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Chemistry

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Also known as: Iron hydroxide oxide, Iron(3+);oxygen(2-);hydroxide, Iron hydroxide oxide nanoparticles / nanopowder, Iron oxide hydroxide, Iron hydroxide nanorods, Ferric oxy-hydroxide
Molecular Formula
FeHO2
Molecular Weight
88.85  g/mol
InChI Key
IEECXTSVVFWGSE-UHFFFAOYSA-M
FDA UNII
87PZU03K0K

Iron Sucrose
An antiferromagnetic material; constitutes the core of natural ferritin.
Ferric oxyhydroxide is a Phosphate Binder. The mechanism of action of ferric oxyhydroxide is as a Phosphate Chelating Activity.
1 2D Structure

Iron Sucrose

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
iron(3+);oxygen(2-);hydroxide
2.1.2 InChI
InChI=1S/Fe.H2O.O/h;1H2;/q+3;;-2/p-1
2.1.3 InChI Key
IEECXTSVVFWGSE-UHFFFAOYSA-M
2.1.4 Canonical SMILES
[OH-].[O-2].[Fe+3]
2.2 Other Identifiers
2.2.1 UNII
87PZU03K0K
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5fe2o3.9h2o

2. Ferric Hydroxide Oxide

3. Ferric Hydroxide Oxide (feooh)

4. Ferric Oxy-hydroxide

5. Ferric Oxyhydroxide (feo2h)

6. Ferrihydrite

7. Iron Hydroxide Oxide (fe(oh)o)

8. Iron Hydroxide Oxide (feo(oh))

9. Iron(iii) Oxyhydroxide

2.3.2 Depositor-Supplied Synonyms

1. Iron Hydroxide Oxide

2. Iron(3+);oxygen(2-);hydroxide

3. Iron Hydroxide Oxide Nanoparticles / Nanopowder

4. Iron Oxide Hydroxide

5. Iron Hydroxide Nanorods

6. Ferric Oxy-hydroxide

7. Ferric Hydroxide [mi]

8. Dtxsid3042057

9. Ferric Oxyhydroxide (feo2h)

10. Ferric Hydroxide Oxide (feooh)

11. Db14695

12. Iron Hydroxide Oxide (feo(oh))

13. Iron Oxide Hydroxide, Aqueous Nanoparticle Dispersion, <5 Nm (dls), 20% Solids By Weight, Ph ~3, 99.5% Trace Metals Basis

2.3.3 Other Synonyms

1. Feojectin

2. Ferplex Ss

3. Ferrivenin

4. Iviron

5. Proferrin

6. Sucrofer

7. Iron Sugar

8. Saccharated Iron

9. Venoferrum

10. Fesin

11. Ferrum Vitis

12. Hippiron

13. Ferum Hausmann

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 88.85 g/mol
Molecular Formula FeHO2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass88.932590 g/mol
Monoisotopic Mass88.932590 g/mol
Topological Polar Surface Area2 Ų
Heavy Atom Count3
Formal Charge0
Complexity0
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameVelphoro
PubMed HealthSucroferric Oxyhydroxide (By mouth)
Drug ClassesPhosphate Binder
Active IngredientSucroferric oxyhydroxide
Dosage FormTablet, chewable
RouteOral
Strength500mg
Market StatusPrescription
CompanyVifor Fresenius

2 of 2  
Drug NameVelphoro
PubMed HealthSucroferric Oxyhydroxide (By mouth)
Drug ClassesPhosphate Binder
Active IngredientSucroferric oxyhydroxide
Dosage FormTablet, chewable
RouteOral
Strength500mg
Market StatusPrescription
CompanyVifor Fresenius

5 Pharmacology and Biochemistry
5.1 FDA Pharmacological Classification
5.1.1 Active Moiety
FERRIC OXYHYDROXIDE
5.1.2 FDA UNII
87PZU03K0K
5.1.3 Pharmacological Classes
Mechanisms of Action [MoA] - Phosphate Chelating Activity

API SUPPLIERS

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01

Dr. Reddy's Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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02

Shanghai Minbiotech

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothShanghai Minbiotech is the leading producer of biopharmaceuticals and a variety of high-end generic & innovative drugs.

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03

Biophore India Pharmaceuticals Pvt...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothBiophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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05

Jai Radhe Sales

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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Biophore India Pharmaceuticals Pvt...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothBiophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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07

Biophore India Pharmaceuticals Pvt...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothBiophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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08

Opocrin SpA

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Opocrin SpA

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09

Nanjing Lifenergy R&D Co Ltd

China

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euroPLX 86 Munich
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Nanjing Lifenergy R&D Co Ltd

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10

Global Calcium

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

euroPLX 86 Munich
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Global Calcium

India

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MAHARASHTRA","supplier":"ALCON BIOSCIENCES","supplierCountry":"INDIA","foreign_port":"AMMAN","customer":"TO ORDER.","customerCountry":"JORDAN","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"80","totalValueFC":"1734.4","currency":"USD","unitRateINR":5829.2799999999997,"date":"25-Oct-2024","totalValueINR":"145732","totalValueInUsd":"1734.4","indian_port":"Bombay Air","hs_no":"29181590","bill_no":"5144848","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"JORDAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"112,, MARINE CHAMBERS,, MUMBAI. MAHARASHTRA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1682620200,"product":"IRON SUCROSE ( FOR R & D USE ONLY)","address":"Kalpataru Inspire, 3rd floor, off Western Express Highway Santacruz E","city":"Mumbai","supplier":"CHONGQING CARELIFE PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"NA","customer":"LUPIN LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"2500","totalValueFC":"2537.8","currency":"USD","unitRateINR":"207980.6","date":"28-Apr-2023","totalValueINR":"207980.6","totalValueInUsd":"2537.8","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"5723820","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"Kalpataru Inspire, 3rd floor, off Western Express Highway Santacruz E"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1701973800,"product":"IRON SUCROSE, BATCH NO:IRS-202203102, IRS-202205105 (5 KGS)","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"CHONGQING CARELIFE PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"CHONGQING","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1800","totalValueFC":"9114.3","currency":"USD","unitRateINR":"151740","date":"08-Dec-2023","totalValueINR":"758700","totalValueInUsd":"9114.3","indian_port":"Ahmedabad Air","hs_no":"29319090","bill_no":"9133075","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHONGQING","supplierAddress":"3 HUA NANYI ROAD, CHONGQING (CHANGSHOU) CHEMICAL INDUSTRY PARK,CHONGQING, CHINA CHINA","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"}]
04-Feb-2021
25-Oct-2024
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Drugs in Development

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Details:

RBT-1 (stannic protoporfin/iron sucrose), is a potent inducer of anti-inflammatory, antioxidant and iron-scavenging pathways, reduces post-op complications following cardiothoracic surgery.


Lead Product(s): Stannic Protoporfin,Iron Sucrose

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: RBT-1

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 09, 2024

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01

BioFlorida Conference
Not Confirmed
BioFlorida Conference
Not Confirmed

Details : RBT-1 (stannic protoporfin/iron sucrose), is a potent inducer of anti-inflammatory, antioxidant and iron-scavenging pathways, reduces post-op complications following cardiothoracic surgery.

Brand Name : RBT-1

Molecule Type : Small molecule

Upfront Cash : Not Applicable

January 09, 2024

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Details:

RBT-1 (stannic protoporfin/iron sucrose) is a potent inducer of anti-inflammatory, antioxidant and iron-scavenging pathways currently in Phase 3 [NCT # 06021457] for its lead indication to reduce post-operative complications following cardiothoracic surgery.


Lead Product(s): Stannic Protoporfin,Iron Sucrose

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: RBT-1

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 25, 2023

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02

BioFlorida Conference
Not Confirmed
BioFlorida Conference
Not Confirmed

Details : RBT-1 (stannic protoporfin/iron sucrose) is a potent inducer of anti-inflammatory, antioxidant and iron-scavenging pathways currently in Phase 3 [NCT # 06021457] for its lead indication to reduce post-operative complications following cardiothoracic surg...

Brand Name : RBT-1

Molecule Type : Small molecule

Upfront Cash : Not Applicable

October 25, 2023

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Details:

The proceeds will advance RBT-1 through a pivotal Phase 3 trial for reducing the risk of post-operative complications following cardiothoracic surgery. RBT-1 (stannic protoporfin/iron sucrose) is a potent inducer of anti-inflammatory, antioxidant and iron-scavenging pathways.


Lead Product(s): Iron Sucrose,Stannus Protoporphyrin

Therapeutic Area: Nephrology Brand Name: RBT-1

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Juniper Point

Deal Size: $72.0 million Upfront Cash: Undisclosed

Deal Type: Series B Financing September 12, 2023

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03

BioFlorida Conference
Not Confirmed
BioFlorida Conference
Not Confirmed

Details : The proceeds will advance RBT-1 through a pivotal Phase 3 trial for reducing the risk of post-operative complications following cardiothoracic surgery. RBT-1 (stannic protoporfin/iron sucrose) is a potent inducer of anti-inflammatory, antioxidant and iro...

Brand Name : RBT-1

Molecule Type : Small molecule

Upfront Cash : Undisclosed

September 12, 2023

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Details:

The proceeds will advance RBT-1 (stannic protoporfin/iron sucrose), a potent inducer of anti-inflammatory, antioxidant and iron scavenging pathways, through Phase 3 trial for reducing the risk of post-operative complications following cardiothoracic surgery.


Lead Product(s): Stannic Protoporfin,Iron Sucrose

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: RBT-1

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Undisclosed

Deal Size: $47.0 million Upfront Cash: Undisclosed

Deal Type: Series B Financing July 18, 2023

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04

BioFlorida Conference
Not Confirmed
BioFlorida Conference
Not Confirmed

Details : The proceeds will advance RBT-1 (stannic protoporfin/iron sucrose), a potent inducer of anti-inflammatory, antioxidant and iron scavenging pathways, through Phase 3 trial for reducing the risk of post-operative complications following cardiothoracic surg...

Brand Name : RBT-1

Molecule Type : Small molecule

Upfront Cash : Undisclosed

July 18, 2023

blank

Details:

RBT-1 (stannic protoporfin/iron sucrose) is a potent inducer of anti-inflammatory, antioxidant and iron-scavenging pathways that is advancing toward for its lead indication to reduce post-operative complications following cardiothoracic surgery.


Lead Product(s): Iron Sucrose,Stannus Protoporphyrin

Therapeutic Area: Nephrology Brand Name: RBT-1

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable July 11, 2023

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05

BioFlorida Conference
Not Confirmed
BioFlorida Conference
Not Confirmed

Details : RBT-1 (stannic protoporfin/iron sucrose) is a potent inducer of anti-inflammatory, antioxidant and iron-scavenging pathways that is advancing toward for its lead indication to reduce post-operative complications following cardiothoracic surgery.

Brand Name : RBT-1

Molecule Type : Small molecule

Upfront Cash : Not Applicable

July 11, 2023

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Details:

RBT-1 (Iron sucrose), treated patients demonstrated a highly significant increase in anti-inflammatory and antioxidant biomarkers of cytoprotective preconditioning. The biomarkers assessed were interleukin-10, heme oxygenase-1 and ferritin.


Lead Product(s): Iron Sucrose,Stannus Protoporphyrin

Therapeutic Area: Nephrology Brand Name: RBT-1

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 05, 2023

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06

BioFlorida Conference
Not Confirmed
BioFlorida Conference
Not Confirmed

Details : RBT-1 (Iron sucrose), treated patients demonstrated a highly significant increase in anti-inflammatory and antioxidant biomarkers of cytoprotective preconditioning. The biomarkers assessed were interleukin-10, heme oxygenase-1 and ferritin.

Brand Name : RBT-1

Molecule Type : Small molecule

Upfront Cash : Not Applicable

January 05, 2023

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  • Development Update

Details:

Velphoro (sucroferric oxyhydroxide) ® is a non-calcium, iron-based, chewable phosphate binder approved for the control of phosphate levels in the blood of adults with chronic kidney disease on dialysis.


Lead Product(s): Iron Sucrose

Therapeutic Area: Nephrology Brand Name: Velphoro

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Teva Pharmaceutical Industries

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 22, 2022

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07

Vifor Fresenius Medical Care Renal Pharma

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BioFlorida Conference
Not Confirmed

Vifor Fresenius Medical Care Renal Pharma

Country
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BioFlorida Conference
Not Confirmed

Details : Velphoro (sucroferric oxyhydroxide) ® is a non-calcium, iron-based, chewable phosphate binder approved for the control of phosphate levels in the blood of adults with chronic kidney disease on dialysis.

Brand Name : Velphoro

Molecule Type : Small molecule

Upfront Cash : Not Applicable

August 22, 2022

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Details:

RBT-1 (Iron Sucrose) met primary endpoint of increasing the expression of biomarkers of cytoprotective preconditioning; positive data supports the potential for RBT-1 to impact clinical outcomes in cardiothoracic surgery patients.


Lead Product(s): Iron Sucrose,Stannus Protoporphyrin

Therapeutic Area: Nephrology Brand Name: RBT-1

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 15, 2022

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08

BioFlorida Conference
Not Confirmed
BioFlorida Conference
Not Confirmed

Details : RBT-1 (Iron Sucrose) met primary endpoint of increasing the expression of biomarkers of cytoprotective preconditioning; positive data supports the potential for RBT-1 to impact clinical outcomes in cardiothoracic surgery patients.

Brand Name : RBT-1

Molecule Type : Small molecule

Upfront Cash : Not Applicable

June 15, 2022

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Details:

Proceeds from the recent financing will be used to advance Renibus’ pipeline, including the company’s lead candidates, RBT-1 for prevention of acute kidney injury (AKI), currently in a large (126 patients), randomized, double-blind study in AKI in a cardiac surgery setting.


Lead Product(s): Iron Sucrose,Stannus Protoporphyrin

Therapeutic Area: Nephrology Brand Name: RBT-1

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Undisclosed

Deal Size: $35.0 million Upfront Cash: Undisclosed

Deal Type: Series A Financing February 15, 2022

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09

BioFlorida Conference
Not Confirmed
BioFlorida Conference
Not Confirmed

Details : Proceeds from the recent financing will be used to advance Renibus’ pipeline, including the company’s lead candidates, RBT-1 for prevention of acute kidney injury (AKI), currently in a large (126 patients), randomized, double-blind study in AKI in a ...

Brand Name : RBT-1

Molecule Type : Small molecule

Upfront Cash : Undisclosed

February 15, 2022

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Details:

This Phase 2 study will evaluate the efficacy of RBT-1 in generating a preconditioning response as measured by a composite of biomarkers in subjects who are at risk for AKI following cardiac surgery.


Lead Product(s): Iron Sucrose,Stannus Protoporphyrin

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Brand Name: RBT-1

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 11, 2021

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10

BioFlorida Conference
Not Confirmed
BioFlorida Conference
Not Confirmed

Details : This Phase 2 study will evaluate the efficacy of RBT-1 in generating a preconditioning response as measured by a composite of biomarkers in subjects who are at risk for AKI following cardiac surgery.

Brand Name : RBT-1

Molecule Type : Small molecule

Upfront Cash : Not Applicable

March 11, 2021

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