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Chemistry

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Also known as: 13087-53-1, Meglumine iotalamate, Conray, Meglumine iothalamate, Iotalamate meglumine, Xuw72gop7w
Molecular Formula
C18H26I3N3O9
Molecular Weight
809.1  g/mol
InChI Key
VLHUSFYMPUDOEL-WZTVWXICSA-N
FDA UNII
XUW72GOP7W

Iothalamate Meglumine
A radiopaque medium used for urography, angiography, venography, and myelography. It is highly viscous and binds to plasma proteins.
1 2D Structure

Iothalamate Meglumine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
2.1.2 InChI
InChI=1S/C11H9I3N2O4.C7H17NO5/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-2H3,(H,15,18)(H,16,17)(H,19,20);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
2.1.3 InChI Key
VLHUSFYMPUDOEL-WZTVWXICSA-N
2.1.4 Canonical SMILES
CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)C(=O)NC)I.CNCC(C(C(C(CO)O)O)O)O
2.1.5 Isomeric SMILES
CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)C(=O)NC)I.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
2.2 Other Identifiers
2.2.1 UNII
XUW72GOP7W
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Conray 60

2. Iotalamate Meglumine

3. Iotalamate, Meglumine

4. Iotalamate, Methylglucamine

5. Iothalamate, Meglumine

6. Iothalamate, Methylglucamine

7. Iothalamic Acid Meglumine

8. Iothalamic Acid Methylglucamine

9. Meglumine Iotalamate

10. Meglumine Iothalamate

11. Meglumine, Iotalamate

12. Meglumine, Iothalamate

13. Meglumine, Iothalamic Acid

14. Methylglucamine Iotalamate

15. Methylglucamine Iothalamate

16. Methylglucamine, Iothalamic Acid

2.3.2 Depositor-Supplied Synonyms

1. 13087-53-1

2. Meglumine Iotalamate

3. Conray

4. Meglumine Iothalamate

5. Iotalamate Meglumine

6. Xuw72gop7w

7. Iothalamate Meglumine [usp]

8. Meglumine Iotalamate Injection

9. 1-deoxy-1-(methylamino)-d-glucitol 3-(acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]benzoate

10. 3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic Acid;(2r,3r,4r,5s)-6-(methylamino)hexane-1,2,3,4,5-pentol

11. 1-deoxy-1-(methylamino)-d-glucitol 5-acetamido-2,4,6-triiodo-n-methylisophthalamate (salt)

12. Iothalamate Meglumine (usp)

13. Conray 60

14. Conray Meglumin

15. Meglumine Conray

16. Methylglucamine Iotalamate

17. Cysto-conray

18. Methylglucamine Iothalamate

19. Cysto-conray Ii

20. 3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic Acid;6-(methylamino)hexane-1,2,3,4,5-pentol

21. Benzoic Acid, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)-, Compd. With 1-deoxy-1-(methylamino)-d-glucitol (1:1)

22. Contrix 28

23. Conray 30

24. Conray 43

25. Meglumine Isothalamate

26. Conray Meglumine 282

27. Iothalamate Methylglucamine

28. Iotalamate De Methylglucamine

29. Iothalamate Methylglucamine Salt

30. Jotalamsaeure Methylglucaminesalz

31. 1-deoxy-1-(methylamino)-d-glucitol 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoate

32. Einecs 235-998-9

33. Conray (tn)

34. Iothalamic Acid N-methylgucamine Salt

35. Iotalamate De Methylglucamine [french]

36. Iotalamic Acid Meglumine

37. Jotalamsaeure Methylglucaminesalz [german]

38. Unii-xuw72gop7w

39. Meglumine Iothalamate [ban]

40. D-glucitol, 1-deoxy-1-(methylamino)-, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoate (salt)

41. Meglumine Iotalamate (jp17)

42. Schembl180546

43. Chembl1201125

44. Chebi:31714

45. Dtxsid10926949

46. Iothalamate Meglumine [vandf]

47. Meglumine Iotalamate [mart.]

48. Iotalamate Meglumine [who-dd]

49. Isophthalamic Acid, 5-acetamido-2,4,6-triiodo-n-methyl-, Compd. With 1-deoxy-1-(methylamino)-d-glucitol (1:1)

50. Iothalamate Meglumine [orange Book]

51. Iothalamate Meglumine [usp Impurity]

52. D01999

53. Vascoray Component Iothalamate Meglumine

54. Iothalamate Meglumine Component Of Vascoray

55. Iothalamic Acid N-methylglucamine Salt [mi]

56. Q27294007

57. 5-acetamido-2,4,6-triiodo-n-methylisophthalamic Acid-methylglucamine

58. Benzoic Acid, 3-(acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]-, Compd. With D-glucitol, 1-deoxy-1-(methylamino)- (1:1)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 809.1 g/mol
Molecular Formula C18H26I3N3O9
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass808.8803 g/mol
Monoisotopic Mass808.8803 g/mol
Topological Polar Surface Area209 Ų
Heavy Atom Count33
Formal Charge0
Complexity555
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 8  
Drug NameConray 30
Drug LabelConray 30 is a sterile aqueous solution intended for use as a diagnostic radiopaque medium. Conray 30 contains 30% w/v iothalamate meglumine which is 1-deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6 triiodo-N-methylisophthalamate (salt), and has...
Active IngredientIothalamate meglumine
Dosage FormInjectable
RouteInjection
Strength30%
Market StatusPrescription
CompanyMallinckrodt

2 of 8  
Drug NameConray 43
Drug LabelConray 43 is a sterile aqueous solution intended for use as a diagnostic radiopaque medium. Conray 43 contains 43% w/v iothalamate meglumine which is 1-deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophthalamate (salt), and has...
Active IngredientIothalamate meglumine
Dosage FormInjectable
RouteInjection
Strength43%
Market StatusPrescription
CompanyMallinckrodt

3 of 8  
Drug NameCysto-conray
Drug LabelCysto-Conray II is a sterile aqueous solution intended for instillation as a diagnostic radiopaque medium. Cysto-Conray II contains 17.2% w/v iothalamate meglumine which is 1-Deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophtha...
Active IngredientIothalamate meglumine
Dosage FormSolution
Routeintravesical, ureteral
Strength43%
Market StatusPrescription
CompanyMallinckrodt

4 of 8  
Drug NameCysto-conray ii
Drug LabelCysto-Conray II is a sterile aqueous solution intended for instillation as a diagnostic radiopaque medium. Cysto-Conray II contains 17.2% w/v iothalamate meglumine which is 1-Deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophtha...
Active IngredientIothalamate meglumine
Dosage FormSolution
RouteIntravesical
Strength17.2%
Market StatusPrescription
CompanyMallinckrodt

5 of 8  
Drug NameConray 30
Drug LabelConray 30 is a sterile aqueous solution intended for use as a diagnostic radiopaque medium. Conray 30 contains 30% w/v iothalamate meglumine which is 1-deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6 triiodo-N-methylisophthalamate (salt), and has...
Active IngredientIothalamate meglumine
Dosage FormInjectable
RouteInjection
Strength30%
Market StatusPrescription
CompanyMallinckrodt

6 of 8  
Drug NameConray 43
Drug LabelConray 43 is a sterile aqueous solution intended for use as a diagnostic radiopaque medium. Conray 43 contains 43% w/v iothalamate meglumine which is 1-deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophthalamate (salt), and has...
Active IngredientIothalamate meglumine
Dosage FormInjectable
RouteInjection
Strength43%
Market StatusPrescription
CompanyMallinckrodt

7 of 8  
Drug NameCysto-conray
Drug LabelCysto-Conray II is a sterile aqueous solution intended for instillation as a diagnostic radiopaque medium. Cysto-Conray II contains 17.2% w/v iothalamate meglumine which is 1-Deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophtha...
Active IngredientIothalamate meglumine
Dosage FormSolution
Routeintravesical, ureteral
Strength43%
Market StatusPrescription
CompanyMallinckrodt

8 of 8  
Drug NameCysto-conray ii
Drug LabelCysto-Conray II is a sterile aqueous solution intended for instillation as a diagnostic radiopaque medium. Cysto-Conray II contains 17.2% w/v iothalamate meglumine which is 1-Deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophtha...
Active IngredientIothalamate meglumine
Dosage FormSolution
RouteIntravesical
Strength17.2%
Market StatusPrescription
CompanyMallinckrodt

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Contrast Media

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
X-Ray Contrast Activity [MoA]; Radiographic Contrast Agent [EPC]

DRUG PRODUCT COMPOSITIONS

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DOSAGE - INJECTABLE;INJECTION - 43%

USFDA APPLICATION NUMBER - 13295

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DOSAGE - INJECTABLE;INJECTION - 60%

USFDA APPLICATION NUMBER - 13295

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DOSAGE - INJECTABLE;INJECTION - 30%

USFDA APPLICATION NUMBER - 16983

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