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Chemistry

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Also known as: Ori-9020, 475650-36-3, Sb-40, Tq0a9fiv71, O-(((2r,3s,5r)-5-(6-amino-9h-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) o-((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl) s-hydrogen phosphorothioate, 2'-o-methyl-p-thiouridylyl-(3'->5')-2'-deoxyadenosine
Molecular Formula
C20H26N7O10PS
Molecular Weight
587.5  g/mol
InChI Key
LYMICVBGNUEHGE-FUQPUAIBSA-N
FDA UNII
TQ0A9FIV71

Inarigivir
Inarigivir is under investigation in clinical trial NCT03434353 (Study to Evaluate the Antiviral Activity of Inarigivir (GS-9992) Plus Tenofovir Alafenamide (TAF) for 12 Weeks in Adults With Chronic Hepatitis B (CHB)).
1 2D Structure

Inarigivir

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(2R,3R,4R,5R)-4-[[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione
2.1.2 InChI
InChI=1S/C20H26N7O10PS/c1-33-16-15(10(5-28)36-19(16)26-3-2-12(30)25-20(26)31)37-38(32,39)34-6-11-9(29)4-13(35-11)27-8-24-14-17(21)22-7-23-18(14)27/h2-3,7-11,13,15-16,19,28-29H,4-6H2,1H3,(H,32,39)(H2,21,22,23)(H,25,30,31)/t9-,10+,11+,13+,15+,16+,19+,38?/m0/s1
2.1.3 InChI Key
LYMICVBGNUEHGE-FUQPUAIBSA-N
2.1.4 Canonical SMILES
COC1C(C(OC1N2C=CC(=O)NC2=O)CO)OP(=S)(O)OCC3C(CC(O3)N4C=NC5=C(N=CN=C54)N)O
2.1.5 Isomeric SMILES
CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)OP(=S)(O)OC[C@@H]3[C@H](C[C@@H](O3)N4C=NC5=C(N=CN=C54)N)O
2.2 Other Identifiers
2.2.1 UNII
TQ0A9FIV71
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ori 9020

2. Ori-9020

3. Ori9020

2.3.2 Depositor-Supplied Synonyms

1. Ori-9020

2. 475650-36-3

3. Sb-40

4. Tq0a9fiv71

5. O-(((2r,3s,5r)-5-(6-amino-9h-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) O-((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl) S-hydrogen Phosphorothioate

6. 2'-o-methyl-p-thiouridylyl-(3'->5')-2'-deoxyadenosine

7. Adenosine, 2'-o-methyl-p-thiouridylyl-(3'->5')-2'-deoxy-

8. Unii-tq0a9fiv71

9. Chembl1084430

10. Ex-a3427

11. Mfcd31727872

12. Inarigivir(ori-9020,sb-9000)

13. Db15062

14. 1-[(2r,3r,4r,5r)-4-[[(2r,3s,5r)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione

15. Ac-36511

16. Hy-101954

17. Cs-0022217

18. D70024

19. 2'-o-methyl-p-thiouridylyl-(3',5')-2'-deoxy-adenosine

20. 2'-o-methyl-p-thiouridylyl-(3'?5')-2'-deoxy-adenosine

21. 5'-o-[hydroxy(2'-o-methyl-3'-uridyloxy)thiophophinyl]-2'-deoxyadenosine

22. 1-[(2r,3r,4r,5r)-4-[[(2r,3s,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-sulfanyl-phosphoryl]oxy-5-(hydroxymethyl)-3-methoxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione

2.4 Create Date
2006-07-04
3 Chemical and Physical Properties
Molecular Weight 587.5 g/mol
Molecular Formula C20H26N7O10PS
XLogP3-1.8
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count15
Rotatable Bond Count9
Exact Mass587.11994822 g/mol
Monoisotopic Mass587.11994822 g/mol
Topological Polar Surface Area258 Ų
Heavy Atom Count39
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 475650-36-3 / Inarigivir API manufacturers, exporters & distributors?

Inarigivir manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Inarigivir API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Inarigivir manufacturer or Inarigivir supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Inarigivir manufacturer or Inarigivir supplier.

PharmaCompass also assists you with knowing the Inarigivir API Price utilized in the formulation of products. Inarigivir API Price is not always fixed or binding as the Inarigivir Price is obtained through a variety of data sources. The Inarigivir Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Inarigivir

Synonyms

Ori-9020, 475650-36-3, Sb-40, Tq0a9fiv71, O-(((2r,3s,5r)-5-(6-amino-9h-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) o-((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl) s-hydrogen phosphorothioate, 2'-o-methyl-p-thiouridylyl-(3'->5')-2'-deoxyadenosine

Cas Number

475650-36-3

Unique Ingredient Identifier (UNII)

TQ0A9FIV71

About Inarigivir

Inarigivir is under investigation in clinical trial NCT03434353 (Study to Evaluate the Antiviral Activity of Inarigivir (GS-9992) Plus Tenofovir Alafenamide (TAF) for 12 Weeks in Adults With Chronic Hepatitis B (CHB)).

Inarigivir Manufacturers

A Inarigivir manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Inarigivir, including repackagers and relabelers. The FDA regulates Inarigivir manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Inarigivir API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Inarigivir Suppliers

A Inarigivir supplier is an individual or a company that provides Inarigivir active pharmaceutical ingredient (API) or Inarigivir finished formulations upon request. The Inarigivir suppliers may include Inarigivir API manufacturers, exporters, distributors and traders.

Inarigivir GMP

Inarigivir Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Inarigivir GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Inarigivir GMP manufacturer or Inarigivir GMP API supplier for your needs.

Inarigivir CoA

A Inarigivir CoA (Certificate of Analysis) is a formal document that attests to Inarigivir's compliance with Inarigivir specifications and serves as a tool for batch-level quality control.

Inarigivir CoA mostly includes findings from lab analyses of a specific batch. For each Inarigivir CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Inarigivir may be tested according to a variety of international standards, such as European Pharmacopoeia (Inarigivir EP), Inarigivir JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Inarigivir USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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