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Iophendylate

Iophendylate

Synopsis, Chemistry

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Also known as: Ethyl 10-(4-iodophenyl)undecanoate, 99-79-6, Iofendylatum, Ethyl 10-(p-iodophenyl)undecylate, Ethyl 10-(p-iodophenyl)hendecanoate, 6v3i57k9ul

Molecular Formula

C₁₉H₂₉IO₂

Molecular Weight

416.3 g/mol

InChI Key

LAYLQVBQIBQVLL-UHFFFAOYSA-N

FDA UNII

6V3I57K9UL

An inert iodine-containing agent which is opaque to X-RAYS. It is used mainly for BRAIN and SPINAL CORD visualization.

1 2D Structure

Iophendylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

ethyl 10-(4-iodophenyl)undecanoate

2.1.2 InChI

InChI=1S/C19H29IO2/c1-3-22-19(21)11-9-7-5-4-6-8-10-16(2)17-12-14-18(20)15-13-17/h12-16H,3-11H2,1-2H3

2.1.3 InChI Key

LAYLQVBQIBQVLL-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCOC(=O)CCCCCCCCC(C)C1=CC=C(C=C1)I

2.2 Other Identifiers

2.2.1 UNII

6V3I57K9UL

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ethiodan

2. Iodophendylate

3. Ioglunide

4. Iophendylate

5. Isophendylate

6. Maiodil

7. Myodil

8. Panthopaque

9. Pantopaque

2.3.2 Depositor-Supplied Synonyms

1. Ethyl 10-(4-iodophenyl)undecanoate

2. 99-79-6

3. Iofendylatum

4. Ethyl 10-(p-iodophenyl)undecylate

5. Ethyl 10-(p-iodophenyl)hendecanoate

6. 6v3i57k9ul

7. Jofendylatum

8. Iophendylate, P-

9. Ethiodan

10. Mulsopaque

11. Neurotrast

12. Myodil

13. Myodyl

14. Mulsopaque; Myodil; Myodyl; Neurotrast; Pantopaque

15. Iofendilato

16. P-iophendylate

17. Iofendylatum [inn-latin]

18. Iofendilato [inn-spanish]

19. Hsdb 3346

20. Ethyl 10-(p-iodophenyl)undecanoate

21. Iofendylate [inn:ban]

22. Einecs 202-787-8

23. Brn 2661373

24. Unii-6v3i57k9ul

25. Iophendilate

26. Undecanoic Acid, 10-(p-iodophenyl)-, Ethyl Ester

27. Jofendylate

28. Benzenedecanoic Acid, 4-iodo-iota-methyl-, Ethyl Ester

29. Iophendylate [mi]

30. Chembl951

31. 3-09-00-02627 (beilstein Handbook Reference)

32. Schembl492663

33. Dtxsid2052869

34. Ethyl10-(4-iodophenyl)undecanoate

35. Hy-a0223

36. Akos005267217

37. Cs-0017569

38. Ft-0682962

39. Q3801357

40. W-100019

41. Benzenedecanoic Acid, 4-iodo-.iota.-methyl-, Ethyl Ester

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₉IO₂
Molecular Weight	416.3 g/mol
XLogP3	7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	12
Exact Mass	416.12123 g/mol
Monoisotopic Mass	416.12123 g/mol
Topological Polar Surface Area	26.3 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	285
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

Contrast Media

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

IT IS ABSORBABLE, IODIZED FATTY ACID COMPD OF LOW VISCOSITY DESIGNED ESPECIALLY FOR MYELOGRAPHY. ... IT IS EQUALLY USEFUL FOR VISUALIZATION OF ALL REGIONS OF SPINAL CORD, ALTHOUGH THIS MAY BE TECHNICALLY MORE DIFFICULT IN CERVICAL & THORACIC REGIONS. ... IOPHENDYLATE ALSO IS USED IN EMULSIFIED AQUEOUS FORM AS CONTRAST MEDIUM FOR VISUALIZATION OF BILIARY TREE, SINUS TRACTS, & CERTAIN BODY CAVITIES.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 802

IT IS COMMONLY USED FOR VISUALIZATION OF TUMORS OR HERNIATION OF INTERVERTEBRAL DISC OR OTHER LESIONS COMPRESSING SPINAL CORD.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1215

VET: TO OUTLINE SALIVARY GLANDS, DRAINING SINUSES, OR FISTULAS; IT MAY BE SAFE (1-3 ML) IN SPINAL VENTRICULOGRAPHY OF DOGS.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 285

DOSE- USUAL, MYELOGRAPHY, INTRATHECAL OR BY SPECIAL INJECTION

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1215

4.2 Drug Warning

THIS AGENT SHOULD NOT BE USED INTRAVASCULARLY. ... AGENT SHOULD NOT BE USED WHEN LUMBAR PUNCTURE IS CONTRAINDICATED; &, TO AVOID SUBDURAL & EXTRA-ARACHNOID EXTRAVASATION, IT SHOULD NOT BE EMPLOYED WITHIN 10 DAYS OF PREVIOUS LUMBAR PUNCTURE.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 802

...PERSISTENT LEVELS IN BODY INTERFERE WITH TRACER STUDIES WITH RADIOACTIVE IODINE.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1215

WHEN BULK OF MATERIAL IS REMOVED...INCIDENCE OF SIDE REACTIONS IS LOW.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 802

IN GENERAL, IODINATED CONTRAST MEDIA SHOULD BE ADMINISTERED WITH CAUTION IN PATIENTS WITH HEPATIC OR RENAL DYSFUNCTION. ... THE INJECTION OF IODIZED FATTY ACIDS IS ESSENTIALLY A SURGICAL PROCEDURE THAT INVOLVES RISK. THE FOLLOWING CAUTIONS SHOULD BE BORNE IN MIND. PREPARATIONS THAT HAVE AGED & DARKENED BEYOND THE ORIGINAL COLOR SHOULD NOT BE USED. ... THE COMPOUNDS SHOULD NOT BE ADMINISTERED TO INDIVIDUALS WITH HISTORY OF SENSITIVITY TO IODIDES. /IODINATED CONTRAST MEDIA/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 803

For more Drug Warnings (Complete) data for IOPHENDYLATE (6 total), please visit the HSDB record page.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Contrast Media

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)

5.2 ATC Code

V - Various

V08 - Contrast media

V08A - X-ray contrast media, iodinated

V08AD - Non-watersoluble x-ray contrast media

V08AD04 - Iofendylate