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ACTIVE PHARMA INGREDIENTS

7 API Suppliers, 2 USDMF, 1 KDMF, 5 Listed Suppliers, $ API Reference Price

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2 USDMF
1 KDMF
5 Listed Suppliers
$ API Reference Price

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Inke Indacaterol Acetate

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 1000160-96-2, Ryi4401dtm, Indacaterol acetate (jan), Indacaterol acetate [jan], Acetic acid;5-[(1r)-2-[(5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one, Unii-ryi4401dtm

Molecular Formula

C₂₆H₃₂N₂O₅

Molecular Weight

452.5 g/mol

InChI Key

HZHXFIDENGBQFQ-FTBISJDPSA-N

FDA UNII

RYI4401DTM

1 2D Structure

Indacaterol Acetate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

acetic acid;5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

2.1.2 InChI

InChI=1S/C24H28N2O3.C2H4O2/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24;1-2(3)4/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29);1H3,(H,3,4)/t22-;/m0./s1

2.1.3 InChI Key

HZHXFIDENGBQFQ-FTBISJDPSA-N

2.1.4 Canonical SMILES

CCC1=C(C=C2CC(CC2=C1)NCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.CC(=O)O

2.1.5 Isomeric SMILES

CCC1=C(C=C2CC(CC2=C1)NC[C@@H](C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.CC(=O)O

2.2 Other Identifiers

2.2.1 UNII

RYI4401DTM

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 1000160-96-2

2. Ryi4401dtm

3. Indacaterol Acetate (jan)

4. Indacaterol Acetate [jan]

5. Acetic Acid;5-[(1r)-2-[(5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one

6. Unii-ryi4401dtm

7. Indacaterol Acetic

8. Schembl362019

9. Chembl4297657

10. Dtxsid70142865

11. Ex-a6068

12. Indacaterol Acetate [who-dd]

13. D11009

14. Q27288350

15. (r)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one Acetate

2.4 Create Date

2008-02-26

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₃₂N₂O₅
Molecular Weight	452.5 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	452.23112213 g/mol
Monoisotopic Mass	452.23112213 g/mol
Topological Polar Surface Area	119 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	620
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

API SUPPLIERS

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USDMF

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KDMF

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Listed Suppliers

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API Reference Price

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MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1627410600,"product":"INDACATEROL ACETATE GRADE: IH","address":"FLAT,NO.505, 5TH FLR.,UNIQUE TOWER,S.V.ROAD,NR.KAMATH CLUB,GOREGAON(W)","city":"MUMBAI, MAHARASHTRA","supplier":"MELODY HEALTHCARE PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"LAHORE","customer":"SHIPPER","customerCountry":"PAKISTAN","quantity":"0.08","actualQuantity":"75","unit":"GMS","unitRateFc":"392.4","totalValueFC":"28449.9","currency":"USD","unitRateINR":28270.406666666666,"date":"28-Jul-2021","totalValueINR":"2120280.5","totalValueInUsd":"28449.9","indian_port":"BOMBAY AIR","hs_no":"29181990","bill_no":"3441715","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"FLAT,NO.505, 5TH FLR.,UNIQUE TOWER,S.V.ROAD,NR.KAMATH CLUB,GOREGAON(W), MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1643308200,"product":"INDACATEROL ACETATE GRADE: IH","address":"FLAT NO.1003,10TH FLR,UNIQUE TOWER ,,S.V.ROAD,NR.KAMATH CLUB,GOREGAON","city":"MUMBAI,MAHARASHTRA","supplier":"MELODY HEALTHCARE PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"TO THE ORDER OF","customerCountry":"BANGLADESH","quantity":"0.17","actualQuantity":"0.17","unit":"KGS","unitRateFc":"350000","totalValueFC":"58676.3","currency":"USD","unitRateINR":25711764.705882352,"date":"28-Jan-2022","totalValueINR":"4371000","totalValueInUsd":"58676.3","indian_port":"BOMBAY AIR","hs_no":"29181990","bill_no":"7790325","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"FLAT NO.1003,10TH FLR,UNIQUE TOWER ,,S.V.ROAD,NR.KAMATH CLUB,GOREGAON, MUMBAI,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1656873000,"product":"INDACATEROL ACETATE GRADE: IH","address":"FLAT NO.1003,10TH FLR,UNIQUE TOWER ,,S.V.ROAD,NR.KAMATH CLUB,GOREGAON","city":"MUMBAI,MAHARASHTRA","supplier":"MELODY HEALTHCARE PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"CAIRO","customer":"TO THE ORDER OF","customerCountry":"EGYPT","quantity":"0.02","actualQuantity":"0.02","unit":"KGS","unitRateFc":"375000","totalValueFC":"7155.7","currency":"USD","unitRateINR":28450000,"date":"04-Jul-2022","totalValueINR":"569000","totalValueInUsd":"7155.7","indian_port":"BOMBAY AIR","hs_no":"29181990","bill_no":"2584931","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"EGYPT","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"FLAT NO.1003,10TH FLR,UNIQUE TOWER ,,S.V.ROAD,NR.KAMATH CLUB,GOREGAON, MUMBAI,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704825000,"product":"PHARMA.RAW MATERIAL,ACTIVE PHARMA INGREDIENT,PACKING DETAILS:1 X 0.008 KGS INDACATEROL ACETATE GRADE:IH CAS:1000160-96-2","address":"FLAT,NO.505, 5TH FLR.,UNIQUE TOWER,","city":"MUMBAI, MAHARASHTRA","supplier":"MELODY HEALTHCARE PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"AS PER INVOICE","customerCountry":"PAKISTAN","quantity":"0.01","actualQuantity":"0.008","unit":"KGS","unitRateFc":"424000","totalValueFC":"3330.5","currency":"USD","unitRateINR":34600357.5,"date":"10-Jan-2024","totalValueINR":"276802.86","totalValueInUsd":"3330.5","indian_port":"Bombay Air","hs_no":"29181990","bill_no":"6641880","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"FLAT,NO.505, 5TH FLR.,UNIQUE TOWER,, 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MAHARASHTRA","customerAddress":""}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

01 Vectura Ltd

United Kingdom

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Not Confirmed

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Lead Product(s) : Indacaterol Acetate,Glycopyrronium Bromide,Mometasone Furoate

Therapeutic Area : Pulmonary/Respiratory Diseases

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Novartis Pharmaceuticals Corporation

Deal Size : Not Applicable

Deal Type : Not Applicable

DEALS_DEV

QVM149 Receives Regulatory Approval in Europe and Japan

Details : QVM149 combines the bronchodilation of indacaterol acetate (a LABA) and the antimuscarinic effects of glycopyrronium bromide (a LAMA) with mometasone furoate in a precise once-daily formulation, delivered via the dose-confirming Breezhaler® device.

Brand Name : Enerzair Breezhaler

Molecule Type : Small molecule

Upfront Cash : Not Applicable

July 07, 2020