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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

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CEP/COS

CEP/COS Certifications

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JDMF

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NDC API

NDC API

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VMF

NDC API

API REF. PRICE (USD/KG)

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FDF

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Canada

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USP

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Chemistry

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Also known as: 63610-08-2, Ibustrin, Indobufen [inn], K-3920, 2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]butanoic acid, 6t9949g4lz
Molecular Formula
C18H17NO3
Molecular Weight
295.3  g/mol
InChI Key
AYDXAULLCROVIT-UHFFFAOYSA-N
FDA UNII
6T9949G4LZ

Indobufen
Indobufen has been used in trials studying the supportive care and prevention of Atrial Fibrillation.
1 2D Structure

Indobufen

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]butanoic acid
2.1.2 InChI
InChI=1S/C18H17NO3/c1-2-15(18(21)22)12-7-9-14(10-8-12)19-11-13-5-3-4-6-16(13)17(19)20/h3-10,15H,2,11H2,1H3,(H,21,22)
2.1.3 InChI Key
AYDXAULLCROVIT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCC(C1=CC=C(C=C1)N2CC3=CC=CC=C3C2=O)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
6T9949G4LZ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(4-(1-oxo-2-isoindolinyl)phenyl)butyric Acid

2. Ibustrin

3. Indobufen, (+-)-isomer

4. K 3920

2.3.2 Depositor-Supplied Synonyms

1. 63610-08-2

2. Ibustrin

3. Indobufen [inn]

4. K-3920

5. 2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]butanoic Acid

6. 6t9949g4lz

7. Indobufen (inn)

8. 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoic Acid

9. Benzeneacetic Acid, 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-ethyl-

10. (2s)-2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]butanoic Acid

11. Benzeneacetic Acid, 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-.alpha.-ethyl-

12. K-2930

13. Indobufene

14. Indobufenum

15. K 3920

16. Indobufene [inn-french]

17. Indobufenum [inn-latin]

18. 2-(4-(1-oxo-2-isoindolinyl)phenyl)butyric Acid

19. (+/-)-2-[p-(1-oxo-2-isoindolinyl)phenyl]butyric Acid

20. Unii-6t9949g4lz

21. (+/-)-2-(p-(1-oxo-2-isoindolinyl)phenyl)butyric Acid

22. 36690-96-7

23. Einecs 264-364-4

24. (+/-)-indobufen

25. Enamine_001568

26. Indobufen [mi]

27. Indobufen [mart.]

28. Indobufen [who-dd]

29. Dsstox_cid_31578

30. Dsstox_rid_97463

31. Dsstox_gsid_57789

32. Oprea1_118499

33. Schembl140517

34. (+-)-2-(4-(1-oxo-2-isoindolinyl)phenyl)buttersaeure

35. Chembl1765292

36. Dtxsid7057789

37. 1-oxo-2-(p-((alpha-ethyl)carboxymethyl)phenyl)isoindoline

38. Chebi:135239

39. (+-)-2-(4-(1,3-dihydro-1-oxo-2-isoindolyl)buttersaeure

40. Hms1398h06

41. Amy33419

42. Bcp04485

43. Tox21_113871

44. Ac-672

45. Mfcd00572250

46. S5019

47. 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-ethyl-benzeneacetic Acid

48. Akos015917718

49. Ccg-267421

50. Db12545

51. Ks-5220

52. Sb66092

53. Ncgc00253758-01

54. Hy-18763

55. Cas-63610-08-2

56. Cs-0014291

57. Ft-0616451

58. D07141

59. D70894

60. 610i082

61. A851741

62. J-521529

63. Q3798322

64. (+-)-2-(p-(1-oxo-2-isoindolinyl)phenyl)butyric Acid

65. 2-(4-(1-carboxypropyl)phenyl)-1-isoindolinone

66. Butyric Acid, 2-(p-(1-oxo-2-isoindolinyl)phenyl)-, (+-)-

67. 1-oxo-2-(p-((.alpha.-ethyl)carboxymethyl)phenyl)isoindoline

68. 4-(1,3-dihydro-1-oxo-(2h)-isoindol-2-yl)-alpha-ethylbenzeneacetic Acid

69. 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-.alpha.-ethylbenzeneacetic Acid

70. Benzeneacetic Acid, 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-ethyl-, (+-)-

71. Benzeneacetic Acid, 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-.alpha.-ethyl-, (+/-)-

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 295.3 g/mol
Molecular Formula C18H17NO3
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass295.12084340 g/mol
Monoisotopic Mass295.12084340 g/mol
Topological Polar Surface Area57.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity428
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Platelet Aggregation Inhibitors

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)


Cyclooxygenase Inhibitors

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)


4.2 ATC Code

B - Blood and blood forming organs

B01 - Antithrombotic agents

B01A - Antithrombotic agents

B01AC - Platelet aggregation inhibitors excl. heparin

B01AC10 - Indobufen


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ABOUT THIS PAGE

Indobufen Manufacturers

A Indobufen manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Indobufen, including repackagers and relabelers. The FDA regulates Indobufen manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Indobufen API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Indobufen manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Indobufen Suppliers

A Indobufen supplier is an individual or a company that provides Indobufen active pharmaceutical ingredient (API) or Indobufen finished formulations upon request. The Indobufen suppliers may include Indobufen API manufacturers, exporters, distributors and traders.

click here to find a list of Indobufen suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Indobufen GMP

Indobufen Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Indobufen GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Indobufen GMP manufacturer or Indobufen GMP API supplier for your needs.

Indobufen CoA

A Indobufen CoA (Certificate of Analysis) is a formal document that attests to Indobufen's compliance with Indobufen specifications and serves as a tool for batch-level quality control.

Indobufen CoA mostly includes findings from lab analyses of a specific batch. For each Indobufen CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Indobufen may be tested according to a variety of international standards, such as European Pharmacopoeia (Indobufen EP), Indobufen JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Indobufen USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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