Find Istaroxime manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 203737-93-3, Istaroxime, (e)-, Pst-2744, W40687go3s, (3e,5s,8r,9s,10r,13s,14s)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione, 203738-46-9
Molecular Formula
C21H32N2O3
Molecular Weight
360.5  g/mol
InChI Key
MPYLDWFDPHRTEG-PAAYLBSLSA-N
FDA UNII
W40687GO3S

Istaroxime
1 2D Structure

Istaroxime

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione
2.1.2 InChI
InChI=1S/C21H32N2O3/c1-20-7-5-13(23-26-10-9-22)11-17(20)18(24)12-14-15-3-4-19(25)21(15,2)8-6-16(14)20/h14-17H,3-12,22H2,1-2H3/b23-13+/t14-,15-,16-,17+,20+,21-/m0/s1
2.1.3 InChI Key
MPYLDWFDPHRTEG-PAAYLBSLSA-N
2.1.4 Canonical SMILES
CC12CCC(=NOCCN)CC1C(=O)CC3C2CCC4(C3CCC4=O)C
2.1.5 Isomeric SMILES
C[C@]12CC/C(=N\OCCN)/C[C@@H]1C(=O)C[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C
2.2 Other Identifiers
2.2.1 UNII
W40687GO3S
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-((2-aminoethoxy)imino)androstane-6,17-dione

2. 3-((2-aminoethoxy)imino)androstane-6,17-dione Hydrochloride

3. Pst 2744

4. Pst-2744

5. Pst2744

2.3.2 Depositor-Supplied Synonyms

1. 203737-93-3

2. Istaroxime, (e)-

3. Pst-2744

4. W40687go3s

5. (3e,5s,8r,9s,10r,13s,14s)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione

6. 203738-46-9

7. 3-((2-aminoethoxy)imino)-5alpha-androstan-6,17-dione

8. Debio-0614

9. Istaroxime [inn]

10. Unii-w8i9h2tppl

11. Pst 2744

12. St-2744

13. W8i9h2tppl

14. Unii-w40687go3s

15. Chembl469045

16. Schembl7285904

17. Dtxsid20870222

18. Akos024259258

19. Cs-1531

20. Db06157

21. Ac-36855

22. As-78198

23. Hy-15718

24. 5-alpha-androstan-6,17-dione, 3-((2-aminoethoxy)imino)-

25. Androstane-3,6,17-trione, 3-(o-(2-aminoethyl)oxime), (3e,5alpha)-

26. Androstane-3,6,17-trione, 3-(o-(2-aminoethyl)oxime), (3e,5.alpha.)-

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 360.5 g/mol
Molecular Formula C21H32N2O3
XLogP31.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass360.24129289 g/mol
Monoisotopic Mass360.24129289 g/mol
Topological Polar Surface Area81.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity645
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in heart disease.


5 Pharmacology and Biochemistry
5.1 Mechanism of Action

Reduces the sodium-potassium adenosine triphosphatase (ATPase) activity and stimulates the sarcoplasmic calcium ATPase isoform 2 reuptake function.


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Looking for 203738-46-9 / Istaroxime API manufacturers, exporters & distributors?

Istaroxime manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Istaroxime API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Istaroxime manufacturer or Istaroxime supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Istaroxime manufacturer or Istaroxime supplier.

PharmaCompass also assists you with knowing the Istaroxime API Price utilized in the formulation of products. Istaroxime API Price is not always fixed or binding as the Istaroxime Price is obtained through a variety of data sources. The Istaroxime Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Istaroxime

Synonyms

203737-93-3, Istaroxime, (e)-, Pst-2744, W40687go3s, (3e,5s,8r,9s,10r,13s,14s)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione, 203738-46-9

Cas Number

203738-46-9

Unique Ingredient Identifier (UNII)

W40687GO3S

Istaroxime Manufacturers

A Istaroxime manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Istaroxime, including repackagers and relabelers. The FDA regulates Istaroxime manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Istaroxime API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Istaroxime Suppliers

A Istaroxime supplier is an individual or a company that provides Istaroxime active pharmaceutical ingredient (API) or Istaroxime finished formulations upon request. The Istaroxime suppliers may include Istaroxime API manufacturers, exporters, distributors and traders.

Istaroxime GMP

Istaroxime Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Istaroxime GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Istaroxime GMP manufacturer or Istaroxime GMP API supplier for your needs.

Istaroxime CoA

A Istaroxime CoA (Certificate of Analysis) is a formal document that attests to Istaroxime's compliance with Istaroxime specifications and serves as a tool for batch-level quality control.

Istaroxime CoA mostly includes findings from lab analyses of a specific batch. For each Istaroxime CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Istaroxime may be tested according to a variety of international standards, such as European Pharmacopoeia (Istaroxime EP), Istaroxime JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Istaroxime USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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