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1. Tri-iodomethane
1. Triiodomethane
2. 75-47-8
3. Methane, Triiodo-
4. Carbon Triiodide
5. Jodoform
6. Chi3
7. Trijodmethane
8. Nci-c04568
9. Iodoformum
10. Nsc-26251
11. Chebi:37758
12. Kxi2j76489
13. Ncgc00091389-01
14. Dsstox_cid_743
15. Dezinfekt V
16. Dsstox_rid_75765
17. Jodoform [czech]
18. Dsstox_gsid_20743
19. Iodoform [jan]
20. Trijodmethane [czech]
21. Cas-75-47-8
22. Ccris 346
23. Hsdb 4099
24. Iodoform [usp:jan]
25. Einecs 200-874-5
26. Nsc 26251
27. Unii-kxi2j76489
28. Methyl Triiodide
29. Ai3-52396
30. Iodoform (tn)
31. Tris(iodanyl)methane
32. Mfcd00001069
33. Iodoform, 99%
34. Iodoform [hsdb]
35. Iodoform [inci]
36. Iodoform [mi]
37. Wln: Iyii
38. Iodoformum [hpus]
39. Iodoform (jp17/usp)
40. Iodoform [mart.]
41. Iodoform [who-dd]
42. Iodoform, Saj First Grade
43. Chembl1451116
44. Dtxsid4020743
45. Iodoform [usp Monograph]
46. Nsc26251
47. Zinc6827595
48. Tox21_111124
49. Tox21_202389
50. Tox21_302774
51. Akos009031506
52. Iodoform, Purum, >=99.0% (at)
53. Db13813
54. Iodoform, Puriss., 99.0-100.5%
55. S12111
56. Ncgc00091389-02
57. Ncgc00091389-03
58. Ncgc00256394-01
59. Ncgc00259938-01
60. As-14199
61. Ft-0627266
62. D01910
63. A838427
64. Q412393
65. J-650249
| Molecular Weight | 393.732 g/mol |
|---|---|
| Molecular Formula | CHI3 |
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 393.7212 g/mol |
| Monoisotopic Mass | 393.7212 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 4 |
| Formal Charge | 0 |
| Complexity | 8 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Iodoform /was used/ as an antiseptic wound powder for a long time: today its use is limited.
Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. 7(79) 803
FORMERLY WAS EMPLOYED AS A TOPICAL AND INTRAVITREAL ANTISEPTIC.
Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 524
ANTI-INFECTIVE (TOPICAL)
Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 863
MEDICATION (VET): ANTISEPTIC, DISINFECTANT FOR SUPERFICIAL LESIONS & IN THE FEMALE REPRODUCTIVE TRACT
Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 863
THERAP CAT: Anti-infective (topical)
Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 863
No approved therapeutic indications.
Iodoform exhibits antibacterial activities after topical application. In a comparative study of wound dressing agents, iodoform gauze exerted an antibacterial effect 3 hours after the start of bacterial growth of _E. coli_ and subsequently maintained the strong antibacterial effectiveness. A study demonstrated that direct and indirect exposure to high concentrations of iodoform induces a cytotoxic effect on cultures of macrophages and epithelial cells _in vitro_, while cell proliferation was enhanced at low concentrations of iodoform. This cytotoxic effect of iodoform in root canals may further lead to long-term local irritation to follicles of permanent successors and formation of cyst-like radiolucent defects.
D - Dermatologicals
D09 - Medicated dressings
D09A - Medicated dressings
D09AA - Medicated dressings with antiinfectives
D09AA13 - Iodoform
Absorption
Iodoform is reported to be absorbed through denuded skin, wounds or mucous membranes.
Route of Elimination
No pharmacokinetic data available.
Volume of Distribution
No pharmacokinetic data available.
Clearance
No pharmacokinetic data available.
It is expected to be oxidized to iodine.
HALOFORMS ARE METABOLIZED TO CARBON MONOXIDE BY HEPATIC MICROSOMAL MIXED FUNCTION OXIDASES & THIS REACTION IS MARKEDLY STIMULATED BY SULFHYDRYL COMPOUNDS. /HALOFORMS/
PMID:526325 STEVENS JL, ANDERS MW; BIOCHEM PHARM 28: 3189-94 (1979)
TRIHALOMETHANES (HALOFORMS) WERE METABOLIZED TO CARBON MONOXIDE BY A RAT LIVER MICROSOMAL FRACTION REQUIRING BOTH NADPH AND MOLECULAR OXYGEN FOR MAXIMAL ACTIVITY. THE METABOLISM OF HALOFORMS TO CARBON MONOXIDE FOLLOWED THE HALIDE ORDER; IODOFORM YIELDED THE GREATEST AMOUNT OF CARBON MONOXIDE, WHEREAS CHLOROFORM YIELDED THE SMALLEST AMOUNT.
PMID:15814 AHMED AE ET AL; DRUG METAB DISPOS 5 (2): 198-204 (1977)
ADMINISTRATION OF HALOFORMS (TRIHALOMETHANES) TO RATS LED TO SUBSTANTIAL ELEVATIONS IN BLOOD CARBON MONOXIDE LEVELS. /TRIHALOMETHANES/
PMID:30605 ANDERS MW ET AL; DRUG METAB DISPOS 6 (5): 556-60 (1978)
No pharmacokinetic data available.
While the mechanism of action of iodoform remains unclear, it is proposed that iodoform releases iodine, which denatures bacterial proteins by oxidation of the free iodine. Iodoform may also play a role in chemical debridement for effective necrotic wound healing and tissue damage repair via collagen fibrinolysis; upon treatment in necrotic tissue, iodoform reduced the size of the macromolecules containing collagen I in wound surface proteins. In human gingival fibroblasts _in vitro_, high concentrations of iodoform was shown to decrease the viability of macrophages and epithelial cells and reduced the secretion of _P. gingivalis_-induced TNF. P. gingivalis is an anaerobic bacteria present in anaerobic oral niches including periapical sites and periodontal pockets.
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ABOUT THIS PAGE
A Iodoform manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Iodoform, including repackagers and relabelers. The FDA regulates Iodoform manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Iodoform API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Iodoform manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Iodoform supplier is an individual or a company that provides Iodoform active pharmaceutical ingredient (API) or Iodoform finished formulations upon request. The Iodoform suppliers may include Iodoform API manufacturers, exporters, distributors and traders.
click here to find a list of Iodoform suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Iodoform DMF (Drug Master File) is a document detailing the whole manufacturing process of Iodoform active pharmaceutical ingredient (API) in detail. Different forms of Iodoform DMFs exist exist since differing nations have different regulations, such as Iodoform USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Iodoform DMF submitted to regulatory agencies in the US is known as a USDMF. Iodoform USDMF includes data on Iodoform's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Iodoform USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Iodoform suppliers with USDMF on PharmaCompass.
The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.
The Iodoform Drug Master File in Japan (Iodoform JDMF) empowers Iodoform API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).
PMDA reviews the Iodoform JDMF during the approval evaluation for pharmaceutical products. At the time of Iodoform JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.
click here to find a list of Iodoform suppliers with JDMF on PharmaCompass.
A Iodoform written confirmation (Iodoform WC) is an official document issued by a regulatory agency to a Iodoform manufacturer, verifying that the manufacturing facility of a Iodoform active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Iodoform APIs or Iodoform finished pharmaceutical products to another nation, regulatory agencies frequently require a Iodoform WC (written confirmation) as part of the regulatory process.
click here to find a list of Iodoform suppliers with Written Confirmation (WC) on PharmaCompass.
National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Iodoform as an active pharmaceutical ingredient (API).
The FDA updates the NDC directory daily. The NDC numbers for Iodoform API and other APIs are published in this directory by the FDA.
The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.
Pharmaceutical companies that manufacture Iodoform as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.
The NDC directory also contains data on finished compounded human drug products that contain Iodoform and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Iodoform NDC to their finished compounded human drug products, they may choose to do so.
click here to find a list of Iodoform suppliers with NDC on PharmaCompass.
Iodoform Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Iodoform GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Iodoform GMP manufacturer or Iodoform GMP API supplier for your needs.
A Iodoform CoA (Certificate of Analysis) is a formal document that attests to Iodoform's compliance with Iodoform specifications and serves as a tool for batch-level quality control.
Iodoform CoA mostly includes findings from lab analyses of a specific batch. For each Iodoform CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Iodoform may be tested according to a variety of international standards, such as European Pharmacopoeia (Iodoform EP), Iodoform JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Iodoform USP).
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