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Ivermectin

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ACTIVE PHARMA INGREDIENTS

34 API Suppliers, 7 USDMF, 10 CEP/COS, 3 JDMF, 20 NDC API, 10 VMF, 21 Listed Suppliers, $ API Reference Price

34 API Suppliers
7 USDMF
10 CEP/COS
3 JDMF
20 NDC API
10 VMF
21 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

22 Drugs in Development

22 Drugs in Development

FINISHED DOSAGE FORMULATIONS

72 FDF Dossiers, 11 FDA Orange Book, 9 Europe, 20 Canada, 2 Australia, 1 South Africa, 29 Listed Dossiers

72 FDF Dossiers
11 FDA Orange Book
9 Europe
20 Canada
2 Australia
1 South Africa
29 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

LOTION;TOPICAL - 0.5%, CREAM;TOPICAL - 1%

drugProductComposition
LOTION;TOPICAL - 0.5%
CREAM;TOPICAL - 1%

RELATED EXCIPIENT COMPANIES

5 SPI Pharma, 2 DKSH, 3 Faran Shimi Pharmaceutical, 10 Gangwal Healthcare, 4 Nanjing Well Pharmaceutical, 6 Actylis, 6 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 8 BASF, 1 Corel Pharma Chem, 3 DFE Pharma, 1 Finar, 8 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 5 Kerry, 1 Lubrizol Life Science Health, 9 Microlex e.U, 1 Nanjing Bold Chemical, 1 Pharmatrans-Sanaq, 4 Pluviaendo, 3 Prachin Chemical, 14 Roquette, 8 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 1 Valens Pharmachem, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

34 Fillers, Diluents & Binders, 23 Direct Compression, 19 Topical, 18 Thickeners and Stabilizers, 18 Disintegrants & Superdisintegrants, 16 Solubilizers, 12 Lubricants & Glidants, 12 Co-Processed Excipients, 11 Emulsifying Agents, 9 Parenteral, 9 Granulation, 6 Film Formers & Plasticizers, 6 Controlled & Modified Release, 5 Taste Masking, 5 Surfactant & Foaming Agents, 5 Chewable & Orodispersible Aids, 4 Coating Systems & Additives, 3 Rheology Modifiers, 2 API Stability Enhancers

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 75 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
75 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 11 Finished Drug Prices, 6 Annual Reports

globalSalesInformation
2 US Medicaid Prescriptions
11 Finished Drug Prices
6 Annual Reports

MARKET PLACE

50 APIs, 7 FDF Dossiers

marketPlace
50 APIs
7 FDF Dossiers

PATENTS & EXCLUSIVITIES

12 US Patents, 9 Health Canada Patents

patents
12 US Patents
9 Health Canada Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 1 Others

otherSolutions
1 EDQM
1 USP
1 Others

ANALYTICAL

1 BioAnalytical Methods

otherMethods
1 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 325

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

22DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

3,166,548

Annual Reports (USD Million)

2,073

Finished Drug Prices

124 RELATED EXCIPIENT COMPANIES

217EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Ivermectin, Dihydroavermectin b1a, 70288-86-7, 22,23-dihydroavermectin b1a, 70161-11-4, Ivermectin component b1a

Molecular Formula

C₄₈H₇₄O₁₄

Molecular Weight

875.1 g/mol

InChI Key

AZSNMRSAGSSBNP-XPNPUAGNSA-N

FDA UNII

91Y2202OUW

A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.

1 2D Structure

Ivermectin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-6'-[(2S)-butan-2-yl]-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one

2.1.2 InChI

InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

2.1.3 InChI Key

AZSNMRSAGSSBNP-XPNPUAGNSA-N

2.1.4 Canonical SMILES

CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C

2.1.5 Isomeric SMILES

CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C

2.2 Other Identifiers

2.2.1 UNII

91Y2202OUW

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Eqvalan

2. Ivermectin

3. Ivomec

4. Mectizan

5. Mk 933

6. Mk-933

7. Mk933

8. Stromectol

2.3.2 Depositor-Supplied Synonyms

1. Ivermectin

2. Dihydroavermectin B1a

3. 70288-86-7

4. 22,23-dihydroavermectin B1a

5. 70161-11-4

6. Ivermectin Component B1a

7. 71827-03-7

8. Avermectin H2b1a

9. 5-o-demethyl-22,23-dihydroavermectin A1a

10. Chebi:63941

11. 91y2202ouw

12. (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranosyl)-3-o-methyl-alpha-l-arabino-hexopyranoside

13. Mk-933

14. (1r,4s,5's,6r,6'r,8r,10e,12s,13s,14e,16e,20r,21r,24s)-6'-[(2s)-butan-2-yl]-21,24-dihydroxy-12-[(2r,4s,5s,6s)-5-[(2s,4s,5s,6s)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one

15. Ivermectin B1a-d2

16. C48h74o14

17. Unii-91y2202ouw

18. 22,23-dihydroavermectin B(1)a

19. Ncgc00163233-01

20. Ivermectin (ivm)

21. Ivm

22. Einecs 276-046-2

23. Dihydro Avermectin Bla

24. Brn 4643153

25. 22,23-dihydro-5-o-demethylavermectin A1a

26. H2b1a

27. Prestwick3_000156

28. Dsstox_cid_3181

29. Ivermectin (mk-0933)

30. Dsstox_rid_76909

31. Dsstox_gsid_23181

32. Bspbio_000292

33. Schembl312795

34. Bpbio1_000322

35. Chembl263291

36. Dtxsid8023181

37. Chebi:94551

38. Hms2089m09

39. Hms2095o14

40. Hms3712o14

41. Wca82703

42. Tox21_112034

43. Bdbm50409816

44. Mfcd30496678

45. S1351

46. Akos027470116

47. Ivermectin Component B1a [mi]

48. Zinc238808778

49. Zinc252286706

50. Ac-6014

51. Ccg-220156

52. Ncgc00186639-01

53. Ncgc00186639-03

54. As-14167

55. Bi166167

56. Cas-71827-03-7

57. Hy-126937

58. Ab00513813

59. Cs-0108408

60. 22,23-dihydroavermectin B1a; Ivermectin

61. Ab00513813-02

62. Ab00513813-03

63. Ab00513813_04

64. Avermectin A1a, 22,23-dihydro-5-o-demethyl-

65. 288i867

66. Ivermectin, Antibiotic For Culture Media Use Only

67. Q-201262

68. Brd-k24652731-001-02-7

69. Brd-k85554912-001-08-9

70. Q27132923

71. Ivermectin, British Pharmacopoeia (bp) Reference Standard

72. Ivermectin, European Pharmacopoeia (ep) Reference Standard

73. Ivermectin, United States Pharmacopeia (usp) Reference Standard

74. Ivermectin, Pharmaceutical Secondary Standard; Certified Reference Material

75. (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17

76. Clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranosyl)-3-o-methyl-alpha-l-arabino-hexopyranoside

2.4 Create Date

2005-11-20

3 Chemical and Physical Properties

Molecular Formula	C₄₈H₇₄O₁₄
Molecular Weight	875.1 g/mol
XLogP3	4.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	8
Exact Mass	874.50785703 g/mol
Monoisotopic Mass	874.50785703 g/mol
Topological Polar Surface Area	170 Å²
Heavy Atom Count	62
Formal Charge	0
Complexity	1680
Isotope Atom Count	0
Defined Atom Stereocenter Count	20
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	3
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Treatment of rosacea

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antiparasitic Agents

Drugs used to treat or prevent parasitic infections. (See all compounds classified as Antiparasitic Agents.)

Insecticides

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Pediculicide [EPC]; Antiparasitic [EPC]

5.3 ATC Code

D - Dermatologicals

D11 - Other dermatological preparations

D11A - Other dermatological preparations

D11AX - Other dermatologicals

D11AX22 - Ivermectin

P - Antiparasitic products, insecticides and repellents

P02 - Anthelmintics

P02C - Antinematodal agents

P02CF - Avermectines

P02CF01 - Ivermectin

API SUPPLIERS

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CEP/COS

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JDMF

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NDC API

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VMF

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - LOTION;TOPICAL - 0.5%

USFDA APPLICATION NUMBER - 202736

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USFDA APPLICATION NUMBER - 206255

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Ivermectin

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

34 API Suppliers

7 USDMF

10 CEP/COS

3 JDMF

20 NDC API

10 VMF

21 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

22 Drugs in Development

FINISHED DOSAGE FORMULATIONS

72 FDF Dossiers

11 FDA Orange Book

9 Europe

20 Canada

2 Australia

1 South Africa

29 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

LOTION;TOPICAL - 0.5%

CREAM;TOPICAL - 1%

RELATED EXCIPIENT COMPANIES

5 SPI Pharma

2 DKSH

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6 Actylis

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8 BASF

1 Corel Pharma Chem

3 DFE Pharma

1 Finar

8 Gangwal Chemicals

1 Ideal Cures Pvt Ltd

3 Ingredion Pharma Solutions

5 Kerry

1 Lubrizol Life Science Health

9 Microlex e.U

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1 Pharmatrans-Sanaq

4 Pluviaendo

3 Prachin Chemical

14 Roquette

8 Seppic

4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

9 Sigachi Industries

1 Valens Pharmachem

3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

34 Fillers, Diluents & Binders

23 Direct Compression

19 Topical

18 Thickeners and Stabilizers

18 Disintegrants & Superdisintegrants

16 Solubilizers

12 Lubricants & Glidants

12 Co-Processed Excipients

11 Emulsifying Agents

9 Parenteral

9 Granulation

6 Film Formers & Plasticizers

6 Controlled & Modified Release

5 Taste Masking

5 Surfactant & Foaming Agents

5 Chewable & Orodispersible Aids

4 Coating Systems & Additives

3 Rheology Modifiers

2 API Stability Enhancers

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2 DATA COMPILATION #PharmaFlow

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