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Iodide-123

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

FINISHED DOSAGE FORMULATIONS

15 FDF Dossiers, 15 South Africa

15 FDF Dossiers
15 South Africa

Synopsis

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Chemistry

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Also known as: Iodine-123(1-), Iodide (123i(1-)), Iodide i-123, 69239-56-1, 98qpv8670c, I-123

Molecular Formula

I-

Molecular Weight

122.90559 g/mol

InChI Key

XMBWDFGMSWQBCA-AHCXROLUSA-M

FDA UNII

98QPV8670C

Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect the decay by electron capture to tellurium-123. Iodine is commonly used in thyroid function diagnostic tests as this gland normally absorbs iodine through the diet for formation of the thyroid hormones triiodothyronine (T3) and its prohormone, thyroxine (T4). Radioactive I-123 in particular is effective for this use as its half-life of approximately 13.13 h (hours) is ideal for the 24-h (hour) iodine uptake test and it has a reduced radiation burden as compared to I-131.

1 2D Structure

Iodide-123

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

iodine-123(1-)

2.1.2 InChI

InChI=1S/HI/h1H/p-1/i1-4

2.1.3 InChI Key

XMBWDFGMSWQBCA-AHCXROLUSA-M

2.1.4 Canonical SMILES

[I-]

2.1.5 Isomeric SMILES

[123I-]

2.2 Other Identifiers

2.2.1 UNII

98QPV8670C

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Iodine-123(1-)

2. Iodide (123i(1-))

3. Iodide I-123

4. 69239-56-1

5. 98qpv8670c

6. I-123

7. Iodide-123

8. Unii-98qpv8670c

9. Iodine 123

10. Iodide I-123 Ion

11. Iodide Ion I 123

12. Iodide, I-123

13. Iodide Ion (123 I)

14. Dtxsid40988959

15. Db09420

16. 123i-

17. Q3801335

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	I-
Molecular Weight	122.90559 g/mol
XLogP3	0.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	122.90559 g/mol
Monoisotopic Mass	122.90559 g/mol
Topological Polar Surface Area	0 Å²
Heavy Atom Count	1
Formal Charge	-1
Complexity	0
Isotope Atom Count	1
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Administration of Sodium Iodide I 123 Capsules is indicated as a diagnostic procedure to be used in evaluating thyroid function and/or morphology.

FDA Label

5 Pharmacology and Biochemistry

5.1 Biological Half-Life

Iodine-123 decays by electron capture with a physical half-life of 13.2 hours

5.2 Mechanism of Action

Sodium Iodide I-123 is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect the decay by electron capture to tellurium-123. Iodine is commonly used in thyroid function diagnostic tests as this gland normally absorbs iodine through the diet for formation of the thyroid hormones triiodothyronine (T3) and its prohormone, thyroxine (T4).

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