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1. Calcium, Saccharin
2. Saccharin Calcium
3. Saccharin Sodium
1. 81-07-2
2. O-benzoic Sulfimide
3. O-sulfobenzimide
4. Saccharine
5. Saccharimide
6. Benzosulfimide
7. Benzoic Sulfimide
8. Garantose
9. O-benzosulfimide
10. Benzosulphimide
11. Saccharinose
12. Saccharinol
13. Gluside
14. Benzosulfinide
15. Hermesetas
16. Saccharol
17. Glucid
18. Sweeta
19. Saccharin Acid
20. 1,2-benzisothiazol-3(2h)-one, 1,1-dioxide
21. Benzoic Sulphimide
22. Saccharin Insoluble
23. 1,2-benzisothiazol-3(2h)-one 1,1-dioxide
24. Kandiset
25. Sacarina
26. Sucrette
27. Zaharina
28. Saxin
29. Sykose
30. Benzo-2-sulphimide
31. O-benzoyl Sulfimide
32. Sucre Edulcor
33. O-benzoic Sulphimide
34. Benzoylsulfonic Imide
35. O-sulfobenzoic Acid Imide
36. O-benzosulphimide
37. Insoluble Saccharin
38. 550 Saccharine
39. Sacharin
40. Natreen
41. O-benzoyl Sulphimide
42. Anhydro-o-sulfaminebenzoic Acid
43. 2,3-dihydro-3-oxobenzisosulfonazole
44. 2-sulphobenzoic Imide
45. Benzoic Acid Sulfimide
46. Benzo[d]isothiazol-3(2h)-one 1,1-dioxide
47. 1,1-dioxo-1,2-benzothiazol-3-one
48. 1,2-dihydro-2-ketobenzisosulfonazole
49. 3-benzisothiazolinone 1,1-dioxide
50. 3-hydroxybenzisothiazole S,s-dioxide
51. 2,3-dihydro-3-oxobenzisosulphonazole
52. 1,2-dihydro-2-ketobenzisosulphonazole
53. 2-sulfobenzoic Acid Imide
54. Rcra Waste Number U202
55. Saccharin, Insoluble
56. 1,2-benzisothiazolin-3-one 1,1-dioxide
57. Saccharin Sodium
58. 3-hydroxybenzisothiazole-s,s-dioxide
59. Saccharinum
60. Syncal
61. O-benzoic Acid Sulfimide
62. Benzo-sulphinide
63. Cristallose
64. Crystallose
65. Kristallose
66. Willosetten
67. Madhurin
68. Sucromat
69. Sodium Saccharin
70. Saccharin Soluble
71. Sodium Saccharide
72. Sodium Saccharine
73. Soluble Saccharin
74. 1,2-benzisothiazolin-3-one, 1,1-dioxide
75. Saccharine Soluble
76. Sodium Saccharinate
77. Nsc-5349
78. Fst467xs7d
79. Saccharin, Sodium Salt
80. Sodium O-benzosulfimide
81. 1,1-dioxide-1,2-benzisothiazolin-3-one
82. Chembl310671
83. 1,1-dioxo-1,2-benzisothiazol-3(2h)-one
84. 1,2-benzothiazol-3(2h)-one 1,1-dioxide
85. Ins No.954(i)
86. Chebi:32111
87. O-sulfonbenzoic Acid Imide Sodium Salt
88. Ins-954(i)
89. 1,1-dioxo-1,2-dihydro-benzo[d]isothiazol-3-one
90. 1,1-diox-1,2-benzisothiazol-3-one
91. 2,3-dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide
92. Ncgc00094918-03
93. E-954(i)
94. E954
95. 1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]-isothiazol-3-one
96. Saccharin, Soluble
97. 1,2-benzisothiazoline-3-one 1,1-dioxide
98. Dsstox_cid_1251
99. 1,1-dioxide-1,2-benzisothiazol-3(2h)-one
100. Dsstox_rid_76039
101. Sacharin [czech]
102. Dsstox_gsid_21251
103. Saccharin And Salts
104. Benzosulfimide, O-
105. Saccharin [usan]
106. Sulfobenzimide, O-
107. 2,3-dihydro-1$l^{6},2-benzothiazole-1,1,3-trione
108. 2,3-dihydro-1,2-benzoisothiazol-3-one-1,1-dioxide
109. Artificial Sweetening Substanz Gendorf 450
110. Sodium 1,2 Benzisothiazolin-3-one 1,1-dioxide
111. 128-44-9
112. Cas-81-07-2
113. Saccharin [nf]
114. Nsc4867
115. Nsc5731
116. Lsa
117. Hsdb 669
118. Tolunene-2-sulfonamide
119. Nsc 5349
120. Nsc 5731
121. Einecs 201-321-0
122. Rcra Waste No. U202
123. Unii-fst467xs7d
124. Glycophenol
125. Neosaccharin
126. Ai3-38107
127. Sr-01000389315
128. Dtxsid5021251
129. Benzo-2-sulfiide
130. O-benzoylsulfimide
131. Saccharin Nitranion
132. 2-sulfobenzoicimide
133. O-sulfobenzoic Imide
134. Sweeta (tn)
135. O-sulphobenzoic Imide
136. 2-sulfobenzoic Imide
137. Spectrum_000213
138. Saccharin, >=98%
139. Saccharin, >=99%
140. Saccharin [fcc]
141. Saccharin [jan]
142. Saccharin [ii]
143. Saccharin [mi]
144. Saccharin [hsdb]
145. Saccharin [iarc]
146. Saccharin [inci]
147. Saccharin (jp15/nf)
148. Saccharin (jp17/nf)
149. Spectrum2_001432
150. Spectrum3_001475
151. Spectrum4_000449
152. Spectrum5_001181
153. Saccharin [vandf]
154. Saccharinum [hpus]
155. Saccharin [mart.]
156. Wln: T56 Bswmvj
157. Ec 201-321-0
158. Saccharin [usp-rs]
159. Saccharin [who-dd]
160. Schembl3816
161. Saccharin, Puriss., 98%
162. Nciopen2_005140
163. Nciopen2_005180
164. Bspbio_003029
165. Kbiogr_000838
166. Kbioss_000693
167. Divk1c_000164
168. Spectrum1501171
169. Spbio_001564
170. Gtpl5432
171. Saccharin [ep Monograph]
172. Bdbm29278
173. Hms500i06
174. Kbio1_000164
175. Kbio2_000693
176. Kbio2_003261
177. Kbio2_005829
178. Kbio3_002529
179. Nsc5349
180. 2q38
181. Ninds_000164
182. 1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one
183. Hms1921n03
184. Hms2092j09
185. Pharmakon1600-01501171
186. Bcp29068
187. Hy-y0272
188. Str03759
189. Zinc2560357
190. 3-benzisothiazolinone 1, 1-dioxide
191. O-benzoic Sulfimide;o-sulfobenzimide
192. Tox21_111358
193. Tox21_201880
194. Tox21_302950
195. Bbl015343
196. Ccg-39011
197. Mfcd00005866
198. Nsc757878
199. S4819
200. Stk803263
201. 2, 3-dihydro-3-oxobenzisosulfonazole
202. 2,3-dihydro-3-oxo-benzisosulfonazole
203. Akos000120481
204. Akos017272711
205. Saccharin (only Persons Who Manufacture Are Subject, No Supplier Notification)
206. Tox21_111358_1
207. 1, 2-dihydro-2-ketobenzisosulfonazole
208. Db12418
209. Nsc-757878
210. Idi1_000164
211. 1.2-benzoisothiazole-3-on-1.1-dioxide
212. Benzisosulfonazole, 2,3-dihydro-3-oxo-
213. Ncgc00094918-01
214. Ncgc00094918-02
215. Ncgc00094918-04
216. Ncgc00094918-05
217. Ncgc00094918-06
218. Ncgc00094918-07
219. Ncgc00094918-09
220. Ncgc00256329-01
221. Ncgc00259429-01
222. 1,2-benzisothiazoline-3-one-1,1-dioxide
223. 1.2 -benzoisothiazole-3-on 1.1-dioxide
224. Sbi-0051671.p002
225. 1, 2-benzisothiazolin-3-one 1,1-dioxide
226. 1,2-benzisothiazol-3(2h)-one-1,1-dioxide
227. B0004
228. Cs-0013120
229. Ft-0674493
230. Ft-0674494
231. D01085
232. D70140
233. 1, 2-benzisothiazol-3(2h)-one, 1,1-dioxide
234. 3-keto-2h,3h-1,2-benzisothiazole 1,1-dioxide
235. Ab00052233-04
236. Ab00052233_05
237. 2,3-dihydro-1??,2-benzothiazole-1,1,3-trione
238. Q191381
239. Saccharin (229 Degrees C) Melting Point Standard
240. 1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazole
241. 1,2-benzisothiazol-3(2h)-one 1,1-dioxide, 9ci
242. 2,3-dihydro-1,2-benzisothiazol-3-one-1,1-dioxide
243. 2,3-dihydro-3-oxo-1,2-benzisothiazol-1,1-dioxide
244. Sr-01000389315-2
245. W-200289
246. 03ac8ec2-d02a-464c-a7c3-7cabd643cc1e
247. 2,3-dihydro-1lambda6,2-benzothiazole-1,1,3-trione
248. Brd-k46493214-001-03-4
249. 1, 2-benzisothiazolin-3-one, 1,1-dioxide, Sodium Salt
250. 1, 2-benzothiazol-3(2h)-one 1,1-dioxide Sodium Salt
251. F0001-2092
252. Z256708526
253. 1, 2-benzisothiazol-3(2h)-one, 1,1-dioxide, Sodium Salt
254. 1,1-dioxo-1,2-dihydro-1lambda6-benzo[d]isothiazol-3-one
255. Saccharin, European Pharmacopoeia (ep) Reference Standard
256. Mettler-toledo Calibration Substance Me 51143091, Saccharin
257. Saccharin, United States Pharmacopeia (usp) Reference Standard
258. Saccharin, Pharmaceutical Secondary Standard; Certified Reference Material
259. Mettler-toledo Calibration Substance Me 51143091, Saccharin, Traceable To Primary Standards (lgc)
| Molecular Weight | 183.19 g/mol |
|---|---|
| Molecular Formula | C7H5NO3S |
| XLogP3 | 0.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 0 |
| Exact Mass | 182.99901420 g/mol |
| Monoisotopic Mass | 182.99901420 g/mol |
| Topological Polar Surface Area | 71.6 Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 303 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Sweetening Agents
Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed) (See all compounds classified as Sweetening Agents.)
TRANSPLACENTAL TRANSFER OF ... (14)C-SACCHARIN ADMIN BY IV INFUSION TO RHESUS MONKEYS IN LATE PREGNANCY, WAS RAPID, BUT SLIGHT. (14)C WAS CLEARED MORE SLOWLY FROM FETAL THAN FROM MATERNAL BLOOD, & WAS DISTRIBUTED IN ALL FETAL TISSUES EXAMINED ... WAS ONLY BIOTRANSFORMED TO LIMITED EXTENT & WAS RAPIDLY EXCRETED ... .
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 150
Three groups of five men were given sodium saccharin in single oral doses of 50, 150 or 333 mg/60 kg bw. Peak plasma concentrations occurred between 30 and 60 min after dosing, and 60 and 76% was excreted unchanged in urine at 6 and 24 h, respectively. /Sodium saccharin/
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V73 570 (1999)
IN 3 VOLUNTEERS, 85-92% OF DOSES OF 1 G 3(14)C-SACCHARIN ADMIN ORALLY FOR 21 DAYS WAS EXCRETED UNCHANGED IN THE URINE WITHIN 24 HR; NO METABOLITES WERE FOUND. WITHIN 48 HR, 92.3% OF A DOSE OF 500 MG (14)C-SACCHARIN WAS EXCRETED IN THE URINE & 5.8% IN THE FECES.
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V22 151 (1980)
After administration of 1-g doses of soluble (sodium) saccharin [form not specified] to three men, saccharin was excreted in the urine quantitatively unchanged by two of the subjects within 48 hr. In a subsequent experiment involving six subjects, none excreted the dose quantitatively within 72 hr, but no metabolism of saccharin was detected. /Sodium saccharin/
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V73 570 (1999)
For more Absorption, Distribution and Excretion (Complete) data for SACCHARIN (13 total), please visit the HSDB record page.
... 3-(14)C-SACCHARIN WAS EXCRETED UNCHANGED, MAINLY IN THE URINE (85-92% IN 24 HR) BY ADULT HUMAN SUBJECTS, BOTH BEFORE & AFTER TAKING 1 G OF SACCHARIN DAILY FOR 21 DAYS; NO METABOLITE OF SACCHARIN WAS FOUND. THESE RESULTS WERE AMPLY CONFIRMED IN ANIMAL EXPERIMENTS, IN WHICH ORALLY ADMIN (14)C-SACCHARIN WAS EXCRETED ENTIRELY UNCHANGED BY RATS ON A NORMAL DIET & BY RATS ON A DIET CONTAINING 1% & 5% OF SACCHARIN FOR UP TO 12 MO. 80-90% OF THE DOSE WAS EXCRETED IN THE URINE, 10-20% IN THE FECES; NO (14)CO2 WAS FOUND IN THE EXHALED AIR, & NO (14)CO3(2-) OR 2-SULFAMOYLBENZOIC ACID IN THE URINE.
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 5: A Review of the Literature Published during 1976 and 1977. London: The Chemical Society, 1979., p. 419
YIELDS IN MONKEYS SULFAMOYLBENZOIC ACID & O-SULFOBENZOIC ACID. /FROM TABLE/
Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. S-1
EXPOSURE OF MALE CHARLES RIVER CDI RATS TO 5% SACCHARIN DIET IN UTERO & THROUGHOUT WEANING, DID NOT INDUCE DETECTABLE METABOLISM. NO METABOLITES WERE DETECTED IN URINE OF NORMAL RATS GIVEN TRACER DOSE. PRETREATMENT WITH 3-METHYLCHOLANTHRENE DID NOT INDUCE SACCHARIN METABOLISM.
PMID:472722 SWEATMAN TW, RENWICK AG; SCIENCE 205 (4410): 1019 (1979)
One female and two male volunteers excreted 85-92% of a dose of 1g (3-14)C- saccharin unchanged in the urine within 24 hr, before or after taking 1 g saccharin daily for 21 days; no metabolites were found.
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V73 570 (1999)
Within 48 h, 92% of a dose of 500 mg [14C]saccharin taken by six male volunteers was excreted in the urine and 5.8% in the faeces. Analysis of urine and feces by highperformance liquid chromatography and thin-layer chromatography revealed only unmetabolized saccharin.
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V73 570 (1999)
In three adult men given an intravenous bolus of 10 mg/kg bw sodium saccharin, the plasma concentration-time curve fitted a two-compartment open model with a terminal half-life of 70 min. /Sodium saccharin/
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V73 570 (1999)
Six women with an average oral daily intake of 100-300 mg saccharin (form not specified) had maximum plasma concentrations after 0.5-1 hr and an elimination half-life of 7.5 hr.
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V73 569 (1999)
...it has been shown that the activation of particular T2R bitter taste receptors is partially involved with the bitter aftertaste sensation of saccharin and acesulfame-K. ... /This study/ addressed the question of whether /they/ could stimulate transient receptor potential vanilloid-1 (TRPV1) receptors, as these receptors are activated by a large range of structurally different chemicals. Moreover, TRPV1 receptors and/or their variants are found in taste receptor cells and in nerve terminals throughout the oral cavity. Hence, TRPV1 activation could be involved in the ... aftertaste or even contribute to the poorly understood metallic taste sensation. Using Ca(2+) imaging on TRPV1 receptors heterologously expressed in the human embryonic kidney (HEK) 293 cells and on dissociated primary sensory neurons,... /it was found/ that in both systems, .../sweeteners/ activate TRPV1 receptors, and, moreover, they sensitize these channels to acid and heat. ... /it was/also found that TRPV1 receptors were activated by CuSO(4), ZnSO(4), and FeSO(4), three salts known to produce a metallic taste sensation. In summary, .../the/ results identify a novel group of compounds that activate TRPV1 and, consequently, provide a molecular mechanism that may account for off tastes of sweeteners and metallic tasting salts.
Riera CE, et al; Am J Physiol Regul Integr Comp Physiol 293 (2): R626-34 (2007)
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PharmaCompass offers a list of Sodium saccharine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sodium saccharine manufacturer or Sodium saccharine supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sodium saccharine manufacturer or Sodium saccharine supplier.
PharmaCompass also assists you with knowing the Sodium saccharine API Price utilized in the formulation of products. Sodium saccharine API Price is not always fixed or binding as the Sodium saccharine Price is obtained through a variety of data sources. The Sodium saccharine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Insoluble saccharin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Insoluble saccharin, including repackagers and relabelers. The FDA regulates Insoluble saccharin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Insoluble saccharin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Insoluble saccharin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Insoluble saccharin supplier is an individual or a company that provides Insoluble saccharin active pharmaceutical ingredient (API) or Insoluble saccharin finished formulations upon request. The Insoluble saccharin suppliers may include Insoluble saccharin API manufacturers, exporters, distributors and traders.
click here to find a list of Insoluble saccharin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
Insoluble saccharin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Insoluble saccharin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Insoluble saccharin GMP manufacturer or Insoluble saccharin GMP API supplier for your needs.
A Insoluble saccharin CoA (Certificate of Analysis) is a formal document that attests to Insoluble saccharin's compliance with Insoluble saccharin specifications and serves as a tool for batch-level quality control.
Insoluble saccharin CoA mostly includes findings from lab analyses of a specific batch. For each Insoluble saccharin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Insoluble saccharin may be tested according to a variety of international standards, such as European Pharmacopoeia (Insoluble saccharin EP), Insoluble saccharin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Insoluble saccharin USP).
