. Q15051261

39. 2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1h-benzoimidazole

40. 2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-5-pyrrol-1-yl-3h-benzoimidazole

41. 2-{[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfinyl}-5-(1h-pyrrol-1-yl)-1h-benzimidazole

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 366.4 g/mol
Molecular Formula C19H18N4O2S
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass366.11504700 g/mol
Monoisotopic Mass366.11504700 g/mol
Topological Polar Surface Area92 Ų
Heavy Atom Count26
Formal Charge0
Complexity502
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API Reference Price

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23-Jan-2021
22-Sep-2024
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Quantity (KGS) & Unit rate (USD/KGS) over time

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ABOUT THIS PAGE

Ilaprazole Manufacturers

A Ilaprazole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ilaprazole, including repackagers and relabelers. The FDA regulates Ilaprazole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ilaprazole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ilaprazole manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ilaprazole Suppliers

A Ilaprazole supplier is an individual or a company that provides Ilaprazole active pharmaceutical ingredient (API) or Ilaprazole finished formulations upon request. The Ilaprazole suppliers may include Ilaprazole API manufacturers, exporters, distributors and traders.

click here to find a list of Ilaprazole suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ilaprazole KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Ilaprazole Drug Master File in Korea (Ilaprazole KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ilaprazole. The MFDS reviews the Ilaprazole KDMF as part of the drug registration process and uses the information provided in the Ilaprazole KDMF to evaluate the safety and efficacy of the drug.

After submitting a Ilaprazole KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ilaprazole API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Ilaprazole suppliers with KDMF on PharmaCompass.

Ilaprazole WC

A Ilaprazole written confirmation (Ilaprazole WC) is an official document issued by a regulatory agency to a Ilaprazole manufacturer, verifying that the manufacturing facility of a Ilaprazole active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Ilaprazole APIs or Ilaprazole finished pharmaceutical products to another nation, regulatory agencies frequently require a Ilaprazole WC (written confirmation) as part of the regulatory process.

click here to find a list of Ilaprazole suppliers with Written Confirmation (WC) on PharmaCompass.

Ilaprazole GMP

Ilaprazole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ilaprazole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ilaprazole GMP manufacturer or Ilaprazole GMP API supplier for your needs.

Ilaprazole CoA

A Ilaprazole CoA (Certificate of Analysis) is a formal document that attests to Ilaprazole's compliance with Ilaprazole specifications and serves as a tool for batch-level quality control.

Ilaprazole CoA mostly includes findings from lab analyses of a specific batch. For each Ilaprazole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ilaprazole may be tested according to a variety of international standards, such as European Pharmacopoeia (Ilaprazole EP), Ilaprazole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ilaprazole USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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