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1. Indium In 111 Oxyquinoline
2. 65389-08-4
3. Indium-111(3+);quinolin-8-olate
4. Indium In-111 Oxine
5. Indium (111 In) Oxyquinoline
6. Indium-111 Oxine
7. Indium In111 Oxine
8. In-111 Oxyquinoline
9. Indium (in111) Oxine
10. Indium 111in Oxyquinoline
11. Indium (in111) Oxyquinoline
12. Indium Oxine In 111 (tn)
13. Indium-111 Oxyquinoline
14. Dtxsid70984005
15. Indium In 111 Oxyquinoline (usp)
16. Indium (111in) Oxyquinoline Solution
17. Db09473
18. D04526
Molecular Weight | 543.4 g/mol |
---|---|
Molecular Formula | C27H18InN3O3 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 6 |
Rotatable Bond Count | 0 |
Exact Mass | 543.03992 g/mol |
Monoisotopic Mass | 543.03992 g/mol |
Topological Polar Surface Area | 108 Ų |
Heavy Atom Count | 34 |
Formal Charge | 0 |
Complexity | 138 |
Isotope Atom Count | 1 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 4 |
1 of 2 | |
---|---|
Drug Name | Indium in-111 oxyquinoline |
Active Ingredient | Indium in-111 oxyquinoline |
Dosage Form | Injectable |
Route | Injection |
Strength | 1mci/ml |
Market Status | Prescription |
Company | Ge Healthcare |
2 of 2 | |
---|---|
Drug Name | Indium in-111 oxyquinoline |
Active Ingredient | Indium in-111 oxyquinoline |
Dosage Form | Injectable |
Route | Injection |
Strength | 1mci/ml |
Market Status | Prescription |
Company | Ge Healthcare |
Indium In 111 oxyquinoline is indicated for radiolabeling autologous leukocytes.
FDA Label
Absorption
After injection of labeled leukocytes into normal volunteers, about 30% of the dose is taken up by spleen and 30% by liver, reaching a plateau at 2-48 hours after injection.
Route of Elimination
Elimination from the body of injected indium In 111 oxyquinoline is probably mainly through decay to stable cadmium since only a negligible amount (less than 1%) of the dose is excreted in feces and urine in 24 hours.
Clearance
Clearance from whole blood and biological distribution can vary considerably with the individual recipient, the condition of the injected cells and labeling techniques used. Clearance from liver and spleen, for the purpose of calculating the radiation dose, is assumed to be equal to the physical half-life of indium In 111 (67.2 hours).
Indium In 111 decays by electron capture with a physical half-life of 67.2 hours (2.8 days). Between 9.5 to 24.4% of the injected dose remains in whole blood and clears with a biological half-time of 2.8 to 5.5 hours. The remainder (13-18%) clears from blood with a biological half-time of 64 to 116 hours.
Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detected with a gamma ray camera. Following intravenous administration, the lipid-soluble complex is able to penetrate platelet cell membranes. Once inside, Indium detaches from the oxyquinoline complexes and becomes attached to cytoplasmic components.
Related Excipient Companies
Excipients by Applications
ABOUT THIS PAGE
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PharmaCompass offers a list of Indium In 111 Oxyquinoline API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Indium In 111 Oxyquinoline manufacturer or Indium In 111 Oxyquinoline supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Indium In 111 Oxyquinoline manufacturer or Indium In 111 Oxyquinoline supplier.
PharmaCompass also assists you with knowing the Indium In 111 Oxyquinoline API Price utilized in the formulation of products. Indium In 111 Oxyquinoline API Price is not always fixed or binding as the Indium In 111 Oxyquinoline Price is obtained through a variety of data sources. The Indium In 111 Oxyquinoline Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Indium In 111 Oxyquinoline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Indium In 111 Oxyquinoline, including repackagers and relabelers. The FDA regulates Indium In 111 Oxyquinoline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Indium In 111 Oxyquinoline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Indium In 111 Oxyquinoline supplier is an individual or a company that provides Indium In 111 Oxyquinoline active pharmaceutical ingredient (API) or Indium In 111 Oxyquinoline finished formulations upon request. The Indium In 111 Oxyquinoline suppliers may include Indium In 111 Oxyquinoline API manufacturers, exporters, distributors and traders.
click here to find a list of Indium In 111 Oxyquinoline suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Indium In 111 Oxyquinoline DMF (Drug Master File) is a document detailing the whole manufacturing process of Indium In 111 Oxyquinoline active pharmaceutical ingredient (API) in detail. Different forms of Indium In 111 Oxyquinoline DMFs exist exist since differing nations have different regulations, such as Indium In 111 Oxyquinoline USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Indium In 111 Oxyquinoline DMF submitted to regulatory agencies in the US is known as a USDMF. Indium In 111 Oxyquinoline USDMF includes data on Indium In 111 Oxyquinoline's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Indium In 111 Oxyquinoline USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Indium In 111 Oxyquinoline suppliers with USDMF on PharmaCompass.
Indium In 111 Oxyquinoline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Indium In 111 Oxyquinoline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Indium In 111 Oxyquinoline GMP manufacturer or Indium In 111 Oxyquinoline GMP API supplier for your needs.
A Indium In 111 Oxyquinoline CoA (Certificate of Analysis) is a formal document that attests to Indium In 111 Oxyquinoline's compliance with Indium In 111 Oxyquinoline specifications and serves as a tool for batch-level quality control.
Indium In 111 Oxyquinoline CoA mostly includes findings from lab analyses of a specific batch. For each Indium In 111 Oxyquinoline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Indium In 111 Oxyquinoline may be tested according to a variety of international standards, such as European Pharmacopoeia (Indium In 111 Oxyquinoline EP), Indium In 111 Oxyquinoline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Indium In 111 Oxyquinoline USP).