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Also known as: 83-73-8, Diiodohydroxyquinoline, 5,7-diiodoquinolin-8-ol, 5,7-diiodo-8-hydroxyquinoline, 5,7-diiodo-8-quinolinol, Diiodoquin
Molecular Formula
C9H5I2NO
Molecular Weight
396.95  g/mol
InChI Key
UXZFQZANDVDGMM-UHFFFAOYSA-N
FDA UNII
63W7IE88K8

Iodoquinol
One of the halogenated 8-quinolinols widely used as an intestinal antiseptic, especially as an antiamebic agent. It is also used topically in other infections and may cause CNS and eye damage. It is known by very many similar trade names world-wide.
1 2D Structure

Iodoquinol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5,7-diiodoquinolin-8-ol
2.1.2 InChI
InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
2.1.3 InChI Key
UXZFQZANDVDGMM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC2=C(C(=C(C=C2I)I)O)N=C1
2.2 Other Identifiers
2.2.1 UNII
63W7IE88K8
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Diiodohydroxyquin

2. Diiodohydroxyquinoline

3. Diiodoquin

4. Diodoquin

5. Diodoxyquinoline

6. Diquinol

7. Entero Diyod

8. Entero-diyod

9. Enterodiyod

10. Entodiba

11. Sebaquin

12. Yodoxin

2.3.2 Depositor-Supplied Synonyms

1. 83-73-8

2. Diiodohydroxyquinoline

3. 5,7-diiodoquinolin-8-ol

4. 5,7-diiodo-8-hydroxyquinoline

5. 5,7-diiodo-8-quinolinol

6. Diiodoquin

7. Diodoquin

8. Yodoxin

9. Diiodohydroxyquin

10. Lanodoxin

11. Searlequin

12. Zoaquin

13. Ioquin

14. Quinadome

15. Sebaquin

16. 8-quinolinol, 5,7-diiodo-

17. Diodohydroxyquin

18. Dijodoxichinoline

19. Enterodiamoebin

20. Diamoebin

21. Dinoleine

22. Diodoquine

23. Diodoxylin

24. Direxiode

25. Disoquin

26. Embequin

27. Enterosept

28. Floraquin

29. Fluoraquin

30. Moebiquin

31. Dyodin

32. Di-quinol

33. Stanquinate

34. Rafamebin

35. 5,7-diiodo-oxine

36. Ioquin Suspension

37. Dijodoxichinolinum

38. 8-hydroxy-5,7-diiodoquinoline

39. 5,7-diodo-8-quinolinol

40. Diodoxyquinoleine

41. Diiodoidrossichinolina

42. Panaquin

43. Diiodohidroxiquinoleina

44. Diiodohydroxyquinoleine

45. Diiodohydroxyquinolinum

46. Ss 578

47. Enterodiamoebine

48. Nsc 8704

49. Nsc-8704

50. 5,7-diiod-8-chinolinol [iupac]

51. Diiodohydroxyquinoline [inn]

52. Mls000069404

53. Chebi:5950

54. 63w7ie88k8

55. Mmv002817

56. Ss-578

57. Ncgc00018098-04

58. Smr000059090

59. Dsstox_cid_3155

60. Dsstox_rid_76894

61. Diiodohydroxyquinoline (inn)

62. Dsstox_gsid_23155

63. Iodoquinol [usan]

64. Caswell No. 354

65. Iodoquinol;5,7-diiodo-8-hydroxyquinoline;5,7-diiodo-8-quinolinol

66. Cas-83-73-8

67. Diiodoidrossichinolina [dcit]

68. Hsdb 3224

69. Sr-01000002969

70. Diiodohydroxyquinolinum [inn-latin]

71. Iodoquinol [usan:usp]

72. Diiodohydroxyquinoleine [inn-french]

73. Einecs 201-497-9

74. 5,7-diiod-8-chinolinol

75. Diiodohidroxiquinoleina [inn-spanish]

76. Epa Pesticide Chemical Code 024003

77. Brn 0153639

78. Searlewuin

79. Meobiquin

80. Unii-63w7ie88k8

81. Ai3-16443

82. 5,7-diiodooxine

83. Component Of Vytone

84. Iodoquinol (usp)

85. Yodoxin (tn)

86. Mfcd00006789

87. Spectrum_000943

88. Iodoquinol [mi]

89. 8-quinolinol,7-diiodo-

90. Spectrum2_001041

91. Spectrum3_000470

92. Spectrum4_000020

93. Spectrum5_000872

94. Iodoquinol [hsdb]

95. 4,7-diiodo-8-quinolinol

96. Bmse000836

97. Ec 201-497-9

98. Cid_3728

99. Schembl3460

100. Iodoquinol [usp-rs]

101. Bspbio_002180

102. Cbdive_011080

103. Kbiogr_000399

104. Kbioss_001423

105. Ksc-8-193

106. Chembl86754

107. Divk1c_000119

108. Spectrum1500353

109. Spbio_000962

110. Di-iodohydroxy Quinoline

111. Dtxsid6023155

112. 5,7-bis(iodanyl)quinolin-8-ol

113. Bdbm66035

114. Hms500f21

115. Kbio1_000119

116. Kbio2_001423

117. Kbio2_003991

118. Kbio2_006559

119. Kbio3_001400

120. Uxzfqzandvdgmm-uhfffaoysa-

121. Iodoquinol [usp Impurity]

122. Nsc8704

123. Ninds_000119

124. Wln: T66 Bnj Gi Ii Jq

125. Hms1920h05

126. Hms2091n15

127. Hms2230g24

128. Hms3369c20

129. Iodoquinol [usp Monograph]

130. Kuc105860n

131. Pharmakon1600-01500353

132. Hy-b1400

133. Zinc3830942

134. Tox21_110823

135. Ccg-40132

136. Nsc757077

137. S4565

138. Stk070581

139. Diiodohydroxyquinoline [mart.]

140. Akos000120804

141. Tox21_110823_1

142. 5,7-diiodo-8-hydroxyquinoline, 97%

143. Cs-4910

144. Db09115

145. Diiodohydroxyquinoline [who-dd]

146. Iodoquinol (5,7-diiodoquinolin-8-ol)

147. Nsc-757077

148. Idi1_000119

149. Ncgc00018098-01

150. Ncgc00018098-02

151. Ncgc00018098-03

152. Ncgc00018098-05

153. Ncgc00018098-07

154. Ncgc00018098-08

155. Ncgc00021685-03

156. Ncgc00021685-04

157. Ds-17759

158. Sbi-0051417.p003

159. Db-056739

160. Am20061527

161. D1736

162. Ft-0619847

163. C07636

164. D00581

165. F12461

166. Ab00052024_12

167. An-329/13210059

168. Q5276473

169. Sr-01000002969-2

170. Sr-01000002969-5

171. Brd-k75855670-001-06-8

172. F3034-0058

173. Iodoquinol, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 396.95 g/mol
Molecular Formula C9H5I2NO
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass396.84606 g/mol
Monoisotopic Mass396.84606 g/mol
Topological Polar Surface Area33.1 Ų
Heavy Atom Count13
Formal Charge0
Complexity191
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Amebicides; Anti-Infective Agents, Local

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


...MAY BE USED IN LOCAL & SYSTEMIC TREATMENT OF TRICHOMONAS VAGINALIS VAGINITIS & INFECTIONS CAUSED BY TRICHOMONAS HOMINIS (INTESTINALIS). IT IS USED IN TOPICAL TREATMENT OF CERTAIN FUNGAL CUTANEOUS INFECTIONS & IN ECZEMA IN WHICH FUNGAL INFECTION IS COMPLICATION.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1159


...HAVE BEEN USED FOR TREATMENT OF VARIOUS DERMATOLOGICAL DISORDERS, & LARGE DOSES HAVE BEEN EMPLOYED ORALLY IN TREATMENT OF ACRODERMATITIS ENTEROPATHICA, RARE, POTENTIALLY FATAL PEDIATRIC CONDITION.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1074


...EFFECTIVE FOR INTESTINAL AMEBIASIS &...FOR TREATMENT OF ASYMPTOMATIC PASSERS OF CYSTS. ...USEFUL FOR AMBULATORY & MASS TREATMENT. THEY ARE INEXPENSIVE. ...OF VALUE IN CASES OF LAMBLIASIS RESISTANT TO QUINACRINE THERAPY, IN BALANTIDIAL DYSENTERY, & IN INTESTINAL INFECTIONS DUE TO DIENTAMEBA FRAGILIS. /8-HYDROXYQUINOLINES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1074


For more Therapeutic Uses (Complete) data for DIIODOHYDROXYQUIN (8 total), please visit the HSDB record page.


4.2 Drug Warning

WHILE...EFFECTIVE IN CYST-PASSING PT, THEY ARE MUCH LESS EFFECTIVE IN TREATMENT OF ACUTE AMEBIC DYSENTERY.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1073


USE OF THESE AGENTS TO TREAT "TRAVELER'S DIARRHEA" & CHRONIC NONSPECIFIC DIARRHEA IN CHILDREN /PRC: OR ADULTS/ CANNOT BE CONDONED, SINCE SUCH CONDITIONS ARE SELF-LIMITED & ANY POSSIBLE THERAPEUTIC BENEFIT DOES NOT JUSTIFY RISK OF SERIOUS NEUROTOXICITY. /8-HYDROXYQUINOLINES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1074


THESE DRUGS ARE CONTRAINDICATED IN PT WITH HEPATIC DAMAGE OR IODINE INTOLERANCE. ...THESE AGENTS INTERFERE WITH CERTAIN THYROID FUNCTION TESTS FOR MO BECAUSE OF THEIR CONTENT OF IODINE. /8-HYDROXYQUINOLINES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1074


...IT NOW APPEARS THAT GI-NEUROLOGIC SYNDROME OF OBSCURE ETIOLOGY, COMMON IN REGIONS WHERE DIIODOHYDROXYQUIN IS USED, IS CAUSED BY DRUG... FOR THIS REASON, JAPAN WITHDREW SUCH DRUGS FROM MARKET.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1159


VET: COMMERCIAL PREPN MAY CAUSE YELLOW-BROWN STAINING OF WHITE HAIR. USE MAY ALTER SERUM PROTEIN-BOUND IODINE TEST.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 177


4.3 Minimum/Potential Fatal Human Dose

4(?). 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG, BETWEEN 1 TEASPOON & 1 OZ FOR 70 KG PERSON (150 LB). ...ITS TOXICITY IS UNPREDICTABLE.

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-234


4.4 Drug Indication

Used in the treatment of amoebiasis.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Amebicides

Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal. (See all compounds classified as Amebicides.)


5.2 ATC Code

G - Genito urinary system and sex hormones

G01 - Gynecological antiinfectives and antiseptics

G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids

G01AC - Quinoline derivatives

G01AC01 - Diiodohydroxyquinoline


5.3 Absorption, Distribution and Excretion

AFTER ORAL ADMIN, VARIABLE BUT SIGNIFICANT PORTION OF INGESTED DOSE IS ABSORBED. ... DIIODOHYDROXYQUIN WAS LEAST WELL ABSORBED--ONLY 1/3 AS MUCH AS IODOCHLORHYDROXYQUIN. BULK OF THESE DRUGS IS PASSED IN FECES.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1073


5.4 Mechanism of Action

Unknown.


...IT IS NOT KNOWN IF THEY ARE EFFECTIVE IN INTESTINAL AMEBIASIS SOLELY BY VIRTUE OF THEIR PRESENCE IN LUMEN OF BOWEL OR ALSO IN PART BY THEIR PRESENCE IN CIRCULATION. /8-HYDROXYQUINOLINES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1073


...8-HYDROXYQUINOLINES ARE DIRECTLY AMEBICIDAL. THEY ARE ACTIVE AGAINST BOTH MOTILE & CYSTIC FORMS, BUT THEIR EFFICACY IN ELIMINATING CYSTS IS PROBABLY BASED ON THEIR ABILITY TO DESTROY TROPHOZOITES. THEY ACT ONLY ON AMEBAE IN INTESTINAL TRACT & ARE INEFFECTIVE IN AMEBIC ABSCESS & HEPATITIS. /8-HYDROXYQUINOLINES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1073


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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,TURKAPALLY-V SHAMIRPET"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728498600,"product":"2-IODOQUINOLINE - CS-0037774 - 6560-83-4","address":"102\/12 KRISHNA GREENLAND PARK,KASA","city":"THANE,MAHARASHTRA","supplier":"SHANGHAI KAIXIN PHARMACEUTICALS CO.","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"JINAY PHARMACEUTICALS PRIVATE ","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"11.6","totalValueFC":"58.5","currency":"USD","unitRateINR":"982.6","date":"10-Oct-2024","totalValueINR":"4912.81","totalValueInUsd":"58.5","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"6058240","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":",LTD ROOM 502,5\/F NO.2 BUILDING 720 CAIL ZHANGJIANG HIGH-TECH PARK SHANGHAI CHINA","customerAddress":"102\/12 KRISHNA GREENLAND PARK,KASA"}]
21-Jun-2021
10-Oct-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
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ABOUT THIS PAGE

Iodoquinol Manufacturers

A Iodoquinol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Iodoquinol, including repackagers and relabelers. The FDA regulates Iodoquinol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Iodoquinol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Iodoquinol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Iodoquinol Suppliers

A Iodoquinol supplier is an individual or a company that provides Iodoquinol active pharmaceutical ingredient (API) or Iodoquinol finished formulations upon request. The Iodoquinol suppliers may include Iodoquinol API manufacturers, exporters, distributors and traders.

click here to find a list of Iodoquinol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Iodoquinol WC

A Iodoquinol written confirmation (Iodoquinol WC) is an official document issued by a regulatory agency to a Iodoquinol manufacturer, verifying that the manufacturing facility of a Iodoquinol active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Iodoquinol APIs or Iodoquinol finished pharmaceutical products to another nation, regulatory agencies frequently require a Iodoquinol WC (written confirmation) as part of the regulatory process.

click here to find a list of Iodoquinol suppliers with Written Confirmation (WC) on PharmaCompass.

Iodoquinol NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Iodoquinol as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Iodoquinol API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Iodoquinol as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Iodoquinol and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Iodoquinol NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Iodoquinol suppliers with NDC on PharmaCompass.

Iodoquinol GMP

Iodoquinol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Iodoquinol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Iodoquinol GMP manufacturer or Iodoquinol GMP API supplier for your needs.

Iodoquinol CoA

A Iodoquinol CoA (Certificate of Analysis) is a formal document that attests to Iodoquinol's compliance with Iodoquinol specifications and serves as a tool for batch-level quality control.

Iodoquinol CoA mostly includes findings from lab analyses of a specific batch. For each Iodoquinol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Iodoquinol may be tested according to a variety of international standards, such as European Pharmacopoeia (Iodoquinol EP), Iodoquinol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Iodoquinol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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