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    Chemistry

    Click the arrow to open the dropdown
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    Also known as: 87-33-2, Isordil, Sorbide nitrate, Sorbidnitrate, Nitrosorbide, Sorbitrate
    Molecular Formula
    C6H8N2O8
    Molecular Weight
    236.14  g/mol
    InChI Key
    MOYKHGMNXAOIAT-JGWLITMVSA-N
    FDA UNII
    IA7306519N
    Isosorbide Dinitrate
    A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
    Isosorbide dinitrate is a Nitrate Vasodilator. The physiologic effect of isosorbide dinitrate is by means of Vasodilation.
    1 2D Structure

    Isosorbide Dinitrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(3S,3aS,6R,6aS)-3-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate
    2.1.2 InChI
    InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1
    2.1.3 InChI Key
    MOYKHGMNXAOIAT-JGWLITMVSA-N
    2.1.4 Canonical SMILES
    C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O[N+](=O)[O-]
    2.1.5 Isomeric SMILES
    C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O[N+](=O)[O-])O[N+](=O)[O-]
    2.2 Other Identifiers
    2.2.1 UNII
    IA7306519N
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cardonit 40

    2. Dilatrate

    3. Dinitrate, Isosorbide

    4. Iso Bid

    5. Iso-bid

    6. Isobid

    7. Isodinit

    8. Isoket

    9. Isoket Retard 120

    10. Isoket Retard-120

    11. Isoket Retard120

    12. Isomak R

    13. Isordil

    14. Isotrate

    15. Nitrosorbide

    16. Sorbitrate

    17. Sorbonit

    2.3.2 Depositor-Supplied Synonyms

    1. 87-33-2

    2. Isordil

    3. Sorbide Nitrate

    4. Sorbidnitrate

    5. Nitrosorbide

    6. Sorbitrate

    7. Dinitrosorbide

    8. Isoket

    9. Dilatrate-sr

    10. Sorbidilat

    11. Vascardin

    12. Carvasin

    13. Flindix

    14. Isorbid

    15. Isotrate

    16. Sorbonit

    17. Cardis

    18. Isdn

    19. Carvanil

    20. Cedocard

    21. Claodical

    22. Cornilat

    23. Corosorbide

    24. Difutrat

    25. Dilatrate

    26. Harrical

    27. Iso-bid

    28. Myorexon

    29. Nitrosorbid

    30. Nitrosorbon

    31. Resoidan

    32. Sorbangil

    33. Sorbislo

    34. Vasodilat

    35. Vasorbate

    36. Coronex

    37. Emoper

    38. Korodil

    39. Lomilan

    40. Maycor

    41. Rigedal

    42. Sorquad

    43. Tinidil

    44. Nosim

    45. Xanyl

    46. Sorbide, Dinitrate

    47. Isordil Tembids

    48. Rifloc Retard

    49. Dinitroisosorbide

    50. Cardio 10

    51. Dianhydrosorbitol 2,5-dinitrate

    52. D-isosorbide Dinitrate

    53. Isosorbide 2,5-dinitrate

    54. Isodinit

    55. Isostat

    56. Ibd 20

    57. Isosorbidi Dinitras

    58. Sorbide T.d.

    59. Dinitrate D'isosorbide

    60. Dinitrato De Isosorbida

    61. Astridine

    62. Isochron

    63. D-glucitol, 1,4:3,6-dianhydro-, Dinitrate

    64. Sorbidinitrate

    65. Corovliss

    66. Disorlon

    67. Langoran

    68. Sorbide

    69. Sorquat

    70. 1,4:3,6-dianhydrosorbitol 2,5-dinitrate

    71. Iso-puren

    72. 1,4:3,6-dianhydro-d-glucitol Dinitrate

    73. Sorate-5

    74. Sorate-10

    75. Isomannide-dinitrate

    76. C01da08

    77. Nsc-80038

    78. Isomak R

    79. Cardonit 40

    80. Chebi:6061

    81. Sst-101

    82. Dignionitrat

    83. Angidil

    84. Diniket

    85. Frandol

    86. Laserdil

    87. Sorbidi Nitras

    88. Eurecor

    89. Dilatrate Sr

    90. (3r,3as,6s,6as)-6-(nitrooxy)-hexahydrofuro[3,2-b]furan-3-yl Nitrate

    91. Isomannide Dinitrate

    92. Isosorbidi Nitras

    93. Nsc80038

    94. Iso-mack

    95. D-isosorbide Dinitrate-lactose Mixture

    96. Ia7306519n

    97. Isoket Retard 40

    98. Isd

    99. Isoket Retard 120

    100. Dsstox_cid_25832

    101. Dsstox_rid_81160

    102. Dsstox_gsid_45832

    103. Isosorbide Dinitrato

    104. Isosorbide Dinitrato [dcit]

    105. Glucitol, 1,4:3,6-dianhydro-, Dinitrate, D-

    106. Cedocard Retard

    107. Isosorbidi Dinitras [inn-latin]

    108. Tyb 3215

    109. Diluted Isosorbide Dinitrate

    110. Dinitrate D'isosorbide [inn-french]

    111. Sdm No. 40

    112. Sdm No. 50

    113. Smr000857256

    114. Isordil (tn)

    115. Dinitrato De Isosorbida [inn-spanish]

    116. Dilatrate-sr (tn)

    117. Ccris 1910

    118. Hsdb 3417

    119. Sr-05000001658

    120. Einecs 201-740-9

    121. Nsc 80038

    122. Un2907

    123. (3r,3as,6s,6as)-hexahydrofuro[3,2-b]furan-3,6-diyl Dinitrate

    124. Unii-ia7306519n

    125. Cas-87-33-2

    126. Prestwick_81

    127. 1,4:3,6-dianhydro-2,5-di-o-nitro-d-glucitol

    128. Ncgc00094703-01

    129. Isosorbide-dinitrate

    130. [(3s,3as,6r,6as)-3-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] Nitrate

    131. 1246815-45-1

    132. Spectrum_000163

    133. 1,4:3, 6-dianhydro-d-glucitol Dinitrate

    134. Prestwick0_000714

    135. Prestwick1_000714

    136. Prestwick2_000714

    137. Prestwick3_000714

    138. Spectrum2_001069

    139. Spectrum3_000600

    140. Spectrum4_000025

    141. Spectrum5_001057

    142. 1,4:3,6-dianhydrosorbitol 2, 5-dinitrate

    143. Isosorbide Dinitrate,(s)

    144. Isosorbidi Dinitras Dilutes

    145. Isosorbidi Dinitras Dilutus

    146. Diluted-isosorbide Dinitrate

    147. Ec 201-740-9

    148. Isosorbide Dinitrate [usan:usp:inn:ban:jan]

    149. Schembl8253

    150. Chembl6622

    151. Bspbio_000927

    152. Bspbio_002080

    153. Isosorbide Dinitrate, Diluted

    154. Kbiogr_000429

    155. Kbioss_000643

    156. Mls001333561

    157. Mls001333562

    158. Divk1c_000436

    159. Spectrum1500358

    160. Isosorbide Dinitrate, Diluted-

    161. Spbio_001058

    162. Spbio_002848

    163. Diluted Isosorbide Dinitrate Rs

    164. Bpbio1_001021

    165. Gtpl7051

    166. Dtxsid0045832

    167. Hms501f18

    168. Kbio1_000436

    169. Kbio2_000643

    170. Kbio2_003211

    171. Kbio2_005779

    172. Kbio3_001580

    173. Isosorbide Dinitrate [mi]

    174. Ninds_000436

    175. Hms1570o09

    176. Hms1920h15

    177. Hms2091p05

    178. Hms2097o09

    179. Hms2230c09

    180. Hms3714o09

    181. Isosorbide Dinitrate [inn]

    182. Isosorbide Dinitrate [jan]

    183. Pharmakon1600-01500358

    184. Isosorbide Dinitrate [hsdb]

    185. Isosorbide Dinitrate [usan]

    186. Hy-b1409

    187. 1,6-dianhydro-d-glucitol Dinitrate

    188. Isosorbide Dinitrate [vandf]

    189. Tox21_111317

    190. Ccg-40110

    191. Isosorbide Dinitrate [mart.]

    192. Mfcd00868238

    193. Nsc757080

    194. Zinc18089317

    195. 1,6-dianhydrosorbitol 2,5-dinitrate

    196. Isosorbide Dinitrate [who-dd]

    197. Akos015895227

    198. Akos015960761

    199. Akos015994784

    200. Tox21_111317_1

    201. Db00883

    202. Gs-6631

    203. Isosorbide Dinitrate (jp17/usp/inn)

    204. Nsc-757080

    205. Idi1_000436

    206. Ncgc00178830-01

    207. Ncgc00178830-02

    208. Ncgc00178830-05

    209. Ac-12153

    210. D-glucitol,4:3,6-dianhydro-, Dinitrate

    211. Isosorbide Dinitrate [orange Book]

    212. Bidil Component Isosorbide Dinitrate

    213. Isosorbide Dinitrate [usp Impurity]

    214. Sbi-0051421.p003

    215. Ab00513900

    216. Cs-0013129

    217. Diluted-isosorbide Dinitrate [who-ip]

    218. Glucitol,4:3,6-dianhydro-, Dinitrate, D-

    219. Isosorbide Dinitrate Component Of Bidil

    220. C07456

    221. D00516

    222. H10018

    223. Ab00052026_07

    224. Glucitol, 1,4:3, 6-dianhydro-, Dinitrate, D-

    225. Isosorbidi Dinitras Dilutus [who-ip Latin]

    226. Q179748

    227. 3,6-dianhydro-d-glucitol Dinitrate ; Dilatrate-sr

    228. Sr-05000001658-1

    229. Sr-05000001658-3

    230. Sr-05000001658-5

    231. W-104033

    232. Z2433066075

    233. Isosorbide Mononitrate, Diluted Impurity B [ep Impurity]

    234. (3s,3as,6r,6as)-6-(nitrooxy)-hexahydrofuro[3,2-b]furan-3-yl Nitrate

    235. [(3r,3as,6s,6as)-3-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] Nitrate

    236. [(3s,3as,6r,6as)-6-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl] Nitrate

    237. 54650-95-2

    238. Isosorbide Dinitrate Mixture With Not <60% Lactose, Mannose, Starch Or Calcium Hydrogen Phosphate

    239. Isosorbide Dinitrate Mixture With Not <60% Lactose, Mannose, Starch Or Calcium Hydrogen Phosphate [un2907] [flammable Solid]

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 236.14 g/mol
    Molecular Formula C6H8N2O8
    XLogP31.3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count2
    Exact Mass236.02806522 g/mol
    Monoisotopic Mass236.02806522 g/mol
    Topological Polar Surface Area129 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity268
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 8  
    Drug NameBidil
    PubMed HealthIsosorbide Dinitrate (By mouth)
    Drug ClassesAntianginal, Coronary Vasodilator
    Active IngredientHydralazine hydrochloride; isosorbide dinitrate
    Dosage FormTablet
    RouteOral
    Strength37.5mg; 20mg
    Market StatusPrescription
    CompanyArbor Pharms

    2 of 8  
    Drug NameDilatrate-sr
    PubMed HealthIsosorbide Dinitrate (By mouth)
    Drug ClassesAntianginal, Coronary Vasodilator
    Drug LabelIsosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5 dinitrate, an organic nitrate whose structural formula isand whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins. Each dilatrate-...
    Active IngredientIsosorbide dinitrate
    Dosage FormCapsule, extended release
    RouteOral
    Strength40mg
    Market StatusPrescription
    CompanyAuxilium Pharms

    3 of 8  
    Drug NameIsordil
    Drug LabelIsosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5-dinitrate, an organic nitrate whose structural formula isand whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins.Isosorbide dinitra...
    Active IngredientIsosorbide dinitrate
    Dosage FormTablet
    RouteOral
    Strength30mg; 5mg; 10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyValeant Bermuda

    4 of 8  
    Drug NameIsosorbide dinitrate
    Drug LabelIsosorbide dinitrate, an organic nitrate, is a vasodilator with effects on both arteries and veins. The chemical name for isosorbide dinitrate is 1,4:3,6-dianhydro-D-glucitol dinitrate and the compound has the following structural formula:C6H8N2O8 M....
    Active IngredientIsosorbide dinitrate
    Dosage FormTablet, extended release; Tablet
    RouteOral
    Strength30mg; 5mg; 10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyCorepharma; Hikma Intl Pharms; Sun Pharm Inds; Sandoz; Par Pharm

    5 of 8  
    Drug NameBidil
    PubMed HealthIsosorbide Dinitrate (By mouth)
    Drug ClassesAntianginal, Coronary Vasodilator
    Active IngredientHydralazine hydrochloride; isosorbide dinitrate
    Dosage FormTablet
    RouteOral
    Strength37.5mg; 20mg
    Market StatusPrescription
    CompanyArbor Pharms

    6 of 8  
    Drug NameDilatrate-sr
    PubMed HealthIsosorbide Dinitrate (By mouth)
    Drug ClassesAntianginal, Coronary Vasodilator
    Drug LabelIsosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5 dinitrate, an organic nitrate whose structural formula isand whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins. Each dilatrate-...
    Active IngredientIsosorbide dinitrate
    Dosage FormCapsule, extended release
    RouteOral
    Strength40mg
    Market StatusPrescription
    CompanyAuxilium Pharms

    7 of 8  
    Drug NameIsordil
    Drug LabelIsosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5-dinitrate, an organic nitrate whose structural formula isand whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins.Isosorbide dinitra...
    Active IngredientIsosorbide dinitrate
    Dosage FormTablet
    RouteOral
    Strength30mg; 5mg; 10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyValeant Bermuda

    8 of 8  
    Drug NameIsosorbide dinitrate
    Drug LabelIsosorbide dinitrate, an organic nitrate, is a vasodilator with effects on both arteries and veins. The chemical name for isosorbide dinitrate is 1,4:3,6-dianhydro-D-glucitol dinitrate and the compound has the following structural formula:C6H8N2O8 M....
    Active IngredientIsosorbide dinitrate
    Dosage FormTablet, extended release; Tablet
    RouteOral
    Strength30mg; 5mg; 10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyCorepharma; Hikma Intl Pharms; Sun Pharm Inds; Sandoz; Par Pharm

    4.2 Therapeutic Uses

    Vasodilator Agents

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    In a limited number of patients with diffuse esophageal spasm without gastroesophageal reflux, isosorbide dinitrate has been used effectively to relieve pain, dysphagia and spasm.

    McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1880

    Isosorbide dinitrate (in combination with cardiac glycosides and diuretics or with hydralazine) has been used effectively for the treatment of congestive heart failure or other low cardiac output states.

    McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1880

    ...Isosorbide dinitrate shares the actions of the other nitrates and nitrites. The drug is used for the acute relief of angina pectoris, for prophylactic management in situations likely to provoke angina attacks, and for long term prophylactic management of angina pectoris.

    McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1880

    For more Therapeutic Uses (Complete) data for ISOSORBIDE DINITRATE (9 total), please visit the HSDB record page.

    4.3 Drug Warning

    ...Should be given cautiously in pt with glaucoma.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 788

    Dependence and tolerance may occur during chronic use... These possible consequences, as well as large individual variations in clinical response indicates that long-term therapy with high-dose isosorbide dinitrate requires considerable caution.

    Miller, R. R., and D. J. Greenblatt. Handbook of Drug Therapy. New York: Elsevier North Holland, 1979., p. 321

    Drug rash is occasionally produced by all organic nitrates... /organic nitrates/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 850

    Most frequent complaint by users...is headache ... also paradoxical increase in anginal pain. Mild gastrointestinal disturbances as well as vertigo and other signs of orthostatic hypotension may occur.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 788

    For more Drug Warnings (Complete) data for ISOSORBIDE DINITRATE (10 total), please visit the HSDB record page.

    4.4 Drug Indication

    For the prevention of angina pectoris due to coronary artery disease.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.

    5.2 MeSH Pharmacological Classification

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    Nitric Oxide Donors

    A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81) (See all compounds classified as Nitric Oxide Donors.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    ISOSORBIDE DINITRATE
    5.3.2 FDA UNII
    IA7306519N
    5.3.3 Pharmacological Classes
    Nitrates [CS]; Vasodilation [PE]; Nitrate Vasodilator [EPC]
    5.4 ATC Code

    C01DA08

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    C - Cardiovascular system

    C01 - Cardiac therapy

    C01D - Vasodilators used in cardiac diseases

    C01DA - Organic nitrates

    C01DA08 - Isosorbide dinitrate

    C - Cardiovascular system

    C05 - Vasoprotectives

    C05A - Agents for treatment of hemorrhoids and anal fissures for topical use

    C05AE - Muscle relaxants

    C05AE02 - Isosorbide dinitrate

    5.5 Absorption, Distribution and Excretion

    Absorption

    Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.

    Volume of Distribution

    2 to 4 L/kg

    After sublingual admin, onset of effect is 2-3 min & offset of effect is about 2 hr.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 788

    Following sublingual doses of 5 mg, oral conventional tablets of 5 mg, and oral sustained-release tablets of 20 mg, mean peak isosorbide dinitrate levels of 8.9, 3.1, and 1.4 ng/ml, occurred at 30, 40, and 40 min respectively. Plasma levels...after sustained-release dosage...maintained above half of mean peak level for 10 hours.

    The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 5: A Review of the Literature Published during 1976 and 1977. London: The Chemical Society, 1979., p. 40

    Chronic oral administration of isosorbide dinitrate (120 to 720 mg daily) has resulted in persistence of parent compound and higher concentration of metabolite in plasma.

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 852

    Since denitration markedly reduces activity of organic nitrates, their rapid clearance from blood indicates that transient duration of action under these conditions correlates with concentration of parent compounds. /organic nitrates/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 849

    For more Absorption, Distribution and Excretion (Complete) data for ISOSORBIDE DINITRATE (13 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    Hepatic

    After intravenous or oral admin, primary metabolite in plasma is 5-isosorbide mononitrate.

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 849

    Major route of metabolism of isosorbide dinitrate in man is also by enzymatic denitration followed by formation of glucuronides.

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 849

    Biotransformation of organic nitrates is result of reductive hydrolysis catalyzed by hepatic enzyme glutathione-organic nitrate reductase. Enzyme converts lipid-soluble organic nitrate esters into more water-soluble denitrated metabolites & inorganic nitrite. /organic nitrates/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 848

    ...Biotransformation of isosorbide dinitrate in dogs and in man caused de-esterification. Isosorbide is major urinary metabolite, together with very small amount of the 2- and 5-mononitrates. /isosorbide dinitrate/ was absent from urine of dogs & man.

    The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 1: A Review of the Literature Published Between 1960 and 1969. London: The Chemical Society, 1970., p. 137

    For more Metabolism/Metabolites (Complete) data for ISOSORBIDE DINITRATE (8 total), please visit the HSDB record page.

    5.7 Biological Half-Life

    1 hour

    Half-life 0.7 hours (0.6-2.0; clearance may be decreased and half-life prolonged after chronic dosing.) /from table/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 1971

    The mean plasma elimination half-life of ISMN is approx 5 hr. /Isosorbide mononitrate/

    Medical Economics Co; Physicians Desk Reference 56th ed p.1827 (2002)

    After sublingual admin... biological half-life is about 8 hr... .

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 788

    Biological half-life is about 8 hr; after oral admin, onset is about 30 min & offset 4-6 hr.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 788

    5.8 Mechanism of Action

    Isosorbide dinitrate is converted to the active nitric oxide to activate guanylate cyclase. This activation increases levels of cyclic guanosine 3',5'-monophosphate (cGMP). cGMP activates protein kinases and causes a series of phosphorylation reactions which leads to dephosphorylation of myosin light chains of smooth muscle fibres. Finally there is a release of calcium ions which causes smooth muscle relaxation and vasodilation.

    ...Nitrates...are capable of activating guanylate cyclase and causing marked increase in concentration of cyclic guanosine 3',5'-monophosphate (cyclic GMP) in most tissues. This effect is apparently due to action of nitric oxide...nitric acid probably activates the enzyme directly. /organic nitrates/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 848

    Isosorbide dinitrate inhibited platelet aggregation with collagen, epinephrine, arachidonate, and ionophore, and blocked both primary and secondary aggregation in response to ADP.

    SCHAFER AI ET AL; BLOOD 55(4) 649 (1980)

    API SUPPLIERS

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    DOTTIKON EXCLUSIVE SYNTHESIS AG

    Switzerland

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    DOTTIKON EXCLUSIVE SYNTHESIS AG

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    DMF Review : N/A

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    Submission : 1976-05-07

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    Type : II

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    Registration Number : 217MF11278

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    NDC Package Code : 54864-106

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    Manufacturer Address : Hembrunnstrasse 17 CH-5605 Dottikon Switzerland

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    DMF Review : Reviewed

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    Submission : 1980-02-07

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    Type : Chemical

    Substance Number : 1117

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United States","customerAddress":"CENTAUR HOUSE, SHANTI NAGAR,"}]
    25-Jan-2021
    23-Aug-2024
    KGS
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    Average Price (USD/KGS)

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - 10MG **Federal Registe...DOSAGE - TABLET;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 12093

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    DOSAGE - TABLET;ORAL - 20MG **Federal Registe...DOSAGE - TABLET;ORAL - 20MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 12093

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    DOSAGE - TABLET;ORAL - 30MG **Federal Registe...DOSAGE - TABLET;ORAL - 30MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 12093

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    DOSAGE - TABLET;ORAL - 40MG

    USFDA APPLICATION NUMBER - 12093

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    DOSAGE - TABLET;ORAL - 5MG

    USFDA APPLICATION NUMBER - 12093

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 40M...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 40MG

    USFDA APPLICATION NUMBER - 19790

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    DOSAGE - TABLET;ORAL - 37.5MG;20MG

    USFDA APPLICATION NUMBER - 20727

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