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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

24 API Suppliers, 4 USDMF, 3 EU WC, 3 KDMF, 2 NDC API, 22 Listed Suppliers, $ API Reference Price

24 API Suppliers
4 USDMF
3 EU WC
3 KDMF
2 NDC API
22 Listed Suppliers
$ API Reference Price

INTERMEDIATES

10 Intermediates Suppliers

10 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

27 FDF Dossiers, 2 FDA Orange Book, 15 Europe, 2 Australia, 6 South Africa, 2 Listed Dossiers

27 FDF Dossiers
2 FDA Orange Book
15 Europe
2 Australia
6 South Africa
2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

POWDER;INHALATION - 15.6MCG/INH;27.5MCG/INH, POWDER;INHALATION - EQ 75MCG BASE

drugProductComposition
POWDER;INHALATION - 15.6MCG/INH;27.5MCG/INH
POWDER;INHALATION - EQ 75MCG BASE

RELATED EXCIPIENT COMPANIES

2 Faran Shimi Pharmaceutical, 4 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 2 DFE Pharma, 14 Kerry, 7 Microlex e.U, 2 Pluviaendo, 1 Prachin Chemical, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 2 Sigachi Industries, 1 Vasa Pharmachem

relatedExcipients
2 Faran Shimi Pharmaceutical
4 Gangwal Healthcare
1 Nanjing Well Pharmaceutical
1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
2 DFE Pharma
14 Kerry
7 Microlex e.U
2 Pluviaendo
1 Prachin Chemical
1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
2 Sigachi Industries
1 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

25 Fillers, Diluents & Binders, 8 Direct Compression, 8 Lubricants & Glidants, 5 Co-Processed Excipients, 4 Granulation, 1 Thickeners and Stabilizers, 1 Parenteral, 1 Controlled & Modified Release, 1 Emulsifying Agents

excipientsByApplications
25 Fillers, Diluents & Binders
8 Direct Compression
8 Lubricants & Glidants
5 Co-Processed Excipients
4 Granulation
1 Thickeners and Stabilizers
1 Parenteral
1 Controlled & Modified Release
1 Emulsifying Agents

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 21 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
21 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

16 Finished Drug Prices, 13 Annual Reports

globalSalesInformation
16 Finished Drug Prices
13 Annual Reports

MARKET PLACE

9 APIs

marketPlace
9 APIs

PATENTS & EXCLUSIVITIES

5 US Patents, 2 Health Canada Patents

patents
5 US Patents
2 Health Canada Patents

REF. STANDARDS & IMPURITIES

4 Others

otherSolutions
4 Others

Inke Indacaterol Maleate

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 203,185

MARKET PLACE

API

FDF

10INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

5,296

Finished Drug Prices

38 RELATED EXCIPIENT COMPANIES

54EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 753498-25-8, Arcapta neohaler, Indacaterol (maleate), Indacterol maleate, Indacaterol maleate [usan], Qab149-afa

Molecular Formula

C₂₈H₃₂N₂O₇

Molecular Weight

508.6 g/mol

InChI Key

IREJFXIHXRZFER-PCBAQXHCSA-N

FDA UNII

2JEC1ITX7R

1 2D Structure

Indacaterol Maleate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(Z)-but-2-enedioic acid;5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

2.1.2 InChI

InChI=1S/C24H28N2O3.C4H4O4/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24;5-3(6)1-2-4(7)8/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29);1-2H,(H,5,6)(H,7,8)/b;2-1-/t22-;/m0./s1

2.1.3 InChI Key

IREJFXIHXRZFER-PCBAQXHCSA-N

2.1.4 Canonical SMILES

CCC1=C(C=C2CC(CC2=C1)NCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=CC(=O)O)C(=O)O

2.1.5 Isomeric SMILES

CCC1=C(C=C2CC(CC2=C1)NC[C@@H](C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=C\C(=O)O)\C(=O)O

2.2 Other Identifiers

2.2.1 UNII

2JEC1ITX7R

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 5-(2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1h-quinolin-2-one

2. Arcapta Neohaler

3. Indacaterol

4. Onbrez

5. Qab-149

2.3.2 Depositor-Supplied Synonyms

1. 753498-25-8

2. Arcapta Neohaler

3. Indacaterol (maleate)

4. Indacterol Maleate

5. Indacaterol Maleate [usan]

6. Qab149-afa

7. Qab-149-afa

8. Indacaterol (as Maleate)

9. 2jec1itx7r

10. Chebi:68573

11. 753498-25-8 (malate)

12. Qabi49

13. (r)-5-(2-((5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one Maleate

14. Qab-149 Maleate

15. Unii-2jec1itx7r

16. Qab 149afa

17. Oslif Breezhaler

18. Onbrez Breezhaler

19. Hirobriz Breezhaler

20. (r)-5-[2-[(5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1h)-one Maleate

21. Arcapta Neohaler (tn)

22. Onbrez Inhalation Capsules

23. Indacaterol Maleic Acid Salt

24. Schembl523627

25. Chembl1789842

26. Indacaterol Maleate [mi]

27. Indacaterol Maleate (jan/usan)

28. Indacaterol Maleate [jan]

29. Hms3885o07

30. Indacaterol Maleate [mart.]

31. Hy-14299a

32. Indacaterol Maleate [who-dd]

33. Mfcd20526769

34. Indacaterol Maleate [ema Epar]

35. Ccg-269764

36. Indacaterol Maleate [orange Book]

37. Ac-30121

38. As-10152

39. Ultibro Component Indacaterol Maleate

40. I0927

41. Qva149 Component Indacaterol Maleate

42. S3083

43. Qva-149 Component Indacaterol Maleate

44. D09319

45. Indacaterol Maleate Component Of Utibron

46. Q27137018

47. (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4h- Pyrido(3,2-b)-1,4-oxazin-4-yl)methyl Dihydrogen Phosphate

48. (z)-but-2-enedioic Acid;5-[(1r)-2-[(5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one

49. 2(1h)-quinolinone, 5-((1r)-2-((5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino)-1-hydroxyethyl )-8-hydroxy-, (2z)-2-butenedioate (1:1)

50. 2(1h)-quinolinone, 5-((1r)-2-((5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino)-1-hydroxyethyl)-8-hydroxy-, (2z)-2-butenedioate (1:1)

51. 435273-74-8

52. 5,6-diethyl-n-[(2r)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]indan-2-aminium (2z)-3-carboxyacrylate

53. 5-((1r)-2-((5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino)-1-hydroxyethyl)-8- Hydroxyquinolin-2(1h)-one Hydrogen (2z)-2-butenedioate (salt)

54. 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1h-quinolin-2-one Maleate

55. 5-{(1r)-2-[(5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxyquinolin-2(1h)-one (2z)-but-2-enedioate

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₂₈H₃₂N₂O₇
Molecular Weight	508.6 g/mol
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Exact Mass	508.22095136 g/mol
Monoisotopic Mass	508.22095136 g/mol
Topological Polar Surface Area	156 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	708
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Arcapta neohaler
PubMed Health	Indacaterol (By breathing)
Drug Classes	Bronchodilator
Drug Label	ARCAPTA NEOHALER consists of a dry powder formulation of indacaterol maleate for oral inhalation only with the NEOHALERinhaler. The inhalation powder is packaged in clear gelatin capsules.Each clear, hard gelatin capsule contains a dry powder blend...
Active Ingredient	Indacaterol maleate
Dosage Form	Powder
Route	Inhalation
Strength	eq 75mcg base
Market Status	Prescription
Company	Novartis

2 of 2
Drug Name	Arcapta neohaler
PubMed Health	Indacaterol (By breathing)
Drug Classes	Bronchodilator
Drug Label	ARCAPTA NEOHALER consists of a dry powder formulation of indacaterol maleate for oral inhalation only with the NEOHALERinhaler. The inhalation powder is packaged in clear gelatin capsules.Each clear, hard gelatin capsule contains a dry powder blend...
Active Ingredient	Indacaterol maleate
Dosage Form	Powder
Route	Inhalation
Strength	eq 75mcg base
Market Status	Prescription
Company	Novartis

4.2 Drug Indication

Hirobriz Breezhaler is indicated for maintenance bronchodilator treatment of airflow obstruction in adult patients with chronic obstructive pulmonary disease.

Onbrez Breezhaler is indicated for maintenance bronchodilator treatment of airflow obstruction in adult patients with chronic obstructive pulmonary disease.

Oslif Breezhaler is indicated for maintenance bronchodilator treatment of airflow obstruction in adult patients with chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease

5 Pharmacology and Biochemistry

5.1 ATC Code

R03AC18

API SUPPLIERS

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USDMF

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EU WC

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NDC API

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Listed Suppliers

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API Reference Price

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