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Chemistry

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Also known as: Cholebrine, 16034-77-8, Mp-620, 3-(n-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic acid, Fa675q0e3e, Propanoic acid, 3-(acetyl(3-amino-2,4,6-triiodophenyl)amino)-2-methyl-
Molecular Formula
C12H13I3N2O3
Molecular Weight
613.96  g/mol
InChI Key
GSVQIUGOUKJHRC-UHFFFAOYSA-N
FDA UNII
FA675Q0E3E

Iocetamic Acid
Iocetamic acid is a diagnostic aid (radiopaque medium)
1 2D Structure

Iocetamic Acid

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(N-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic acid
2.1.2 InChI
InChI=1S/C12H13I3N2O3/c1-5(12(19)20)4-17(6(2)18)11-8(14)3-7(13)10(16)9(11)15/h3,5H,4,16H2,1-2H3,(H,19,20)
2.1.3 InChI Key
GSVQIUGOUKJHRC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(CN(C1=C(C=C(C(=C1I)N)I)I)C(=O)C)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
FA675Q0E3E
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cholebrine

2. N-acetyl-n-(3-amino-2,4,6-triiodophenyl)-2-methyl-beta-alanine

2.3.2 Depositor-Supplied Synonyms

1. Cholebrine

2. 16034-77-8

3. Mp-620

4. 3-(n-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic Acid

5. Fa675q0e3e

6. Propanoic Acid, 3-(acetyl(3-amino-2,4,6-triiodophenyl)amino)-2-methyl-

7. Cholimil

8. Colebrina

9. Iocetamic Acid (usan)

10. 3-(n-(3-amino-2,4,6-triiodophenyl)acetamido)-2-methylpropanoic Acid

11. 3-[acetyl(3-amino-2,4,6-triiodophenyl)amino]-2-methylpropanoic Acid

12. Acidum Jocetamicum

13. Cholimil; Drc 1201; Iocetamic Acid; Mp 620

14. Iocetamic Acid [usan]

15. Acido Iocetamico

16. Acide Iocetamique

17. Acidum Iocetamicum

18. Acide Iocetamique [inn-french]

19. Acido Iocetamico [inn-spanish]

20. Acidum Iocetamicum [inn-latin]

21. Hsdb 3344

22. Drc 1201

23. Einecs 240-173-1

24. Mp 620

25. Brn 2171366

26. Unii-fa675q0e3e

27. Cholebrine (tn)

28. Ncgc00016720-01

29. Cas-16034-77-8

30. Iocetamic Acid [usan:usp:inn:ban]

31. Starbld0009604

32. Beta-alanine, N-acetyl-n-(3-amino-2,4,6-triiodophenyl)-2-methyl-

33. N-acetyl-n-(3-amino-2,4,6-triiodophenl)-2-methyl-beta-alanine

34. N-acetyl-n-(3-amino-2,4,6-triiodophenyl)-2-methyl-beta-alanine

35. Prestwick0_000838

36. Prestwick1_000838

37. Prestwick2_000838

38. Prestwick3_000838

39. 3-(acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methylpropanoic Acid

40. Dsstox_cid_3149

41. N-acetyl-n-(2,4,6-triiodo-3-aminophenyl)-beta-aminoisobutyric Acid

42. N-acetyl-n-(3-amino-2,4,6-triiodophenyl)-beta-aminoisobutyric Acid

43. Propionic Acid, 3-(acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methyl-

44. Dsstox_rid_76891

45. Iocetamic Acid [mi]

46. Dsstox_gsid_23149

47. Schembl38499

48. Bspbio_000795

49. Iocetamic Acid [inn]

50. Mls002154025

51. Iocetamic Acid [hsdb]

52. Spbio_002716

53. Iocetamic Acid [vandf]

54. Bpbio1_000875

55. Iocetamic Acid [mart.]

56. Chembl1200770

57. Dtxsid2023149

58. Iocetamic Acid [who-dd]

59. Chebi:91662

60. Hms1570h17

61. Hms2097h17

62. Hms2234p18

63. Hms3373o18

64. Hms3714h17

65. Tox21_110580

66. Iocetamic Acid [orange Book]

67. Ccg-220838

68. Db09403

69. Ncgc00179430-01

70. Ncgc00179430-04

71. Smr001233352

72. Ab00513935

73. D04563

74. Sr-01000838894

75. Q6062203

76. Sr-01000838894-2

77. Brd-a37492983-001-03-8

78. N-acetyl-n-(3-amino-2,4,6-triiodophenyl)-2-methyl-.beta.-alanine

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 613.96 g/mol
Molecular Formula C12H13I3N2O3
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass613.8060 g/mol
Monoisotopic Mass613.8060 g/mol
Topological Polar Surface Area83.6 Ų
Heavy Atom Count20
Formal Charge0
Complexity383
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Contrast Media

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


AN ORAL CHOLECYSTOGRAPHIC AGENT INDICATED FOR RADIOGRAPHIC VISUALIZATION OF GALL BLADDER. ... CONTRACTION OF GALL BLADDER ALSO MAY PROVIDE VISUALIZATION OF BILIARY DUCTS.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1214


TYROPANOATE 3 G, IOCETAMIC ACID 4.5 G, IOPANOIC ACID 3 G & IOCETAMIC ACID 3 G, WERE EVALUATED IN 800 PT. IOCETAMIC ACID IS AS RELIABLE & EFFECTIVE AS TYROPANOATE OR IOPANOIC ACID IN CHOLECYSTOGRAPHY. 3 G DOSE PRODUCES CHOLECYSTOGRAMS AS SATISFACTORY AS 4.5 G WITH LOWER INCIDENCE OF CRAMPS.

PARKS R; DOUBLE-BLIND STUDY OF 4 ORAL CHOLECYSTOGRAPHIC PREPARATIONS; RADIOLOGY 112(SEP) 525 (1974)


4.2 Drug Warning

IT IS CONTRAINDICATED IN PT WITH ACUTE NEPHRITIS AND UREMIA, SINCE IT IS ELIMINATED BY THE KIDNEYS. IT SHOULD NOT BE ADMIN WHEN DISORDERS OF THE GI TRACT EXIST WHICH PREVENT ABSORPTION OF THE MEDIUM.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1214


5 Pharmacology and Biochemistry
5.1 ATC Code

V - Various

V08 - Contrast media

V08A - X-ray contrast media, iodinated

V08AC - Watersoluble, hepatotropic x-ray contrast media

V08AC07 - Iocetamic acid


5.2 Absorption, Distribution and Excretion

...RAPIDLY ABSORBED FOLLOWING ORAL ADMIN, CONJUGATED WITH GLUCURONIC ACID IN LIVER, SECRETED INTO BILE AS RADIOPAQUE GLUCURONIDE, & CONCN IN THE FUNCTIONING GALL BLADDER.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1214


5.3 Metabolism/Metabolites

...CONJUGATED WITH GLUCURONIC ACID IN LIVER...

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1214


ABOUT THIS PAGE

Looking for 16034-77-8 / Iocetamic Acid API manufacturers, exporters & distributors?

Iocetamic Acid manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Iocetamic Acid API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Iocetamic Acid manufacturer or Iocetamic Acid supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Iocetamic Acid manufacturer or Iocetamic Acid supplier.

PharmaCompass also assists you with knowing the Iocetamic Acid API Price utilized in the formulation of products. Iocetamic Acid API Price is not always fixed or binding as the Iocetamic Acid Price is obtained through a variety of data sources. The Iocetamic Acid Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Iocetamic Acid

Synonyms

Cholebrine, 16034-77-8, Mp-620, 3-(n-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic acid, Fa675q0e3e, Propanoic acid, 3-(acetyl(3-amino-2,4,6-triiodophenyl)amino)-2-methyl-

Cas Number

16034-77-8

Unique Ingredient Identifier (UNII)

FA675Q0E3E

About Iocetamic Acid

Iocetamic acid is a diagnostic aid (radiopaque medium)

Iocetamic Acid Manufacturers

A Iocetamic Acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Iocetamic Acid, including repackagers and relabelers. The FDA regulates Iocetamic Acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Iocetamic Acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Iocetamic Acid Suppliers

A Iocetamic Acid supplier is an individual or a company that provides Iocetamic Acid active pharmaceutical ingredient (API) or Iocetamic Acid finished formulations upon request. The Iocetamic Acid suppliers may include Iocetamic Acid API manufacturers, exporters, distributors and traders.

Iocetamic Acid GMP

Iocetamic Acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Iocetamic Acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Iocetamic Acid GMP manufacturer or Iocetamic Acid GMP API supplier for your needs.

Iocetamic Acid CoA

A Iocetamic Acid CoA (Certificate of Analysis) is a formal document that attests to Iocetamic Acid's compliance with Iocetamic Acid specifications and serves as a tool for batch-level quality control.

Iocetamic Acid CoA mostly includes findings from lab analyses of a specific batch. For each Iocetamic Acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Iocetamic Acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Iocetamic Acid EP), Iocetamic Acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Iocetamic Acid USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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