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Also known as: 579-56-6, Duvadilan, Isoxsuprine hcl, Isolait, Dilavase, 4-(1-hydroxy-2-((1-phenoxypropan-2-yl)amino)propyl)phenol hydrochloride
Molecular Formula
C18H24ClNO3
Molecular Weight
337.8  g/mol
InChI Key
QVPSGVSNYPRFAS-UHFFFAOYSA-N

Isoxsuprine Hydrochloride
A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
1 2D Structure

Isoxsuprine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol;hydrochloride
2.1.2 InChI
InChI=1S/C18H23NO3.ClH/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15;/h3-11,13-14,18-21H,12H2,1-2H3;1H
2.1.3 InChI Key
QVPSGVSNYPRFAS-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(COC1=CC=CC=C1)NC(C)C(C2=CC=C(C=C2)O)O.Cl
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Duvadilan

2. Hydrochloride, Isoxsuprine

3. Isoxsuprine

2.2.2 Depositor-Supplied Synonyms

1. 579-56-6

2. Duvadilan

3. Isoxsuprine Hcl

4. Isolait

5. Dilavase

6. 4-(1-hydroxy-2-((1-phenoxypropan-2-yl)amino)propyl)phenol Hydrochloride

7. Benzenemethanol,4-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-, Hydrochloride

8. Mls000028704

9. 579-56-6 (hcl)

10. Smr000058729

11. Vadosilan

12. Dsstox_cid_25328

13. Dsstox_rid_80806

14. Dsstox_gsid_45328

15. Duviculine

16. Navilox

17. 34331-89-0

18. Nsc-757067

19. Duvadilan (tn)

20. Prestwick_500

21. Opera_id_1429

22. Ncgc00016512-01

23. Cas-579-56-6

24. Mls001148084

25. Mls002695887

26. Schembl124661

27. Chembl559180

28. Dtxsid1045328

29. Chebi:31735

30. Hms1568m17

31. Hy-b1270

32. Tox21_110467

33. 4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol;hydrochloride

34. S5669

35. Akos030254697

36. Isoxsuprine Hydrochloride (jp17/usp)

37. Tox21_110467_1

38. Ccg-220068

39. Cs-8212

40. Nc00514

41. Ncgc00018295-05

42. Ncgc00094704-01

43. Ncgc00094704-02

44. Ncgc00094704-03

45. As-76145

46. Db-053134

47. Ft-0603478

48. Isoxsuprine Hydrochloride, Analytical Standard

49. D01748

50. D81952

51. Sr-01000000272

52. Sr-01000000272-2

53. Erythro-isoxsuprine Hydrochloride, Vetranal(tm), Analytical Standard

54. 4-(1-hydroxy-2-((1-phenoxypropan-2-yl)amino)propyl)phenolhydrochloride

55. 4-(1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl)phenol Hydrochloride

56. 5-methyl-2-phenyl-2,5-dihydro-1h-pyrazol-3-yl2-chloronicotinate

57. Isoxsuprine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

58. Isoxsuprine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.2.3 Other Synonyms

1. Dilavase

2. Vasodilian

3. Vasosurpine

4. Isoxuprine

2.3 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 337.8 g/mol
Molecular Formula C18H24ClNO3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass337.1444713 g/mol
Monoisotopic Mass337.1444713 g/mol
Topological Polar Surface Area61.7 Ų
Heavy Atom Count23
Formal Charge0
Complexity299
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count3
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Therapeutic Uses

Adrenergic beta-Agonists; Sympathomimetics; Tocolytic Agents; Vasodilator Agents

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


Isoxsuprine is also used for management of threatened premature labor in pregnancies of 20 or more weeks' gestation. Use in not recommended prior to the 20th week of pregnancy. For isoxsuprine to be most effective, it is recommended that therapy be started as soon as the diagnosis of preterm labor is confirmed. Efficacy in advanced labor has not been established. Use in patients with ruptured membranes must be weighed against the risk of intrauterine infection. /NOT included in US product labeling/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 23rd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2003. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc.


Isoxsuprine has been used in the treatment of dysmenorrhea. /NOT included in US product labeling/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 23rd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2003. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc.


FDA has classified isoxsuprine as being possibly effective for its labeled indications, which include relief of symptoms associated with cerebrovascular insufficiency and peripheral vascular disease, ie, arteriosclerosis obliterans, thromboangiitis obliterans (Buerger's disease), and Raynaud's disease. This classification requires the submission of adequate and well-controlled studies in order to provide substantial evidence of effectiveness. /Included in US product labeling/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 23rd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2003. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc.


For more Therapeutic Uses (Complete) data for ISOXSUPRINE HYDROCHLORIDE (7 total), please visit the HSDB record page.


4.2 Drug Warning

Except under special circumstances, this medication /isoxsuprine hydrochloride/ should not be used immediately postpartum or when the following medical problems exist: For use in management of premature labor only: Cardiac disorders, especially those associated with arrhythmias, or maternal hyperthyroidism (isoxsuprine may precipitate arrhythmias or heart failure; occult cardiac disease may be unmasked) or chorioamnionitis (intrauterine infection) or hemorrhage or intrauterine fetal death or known abnormality (immediate delivery required) or eclampsia (toxemia) and severe pre-eclampsia or pulmonary hypertension.

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 23rd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2003. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc.


Isoxsuprine has both beta-1 and beta-2 adrenergic activity. Maternal hypotension and tachycardia are common side effects. Hypocalcemia, hypoglycemia, hypotension, ileus, and neonatal death are increased after isoxsuprine administration.

Ellenhorn, M.J., S. Schonwald, G. Ordog, J. Wasserberger. Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams and Wilkins, 1997., p. 163


...When injected sc in human beings causes several mm of mercury transient elevation of ocular pressure, max in an hr or two, associated with edema and hyperemia of episcleral tissues.

Grant, W. M. Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, 1974., p. 612


Adverse effects of isoxsuprine include trembling, nervousness, weakness, dizziness, flushing, transient palpitation, tachycardia, chest pain, hypotension, abdominal distress, nausea, vomiting, intestinal distention, and severe rash.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2003. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2003 (Plus Supplements)., p. 1707


For more Drug Warnings (Complete) data for ISOXSUPRINE HYDROCHLORIDE (8 total), please visit the HSDB record page.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Tocolytic Agents

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Adrenergic beta-Agonists

Drugs that selectively bind to and activate beta-adrenergic receptors. (See all compounds classified as Adrenergic beta-Agonists.)


5.2 Absorption, Distribution and Excretion

Isoxsuprine hydrochloride is almost completely absorbed from the gastrointestinal tract. After oral admin of the drug, peak plasma concns occur within 1 hr and persist for about 3 hr. ...Isoxsurprine crosses the placenta. The drug is partially conjugated in the body and is excreted in the urine. Fecal excretion of the drug is negligible.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2003. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2003 (Plus Supplements)., p. 1707


5.3 Biological Half-Life

Mean plasma half-life of the drug is 1.25 hr.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2003. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2003 (Plus Supplements)., p. 1707


5.4 Mechanism of Action

Isoxsuprine produces peripheral vasodilation by a direct effect on vascular smooth muscle, primarily within skeletal muscle with little effect on cutaneous blood flow. Its effects were once thought to be due to beta-adrenergic receptor stimulation but are not reversed by beta-adrenergic blocking agents.

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 23rd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2003. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc.


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ORDER","customerCountry":"INDONESIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"1300","totalValueFC":"3844.8","currency":"USD","unitRateINR":105333.228,"date":"01-Jul-2023","totalValueINR":"315999.684","totalValueInUsd":"3844.8","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"KASHIMIRA, W.E.HIGHWAY, NEXT TO DODIA PETROL PUMP,, THANE ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698345000,"product":"ISOXSUPRINE HCL USP","address":"KASHIMIRA, W.E.HIGHWAY,","city":"THANE ,MAHARASHTRA","supplier":"JAYCO CHEMICAL INDUSTRIES","supplierCountry":"INDIA","foreign_port":"GUARULHOS","customer":"TO THE ORDER .","customerCountry":"BRAZIL","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"900","totalValueFC":"8903.1","currency":"USD","unitRateINR":74100,"date":"27-Oct-2023","totalValueINR":"741000","totalValueInUsd":"8903.1","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"4921138","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BRAZIL","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"KASHIMIRA, W.E.HIGHWAY,, THANE ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703269800,"product":"PHARMACEUTICAL RAW MATERIAL\/BULK DRUGS ISOXSUPRINE HCL USP","address":"309 HARIKRUPA TOWER NR.OLD-","city":"AHMEDABAD","supplier":"JAI RADHE SALES","supplierCountry":"INDIA","foreign_port":"ASUNCION","customer":"TO THE ORDER 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ORDER","customerCountry":"BRAZIL","quantity":"7.00","actualQuantity":"7","unit":"KGS","unitRateFc":"260","totalValueFC":"1797.7","currency":"USD","unitRateINR":21541,"date":"06-Aug-2024","totalValueINR":"150787","totalValueInUsd":"1797.7","indian_port":"Ahmedabad Air","hs_no":"29072990","bill_no":"3004638","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BRAZIL","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"814, `DEVPATH`, BESIDE LAL BUNGLOW,, C.G.ROAD\/ AHMEDABD\/GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725906600,"product":"LUT ARN NO: AD2703241874206 DT:27.03.2024 ISOXSUPRINE HCL USP MFG. 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DE C.V.*","customerCountry":"MEXICO","quantity":"18.00","actualQuantity":"18","unit":"KGS","unitRateFc":"350","totalValueFC":"5986.2","currency":"USD","unitRateINR":27944.444444444445,"date":"10-Oct-2024","totalValueINR":"503000","totalValueInUsd":"5986.2","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"4739692","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MEXICO","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"1,MASTER CHAMBER,, MUMBAI,MAHARASHTRA","customerAddress":""}]
16-Apr-2021
10-Oct-2024
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ABOUT THIS PAGE

Isoxsuprine Hydrochloride Manufacturers

A Isoxsuprine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Isoxsuprine Hydrochloride, including repackagers and relabelers. The FDA regulates Isoxsuprine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Isoxsuprine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Isoxsuprine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Isoxsuprine Hydrochloride Suppliers

A Isoxsuprine Hydrochloride supplier is an individual or a company that provides Isoxsuprine Hydrochloride active pharmaceutical ingredient (API) or Isoxsuprine Hydrochloride finished formulations upon request. The Isoxsuprine Hydrochloride suppliers may include Isoxsuprine Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Isoxsuprine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Isoxsuprine Hydrochloride USDMF

A Isoxsuprine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Isoxsuprine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Isoxsuprine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Isoxsuprine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Isoxsuprine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Isoxsuprine Hydrochloride USDMF includes data on Isoxsuprine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Isoxsuprine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Isoxsuprine Hydrochloride suppliers with USDMF on PharmaCompass.

Isoxsuprine Hydrochloride WC

A Isoxsuprine Hydrochloride written confirmation (Isoxsuprine Hydrochloride WC) is an official document issued by a regulatory agency to a Isoxsuprine Hydrochloride manufacturer, verifying that the manufacturing facility of a Isoxsuprine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Isoxsuprine Hydrochloride APIs or Isoxsuprine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Isoxsuprine Hydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Isoxsuprine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Isoxsuprine Hydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Isoxsuprine Hydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Isoxsuprine Hydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Isoxsuprine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Isoxsuprine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Isoxsuprine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Isoxsuprine Hydrochloride suppliers with NDC on PharmaCompass.

Isoxsuprine Hydrochloride GMP

Isoxsuprine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Isoxsuprine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Isoxsuprine Hydrochloride GMP manufacturer or Isoxsuprine Hydrochloride GMP API supplier for your needs.

Isoxsuprine Hydrochloride CoA

A Isoxsuprine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Isoxsuprine Hydrochloride's compliance with Isoxsuprine Hydrochloride specifications and serves as a tool for batch-level quality control.

Isoxsuprine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Isoxsuprine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Isoxsuprine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Isoxsuprine Hydrochloride EP), Isoxsuprine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Isoxsuprine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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