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Chemistry

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Also known as: 480-19-3, 3-methylquercetin, Isorhamnetol, Quercetin 3'-methyl ether, 3'-methoxyquercetin, 3'-o-methylquercetin
Molecular Formula
C16H12O7
Molecular Weight
316.26  g/mol
InChI Key
IZQSVPBOUDKVDZ-UHFFFAOYSA-N
FDA UNII
07X3IB4R4Z

Isorhamnetin
Isorhamnetin is a metabolite found in or produced by Saccharomyces cerevisiae.
1 2D Structure

Isorhamnetin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one
2.1.2 InChI
InChI=1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
2.1.3 InChI Key
IZQSVPBOUDKVDZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
2.2 Other Identifiers
2.2.1 UNII
07X3IB4R4Z
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3,4',5,7-tetrahydroxy-3'-methoxy-flavone

2. 3,4',5,7-tetrahydroxy-3'-methoxyflavone

3. 3-methyl-quercetin

4. 3-methylquercetin

5. 3-o-methylquercetin

6. Iso-rhamnetin

7. Isorhamnetine

2.3.2 Depositor-Supplied Synonyms

1. 480-19-3

2. 3-methylquercetin

3. Isorhamnetol

4. Quercetin 3'-methyl Ether

5. 3'-methoxyquercetin

6. 3'-o-methylquercetin

7. 3'-methoxy-3,4',5,7-tetrahydroxyflavone

8. 3'-methylquercetin

9. 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-chromen-4-one

10. C.i. 75680

11. 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one

12. 3,4',5,7-tetrahydroxy-3'-methoxyflavone

13. 3-methylquercetine

14. Flavone, 3'-methoxy-3,4',5,7-tetrahydroxy-

15. 4h-1-benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-

16. Flavone, 3,4',5,7-tetrahydroxy-3'-methoxy-

17. 3,5,7,4'-tetrahydroxy-3'-methoxyflavone

18. 07x3ib4r4z

19. Chebi:6052

20. Chembl379064

21. 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone

22. 4h-1-benzopyran-4-one, 2-(3-methoxy-4-hydroxyphenyl)-3,5,7-trihydroxy-

23. Mfcd00017310

24. Isorhamnetine

25. 3,5,7-trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-one

26. Ccris 3791

27. 3'-o-methyl Quercetin

28. Sr-05000002256

29. Einecs 207-545-5

30. Brn 0044723

31. Unii-07x3ib4r4z

32. Isorhanetin,(s)

33. Irh

34. 3,4',5,7-tetrahydroxy-3'-methoxy-flavone

35. 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-1-benzopyran-4-one

36. Quercetin-3'-methyl Ether

37. Isorhamnetin [inci]

38. Oprea1_145406

39. Schembl19235

40. Isorhamnetin [usp-rs]

41. Megxp0_001863

42. Methylquercetin, 3'-o-

43. Acon1_000275

44. Bdbm23409

45. Isorhamnetin, Analytical Standard

46. Dtxsid10197379

47. Zinc517261

48. 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxy-phenyl)chromen-4-one

49. Bcp11534

50. Ex-a6804

51. Hy-n0776

52. Isorhamnetin, >=95.0% (hplc)

53. Lmpk12110002

54. S9111

55. Akos015905141

56. Ccg-208422

57. Ccg-208453

58. Cs-5945

59. Ncgc00163572-01

60. Ncgc00163572-02

61. Ncgc00163572-03

62. Ncgc00180719-01

63. Ac-20263

64. As-71136

65. Db-051498

66. Ft-0603409

67. I1068

68. N1358

69. 3'-methoxy-4',5,7-trihydroxyflavonol

70. 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)

71. 480i193

72. Isorhamnetin (constituent Of Ginkgo) [dsc]

73. Q416138

74. Q-100518

75. Sr-05000002256-2

76. Sr-05000002256-3

77. Brd-k83977206-001-01-4

78. Isorhamnetin, Primary Pharmaceutical Reference Standard

79. Isorhamnetin, United States Pharmacopeia (usp) Reference Standard

80. 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-benzopyran-4-one

81. 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-chromen-4-one #

2.4 Create Date
2005-03-28
3 Chemical and Physical Properties
Molecular Weight 316.26 g/mol
Molecular Formula C16H12O7
XLogP31.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass316.05830272 g/mol
Monoisotopic Mass316.05830272 g/mol
Topological Polar Surface Area116 Ų
Heavy Atom Count23
Formal Charge0
Complexity503
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Metabolism/Metabolites

Isorhamnetin has known human metabolites that include (2S,3S,4S,5R)-6-[5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


REF. STANDARDS & IMPURITIES

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Isorhamnetin Manufacturers

A Isorhamnetin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Isorhamnetin, including repackagers and relabelers. The FDA regulates Isorhamnetin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Isorhamnetin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Isorhamnetin Suppliers

A Isorhamnetin supplier is an individual or a company that provides Isorhamnetin active pharmaceutical ingredient (API) or Isorhamnetin finished formulations upon request. The Isorhamnetin suppliers may include Isorhamnetin API manufacturers, exporters, distributors and traders.

Isorhamnetin GMP

Isorhamnetin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Isorhamnetin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Isorhamnetin GMP manufacturer or Isorhamnetin GMP API supplier for your needs.

Isorhamnetin CoA

A Isorhamnetin CoA (Certificate of Analysis) is a formal document that attests to Isorhamnetin's compliance with Isorhamnetin specifications and serves as a tool for batch-level quality control.

Isorhamnetin CoA mostly includes findings from lab analyses of a specific batch. For each Isorhamnetin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Isorhamnetin may be tested according to a variety of international standards, such as European Pharmacopoeia (Isorhamnetin EP), Isorhamnetin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Isorhamnetin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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