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Chemistry

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Also known as: 28179-44-4, Acido ioxitalamico, Acide ioxitalamique, Acidum ioxitalamicum, Iooxitalamic acid, Ag 58107
Molecular Formula
C12H11I3N2O5
Molecular Weight
643.94  g/mol
InChI Key
OLAOYPRJVHUHCF-UHFFFAOYSA-N
FDA UNII
967RDI7Z6K

Ioxitalamic Acid
Ioxitalamate is an ionic iodinated contrast medium. It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg. Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995. Until the last review in 2015, this drug is still available in the market.
1 2D Structure

Ioxitalamic Acid

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoic acid
2.1.2 InChI
InChI=1S/C12H11I3N2O5/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22)
2.1.3 InChI Key
OLAOYPRJVHUHCF-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)C(=O)NCCO)I
2.2 Other Identifiers
2.2.1 UNII
967RDI7Z6K
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-acetamido-n-(2- Hydroxyethyl)-2,4,6-triiodoisophthalamic Acid

2. Agelix

3. Ioxitalamic Acid, Sodium Salt

4. Ioxithalamate

5. Sodium Ioxithalamate

6. Telebrix

7. Telebrix 38

8. Vasobrix

2.3.2 Depositor-Supplied Synonyms

1. 28179-44-4

2. Acido Ioxitalamico

3. Acide Ioxitalamique

4. Acidum Ioxitalamicum

5. Iooxitalamic Acid

6. Ag 58107

7. Ioxithalamic Acid

8. 3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoic Acid

9. Telebrix

10. 3-acetamido-5-((2-hydroxyethyl)carbamoyl)-2,4,6-triiodobenzoic Acid

11. Ioxitalamic Acid Sodium Salt

12. 967rdi7z6k

13. Chebi:83517

14. Ag-58107

15. Ioxitalamic Acid (inn)

16. 3-(acetamido)-5-[[(2-hydroxyethyl)amino]carbonyl]-2,4,6-triiodo-benzoic Acid

17. Ioxitalamic Acid [inn]

18. Vasobrix

19. 5-acetamido-n-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic Acid

20. 3-(acetylamino)-5-[[(2-hydroxyethyl)amino]carbonyl]-2,4,6-triiodobenzoic Acid

21. 3-(acetylamino)-5-{[(2-hydroxyethyl)amino]carbonyl}-2,4,6-triiodobenzoic Acid

22. Acido Iossitalamico

23. Acidum Joxitalamicum

24. Ioxitalamic Acid [inn:dcf]

25. Ioxitalamicacid

26. Acido Iossitalamico [dcit]

27. Unii-967rdi7z6k

28. 3-(acetylamino)-5-(((2-hydroxyethyl)amino)carbonyl)-2,4,6-triiodobenzoic Acid

29. Acide Ioxitalamique [inn-french]

30. Acido Ioxitalamico [inn-spanish]

31. Acidum Ioxitalamicum [inn-latin]

32. Einecs 248-887-5

33. Mls006010884

34. Schembl455411

35. Acido Ioxitalamico;ioxitalamate

36. Chembl2107239

37. Dtxsid60182457

38. Ioxitalamic Acid [mart.]

39. Ioxitalamic Acid [who-dd]

40. Act03777

41. Amy24792

42. Bcp34384

43. Zinc4216615

44. Mfcd00867942

45. Sodium 3-acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoate

46. Db13444

47. Smr004701800

48. Ft-0659353

49. D07418

50. F20665

51. 179i444

52. Sr-01000945067

53. Q3604532

54. Sr-01000945067-1

55. W-110718

56. 5-acetamido-2,4,6-triiodo-n-(2-hydroxyethyl)-isophthalamic Acid

57. 3-(acetylamino)-5-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic Acid

58. 3-acetamido-2,4,6-triiodo-(n-beta-hydroxyethyl)isophthalic Acid Monoamide

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 643.94 g/mol
Molecular Formula C12H11I3N2O5
XLogP31.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass643.7802 g/mol
Monoisotopic Mass643.7802 g/mol
Topological Polar Surface Area116 Ų
Heavy Atom Count22
Formal Charge0
Complexity451
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Ioxitalamate in both of its available forms is indicated for exploration of the digestive tract by tomodensitometry or by regular gastroduodenal radiography. Its use is restrained to the cases in which the administration of barium sulfate is not recommended or contraindicated. The intravascular administration of ioxitalamate is contraindicated as it may present significant side effects.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Ioxitalamate presents a very large osmolality which is related to the presence of renal toxicity, vasodilatation, bradycardia and pulmonary hypertension. This large osmolality allows ioxitalamate to move slowly in the bowel allowing for analysis for later follow excretion in the feces.


5.2 MeSH Pharmacological Classification

Contrast Media

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)


5.3 ATC Code

V08AA05

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


V - Various

V08 - Contrast media

V08A - X-ray contrast media, iodinated

V08AA - Watersoluble, nephrotropic, high osmolar x-ray contrast media

V08AA05 - Ioxitalamic acid


5.4 Absorption, Distribution and Excretion

Absorption

When administered ioxitalamate is not absorbed in the GI tract. In the case of presence of an intestinal perforation, ioxitalamate is completely absorbed. When administered intravascularly, ioxitalamate is rapidly distributed in the interstitial space and intravascular compartment.


Route of Elimination

As ioxitalamate is not absorbed in the normal intestine, the elimination route of this compound is entirely performed by the feces. When absorbed due to the presence of an intestinal perforation, ioxitalamate presents a rapid renal elimination. when ioxitalamate is administered intravascularly, it is eliminated unchanged mainly via renal excretion through glomerular filtration without reabsorption or tubular secretion. In the cases of renal failure, the elimination is mainly performed in the biliary, salivary, sudoral and colic route.


Volume of Distribution

The volume of distribution of ioxitalamate is 194 ml/kg.


Clearance

The total clearance rate of ioxitalamate is 120 ml/min.


5.5 Metabolism/Metabolites

The rapid clearance suggests that ioxitalamate is not metabolized in the body.


5.6 Biological Half-Life

The elimination half-life of ioxitalamate is 1.1 hours.


5.7 Mechanism of Action

Ioxitalamate acts as a bowel opacifier which facilitates the interpretation of the anatomy and differentiation of bowel loops from soft tissue masses.


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Ioxitalamic Acid manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ioxitalamic Acid API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ioxitalamic Acid manufacturer or Ioxitalamic Acid supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ioxitalamic Acid manufacturer or Ioxitalamic Acid supplier.

PharmaCompass also assists you with knowing the Ioxitalamic Acid API Price utilized in the formulation of products. Ioxitalamic Acid API Price is not always fixed or binding as the Ioxitalamic Acid Price is obtained through a variety of data sources. The Ioxitalamic Acid Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ioxitalamic Acid

Synonyms

28179-44-4, Acido ioxitalamico, Acide ioxitalamique, Acidum ioxitalamicum, Iooxitalamic acid, Ag 58107

Cas Number

28179-44-4

Unique Ingredient Identifier (UNII)

967RDI7Z6K

About Ioxitalamic Acid

Ioxitalamate is an ionic iodinated contrast medium. It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg. Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995. Until the last review in 2015, this drug is still available in the market.

Ioxitalamic Acid Manufacturers

A Ioxitalamic Acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ioxitalamic Acid, including repackagers and relabelers. The FDA regulates Ioxitalamic Acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ioxitalamic Acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ioxitalamic Acid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ioxitalamic Acid Suppliers

A Ioxitalamic Acid supplier is an individual or a company that provides Ioxitalamic Acid active pharmaceutical ingredient (API) or Ioxitalamic Acid finished formulations upon request. The Ioxitalamic Acid suppliers may include Ioxitalamic Acid API manufacturers, exporters, distributors and traders.

click here to find a list of Ioxitalamic Acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ioxitalamic Acid GMP

Ioxitalamic Acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ioxitalamic Acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ioxitalamic Acid GMP manufacturer or Ioxitalamic Acid GMP API supplier for your needs.

Ioxitalamic Acid CoA

A Ioxitalamic Acid CoA (Certificate of Analysis) is a formal document that attests to Ioxitalamic Acid's compliance with Ioxitalamic Acid specifications and serves as a tool for batch-level quality control.

Ioxitalamic Acid CoA mostly includes findings from lab analyses of a specific batch. For each Ioxitalamic Acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ioxitalamic Acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Ioxitalamic Acid EP), Ioxitalamic Acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ioxitalamic Acid USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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