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    Chemistry

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    Also known as: 26807-65-8, Noranat, Veroxil, Tertensif, Lozol, Indaflex
    Molecular Formula
    C16H16ClN3O3S
    Molecular Weight
    365.8  g/mol
    InChI Key
    NDDAHWYSQHTHNT-UHFFFAOYSA-N
    FDA UNII
    F089I0511L
    Indapamide
    A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
    Indapamide is a Thiazide-like Diuretic. The physiologic effect of indapamide is by means of Increased Diuresis.
    1 2D Structure

    Indapamide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
    2.1.2 InChI
    InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
    2.1.3 InChI Key
    NDDAHWYSQHTHNT-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1CC2=CC=CC=C2N1NC(=O)C3=CC(=C(C=C3)Cl)S(=O)(=O)N
    2.2 Other Identifiers
    2.2.1 UNII
    F089I0511L
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Metindamide

    2. S 1520

    3. S-1520

    4. S1520

    5. Se 1520

    6. Se-1520

    7. Se1520

    2.3.2 Depositor-Supplied Synonyms

    1. 26807-65-8

    2. Noranat

    3. Veroxil

    4. Tertensif

    5. Lozol

    6. Indaflex

    7. Arifon

    8. Fludex

    9. Indamol

    10. Bajaten

    11. Ipamix

    12. Tandix

    13. Natrilix

    14. Damide

    15. Pressurai

    16. Indapamida

    17. Indapamidum

    18. Natrix

    19. Indapamidum [inn-latin]

    20. Indapamida [inn-spanish]

    21. Se-1520

    22. Flupamid

    23. Indamide

    24. 1-(4-chloro-3-sulfamoylbenzamido)-2-methylindoline

    25. Fludin

    26. Lorvas

    27. 4-chloro-n-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide

    28. S-1520

    29. Benzamide, 3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)-

    30. 4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide

    31. Indapamide (lozol)

    32. Flubest

    33. 4-chloro-n-(2-methyl-2,3-dihydro-1h-indol-1-yl)-3-sulfamoylbenzamide

    34. Metindamide

    35. Cormil

    36. Nsc-757075

    37. N-(4-chloro-3-sulfamoylbenzamido)-2-methylindoline

    38. Mls000028554

    39. Chebi:5893

    40. 26807-65-8(free Base)

    41. Kyd-041

    42. Benzamide, 4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoyl-

    43. F089i0511l

    44. Ncgc00018172-03

    45. Smr000058829

    46. 4-chloro-n-(2-methylindolin-1-yl)-3-sulfamoylbenzamide

    47. Dsstox_cid_24633

    48. Dsstox_rid_80366

    49. Dsstox_gsid_44633

    50. Se 1520

    51. Rhc 2555

    52. Usv 2555

    53. Natrix (tn)

    54. Lozol (tn)

    55. Sr-01000003079

    56. Einecs 248-012-7

    57. Mfcd00079375

    58. Brn 1604026

    59. Unii-f089i0511l

    60. Hypen Sr

    61. 3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)benzamide

    62. Indapamide [usan:usp:inn:ban:jan]

    63. Spectrum_000917

    64. Indapamide [mi]

    65. Opera_id_110

    66. Indapamide [inn]

    67. Indapamide [jan]

    68. Prestwick3_000220

    69. Spectrum2_000980

    70. Spectrum3_000467

    71. Spectrum4_000017

    72. Spectrum5_000866

    73. Indapamide [usan]

    74. S1520

    75. Indapamide [vandf]

    76. Chembl406

    77. Indapamide (jp17/usp)

    78. Indapamide [mart.]

    79. Indapamide [usp-rs]

    80. Indapamide [who-dd]

    81. Schembl41303

    82. Bspbio_000239

    83. Bspbio_002174

    84. Kbiogr_000393

    85. Kbioss_001397

    86. 5-20-06-00348 (beilstein Handbook Reference)

    87. Mls001148152

    88. Mls002222229

    89. Mls006011900

    90. Divk1c_000508

    91. Spectrum1500349

    92. Spbio_001019

    93. Bpbio1_000263

    94. Gtpl7203

    95. Dtxsid7044633

    96. Indapamide [ep Impurity]

    97. Indapamide [orange Book]

    98. Bdbm25901

    99. Hms501j10

    100. Kbio1_000508

    101. Kbio2_001397

    102. Kbio2_003965

    103. Kbio2_006533

    104. Kbio3_001394

    105. Indapamide [ep Monograph]

    106. Ninds_000508

    107. Hms1920f19

    108. Hms2090m16

    109. Hms2091n07

    110. Hms2095l21

    111. Hms2231g13

    112. Hms3259c14

    113. Hms3369j20

    114. Hms3655e06

    115. Hms3712l21

    116. Hms3748k05

    117. Indapamide [usp Monograph]

    118. Pharmakon1600-01500349

    119. Indapamide 1.0 Mg/ml In Methanol

    120. Amy31945

    121. Bcp04140

    122. Hy-b0259

    123. Tox21_110775

    124. Tox21_113182

    125. Tox21_302687

    126. Ccg-40198

    127. Nsc757075

    128. S1730

    129. Stl257105

    130. Stl455045

    131. 3-(aminosulfonyl)-4-chloro-n-(2-methyl-2,3-dihydro-1h-indol-1-yl)benzamide

    132. Akos015888148

    133. Tox21_110775_1

    134. Ab03037

    135. Ac-2073

    136. Db00808

    137. Ks-5219

    138. Nc00568

    139. Nsc 757075

    140. Benzamide, 3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-l-yl)-

    141. Idi1_000508

    142. Ncgc00018172-02

    143. Ncgc00018172-04

    144. Ncgc00018172-06

    145. Ncgc00018172-08

    146. Ncgc00018172-09

    147. Ncgc00089727-02

    148. Ncgc00089727-03

    149. Ncgc00256884-01

    150. Sbi-0051415.p003

    151. Db-047020

    152. Ab00052021

    153. I0730

    154. Sw198686-2

    155. A23574

    156. D00345

    157. Ab00052021-14

    158. Ab00052021-15

    159. Ab00052021_16

    160. Ab00052021_17

    161. 807i658

    162. Indapamide, Analytical Standard, For Drug Analysis

    163. J-016554

    164. Q1078392

    165. Sr-01000003079-2

    166. Sr-01000003079-3

    167. Brd-a95869247-001-04-6

    168. Brd-a95869247-001-14-5

    169. Z2786158257

    170. Indapamide, British Pharmacopoeia (bp) Reference Standard

    171. Indapamide, European Pharmacopoeia (ep) Reference Standard

    172. Indapamide, United States Pharmacopeia (usp) Reference Standard

    173. 3-aminosulfonyl-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)benzamide

    174. 4-chloro-3-aminosulphonyl-n-(2,3-dihydro2-methyl-1h-indol-1-yl)benzamide

    175. Indapamide, Pharmaceutical Secondary Standard; Certified Reference Material

    176. 3-(aminosulphonyl)-4-chloro-n-(2-methyl-2,3-dihydro-1h-indol-1--yl)benzamide

    177. 3-(aminosulphonyl)-4-chloro-n-(2-methyl-2,3-dihydro-1h-indol-1-yl)benzamide

    178. 4-chloro-n-(2-methyl-2,3-dihydro-1h-indol-1-yl)-3-sulfamoylbenzenecarboximidic Acid

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 365.8 g/mol
    Molecular Formula C16H16ClN3O3S
    XLogP32.9
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count3
    Exact Mass365.0600902 g/mol
    Monoisotopic Mass365.0600902 g/mol
    Topological Polar Surface Area101 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity580
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameIndapamide
    PubMed HealthIndapamide (By mouth)
    Drug ClassesCardiovascular Agent
    Drug LabelIndapamide is an oral antihypertensive/diuretic. Its molecule contains both a polar sulfamoyl chlorobenzamide moiety and a lipid-soluble methylindoline moiety. It differs chemically from the thiazides in that it does not possess the thiazide ring sys...
    Active IngredientIndapamide
    Dosage FormTablet
    RouteOral
    Strength2.5mg; 1.25mg
    Market StatusPrescription
    CompanyMylan Pharms; Ivax Sub Teva Pharms; Actavis Elizabeth; Mylan

    2 of 2  
    Drug NameIndapamide
    PubMed HealthIndapamide (By mouth)
    Drug ClassesCardiovascular Agent
    Drug LabelIndapamide is an oral antihypertensive/diuretic. Its molecule contains both a polar sulfamoyl chlorobenzamide moiety and a lipid-soluble methylindoline moiety. It differs chemically from the thiazides in that it does not possess the thiazide ring sys...
    Active IngredientIndapamide
    Dosage FormTablet
    RouteOral
    Strength2.5mg; 1.25mg
    Market StatusPrescription
    CompanyMylan Pharms; Ivax Sub Teva Pharms; Actavis Elizabeth; Mylan

    4.2 Drug Indication

    Indapamide is a diuretic indicated for use as monotherapy or in combination with other blood pressure-lowering agents to treat hypertension. It may also be used to treat fluid and salt retention associated with congestive heart failure.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Classified as a sulfonamide diuretic, indapamide is an effective antihypertensive agent and by extension, has shown efficacy in the prevention of target organ damage. Administration of indapamide produces water and electrolyte loss, with higher doses associated with increased diuresis. Severe and clinically significant electrolyte disturbances may occur with indapamide use - for example, hypokalemia resulting from renal potassium loss may lead to QTc prolongation. Further electrolyte imbalances may occur due to renal excretion of sodium, chloride, and magnesium. Other indapamide induced changes include increases in plasma renin and aldosterone, and reduced calcium excretion in the urine. In many studies investigating the effects of indapamide in both non-diabetic and diabetic hypertensive patients, glucose tolerance was not significantly altered. However, additional studies are necessary to assess the long term metabolic impacts of indapamide, since thiazide related impaired glucose tolerance can take several years to develop in non-diabetic patients.

    5.2 MeSH Pharmacological Classification

    Diuretics

    Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Sodium Chloride Symporter Inhibitors

    Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA. (See all compounds classified as Sodium Chloride Symporter Inhibitors.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    INDAPAMIDE
    5.3.2 FDA UNII
    F089I0511L
    5.3.3 Pharmacological Classes
    Thiazide-like Diuretic [EPC]; Increased Diuresis [PE]
    5.4 ATC Code

    C03BA11

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    C - Cardiovascular system

    C03 - Diuretics

    C03B - Low-ceiling diuretics, excl. thiazides

    C03BA - Sulfonamides, plain

    C03BA11 - Indapamide

    5.5 Absorption, Distribution and Excretion

    Absorption

    The bioavailability of indapamide is virtually complete after an oral dose and is unaffected by food or antacids. Indapamide is highly lipid-soluble due to its indoline moiety - a characteristic that likely explains why indapamides renal clearance makes up less than 10% of its total systemic clearance. The Tmax occurs approximately 2.3 hours after oral administration. The Cmax and AUC0-24 values are 263 ng/mL and 2.95 ug/hr/mL, respectively.

    Route of Elimination

    An estimated 60-70% of indapamide is eliminated in the urine, while 16-23% is eliminated in the feces.

    Volume of Distribution

    Some sources report an apparent volume of distribution of 25 L for indapamide, while others report a value of approximately 60 L.

    Clearance

    Indapamide's renal and hepatic clearance values are reported to be 1.71 mL/min and 20-23.4 mL/min, respectively.

    5.6 Metabolism/Metabolites

    As a result of extensive metabolism in the liver, the majority of indapamide excreted is metabolized, with only 7% remaining unchanged. In humans, as many as 19 distinct indapamide metabolites may be produced, although not all have been identified. There are several metabolic routes through which indapamide may be metabolized, and CYP3A4 is the main enzyme involved in the corresponding hydroxylation, carboxylation, and dehydrogenation reactions. Indapamide can undergo dehydrogenation to form M5, then oxidation to form M4, then further hydroxylation at the indole moiety to form M2. These reactions are facilitated by CYP3A4. Another route of metabolism occurs when indapamide is first hydroxylated to M1 by CYP3A4. M1 then undergoes dehydrogenation to form M3 and is further oxidized to form M2. Hydroxylation of indapamides indole moiety is thought to form the major metabolite (M1), which is less pharmacologically active compared to its parent compound according to animal studies. Indapamide may also undergo epoxidation via CYP3A4 to form a reactive epoxide intermediate. The unstable epoxide intermediate may then undergo dihydroxylation via microsomal epoxide hydrolase to form M6, or glutathione conjugation to form M7.

    5.7 Biological Half-Life

    Indapamide is characterized by biphasic elimination. In healthy subjects, indapamide's elimination half-life can range from 13.9 to 18 hours. The long half-life is conducive to once-daily dosing.

    5.8 Mechanism of Action

    Indapamide acts on the nephron, specifically at the proximal segment of the distal convoluted tubule where it inhibits the Na+/Cl- cotransporter, leading to reduced sodium reabsorption. As a result, sodium and water are retained in the lumen of the nephron for urinary excretion. The effects that follow include reduced plasma volume, reduced venous return, lower cardiac output, and ultimately decreased blood pressure. Interestingly, it is likely that thiazide-like diuretics such as indapamide have additional blood pressure lowering mechanisms that are unrelated to diuresis. This is exemplified by the observation that the antihypertensive effects of thiazides are sustained 4-6 weeks after initiation of therapy, despite recovering plasma and extracellular fluid volumes. Some studies have suggested that indapamide may decrease responsiveness to pressor agents while others have suggested it can decrease peripheral resistance. Although it is clear that diuresis contributes to the antihypertensive effects of indapamide, further studies are needed to investigate the medications ability to decrease peripheral vascular resistance and relax vascular smooth muscle.

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GUJARAT","supplier":"BIOINDUSTRIA L.I.M. SPA","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"TORRENT PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"1030","totalValueFC":"113279.9","currency":"EUR","unitRateINR":"95017.5","date":"06-Aug-2024","totalValueINR":"9501750","totalValueInUsd":"113279.9","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"4906027","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"15067, NOVI LIGURE AL VIA DE AMBROSIIS 2-4-6 ITALY-15067SDNF ITALY","customerAddress":"TORRENT HOUSE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723573800,"product":"INDAPAMIDE EP (BATCH NO.3ND.0623)","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"REFARMED CHEMICALS","supplierCountry":"ITALY","foreign_port":"BASLE","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.76","actualQuantity":"0.76","unit":"KGS","unitRateFc":"1020","totalValueFC":"852.6","currency":"EUR","unitRateINR":"94095","date":"14-Aug-2024","totalValueINR":"71512.2","totalValueInUsd":"852.6","indian_port":"Bombay Air","hs_no":"29351000","bill_no":"5053695","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"BASLE","supplierAddress":"VIA GIOVANNI FERRI 15,6904 LUGANO,SDNFSDNF SWITZERLAND","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725906600,"product":"INDAPAMIDE","address":"102,TITAN HOUSE,60 FEET RD,","city":"MUMBAI, MAHARASHTRA","supplier":"NEXCHEM PHARMACEUTICAL CO, LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"TITAN LABORATORIES","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"450","totalValueFC":"22795","currency":"USD","unitRateINR":"38205","date":"10-Sep-2024","totalValueINR":"1910250","totalValueInUsd":"22795","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"5528991","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO 21 TANGXI ROAD ,SUZHOU NEW DISTR ICT 215151 P R CHINA Suzhou New Dis trict, , China China China","customerAddress":"102,TITAN HOUSE,60 FEET RD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729621800,"product":"INDAPAMIDE MICRONIZED","address":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK","city":"KURLA, MUMBAI","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"PIRAMAL PHARMA SOLUTIONS","customerCountry":"INDIA","quantity":"5.96","actualQuantity":"5.96","unit":"KGS","unitRateFc":"2600","totalValueFC":"15666.3","currency":"USD","unitRateINR":"220870","date":"23-Oct-2024","totalValueINR":"1316385.2","totalValueInUsd":"15666.3","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"6291611","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Micronized","supplierPort":"MADRID","supplierAddress":"LUGANO BRANCH VIA.F.PELLI 17 , P.O. BOX 6901 LUGANO SWITZERLAND , , Swi tzerland Switzerland","customerAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729621800,"product":"INDAPAMIDE MICRONIZED","address":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK","city":"KURLA, MUMBAI","supplier":"CHEMO","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"PIRAMAL PHARMA SOLUTIONS","customerCountry":"INDIA","quantity":"11.47","actualQuantity":"11.47","unit":"KGS","unitRateFc":"2600","totalValueFC":"30149.7","currency":"USD","unitRateINR":"220870","date":"23-Oct-2024","totalValueINR":"2533378.9","totalValueInUsd":"30149.7","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"6291611","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Micronized","supplierPort":"MADRID","supplierAddress":"LUGANO BRANCH VIA.F.PELLI 17 , P.O. BOX 6901 LUGANO SWITZERLAND , , Swi tzerland Switzerland","customerAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731349800,"product":"1000064,INDAPAMIDE LOT NO:INMR 2024\/10121 (PHARMACEUTICAL PRODUCTS)","address":"SITE NO.1,BOMMASANDRA INDL.AREA,IV","city":"ANEKAL TALUK,BANGALORE","supplier":"ACIC FINE CHEMICALS","supplierCountry":"CANADA","foreign_port":"TORONTO","customer":"APOTEX INC","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"1645","totalValueFC":"41520.6","currency":"USD","unitRateINR":"140154","date":"12-Nov-2024","totalValueINR":"3503850","totalValueInUsd":"41520.6","indian_port":"Bangalore Air","hs_no":"29339990","bill_no":"6631667","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"TORONTO","supplierAddress":"D-17 CORPORATE PLACE BRANTFORD ONTARIO N3R 8A6 SDNF CA","customerAddress":"SITE NO.1,BOMMASANDRA INDL.AREA,IV"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731868200,"product":"INDAPAMIDE EP (INDAPAMIDE MICRONIZED PH\/EUR) (FOR PHARMACEUTICALS USE ONLY)","address":"TORRENT HOUSE,","city":"AHMEDABAD. GUJARAT","supplier":"REFARMED CHEMICALS","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"TORRENT PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"85.32","actualQuantity":"85.32","unit":"KGS","unitRateFc":"1030","totalValueFC":"94556.7","currency":"EUR","unitRateINR":"93524","date":"18-Nov-2024","totalValueINR":"7979467.68","totalValueInUsd":"94556.7","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"6734760","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN","supplierAddress":"VIA GIOVANNI FERRI 15 6900, LUGANO . SWITZERLAND SDNF SWITZERLAND","customerAddress":"TORRENT HOUSE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734287400,"product":"INDAPAMIDE (FOR PHARMACEUTICALS USE ONLY) INDAPAMIDE (FOR PHARMACEUTICALS USE ONLY)","address":"TORRENT HOUSE,","city":"AHMEDABAD. GUJARAT","supplier":"BIOINDUSTRIA L.I.M. SPA","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"TORRENT PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"1092.5","totalValueFC":"55064.5","currency":"USD","unitRateINR":"93575.5","date":"16-Dec-2024","totalValueINR":"4678775","totalValueInUsd":"55064.5","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"7269264","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"15067, NOVI LIGURE AL VIA DE AMBROS IIS 2-4-6 ITALY-15067 SDNF ITALY","customerAddress":"TORRENT HOUSE,"}]
    15-Jan-2021
    16-Dec-2024
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    ABOUT THIS PAGE

    Looking for 26807-65-8 / Indapamide API manufacturers, exporters & distributors?

    Indapamide manufacturers, exporters & distributors 1

    46

    PharmaCompass offers a list of Indapamide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Indapamide manufacturer or Indapamide supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Indapamide manufacturer or Indapamide supplier.

    PharmaCompass also assists you with knowing the Indapamide API Price utilized in the formulation of products. Indapamide API Price is not always fixed or binding as the Indapamide Price is obtained through a variety of data sources. The Indapamide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Indapamide

    Synonyms

    26807-65-8, Noranat, Veroxil, Tertensif, Lozol, Indaflex

    Cas Number

    26807-65-8

    Unique Ingredient Identifier (UNII)

    F089I0511L

    About Indapamide

    A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.

    Indapamide Manufacturers

    A Indapamide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Indapamide, including repackagers and relabelers. The FDA regulates Indapamide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Indapamide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Indapamide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Indapamide Suppliers

    A Indapamide supplier is an individual or a company that provides Indapamide active pharmaceutical ingredient (API) or Indapamide finished formulations upon request. The Indapamide suppliers may include Indapamide API manufacturers, exporters, distributors and traders.

    click here to find a list of Indapamide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Indapamide USDMF

    A Indapamide DMF (Drug Master File) is a document detailing the whole manufacturing process of Indapamide active pharmaceutical ingredient (API) in detail. Different forms of Indapamide DMFs exist exist since differing nations have different regulations, such as Indapamide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Indapamide DMF submitted to regulatory agencies in the US is known as a USDMF. Indapamide USDMF includes data on Indapamide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Indapamide USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Indapamide suppliers with USDMF on PharmaCompass.

    Indapamide JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Indapamide Drug Master File in Japan (Indapamide JDMF) empowers Indapamide API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Indapamide JDMF during the approval evaluation for pharmaceutical products. At the time of Indapamide JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Indapamide suppliers with JDMF on PharmaCompass.

    Indapamide KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Indapamide Drug Master File in Korea (Indapamide KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Indapamide. The MFDS reviews the Indapamide KDMF as part of the drug registration process and uses the information provided in the Indapamide KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Indapamide KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Indapamide API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Indapamide suppliers with KDMF on PharmaCompass.

    Indapamide CEP

    A Indapamide CEP of the European Pharmacopoeia monograph is often referred to as a Indapamide Certificate of Suitability (COS). The purpose of a Indapamide CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Indapamide EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Indapamide to their clients by showing that a Indapamide CEP has been issued for it. The manufacturer submits a Indapamide CEP (COS) as part of the market authorization procedure, and it takes on the role of a Indapamide CEP holder for the record. Additionally, the data presented in the Indapamide CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Indapamide DMF.

    A Indapamide CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Indapamide CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Indapamide suppliers with CEP (COS) on PharmaCompass.

    Indapamide WC

    A Indapamide written confirmation (Indapamide WC) is an official document issued by a regulatory agency to a Indapamide manufacturer, verifying that the manufacturing facility of a Indapamide active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Indapamide APIs or Indapamide finished pharmaceutical products to another nation, regulatory agencies frequently require a Indapamide WC (written confirmation) as part of the regulatory process.

    click here to find a list of Indapamide suppliers with Written Confirmation (WC) on PharmaCompass.

    Indapamide NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Indapamide as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Indapamide API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Indapamide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Indapamide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Indapamide NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Indapamide suppliers with NDC on PharmaCompass.

    Indapamide GMP

    Indapamide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Indapamide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Indapamide GMP manufacturer or Indapamide GMP API supplier for your needs.

    Indapamide CoA

    A Indapamide CoA (Certificate of Analysis) is a formal document that attests to Indapamide's compliance with Indapamide specifications and serves as a tool for batch-level quality control.

    Indapamide CoA mostly includes findings from lab analyses of a specific batch. For each Indapamide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Indapamide may be tested according to a variety of international standards, such as European Pharmacopoeia (Indapamide EP), Indapamide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Indapamide USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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