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Also known as: Iobenguane sulfate i 123, Adreview, Iobenguane sulfate i 123 [usan], Iobenguane sulphate i 123, Iobenguane sulphate i-123, Iobenguane i 123 hemisulfate
Molecular Formula
C16H22I2N6O4S
Molecular Weight
640.3  g/mol
InChI Key
XNACDNPGABUBFR-FKNPGSCZSA-N
FDA UNII
23X1185WBO

Iobenguane Sulfate I 123
Iobenguane Sulfate I-123 is the neurotransmitter analogue 3-nitrobenzylguanidine conjugated to iodine I 123 and used as a gamma-emitting imaging agent. The adrenergic tissue uptake and storage of I-123 metaiodobenzylguanidine (I-123 MIBG) mimics that of norepinephrine (NE). The distribution of this agent enables the scintigraphic imaging of neural crest tumors, such as neuroblastoma and pheochromocytoma.
Iobenguane sulfate i-123 is a Radioactive Diagnostic Agent. The mechanism of action of iobenguane sulfate i-123 is as a Radiopharmaceutical Activity.
1 2D Structure

Iobenguane Sulfate I 123

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(3-(123I)iodanylphenyl)methyl]guanidine;sulfuric acid
2.1.2 InChI
InChI=1S/2C8H10IN3.H2O4S/c2*9-7-3-1-2-6(4-7)5-12-8(10)11;1-5(2,3)4/h2*1-4H,5H2,(H4,10,11,12);(H2,1,2,3,4)/i2*9-4;
2.1.3 InChI Key
XNACDNPGABUBFR-FKNPGSCZSA-N
2.1.4 Canonical SMILES
C1=CC(=CC(=C1)I)CN=C(N)N.C1=CC(=CC(=C1)I)CN=C(N)N.OS(=O)(=O)O
2.1.5 Isomeric SMILES
C1=CC(=CC(=C1)[123I])CN=C(N)N.C1=CC(=CC(=C1)[123I])CN=C(N)N.OS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
23X1185WBO
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Iobenguane Sulfate I 123

2. Adreview

3. Iobenguane Sulfate I 123 [usan]

4. Iobenguane Sulphate I 123

5. Iobenguane Sulphate I-123

6. Iobenguane I 123 Hemisulfate

7. Iobenguane I-123 Hemisulfate

8. Iobenguane I 123 Hemisulphate

9. Iobenguane I-123 Hemisulphate

10. Iobenguane, I-123 Hemisulfate

11. Iobenguane, I-123 Hemisulphate

12. 23x1185wbo

13. Iodobenzylguanidine Sulfate I 123

14. (m-iodo-(sup 123)i)-benzyl)guanidine Sulfate (2:1)

15. ((3-(iodo-(sup 123)i)-phenyl)methyl)guanidine Sulfate (2:1)

16. Unii-23x1185wbo

17. Mibg-i-123

18. Chembl3989523

19. Db09546

20. Iodobenzylguanidine Sulphate I 123

21. Iobenguane Sulfate I 123 [who-dd]

22. Iobenguane Sulfate I-123 [orange Book]

23. (m-iodo-(sup 123)i-benzyl)guanidine Sulfate (2:1)

24. Q27253781

25. (m-iodo-(sup 123)i)-benzyl)guanidine Sulphate (2:1)

26. Guanidine, ((3-(iodo-(sup 123)i)phenyl)methyl)-, Sulfate (2:1)

27. ((3-(iodo-(sup 123)i)-phenyl)methyl)guanidine Sulphate (2:1)

28. 123791-28-6

2.4 Create Date
2012-03-21
3 Chemical and Physical Properties
Molecular Weight 640.3 g/mol
Molecular Formula C16H22I2N6O4S
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass639.95350 g/mol
Monoisotopic Mass639.95350 g/mol
Topological Polar Surface Area212 Ų
Heavy Atom Count29
Formal Charge0
Complexity247
Isotope Atom Count2
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameAdreview
PubMed HealthIobenguane I 123 (Injection)
Drug ClassesDiagnostic Agent, Radiopharmaceutical Imaging
Active IngredientIobenguane sulfate i-123
Dosage FormSolution
RouteIntravenous
Strength10mci/5ml (2mci/ml)
Market StatusPrescription
CompanyGe Healthcare

2 of 2  
Drug NameAdreview
PubMed HealthIobenguane I 123 (Injection)
Drug ClassesDiagnostic Agent, Radiopharmaceutical Imaging
Active IngredientIobenguane sulfate i-123
Dosage FormSolution
RouteIntravenous
Strength10mci/5ml (2mci/ml)
Market StatusPrescription
CompanyGe Healthcare

4.2 Drug Indication

For use in the diagnostic imaging of adrenergically inervated tissues for the purposes of detecting metastatic pheochromocytoma or neuroblastoma. Also used to assess the sympathetic inervation of the myocardium via determination of the heart to mediastinum ratio of radioactivity in patients with New York Heart Association class II or III heart failure.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Iobenguane I-123 is taken up by and stored in adrenergic nerve terminals allowing for the radiographic imaging of adrenergically inervated organs and tissues.


5.2 FDA Pharmacological Classification
5.2.1 Active Moiety
IOBENGUANE SULFATE I-123
5.2.2 FDA UNII
23X1185WBO
5.2.3 Pharmacological Classes
Mechanisms of Action [MoA] - Radiopharmaceutical Activity
5.3 Absorption, Distribution and Excretion

Route of Elimination

Primarily eliminated via the urine as the parent compound (70-90%). A small amount is eliminated in the urine as m-iodohippuric acid (


5.4 Metabolism/Metabolites

Metabolized to m-iodohippuric acid and free radioiodide. The metabolism of iobenguane I-123 and the enzymes involved has not been well studied.


5.5 Mechanism of Action

Iobenguane I-123 is transported into adrenergic nerve terminals via the noradrenaline uptake transporter. It is rapidly cleared from systemic circulation and collected in adrenergically invervated tissues. This allows for gamma-scintigraphic imaging of these tissues and their associated organs for diagnostic purposes.


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