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    Also known as: 83-73-8, Diiodohydroxyquinoline, 5,7-diiodoquinolin-8-ol, 5,7-diiodo-8-hydroxyquinoline, 5,7-diiodo-8-quinolinol, Diiodoquin
    Molecular Formula
    C9H5I2NO
    Molecular Weight
    396.95  g/mol
    InChI Key
    UXZFQZANDVDGMM-UHFFFAOYSA-N
    FDA UNII
    63W7IE88K8
    Iodoquinol
    One of the halogenated 8-quinolinols widely used as an intestinal antiseptic, especially as an antiamebic agent. It is also used topically in other infections and may cause CNS and eye damage. It is known by very many similar trade names world-wide.
    1 2D Structure

    Iodoquinol

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5,7-diiodoquinolin-8-ol
    2.1.2 InChI
    InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
    2.1.3 InChI Key
    UXZFQZANDVDGMM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC2=C(C(=C(C=C2I)I)O)N=C1
    2.2 Other Identifiers
    2.2.1 UNII
    63W7IE88K8
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Diiodohydroxyquin

    2. Diiodohydroxyquinoline

    3. Diiodoquin

    4. Diodoquin

    5. Diodoxyquinoline

    6. Diquinol

    7. Entero Diyod

    8. Entero-diyod

    9. Enterodiyod

    10. Entodiba

    11. Sebaquin

    12. Yodoxin

    2.3.2 Depositor-Supplied Synonyms

    1. 83-73-8

    2. Diiodohydroxyquinoline

    3. 5,7-diiodoquinolin-8-ol

    4. 5,7-diiodo-8-hydroxyquinoline

    5. 5,7-diiodo-8-quinolinol

    6. Diiodoquin

    7. Diodoquin

    8. Yodoxin

    9. Diiodohydroxyquin

    10. Lanodoxin

    11. Searlequin

    12. Zoaquin

    13. Ioquin

    14. Quinadome

    15. Sebaquin

    16. 8-quinolinol, 5,7-diiodo-

    17. Diodohydroxyquin

    18. Dijodoxichinoline

    19. Enterodiamoebin

    20. Diamoebin

    21. Dinoleine

    22. Diodoquine

    23. Diodoxylin

    24. Direxiode

    25. Disoquin

    26. Embequin

    27. Enterosept

    28. Floraquin

    29. Fluoraquin

    30. Moebiquin

    31. Dyodin

    32. Di-quinol

    33. Stanquinate

    34. Rafamebin

    35. 5,7-diiodo-oxine

    36. Ioquin Suspension

    37. Dijodoxichinolinum

    38. 8-hydroxy-5,7-diiodoquinoline

    39. 5,7-diodo-8-quinolinol

    40. Diodoxyquinoleine

    41. Diiodoidrossichinolina

    42. Panaquin

    43. Diiodohidroxiquinoleina

    44. Diiodohydroxyquinoleine

    45. Diiodohydroxyquinolinum

    46. Ss 578

    47. Enterodiamoebine

    48. Nsc 8704

    49. Nsc-8704

    50. 5,7-diiod-8-chinolinol [iupac]

    51. Diiodohydroxyquinoline [inn]

    52. Mls000069404

    53. Chebi:5950

    54. 63w7ie88k8

    55. Mmv002817

    56. Ss-578

    57. Ncgc00018098-04

    58. Smr000059090

    59. Dsstox_cid_3155

    60. Dsstox_rid_76894

    61. Diiodohydroxyquinoline (inn)

    62. Dsstox_gsid_23155

    63. Iodoquinol [usan]

    64. Caswell No. 354

    65. Iodoquinol;5,7-diiodo-8-hydroxyquinoline;5,7-diiodo-8-quinolinol

    66. Cas-83-73-8

    67. Diiodoidrossichinolina [dcit]

    68. Hsdb 3224

    69. Sr-01000002969

    70. Diiodohydroxyquinolinum [inn-latin]

    71. Iodoquinol [usan:usp]

    72. Diiodohydroxyquinoleine [inn-french]

    73. Einecs 201-497-9

    74. 5,7-diiod-8-chinolinol

    75. Diiodohidroxiquinoleina [inn-spanish]

    76. Epa Pesticide Chemical Code 024003

    77. Brn 0153639

    78. Searlewuin

    79. Meobiquin

    80. Unii-63w7ie88k8

    81. Ai3-16443

    82. 5,7-diiodooxine

    83. Component Of Vytone

    84. Iodoquinol (usp)

    85. Yodoxin (tn)

    86. Mfcd00006789

    87. Spectrum_000943

    88. Iodoquinol [mi]

    89. 8-quinolinol,7-diiodo-

    90. Spectrum2_001041

    91. Spectrum3_000470

    92. Spectrum4_000020

    93. Spectrum5_000872

    94. Iodoquinol [hsdb]

    95. 4,7-diiodo-8-quinolinol

    96. Bmse000836

    97. Ec 201-497-9

    98. Cid_3728

    99. Schembl3460

    100. Iodoquinol [usp-rs]

    101. Bspbio_002180

    102. Cbdive_011080

    103. Kbiogr_000399

    104. Kbioss_001423

    105. Ksc-8-193

    106. Chembl86754

    107. Divk1c_000119

    108. Spectrum1500353

    109. Spbio_000962

    110. Di-iodohydroxy Quinoline

    111. Dtxsid6023155

    112. 5,7-bis(iodanyl)quinolin-8-ol

    113. Bdbm66035

    114. Hms500f21

    115. Kbio1_000119

    116. Kbio2_001423

    117. Kbio2_003991

    118. Kbio2_006559

    119. Kbio3_001400

    120. Uxzfqzandvdgmm-uhfffaoysa-

    121. Iodoquinol [usp Impurity]

    122. Nsc8704

    123. Ninds_000119

    124. Wln: T66 Bnj Gi Ii Jq

    125. Hms1920h05

    126. Hms2091n15

    127. Hms2230g24

    128. Hms3369c20

    129. Iodoquinol [usp Monograph]

    130. Kuc105860n

    131. Pharmakon1600-01500353

    132. Hy-b1400

    133. Zinc3830942

    134. Tox21_110823

    135. Ccg-40132

    136. Nsc757077

    137. S4565

    138. Stk070581

    139. Diiodohydroxyquinoline [mart.]

    140. Akos000120804

    141. Tox21_110823_1

    142. 5,7-diiodo-8-hydroxyquinoline, 97%

    143. Cs-4910

    144. Db09115

    145. Diiodohydroxyquinoline [who-dd]

    146. Iodoquinol (5,7-diiodoquinolin-8-ol)

    147. Nsc-757077

    148. Idi1_000119

    149. Ncgc00018098-01

    150. Ncgc00018098-02

    151. Ncgc00018098-03

    152. Ncgc00018098-05

    153. Ncgc00018098-07

    154. Ncgc00018098-08

    155. Ncgc00021685-03

    156. Ncgc00021685-04

    157. Ds-17759

    158. Sbi-0051417.p003

    159. Db-056739

    160. Am20061527

    161. D1736

    162. Ft-0619847

    163. C07636

    164. D00581

    165. F12461

    166. Ab00052024_12

    167. An-329/13210059

    168. Q5276473

    169. Sr-01000002969-2

    170. Sr-01000002969-5

    171. Brd-k75855670-001-06-8

    172. F3034-0058

    173. Iodoquinol, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 396.95 g/mol
    Molecular Formula C9H5I2NO
    XLogP33.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass396.84606 g/mol
    Monoisotopic Mass396.84606 g/mol
    Topological Polar Surface Area33.1 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity191
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Amebicides; Anti-Infective Agents, Local

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    ...MAY BE USED IN LOCAL & SYSTEMIC TREATMENT OF TRICHOMONAS VAGINALIS VAGINITIS & INFECTIONS CAUSED BY TRICHOMONAS HOMINIS (INTESTINALIS). IT IS USED IN TOPICAL TREATMENT OF CERTAIN FUNGAL CUTANEOUS INFECTIONS & IN ECZEMA IN WHICH FUNGAL INFECTION IS COMPLICATION.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1159

    ...HAVE BEEN USED FOR TREATMENT OF VARIOUS DERMATOLOGICAL DISORDERS, & LARGE DOSES HAVE BEEN EMPLOYED ORALLY IN TREATMENT OF ACRODERMATITIS ENTEROPATHICA, RARE, POTENTIALLY FATAL PEDIATRIC CONDITION.

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1074

    ...EFFECTIVE FOR INTESTINAL AMEBIASIS &...FOR TREATMENT OF ASYMPTOMATIC PASSERS OF CYSTS. ...USEFUL FOR AMBULATORY & MASS TREATMENT. THEY ARE INEXPENSIVE. ...OF VALUE IN CASES OF LAMBLIASIS RESISTANT TO QUINACRINE THERAPY, IN BALANTIDIAL DYSENTERY, & IN INTESTINAL INFECTIONS DUE TO DIENTAMEBA FRAGILIS. /8-HYDROXYQUINOLINES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1074

    For more Therapeutic Uses (Complete) data for DIIODOHYDROXYQUIN (8 total), please visit the HSDB record page.

    4.2 Drug Warning

    WHILE...EFFECTIVE IN CYST-PASSING PT, THEY ARE MUCH LESS EFFECTIVE IN TREATMENT OF ACUTE AMEBIC DYSENTERY.

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1073

    USE OF THESE AGENTS TO TREAT "TRAVELER'S DIARRHEA" & CHRONIC NONSPECIFIC DIARRHEA IN CHILDREN /PRC: OR ADULTS/ CANNOT BE CONDONED, SINCE SUCH CONDITIONS ARE SELF-LIMITED & ANY POSSIBLE THERAPEUTIC BENEFIT DOES NOT JUSTIFY RISK OF SERIOUS NEUROTOXICITY. /8-HYDROXYQUINOLINES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1074

    THESE DRUGS ARE CONTRAINDICATED IN PT WITH HEPATIC DAMAGE OR IODINE INTOLERANCE. ...THESE AGENTS INTERFERE WITH CERTAIN THYROID FUNCTION TESTS FOR MO BECAUSE OF THEIR CONTENT OF IODINE. /8-HYDROXYQUINOLINES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1074

    ...IT NOW APPEARS THAT GI-NEUROLOGIC SYNDROME OF OBSCURE ETIOLOGY, COMMON IN REGIONS WHERE DIIODOHYDROXYQUIN IS USED, IS CAUSED BY DRUG... FOR THIS REASON, JAPAN WITHDREW SUCH DRUGS FROM MARKET.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1159

    VET: COMMERCIAL PREPN MAY CAUSE YELLOW-BROWN STAINING OF WHITE HAIR. USE MAY ALTER SERUM PROTEIN-BOUND IODINE TEST.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 177

    4.3 Minimum/Potential Fatal Human Dose

    4(?). 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG, BETWEEN 1 TEASPOON & 1 OZ FOR 70 KG PERSON (150 LB). ...ITS TOXICITY IS UNPREDICTABLE.

    Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-234

    4.4 Drug Indication

    Used in the treatment of amoebiasis.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Amebicides

    Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal. (See all compounds classified as Amebicides.)

    5.2 ATC Code

    G - Genito urinary system and sex hormones

    G01 - Gynecological antiinfectives and antiseptics

    G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids

    G01AC - Quinoline derivatives

    G01AC01 - Diiodohydroxyquinoline

    5.3 Absorption, Distribution and Excretion

    AFTER ORAL ADMIN, VARIABLE BUT SIGNIFICANT PORTION OF INGESTED DOSE IS ABSORBED. ... DIIODOHYDROXYQUIN WAS LEAST WELL ABSORBED--ONLY 1/3 AS MUCH AS IODOCHLORHYDROXYQUIN. BULK OF THESE DRUGS IS PASSED IN FECES.

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1073

    5.4 Mechanism of Action

    Unknown.

    ...IT IS NOT KNOWN IF THEY ARE EFFECTIVE IN INTESTINAL AMEBIASIS SOLELY BY VIRTUE OF THEIR PRESENCE IN LUMEN OF BOWEL OR ALSO IN PART BY THEIR PRESENCE IN CIRCULATION. /8-HYDROXYQUINOLINES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1073

    ...8-HYDROXYQUINOLINES ARE DIRECTLY AMEBICIDAL. THEY ARE ACTIVE AGAINST BOTH MOTILE & CYSTIC FORMS, BUT THEIR EFFICACY IN ELIMINATING CYSTS IS PROBABLY BASED ON THEIR ABILITY TO DESTROY TROPHOZOITES. THEY ACT ONLY ON AMEBAE IN INTESTINAL TRACT & ARE INEFFECTIVE IN AMEBIC ABSCESS & HEPATITIS. /8-HYDROXYQUINOLINES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1073

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LIMITED","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"59","totalValueFC":"354.8","currency":"USD","unitRateINR":"5642.1","date":"06-Jul-2022","totalValueINR":"28210.32","totalValueInUsd":"354.8","indian_port":"BANGALORE AIR","hs_no":"29339990","bill_no":"9436381","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2& 3,BOMMASANDRA INDUSTRIAL AREA,IVPHA"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1661538600,"product":"6-BROMO-3-IODOQUINOLINE","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2& 3,BOMMASANDRA INDUSTRIAL AREA,IVPHA","city":"BANGALORE,KARNATAKA","supplier":"COMBI BLOCKS INC.","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"48","totalValueFC":"588.2","currency":"USD","unitRateINR":"4680.3","date":"27-Aug-2022","totalValueINR":"46802.7","totalValueInUsd":"588.2","indian_port":"BANGALORE AIR","hs_no":"29339990","bill_no":"2194969","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2& 3,BOMMASANDRA INDUSTRIAL AREA,IVPHA"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1668018600,"product":"6-BROMO-3-IODOQUINOLINE","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2& 3,BOMMASANDRA INDUSTRIAL AREA,IVPHA","city":"BANGALORE,KARNATAKA","supplier":"COMBI BLOCKS INC.","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.03","actualQuantity":"25","unit":"GMS","unitRateFc":"38.4","totalValueFC":"1194","currency":"USD","unitRateINR":"3897.7","date":"10-Nov-2022","totalValueINR":"97442.64","totalValueInUsd":"1194","indian_port":"BANGALORE AIR","hs_no":"29339990","bill_no":"3245668","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2& 3,BOMMASANDRA INDUSTRIAL AREA,IVPHA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728498600,"product":"2-IODOQUINOLINE - CS-0037774 - 6560-83-4","address":"102\/12 KRISHNA GREENLAND PARK,KASA","city":"THANE,MAHARASHTRA","supplier":"SHANGHAI KAIXIN PHARMACEUTICALS CO.","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"JINAY PHARMACEUTICALS PRIVATE ","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"11.6","totalValueFC":"58.5","currency":"USD","unitRateINR":"982.6","date":"10-Oct-2024","totalValueINR":"4912.81","totalValueInUsd":"58.5","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"6058240","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":",LTD ROOM 502,5\/F NO.2 BUILDING 720 CAIL ZHANGJIANG HIGH-TECH PARK SHANGHAI CHINA","customerAddress":"102\/12 KRISHNA GREENLAND PARK,KASA"}]
    21-Jun-2021
    10-Oct-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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