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1. Iobenguane Sulfate I 123
2. Adreview
3. Iobenguane Sulfate I 123 [usan]
4. Iobenguane Sulphate I 123
5. Iobenguane Sulphate I-123
6. Iobenguane I 123 Hemisulfate
7. Iobenguane I-123 Hemisulfate
8. Iobenguane I 123 Hemisulphate
9. Iobenguane I-123 Hemisulphate
10. Iobenguane, I-123 Hemisulfate
11. Iobenguane, I-123 Hemisulphate
12. 23x1185wbo
13. Iodobenzylguanidine Sulfate I 123
14. (m-iodo-(sup 123)i)-benzyl)guanidine Sulfate (2:1)
15. ((3-(iodo-(sup 123)i)-phenyl)methyl)guanidine Sulfate (2:1)
16. Unii-23x1185wbo
17. Mibg-i-123
18. Chembl3989523
19. Db09546
20. Iodobenzylguanidine Sulphate I 123
21. Iobenguane Sulfate I 123 [who-dd]
22. Iobenguane Sulfate I-123 [orange Book]
23. (m-iodo-(sup 123)i-benzyl)guanidine Sulfate (2:1)
24. Q27253781
25. (m-iodo-(sup 123)i)-benzyl)guanidine Sulphate (2:1)
26. Guanidine, ((3-(iodo-(sup 123)i)phenyl)methyl)-, Sulfate (2:1)
27. ((3-(iodo-(sup 123)i)-phenyl)methyl)guanidine Sulphate (2:1)
28. 123791-28-6
Molecular Weight | 640.3 g/mol |
---|---|
Molecular Formula | C16H22I2N6O4S |
Hydrogen Bond Donor Count | 6 |
Hydrogen Bond Acceptor Count | 6 |
Rotatable Bond Count | 4 |
Exact Mass | 639.95350 g/mol |
Monoisotopic Mass | 639.95350 g/mol |
Topological Polar Surface Area | 212 Ų |
Heavy Atom Count | 29 |
Formal Charge | 0 |
Complexity | 247 |
Isotope Atom Count | 2 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 3 |
1 of 2 | |
---|---|
Drug Name | Adreview |
PubMed Health | Iobenguane I 123 (Injection) |
Drug Classes | Diagnostic Agent, Radiopharmaceutical Imaging |
Active Ingredient | Iobenguane sulfate i-123 |
Dosage Form | Solution |
Route | Intravenous |
Strength | 10mci/5ml (2mci/ml) |
Market Status | Prescription |
Company | Ge Healthcare |
2 of 2 | |
---|---|
Drug Name | Adreview |
PubMed Health | Iobenguane I 123 (Injection) |
Drug Classes | Diagnostic Agent, Radiopharmaceutical Imaging |
Active Ingredient | Iobenguane sulfate i-123 |
Dosage Form | Solution |
Route | Intravenous |
Strength | 10mci/5ml (2mci/ml) |
Market Status | Prescription |
Company | Ge Healthcare |
For use in the diagnostic imaging of adrenergically inervated tissues for the purposes of detecting metastatic pheochromocytoma or neuroblastoma. Also used to assess the sympathetic inervation of the myocardium via determination of the heart to mediastinum ratio of radioactivity in patients with New York Heart Association class II or III heart failure.
FDA Label
Iobenguane I-123 is taken up by and stored in adrenergic nerve terminals allowing for the radiographic imaging of adrenergically inervated organs and tissues.
Route of Elimination
Primarily eliminated via the urine as the parent compound (70-90%). A small amount is eliminated in the urine as m-iodohippuric acid (10%) and free radioiodide (6%). Less than 1% is eliminated in the feces. Iobenguane I-123 is initially rapidly cleared from circulation follwed by a slow clearance from other tissues over 4 days. Retention is the longest in highly adrenergically inervated tissues like the adrenal medulla, heart, and salivary glands. Iobenguane I-123 is not cleared by dialysis.
Metabolized to m-iodohippuric acid and free radioiodide. The metabolism of iobenguane I-123 and the enzymes involved has not been well studied.
Iobenguane I-123 is transported into adrenergic nerve terminals via the noradrenaline uptake transporter. It is rapidly cleared from systemic circulation and collected in adrenergically invervated tissues. This allows for gamma-scintigraphic imaging of these tissues and their associated organs for diagnostic purposes.
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