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1. Biaxsig
2. Claramid
3. Infectoroxit
4. Macrosil
5. Mtw-roxithromycin
6. Rotesan
7. Rotramin
8. Roxi 1a Pharma
9. Roxi Basics
10. Roxi Tad
11. Roxi Von Ct
12. Roxi-paed 1a Pharma
13. Roxi-puren
14. Roxi-q
15. Roxi-saar
16. Roxi-wolff
17. Roxibeta
18. Roxidura
19. Roxigamma
20. Roxigrn
21. Roxihexal
22. Roxithro-lich
23. Roxithromycin
24. Ru 28965
25. Ru 965
26. Ru-28965
27. Ru-965
28. Ru28965
29. Ru965
30. Rulid
1. Roxithromycin
2. 80214-83-1
3. Roxithromycine
4. Roxithromycinum
5. Roxitromicina
6. Ru 965
7. Ru 28965
8. Ru-965
9. Rulid
10. Chebi:48935
11. Nsc-758443
12. Erythromycin 9-(o-((2-methoxyethoxy)methyl)oxime)
13. 21kof230fa
14. Ru-28965
15. 9-(o-((2-methoxyethoxy)methyl)oxime)erythromycin
16. (9e)-erythromycin 9-(o-((2-methoxyethoxy)methyl)oxime)
17. (e)-roxithromycin
18. Roxithromycine [french]
19. Roxithromycinum [latin]
20. Roxitromicina [spanish]
21. (3r,4s,5s,6r,7r,9r,11s,12r,13s,14r,e)-6-(((2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl)oxy)-10-(((2-methoxyethoxy)methoxy)imino)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
22. Rulide (tn)
23. 9-[o-[(2-methoxyethoxy)methyl]oxime]erythromycin
24. Sr-05000001850
25. Chebi:48844
26. Unii-21kof230fa
27. Erythromycin, 9-(o-((2-methoxyethoxy)methyl)oxime), (9e)-
28. Ccris 3461
29. Roxithromycin,(s)
30. (3r,4s,5s,6r,7r,9r,10e,11s,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10
31. Roxithromycin [usan:inn:ban:jan]
32. Rc2952
33. Brn 4286925
34. Spectrum5_001058
35. Roxithromycin [mi]
36. Roxithromycin [inn]
37. Roxithromycin [jan]
38. Roxithromycin [usan]
39. Schembl65985
40. Bspbio_002717
41. Roxithromycin [mart.]
42. Spectrum1503276
43. 9-[o-(2-methoxyethoxymethyl)-oxime] Of Erythromycin
44. Erythromycin, 9-(o-((2-methoxyethoxy)methyl)oxime)
45. Roxithromycin [who-dd]
46. Chembl1214185
47. Hms501d04
48. Hms1922o19
49. Hms2093c11
50. Hms3714l09
51. Pharmakon1600-01503276
52. Roxithromycin (jp17/usan/inn)
53. Roxithromycin [ep Impurity]
54. Hy-b0435
55. Roxithromycin [ep Monograph]
56. Bdbm50248154
57. Ccg-39329
58. Mfcd00214389
59. Nsc758443
60. Zinc96061888
61. Akos015969730
62. Db00778
63. Nsc 758443
64. Idi1_000382
65. Ncgc00178510-01
66. Roxithromycin 100 Microg/ml In Methanol
67. (3r,4s,5s,6r,7r,9r,10e,11s,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one
68. Roxithromycin 1000 Microg/ml In Methanol
69. Sbi-0051809.p002
70. Roxithromycin 100 Microg/ml In Acetonitrile
71. D01710
72. Ab00052342_02
73. Sr-05000001850-1
74. Sr-05000001850-2
75. Brd-k38684403-001-03-9
76. Brd-k38684403-001-05-4
77. Q27895851
78. 9-[o-[(2-methoxyethoxy)methyl]oxime]erythromycin, (9e)-
79. (e)-erythromycin-9-(o-((2-methoxyethoxy)methyl)oxime)
80. Erythromycin 9-(e)-(o-((2-methoxyethoxy)methyl)oxime)
81. Erythromycin A, 9-(o-(2-methoxyethoxymethyl)-oxime)
82. (3r,4s,5s,6r,7r,9r,10e,11s,12r,13s,14r)-4-(2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyloxy)-14-ethyl-7,12,13-trihydroxy-10-{[(2-methoxyethoxy)methoxy]imino}-6-[3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
83. (3r,4s,5s,6r,7r,9r,10e,11s,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one
84. (3r,4s,5s,6r,7r,9r,10e,11s,12r,13s,14r)-6-{[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl]oxy}-10-{[(2-methoxyethoxy)m
85. (3r,4s,5s,6r,7r,9r,10e,11s,12r,13s,14r)-6-{[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl]oxy}-10-{[(2-methoxyethoxy)methoxy]imino}-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
86. (3r,4s,5s,6r,7r,9r,10e,11s,12r,13s,14r)-6-{[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-{o-[(2-methoxyethoxy)methyl]oxime} (non-preferred Name)
87. (3r,4s,5s,6r,7r,9r,11s,12r,13s,14r)-4-((2,6dideoxy-3-c-methyl-3-o-methyl-.alpha.-l-ribo-hexopyranosyl)oxy)-14-ethyl-7,12,13-trihydroxy-10-((e)((2-methoxyethoxy)methoxy)imino)-3,5,7,9,11,13hexamethyl-6-((3,4,6-trideoxy-3-(dimethylamino)-.beta.-d-xylohexopyranosyl)oxy)oxacyclotetradecan-2-one
88. (3r,4s,5s,6r,7r,9r,11s,12r,13s,14r)-4-(2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyloxy)-14-ethyl-7,12,13-trihydroxy-10-{[(2-methoxyethoxy)methoxy]imino}-6-[3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
89. (3r,4s,5s,6r,7r,9r,11s,12r,13s,14r)-6-{[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-10-(2,4,7-trioxa-1-azaoctan-1-ylidene)-1-oxacyclotetradecan-2-one
90. (3r,4s,5s,6r,7r,9r,11s,12r,13s,14r,e)-6-(((2s,3r,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl)oxy)-10-(((2-methoxyethoxy)methoxy)imino)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
| Molecular Weight | 837.0 g/mol |
|---|---|
| Molecular Formula | C41H76N2O15 |
| XLogP3 | 3.1 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 17 |
| Rotatable Bond Count | 13 |
| Exact Mass | 836.52456972 g/mol |
| Monoisotopic Mass | 836.52456972 g/mol |
| Topological Polar Surface Area | 217 Ų |
| Heavy Atom Count | 58 |
| Formal Charge | 0 |
| Complexity | 1310 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 18 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Used to treat respiratory tract, urinary and soft tissue infections.
Roxithromycin has the following antibacterial spectrum in vitro: Streptococcus agalactiae, Streptococcus pneumoniae (Pneumococcus), Neisseria meningitides (Meningococcus), Listeria monocytogenes, Mycoplasma pneumoniae, Chlamydia trachomatis, Ureaplasma urealyticum, Legionella pneumophila, Helicobacter (Campylobacter), Gardnerella vaginalis, Bordetella pertussis, Moraxella catarrhalis (Branhamella Catarrhalis), and Haemophilus ducreyi. Roxithromycin is highly concentrated in polymorphonuclear leukocytes and macrophages, achieving intracellular concentrations greater than those outside the cell. Roxithromycin enhances the adhesive and chemotactic functions of these cells which in the presence of infection produce phagocytosis and bacterial lysis. Roxithromycin also possesses intracellular bactericidal activity.
Anti-Bacterial Agents
Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)
J - Antiinfectives for systemic use
J01 - Antibacterials for systemic use
J01F - Macrolides, lincosamides and streptogramins
J01FA - Macrolides
J01FA06 - Roxithromycin
Absorption
Very rapidly absorbed and diffused into most tissues and phagocytes.
Hepatic. Roxithromycin is only partially metabolised, more than half the parent compound being excreted unchanged. Three metabolites have been identified in urine and faeces: the major metabolite is descladinose roxithromycin, with N-mono and N-di-demethyl roxithromycin as minor metabolites. The respective percentage of roxithromycin and these three metabolites is similar in urine and faeces.
12 hours
Roxithromycin prevents bacterial growth by interfering with their protein synthesis. It binds to the 50S subunit of bacterial ribosomes and inhibits the translocation of peptides.
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PharmaCompass offers a list of Roxithromycin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Roxithromycin manufacturer or Roxithromycin supplier for your needs.
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A Ixor manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ixor, including repackagers and relabelers. The FDA regulates Ixor manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ixor API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
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A Ixor supplier is an individual or a company that provides Ixor active pharmaceutical ingredient (API) or Ixor finished formulations upon request. The Ixor suppliers may include Ixor API manufacturers, exporters, distributors and traders.
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A Ixor DMF (Drug Master File) is a document detailing the whole manufacturing process of Ixor active pharmaceutical ingredient (API) in detail. Different forms of Ixor DMFs exist exist since differing nations have different regulations, such as Ixor USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Ixor DMF submitted to regulatory agencies in the US is known as a USDMF. Ixor USDMF includes data on Ixor's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ixor USDMF is kept confidential to protect the manufacturer’s intellectual property.
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The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.
The Ixor Drug Master File in Japan (Ixor JDMF) empowers Ixor API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).
PMDA reviews the Ixor JDMF during the approval evaluation for pharmaceutical products. At the time of Ixor JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.
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In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.
Pharmaceutical companies submit a Ixor Drug Master File in Korea (Ixor KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ixor. The MFDS reviews the Ixor KDMF as part of the drug registration process and uses the information provided in the Ixor KDMF to evaluate the safety and efficacy of the drug.
After submitting a Ixor KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ixor API can apply through the Korea Drug Master File (KDMF).
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A Ixor CEP of the European Pharmacopoeia monograph is often referred to as a Ixor Certificate of Suitability (COS). The purpose of a Ixor CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ixor EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ixor to their clients by showing that a Ixor CEP has been issued for it. The manufacturer submits a Ixor CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ixor CEP holder for the record. Additionally, the data presented in the Ixor CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ixor DMF.
A Ixor CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ixor CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.
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A Ixor written confirmation (Ixor WC) is an official document issued by a regulatory agency to a Ixor manufacturer, verifying that the manufacturing facility of a Ixor active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Ixor APIs or Ixor finished pharmaceutical products to another nation, regulatory agencies frequently require a Ixor WC (written confirmation) as part of the regulatory process.
click here to find a list of Ixor suppliers with Written Confirmation (WC) on PharmaCompass.
Ixor Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Ixor GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ixor GMP manufacturer or Ixor GMP API supplier for your needs.
A Ixor CoA (Certificate of Analysis) is a formal document that attests to Ixor's compliance with Ixor specifications and serves as a tool for batch-level quality control.
Ixor CoA mostly includes findings from lab analyses of a specific batch. For each Ixor CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Ixor may be tested according to a variety of international standards, such as European Pharmacopoeia (Ixor EP), Ixor JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ixor USP).
