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Immunomycin

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ACTIVE PHARMA INGREDIENTS

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ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Immunomycin, 104987-12-4, Fk520, Fr 900520, Fk 520, L-683590

Molecular Formula

C₄₃H₆₉NO₁₂

Molecular Weight

792.0 g/mol

InChI Key

ZDQSOHOQTUFQEM-NURRSENYSA-N

FDA UNII

AUF4U5NSJK

immunomycin is a natural product found in Streptomyces hygroscopicus and Streptomyces ascomycinicus with data available.

1 2D Structure

Immunomycin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-17-ethyl-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone

2.1.2 InChI

InChI=1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32+,33-,35+,36-,37-,38+,39+,43+/m0/s1

2.1.3 InChI Key

ZDQSOHOQTUFQEM-NURRSENYSA-N

2.1.4 Canonical SMILES

CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C

2.1.5 Isomeric SMILES

CC[C@@H]1/C=C(/C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC)C)\C

2.2 Other Identifiers

2.2.1 UNII

AUF4U5NSJK

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Changchuanmycin

2. Fk 520

3. Fk-520

4. Fr 900520

5. Fr-900520

6. Immunomycin

7. Tacrolimus Related Compound A

2.3.2 Depositor-Supplied Synonyms

1. Immunomycin

2. 104987-12-4

3. Fk520

4. Fr 900520

5. Fk 520

6. L-683590

7. Auf4u5nsjk

8. Fk-520

9. L 683590

10. Chembl8597

11. Chebi:29582

12. Fr-900520

13. 11011-38-4

14. Ascomycin From Streptomyces Hygroscopicus Var. Ascomyceticus

15. Changchuanmycin

16. Ascomycin(fk 520)

17. (3s,4r,5s,8r,9e,12s,14s,15r,16s,18r,19r,22r,26as)-8-ethyl-5,19-dihydroxy-3-{(1e)-1-[(1r,3r,4r)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3h-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4h,23h)-tetrone

18. C43h69no12

19. Unii-auf4u5nsjk

20. Tacrolimus Related Compound A

21. Ascomycin Solution

22. Fr 520

23. Mfcd06198665

24. Nsc 106410

25. Nsc-106410

26. Ascomycin (fk520)

27. Schembl25512

28. Bspbio_001318

29. L 683,590

30. L-683,590

31. Chebi:94818

32. Dtxsid80894126

33. Hms1361b20

34. Hms1791b20

35. Hms1989b20

36. Hms3402b20

37. Ex-a1796

38. Bdbm50068939

39. Fr-520

40. S7411

41. Akos015916691

42. Zinc169289416

43. Ccg-270483

44. Cs-1516

45. Idi1_033788

46. Ncgc00163418-01

47. Ncgc00163418-02

48. 15,19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetram

49. Hy-13557

50. Ascomycin (fk 520, Fr 900520, Imm

51. Tacrolimus Related Compound A [usp-rs]

52. 011a384

53. Q4803998

54. Tacrolimus Related Compound A [usp Impurity]

55. Brd-k88998544-001-02-4

56. Brd-k99369265-001-01-4

57. Tacrolimus Impurity, Ascomycin- [usp Impurity]

58. Tacrolimus Monohydrate Impurity A [ep Impurity]

59. (1r,9s,12s,13r,14s,17r,18e,21s,23s,24r,25s,27r)-17-ethyl-1,14-dihydroxy-12-[(1e)-1-[(1r,3r,4r)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0?,?]octacos-18-ene-2,3,10,16-tetrone

60. (1r,9s,12s,13r,14s,17r,18e,21s,23s,24r,25s,27r)-17-ethyl-1,14-dihydroxy-12-[(e)-1-[(1r,3r,4r)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone

61. (3s,4r,5s,8r,9e,12s,14s,15r,16s,18r ,19r,26as)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,1 9,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1e )-2-[(1r,3r,4r)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetrameth Yl-15,19-epoxy-3h-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4h,23h)tetrone

62. (3s,4r,5s,8r,9e,12s,14s,15r,16s,18r,19r,26as)-8-ethyl-5,19-dihydroxy-3-{(1e)-1-[(1r,3r,4r)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3h-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4h,23h)-tetrone

63. (3s,4r,5s,8r,9e,12s,14s,15r,16s,18r,19r,26as)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1e)-2-[(1r,3r,4r)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3h-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4h,23h)tetrone

64. (ascomycin)17-ethyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0*4,9*]octacos-18-ene-2,3,10,16-tetraone

65. (e)-(9s,12s,13r,14s,17r,21s,23s,24r,25s,27s)-17-ethyl-1,14-dihydroxy-12-[(e)-2-((1r,3r,4r)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0*4,9*]octacos-18-ene-2,3,10,16-tetraone

66. (e)-(s)-17-ethyl-1,14-dihydroxy-12-[(e)-2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0*4,9*]oct Acos-18-ene-2,3,10,16-tetraone

67. (e)-17-ethyl-1,14-dihydroxy-12-[(e)-2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0*4,9*]octacos-18-ene-2,3,10,16-tetraone

68. 135635-46-0

69. 15,19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-8-ethyl-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3s-(3r*(e(1s*,3s*,4s*)),4s*,19s*,26ar*))-

70. 17-ethyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0*4,9*]octacos-18-ene-2,3,10,16-tetraone

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₄₃H₆₉NO₁₂
Molecular Weight	792.0 g/mol
XLogP3	2.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	6
Exact Mass	791.48197664 g/mol
Monoisotopic Mass	791.48197664 g/mol
Topological Polar Surface Area	178 Å²
Heavy Atom Count	56
Formal Charge	0
Complexity	1430
Isotope Atom Count	0
Defined Atom Stereocenter Count	14
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

Immunosuppressive Agents

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (See all compounds classified as Immunosuppressive Agents.)

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ABOUT THIS PAGE

Immunomycin Manufacturers

A Immunomycin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Immunomycin, including repackagers and relabelers. The FDA regulates Immunomycin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Immunomycin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Immunomycin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Immunomycin Suppliers

A Immunomycin supplier is an individual or a company that provides Immunomycin active pharmaceutical ingredient (API) or Immunomycin finished formulations upon request. The Immunomycin suppliers may include Immunomycin API manufacturers, exporters, distributors and traders.

click here to find a list of Immunomycin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Immunomycin USDMF

A Immunomycin DMF (Drug Master File) is a document detailing the whole manufacturing process of Immunomycin active pharmaceutical ingredient (API) in detail. Different forms of Immunomycin DMFs exist exist since differing nations have different regulations, such as Immunomycin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Immunomycin DMF submitted to regulatory agencies in the US is known as a USDMF. Immunomycin USDMF includes data on Immunomycin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Immunomycin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Immunomycin suppliers with USDMF on PharmaCompass.

Immunomycin GMP

Immunomycin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Immunomycin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Immunomycin GMP manufacturer or Immunomycin GMP API supplier for your needs.

Immunomycin CoA

A Immunomycin CoA (Certificate of Analysis) is a formal document that attests to Immunomycin's compliance with Immunomycin specifications and serves as a tool for batch-level quality control.

Immunomycin CoA mostly includes findings from lab analyses of a specific batch. For each Immunomycin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Immunomycin may be tested according to a variety of international standards, such as European Pharmacopoeia (Immunomycin EP), Immunomycin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Immunomycin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.