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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

14 API Suppliers, 2 USDMF, 2 EU WC, 1 KDMF, 3 NDC API, 11 Listed Suppliers, $ API Reference Price

14 API Suppliers
2 USDMF
2 EU WC
1 KDMF
3 NDC API
11 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

7 Drugs in Development

7 Drugs in Development

INTERMEDIATES

3 Intermediates Suppliers

3 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

15 FDF Dossiers, 3 FDA Orange Book, 6 Europe, 3 Canada, 3 South Africa

15 FDF Dossiers
3 FDA Orange Book
6 Europe
3 Canada
3 South Africa

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - EQ 2.3MG BASE, CAPSULE;ORAL - EQ 3MG BASE, CAPSULE;ORAL - EQ 4MG BASE

drugProductComposition
CAPSULE;ORAL - EQ 2.3MG BASE
CAPSULE;ORAL - EQ 3MG BASE
CAPSULE;ORAL - EQ 4MG BASE

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 1 Faran Shimi Pharmaceutical, 6 Gangwal Healthcare, 1 Aeon Procare, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 2 DFE Pharma, 4 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 3 Kerry, 7 Microlex e.U, 1 Pharmatrans-Sanaq, 1 Pluviaendo, 2 Prachin Chemical, 7 Roquette, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 2 Vasa Pharmachem

relatedExcipients
1 SPI Pharma
1 Faran Shimi Pharmaceutical
6 Gangwal Healthcare
1 Aeon Procare
2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
2 DFE Pharma
4 Gangwal Chemicals
1 Ideal Cures Pvt Ltd
3 Kerry
7 Microlex e.U
1 Pharmatrans-Sanaq
1 Pluviaendo
2 Prachin Chemical
7 Roquette
2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
9 Sigachi Industries
2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

20 Fillers, Diluents & Binders, 13 Direct Compression, 12 Lubricants & Glidants, 10 Thickeners and Stabilizers, 8 Co-Processed Excipients, 5 Disintegrants & Superdisintegrants, 5 Controlled & Modified Release, 5 Granulation, 3 Coating Systems & Additives, 2 Film Formers & Plasticizers, 2 Chewable & Orodispersible Aids, 2 Taste Masking, 1 Rheology Modifiers, 1 Emulsifying Agents

excipientsByApplications
20 Fillers, Diluents & Binders
13 Direct Compression
12 Lubricants & Glidants
10 Thickeners and Stabilizers
8 Co-Processed Excipients
5 Disintegrants & Superdisintegrants
5 Controlled & Modified Release
5 Granulation
3 Coating Systems & Additives
2 Film Formers & Plasticizers
2 Chewable & Orodispersible Aids
2 Taste Masking
1 Rheology Modifiers
1 Emulsifying Agents

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 44 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
44 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 6 Finished Drug Prices, 8 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
6 Finished Drug Prices
8 Annual Reports

MARKET PLACE

2 APIs

marketPlace
2 APIs

PATENTS & EXCLUSIVITIES

27 US Patents

patents
27 US Patents

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 59,815

MARKET PLACE

API

FDF

3INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

7DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

340,652,030

Annual Reports (USD Million)

4,714

Finished Drug Prices

52 RELATED EXCIPIENT COMPANIES

89EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 1239908-20-3, Ixazomib citrate (ester), Ixazomib citrate [usan], 46cwk97z3k, 2-[4-(carboxymethyl)-2-[(1r)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolan-4-yl]acetic acid, Unii-46cwk97z3k

Molecular Formula

C₂₀H₂₃BCl₂N₂O₉

Molecular Weight

517.1 g/mol

InChI Key

MBOMYENWWXQSNW-AWEZNQCLSA-N

FDA UNII

46CWK97Z3K

Ixazomib Citrate is the citrate salt form of ixazomib, an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated.

1 2D Structure

Ixazomib Citrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolan-4-yl]acetic acid

2.1.2 InChI

InChI=1S/C20H23BCl2N2O9/c1-10(2)5-14(21-33-19(32)20(34-21,7-16(27)28)8-17(29)30)25-15(26)9-24-18(31)12-6-11(22)3-4-13(12)23/h3-4,6,10,14H,5,7-9H2,1-2H3,(H,24,31)(H,25,26)(H,27,28)(H,29,30)/t14-/m0/s1

2.1.3 InChI Key

MBOMYENWWXQSNW-AWEZNQCLSA-N

2.1.4 Canonical SMILES

B1(OC(=O)C(O1)(CC(=O)O)CC(=O)O)C(CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl

2.1.5 Isomeric SMILES

B1(OC(=O)C(O1)(CC(=O)O)CC(=O)O)[C@H](CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl

2.2 Other Identifiers

2.2.1 UNII

46CWK97Z3K

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 1239908-20-3

2. Ixazomib Citrate (ester)

3. Ixazomib Citrate [usan]

4. 46cwk97z3k

5. 2-[4-(carboxymethyl)-2-[(1r)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolan-4-yl]acetic Acid

6. Unii-46cwk97z3k

7. 1,3,2-dioxaborolane-4,4-diacetic Acid, 2-((1r)-1-((2-((2,5-dichlorobenzoyl)amino)acetyl)amino)-3-methylbutyl)-5-oxo-

8. 1,3,2-dioxaborolane-4,4-diacetic Acid, 2-[(1r)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-

9. 2,2'-(2-((1r)-1-((n-(2,5-dichlorobenzoyl)glycyl)amino)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic Acid

10. 2,2'-{2-[(1r)-1-{[n-(2,5-dichlorobenzoyl)glycyl]amino}-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic Acid

11. Ninlaro (tn)

12. Ixazomib Citrate [mi]

13. Ixazomib Citrate (jan/usan)

14. Ixazomib Citrate [jan]

15. Schembl4427479

16. Chembl3545432

17. Chebi:90939

18. Dtxsid60924652

19. Ixazomib Citrate [who-dd]

20. Bcp16600

21. Ex-a3660

22. Nsc767907

23. S4432

24. Akos030632768

25. Ixazomib Citrate [orange Book]

26. Zinc200299610

27. Cs-1720

28. Nsc-767907

29. Ncgc00522453-01

30. Ncgc00522453-02

31. 2,2'-{2-[(1r)-1-({[(2,5-dichlorobenzoyl)amino]acetyl}amino)-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic Acid

32. Ac-35344

33. As-75031

34. Hy-10452

35. C71946

36. D10131

37. Mln9708; Mln-9708; Mln 9708;ixazomib-prodrug

38. Q27162929

39. (r)-2,2'-(2-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic Acid

40. 2,2'-{2-[(1r)-1-({[(2,5-dichlorobenzoy)amino]acetyl}amino)-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic Acid

41. 2-[(1r)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diacetic Acid

42. 2-[4-(carboxymethyl)-2-[(1r)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]-5-oxo-1,3,2-dioxaborolan-4-yl]acetic Acid

2.3.2 Other Synonyms

1. Ixazomib

2.4 Create Date

2012-03-21

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₃BCl₂N₂O₉
Molecular Weight	517.1 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	11
Exact Mass	516.0873659 g/mol
Monoisotopic Mass	516.0873659 g/mol
Topological Polar Surface Area	168 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	797
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Treatment of systemic light chain amyloidosis

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Listed Suppliers

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API Reference Price

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