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    Chemistry

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    Also known as: 753498-25-8, Arcapta neohaler, Indacaterol (maleate), Indacterol maleate, Indacaterol maleate [usan], Qab149-afa
    Molecular Formula
    C28H32N2O7
    Molecular Weight
    508.6  g/mol
    InChI Key
    IREJFXIHXRZFER-PCBAQXHCSA-N
    FDA UNII
    2JEC1ITX7R
    Indacaterol Maleate
    1 2D Structure

    Indacaterol Maleate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one
    2.1.2 InChI
    InChI=1S/C24H28N2O3.C4H4O4/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24;5-3(6)1-2-4(7)8/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29);1-2H,(H,5,6)(H,7,8)/b;2-1-/t22-;/m0./s1
    2.1.3 InChI Key
    IREJFXIHXRZFER-PCBAQXHCSA-N
    2.1.4 Canonical SMILES
    CCC1=C(C=C2CC(CC2=C1)NCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CCC1=C(C=C2CC(CC2=C1)NC[C@@H](C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    2JEC1ITX7R
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 5-(2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1h-quinolin-2-one

    2. Arcapta Neohaler

    3. Indacaterol

    4. Onbrez

    5. Qab-149

    2.3.2 Depositor-Supplied Synonyms

    1. 753498-25-8

    2. Arcapta Neohaler

    3. Indacaterol (maleate)

    4. Indacterol Maleate

    5. Indacaterol Maleate [usan]

    6. Qab149-afa

    7. Qab-149-afa

    8. Indacaterol (as Maleate)

    9. 2jec1itx7r

    10. Chebi:68573

    11. 753498-25-8 (malate)

    12. Qabi49

    13. (r)-5-(2-((5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one Maleate

    14. Qab-149 Maleate

    15. Unii-2jec1itx7r

    16. Qab 149afa

    17. Oslif Breezhaler

    18. Onbrez Breezhaler

    19. Hirobriz Breezhaler

    20. (r)-5-[2-[(5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1h)-one Maleate

    21. Arcapta Neohaler (tn)

    22. Onbrez Inhalation Capsules

    23. Indacaterol Maleic Acid Salt

    24. Schembl523627

    25. Chembl1789842

    26. Indacaterol Maleate [mi]

    27. Indacaterol Maleate (jan/usan)

    28. Indacaterol Maleate [jan]

    29. Hms3885o07

    30. Indacaterol Maleate [mart.]

    31. Hy-14299a

    32. Indacaterol Maleate [who-dd]

    33. Mfcd20526769

    34. Indacaterol Maleate [ema Epar]

    35. Ccg-269764

    36. Indacaterol Maleate [orange Book]

    37. Ac-30121

    38. As-10152

    39. Ultibro Component Indacaterol Maleate

    40. I0927

    41. Qva149 Component Indacaterol Maleate

    42. S3083

    43. Qva-149 Component Indacaterol Maleate

    44. D09319

    45. Indacaterol Maleate Component Of Utibron

    46. Q27137018

    47. (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4h- Pyrido(3,2-b)-1,4-oxazin-4-yl)methyl Dihydrogen Phosphate

    48. (z)-but-2-enedioic Acid;5-[(1r)-2-[(5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one

    49. 2(1h)-quinolinone, 5-((1r)-2-((5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino)-1-hydroxyethyl )-8-hydroxy-, (2z)-2-butenedioate (1:1)

    50. 2(1h)-quinolinone, 5-((1r)-2-((5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino)-1-hydroxyethyl)-8-hydroxy-, (2z)-2-butenedioate (1:1)

    51. 435273-74-8

    52. 5,6-diethyl-n-[(2r)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]indan-2-aminium (2z)-3-carboxyacrylate

    53. 5-((1r)-2-((5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino)-1-hydroxyethyl)-8- Hydroxyquinolin-2(1h)-one Hydrogen (2z)-2-butenedioate (salt)

    54. 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1h-quinolin-2-one Maleate

    55. 5-{(1r)-2-[(5,6-diethyl-2,3-dihydro-1h-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxyquinolin-2(1h)-one (2z)-but-2-enedioate

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 508.6 g/mol
    Molecular Formula C28H32N2O7
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count8
    Exact Mass508.22095136 g/mol
    Monoisotopic Mass508.22095136 g/mol
    Topological Polar Surface Area156 Ų
    Heavy Atom Count37
    Formal Charge0
    Complexity708
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameArcapta neohaler
    PubMed HealthIndacaterol (By breathing)
    Drug ClassesBronchodilator
    Drug LabelARCAPTA NEOHALER consists of a dry powder formulation of indacaterol maleate for oral inhalation only with the NEOHALERinhaler. The inhalation powder is packaged in clear gelatin capsules.Each clear, hard gelatin capsule contains a dry powder blend...
    Active IngredientIndacaterol maleate
    Dosage FormPowder
    RouteInhalation
    Strengtheq 75mcg base
    Market StatusPrescription
    CompanyNovartis

    2 of 2  
    Drug NameArcapta neohaler
    PubMed HealthIndacaterol (By breathing)
    Drug ClassesBronchodilator
    Drug LabelARCAPTA NEOHALER consists of a dry powder formulation of indacaterol maleate for oral inhalation only with the NEOHALERinhaler. The inhalation powder is packaged in clear gelatin capsules.Each clear, hard gelatin capsule contains a dry powder blend...
    Active IngredientIndacaterol maleate
    Dosage FormPowder
    RouteInhalation
    Strengtheq 75mcg base
    Market StatusPrescription
    CompanyNovartis

    4.2 Drug Indication

    Hirobriz Breezhaler is indicated for maintenance bronchodilator treatment of airflow obstruction in adult patients with chronic obstructive pulmonary disease.

    Onbrez Breezhaler is indicated for maintenance bronchodilator treatment of airflow obstruction in adult patients with chronic obstructive pulmonary disease.

    Oslif Breezhaler is indicated for maintenance bronchodilator treatment of airflow obstruction in adult patients with chronic obstructive pulmonary disease.

    Chronic obstructive pulmonary disease

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    R03AC18

    R03AC18

    R03AC18

    API Reference Price

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P-33M) (INDACATEROL MALEATE MICRONIZED)","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"INKE S.A","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.18","actualQuantity":"0.18","unit":"KGS","unitRateFc":"198000","totalValueFC":"39269.1","currency":"EUR","unitRateINR":"18166500","date":"24-Nov-2023","totalValueINR":"3269970","totalValueInUsd":"39269.1","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"8910139","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Micronized","supplierPort":"BARCELONA","supplierAddress":"AREA INDUSTRIAL DEL LLOBREGAT C\/ARGENT 1 08755 CASTELLBISBAL BARCELONASPAIN Barcelona, , Spain Spain","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703269800,"product":"INDACATEROL MALEATE API (140 GRAM) (BATCH NO. P-33M) (INDACATEROL MALEATE MICRONIZED)","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"INKE S.A","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.14","actualQuantity":"0.14","unit":"KGS","unitRateFc":"198000","totalValueFC":"30752.6","currency":"EUR","unitRateINR":"18285300","date":"23-Dec-2023","totalValueINR":"2559942","totalValueInUsd":"30752.6","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"9375491","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Micronized","supplierPort":"BARCELONA","supplierAddress":"AREA INDUSTRIAL DEL LLOBREGAT C\/ARGENT 1 08755 CASTELLBISBAL BARCELONASPAIN Barcelona, , Spain Spain","customerAddress":"B\/2 MAHALAXMI CHAMBERS"}]
    12-Jan-2021
    23-Sep-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    INTERMEDIATES SUPPLIERS

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    01

    Guangdong Raffles PharmaTech Co Ltd

    China
    2024 ACI Convention
    Not Confirmed
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    Guangdong Raffles PharmaTech Co Ltd

    China
    2024 ACI Convention
    Not Confirmed
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    • EDQM
    • WHO-GMP
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    (R)-N-(2-(8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-...

    CAS Number : 753498-24-7

    End Use API : Indacaterol Maleate

    About The Company : Established in August 2011, Raffles PharmaTech is a high-tech enterprise that focus on development, manufacturing and sales of high-value added active pharmaceu...

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    02

    Guangdong Raffles PharmaTech Co Ltd

    China
    2024 ACI Convention
    Not Confirmed
    arrow

    Guangdong Raffles PharmaTech Co Ltd

    China
    2024 ACI Convention
    Not Confirmed
    arrow
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    • EDQM
    • WHO-GMP
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    5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone

    CAS Number : 173140-90-4

    End Use API : Indacaterol Maleate

    About The Company : Established in August 2011, Raffles PharmaTech is a high-tech enterprise that focus on development, manufacturing and sales of high-value added active pharmaceu...

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    Website

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    03

    Guangdong Raffles PharmaTech Co Ltd

    China
    2024 ACI Convention
    Not Confirmed
    arrow

    Guangdong Raffles PharmaTech Co Ltd

    China
    2024 ACI Convention
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP
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    (R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinol...

    CAS Number : 530084-79-8

    End Use API : Indacaterol Maleate

    About The Company : Established in August 2011, Raffles PharmaTech is a high-tech enterprise that focus on development, manufacturing and sales of high-value added active pharmaceu...

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    04

    Guangdong Raffles PharmaTech Co Ltd

    China
    2024 ACI Convention
    Not Confirmed
    arrow

    Guangdong Raffles PharmaTech Co Ltd

    China
    2024 ACI Convention
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP
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    8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline

    CAS Number : 100331-89-3

    End Use API : Indacaterol Maleate

    About The Company : Established in August 2011, Raffles PharmaTech is a high-tech enterprise that focus on development, manufacturing and sales of high-value added active pharmaceu...

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    Website

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    05

    Guangdong Raffles PharmaTech Co Ltd

    China
    2024 ACI Convention
    Not Confirmed
    arrow

    Guangdong Raffles PharmaTech Co Ltd

    China
    2024 ACI Convention
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP
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    5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochlo...

    CAS Number : 312753-53-0

    End Use API : Indacaterol Maleate

    About The Company : Established in August 2011, Raffles PharmaTech is a high-tech enterprise that focus on development, manufacturing and sales of high-value added active pharmaceu...

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    Digital Content

    Website

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    06

    LinkChem

    China
    2024 ACI Convention
    Not Confirmed
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    LinkChem

    China
    2024 ACI Convention
    Not Confirmed
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    5-acetyl-8-hydroxy-1H-quinolin-2-one

    CAS Number : 62978-73-8

    End Use API : Indacaterol Maleate

    About The Company : LinkChem is a leading China headquartered CMO | CRO provider within the pharmaceutical industry. Our core focus includes: custom synthesis, process development,...

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    07

    Scinvapharma

    India
    2024 ACI Convention
    Not Confirmed
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    Scinvapharma

    India
    2024 ACI Convention
    Not Confirmed
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    8-(benzyloxy)-5-(2-bromoacetyl)quinolin-2(1H)-one

    CAS Number : 100331-89-3

    End Use API : Indacaterol Maleate

    About The Company : Scinva is a startup dedicated to offering high-quality products and services, providing a comprehensive range of services from custom synthesis to the trade of ...

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    08

    Shenzhen HwaGen Pharmaceutical

    China
    2024 ACI Convention
    Not Confirmed
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    Shenzhen HwaGen Pharmaceutical

    China
    2024 ACI Convention
    Not Confirmed
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    • EDQM
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    (R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinol...

    CAS Number : 530084-79-8

    End Use API : Indacaterol Maleate

    About The Company : Shenzhen HwaGen Pharmaceutical Co., Ltd. (HwaGen Pharma) was founded in December of 2015 under the leadership of a “National 1000 Talents Program” expert. B...

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    09

    Vio Chemicals

    Switzerland
    2024 ACI Convention
    Not Confirmed
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    Vio Chemicals

    Switzerland
    2024 ACI Convention
    Not Confirmed
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    5-(2R)-2-oxiranyl-8-(phenylmethoxy)-2(1H)-Quinolin...

    CAS Number : 173140-90-4

    End Use API : Indacaterol Maleate

    About The Company : A Swiss chemical company specialized in custom design, development, production & sourcing of specialty chemicals, intermediates and Active Pharmaceutical Ingred...

    blank

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    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    10

    Vio Chemicals

    Switzerland
    2024 ACI Convention
    Not Confirmed
    arrow

    Vio Chemicals

    Switzerland
    2024 ACI Convention
    Not Confirmed
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    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    5,6-Diethyl-2,3-dihydro-1H-inden-2-amine, hydrochl...

    CAS Number : 312753-53-0

    End Use API : Indacaterol Maleate

    About The Company : A Swiss chemical company specialized in custom design, development, production & sourcing of specialty chemicals, intermediates and Active Pharmaceutical Ingred...

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - POWDER;INHALATION - 15.6MCG/INH;27.5...DOSAGE - POWDER;INHALATION - 15.6MCG/INH;27.5MCG/INH

    USFDA APPLICATION NUMBER - 207930

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    DOSAGE - POWDER;INHALATION - EQ 75MCG BASE

    USFDA APPLICATION NUMBER - 22383

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