Transo Pharm USA Isavuconazonium Sulfate RMU

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

33 API Suppliers, 10 USDMF, 1 KDMF, 7 NDC API, 27 Listed Suppliers, $ API Reference Price

33 API Suppliers
10 USDMF
1 KDMF
7 NDC API
27 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

20 Drugs in Development

20 Drugs in Development

INTERMEDIATES

26 Intermediates Suppliers

26 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

12 FDF Dossiers, 3 FDA Orange Book, 8 Europe, 1 Listed Dossiers

12 FDF Dossiers
3 FDA Orange Book
8 Europe
1 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - 186MG, CAPSULE;ORAL - 74.5MG, POWDER;INTRAVENOUS - 372MG

drugProductComposition
CAPSULE;ORAL - 186MG
CAPSULE;ORAL - 74.5MG
POWDER;INTRAVENOUS - 372MG

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 29 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
29 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

6 Finished Drug Prices, 8 Annual Reports

globalSalesInformation
6 Finished Drug Prices
8 Annual Reports

MARKET PLACE

9 APIs, 1 FDF Dossiers

marketPlace
9 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

14 US Patents, 42 US Exclusivities

patents
14 US Patents
42 US Exclusivities

Isavuconazonium Sulfate

Synopsis

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 946075-13-4, Cresemba, Isavuconazonium (sulfate), Bal-8557-002, Isavuconazonium sulfate [usan], Chebi:85977

Molecular Formula

C₃₅H₃₆F₂N₈O₉S₂

Molecular Weight

814.8 g/mol

InChI Key

LWXUIUUOMSMZKJ-KLFWAVJMSA-M

FDA UNII

31Q44514JV

Isavuconazonium Sulfate is the sulfate ester form of isavuconazonium, a prodrug of the triazole antifungal agent isavuconazole, with broad-spectrum antifungal activity. Upon administration, isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), which catalyzes the demethylation of lanosterol to yield ergosterol, an important component of the fungal cell membrane. Inhibition of CYP51 leads to a decrease in fungal ergosterol production and disrupts synthesis of the fungal cell membrane, which decreases membrane integrity, increases cell membrane permeability and promotes the loss of essential intracellular elements. This results in fungal cell lysis and death.

1 2D Structure

Isavuconazonium Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[2-[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1,2,4-triazol-4-ium-4-yl]ethoxycarbonyl-methylamino]pyridin-3-yl]methyl 2-(methylamino)acetate;hydrogen sulfate

2.1.2 InChI

InChI=1S/C35H35F2N8O5S.H2O4S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3;1-5(2,3)4/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3;(H2,1,2,3,4)/q+1;/p-1/t22-,23?,35+;/m0./s1

2.1.3 InChI Key

LWXUIUUOMSMZKJ-KLFWAVJMSA-M

2.1.4 Canonical SMILES

CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O.OS(=O)(=O)[O-]

2.1.5 Isomeric SMILES

C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O.OS(=O)(=O)[O-]

2.2 Other Identifiers

2.2.1 UNII

31Q44514JV

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-((2r,3r)-3-(4-(4-cyanophenyl)-1,3-thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-((1rs)-1-((methyl(3-((((methylamino)acetyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1h-1,2,4-triazol-4-ium Monosulfate

2. 4-(2-((2r,3r)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1h-1,2,4-triazol-1-yl)butan-2-yl)-1,3-thiazol-4-yl)benzonitrile

3. Ak-1820

4. Ak1820

5. Bal 4815

6. Bal 8557

7. Bal-4815

8. Bal-8557

9. Bal-8557-002

10. Bal4815

11. Bal8557

12. Bal8557-002

13. Cresemba

14. Isavuconazole

2.3.2 Depositor-Supplied Synonyms

1. 946075-13-4

2. Cresemba

3. Isavuconazonium (sulfate)

4. Bal-8557-002

5. Isavuconazonium Sulfate [usan]

6. Chebi:85977

7. Ak1820

8. 31q44514jv

9. Ak-1820

10. Bal8557-002

11. [2-[1-[1-[(2r,3r)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1,2,4-triazol-4-ium-4-yl]ethoxycarbonyl-methylamino]pyridin-3-yl]methyl 2-(methylamino)acetate;hydrogen Sulfate

12. 1-((2r,3r)-3-(4-(4-cyanophenyl)-1,3-thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-((1rs)-1-((methyl(3-((((methylamino)acetyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1h-1,2,4-triazol-4-ium Monosulfate

13. Glycine, N-methyl-, (2-(((1-(1-((2r,3r)-3-(4-(4-cyanophenyl)-2-thiazolyl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4h-1,2,4-triazolium-4-yl)ethoxy)carbonyl)methylamino)-3-pyridinyl)methyl Ester, Sulfate (1:1)

14. Isavuconazonium Sulfate (usan)

15. 1-((2r,3r)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1h-1,2,4-triazol-4-ium Hydrogen Sulfate

16. Unii-31q44514jv

17. Chembl3137333

18. Dtxsid901026216

19. Ex-a1786

20. Isavuconazonium Sulfate [jan]

21. Akos030527357

22. Isavuconazonium Sulfate [who-dd]

23. Ac-31126

24. As-35043

25. Hy-100373

26. Cs-0018702

27. Isavuconazonium Sulfate [orange Book]

28. D10643

29. A900138

30. Q27158829

31. (2-{[(1-{1-[(2r,3r)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1h-1,2,4-triazol-4-ium-4-yl}ethoxy)carbonyl](methyl)amino}pyridin-3-yl)methyl N-methylglycinate Hydrogen Sulfate

2.4 Create Date

2013-12-16

3 Chemical and Physical Properties

Molecular Formula	C₃₅H₃₆F₂N₈O₉S₂
Molecular Weight	814.8 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	15
Exact Mass	814.20147343 g/mol
Monoisotopic Mass	814.20147343 g/mol
Topological Polar Surface Area	273 Å²
Heavy Atom Count	56
Formal Charge	0
Complexity	1290
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Treatment of invasive aspergillosis, Treatment of mucormycosis

Treatment of Candida infections

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Azoles [CS]; Cytochrome P450 3A4 Inhibitors [MoA]; Organic Cation Transporter 2 Inhibitors [MoA]; P-Glycoprotein Inhibitors [MoA]; Azole Antifungal [EPC]

API SUPPLIERS

01

Transo-Pharm USA LLC

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #4B17

TransoPharm USA works in the Sourcing and Management of Active Pharmaceutical Ingredients.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Virupaksha Organics

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #3A97

With Virupaksha, you get a quality product with on-time delivery.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

03

Polpharma

Poland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #24A11

Polpharma is a Polish CDMO of APIs and a significant European API producer, delivering products to companies worldwide.

Contact Supplier

Poland

Virtual Booth

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC KDMF VMF ASMF

AUDIT

04

ChemWerth Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #1D3

ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

05

Biophore India Pharmaceuticals Pvt...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #24A31

Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC

KDMF VMF Others AUDIT

06

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Attending

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

07

Metrochem API Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #3A33

Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC

KDMF VMF Others AUDIT

08

CF Pharma

Hungary

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #2C108

CF Pharma- skilled & highly experienced European API producer based in Hungary.

Contact Supplier

Hungary

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

09

Shanghai Minbiotech

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Attending

Shanghai Minbiotech is the leading producer of biopharmaceuticals and a variety of high-end generic & innovative drugs.

Contact Supplier

China

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Corporate PDF

10

Porton Pharma Solutions

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Booth #5C17

Porton Pharma Solutions: Value creation via innovation & discovery through technical platforms.

Contact Supplier

China

Virtual Booth

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Only 10 entries up to this point, click to access all

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

KDMF

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

NDC API

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

API Reference Price

[{"dataSource":"API Export","activeIngredients":"ISAVUCONAZONIUM SULFATE","year":"2021","qtr":"Q2","strtotime":1621276200,"product":"ISAVUCONAZONIUM SULFATE","address":"FLAT NO.302, BHANU ENCLAVESUNDER NAGAR ,ERRAGADDA","city":"HYDERABAD.AP","supplier":"METROCHEM API PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"BARCELONA","customer":"REIG JOFRE","customerCountry":"SPAIN","quantity":"2.20","actualQuantity":"2200","unit":"GMS","unitRateFc":"40.1","totalValueFC":"86837.6","currency":"USD","unitRateINR":2891.2722727272726,"date":"18-May-2021","totalValueINR":"6360799","totalValueInUsd":"86837.6","indian_port":"HYDERABAD AIR","hs_no":"29335990","bill_no":"1847444","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"FLAT NO.302, BHANU ENCLAVESUNDER NAGAR ,ERRAGADDA, HYDERABAD.AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705689000,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS (API)EXPORT INVOICE NUMBER : F32418003898 DT. 22.12.2023: ISAVUCONAZONIUM SULFATE","address":"PLOT 170-172, CHANDRAMOULI,INDUSTR","city":"SOLAPUR,MAHARASHTRA","supplier":"GLENMARK PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"YELGRAD (BEOGRAD)","customer":"TO THE ORDER..","customerCountry":"SERBIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"18000","totalValueFC":"71042","currency":"USD","unitRateINR":1476106.25,"date":"20-Jan-2024","totalValueINR":"5904425","totalValueInUsd":"71042","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"6888884","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SERBIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT 170-172, CHANDRAMOULI,INDUSTR, SOLAPUR,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717698600,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS (API)EXPORT INVOICE NUMBER : F32518000754 DT. 30.05.2024 ISAVUCONAZONIUM SULFATE","address":"PLOT 170-172, CHANDRAMOULI,INDUSTR","city":"SOLAPUR,MAHARASHTRA","supplier":"GLENMARK PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"YELGRAD (BEOGRAD)","customer":"TO THE ORDER","customerCountry":"SERBIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"18000","totalValueFC":"70975.2","currency":"USD","unitRateINR":1481242.26,"date":"07-Jun-2024","totalValueINR":"5924969.04","totalValueInUsd":"70975.2","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"1496406","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SERBIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT 170-172, CHANDRAMOULI,INDUSTR, SOLAPUR,MAHARASHTRA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1644345000,"product":"5 GRAM API (ISAVUCONAZONIUM SULFATE) , TL NO. TL\/NZ\/22\/000016,","address":"B-310, SOM DATT CHAMBERS, 1,,BHIKA JI CAMA PLACE,","city":"NEW DELHI,DELHI","supplier":"POLPHARMA","supplierCountry":"POLAND","foreign_port":"NA","customer":"FRESENIUS SE & CO. KGAA","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"38","totalValueFC":"386.6","currency":"EUR","unitRateINR":"5795.3","date":"09-Feb-2022","totalValueINR":"28976.46","totalValueInUsd":"386.6","indian_port":"DELHI AIR","hs_no":"29341000","bill_no":"7419625","productDescription":"API","marketType":"REGULATED MARKET","country":"POLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"B-310, SOM DATT CHAMBERS, 1,,BHIKA JI CAMA PLACE,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

Upgrade, download data, analyse, strategize, subscribe with us contact

Drugs in Development

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

INTERMEDIATES SUPPLIERS

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDF Dossiers

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDA Orange Book

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Europe

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Dossiers

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

DRUG PRODUCT COMPOSITIONS

Do you need Business Intel? Ask us

DOSAGE - CAPSULE;ORAL - 186MG

USFDA APPLICATION NUMBER - 207500

DOSAGE - CAPSULE;ORAL - 74.5MG

USFDA APPLICATION NUMBER - 207500

DOSAGE - POWDER;INTRAVENOUS - 372MG

USFDA APPLICATION NUMBER - 207501

Digital Content

Create Content with PharmaCompass, ask us

DATA COMPILATION #PharmaFlow

NEWS #PharmaBuzz

Global Sales Information

Do you need Business Intel? Ask us

Finished Drug Prices

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Annual Reports

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Market Place

Do you need sourcing support? Ask us

APIs

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDF DOSSIERS

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Patents & EXCLUSIVITIES

Check the patents & exclusivity for this product

US Patents

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

US Exclusivities

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

ABOUT THIS PAGE

Find Radio Compass News for Isavuconazonium Sulfate

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

33 API Suppliers

10 USDMF

1 KDMF

7 NDC API

27 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

20 Drugs in Development

INTERMEDIATES

26 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

12 FDF Dossiers

3 FDA Orange Book

8 Europe

1 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - 186MG

CAPSULE;ORAL - 74.5MG

POWDER;INTRAVENOUS - 372MG

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow

29 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

6 Finished Drug Prices

8 Annual Reports

MARKET PLACE

9 APIs

1 FDF Dossiers

PATENTS & EXCLUSIVITIES

14 US Patents

42 US Exclusivities

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 24,093

MARKET PLACE

FINISHED DOSAGE FORMULATIONS

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

01

02

03

04

05

06

07

08

09

10

Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

What are you looking for?