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    Chemistry

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    Also known as: 157283-68-6, Travatan, Travatan z, Izba, Al-6221, Travaprost
    Molecular Formula
    C26H35F3O6
    Molecular Weight
    500.5  g/mol
    InChI Key
    MKPLKVHSHYCHOC-AHTXBMBWSA-N
    FDA UNII
    WJ68R08KX9
    Travoprost
    A cloprostenol derivative that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.
    Travoprost is a Prostaglandin Analog.
    1 2D Structure

    Travoprost

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
    2.1.2 InChI
    InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1
    2.1.3 InChI Key
    MKPLKVHSHYCHOC-AHTXBMBWSA-N
    2.1.4 Canonical SMILES
    CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC(=C2)C(F)(F)F)O)O)O
    2.1.5 Isomeric SMILES
    CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    WJ68R08KX9
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (((1r)-(1alpha(z),2beta(1e,3r*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic Acid, 1-methylethyl Ester

    2. Al 6221

    3. Al-6221

    4. Al6221

    5. Travatan

    6. Travatan Z

    7. Z, Travatan

    2.3.2 Depositor-Supplied Synonyms

    1. 157283-68-6

    2. Travatan

    3. Travatan Z

    4. Izba

    5. Al-6221

    6. Travaprost

    7. Trovoprost

    8. Otx-tp

    9. Chebi:746859

    10. Propan-2-yl (z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate

    11. Al6221

    12. Wj68r08kx9

    13. Nsc-760366

    14. Travoprost [usan]

    15. Travatanz

    16. (z)-isopropyl 7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((r,e)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate

    17. Isopropyl (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-{(1e,3r)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

    18. Travatan (tn)

    19. 5-heptenoic Acid, 7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(1e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, 1-methylethyl Ester, (5z)-

    20. Propan-2-yl (5z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(1e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl]cyclopentyl]hept-5-enoate

    21. Propan-2-yl (5z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-{(1e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate

    22. Travoprostum

    23. Unii-wj68r08kx9

    24. (((1r)-(1alpha(z),2beta(1e,3r*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic Acid, 1-methylethyl Ester

    25. (+)-fluprostenol Isopropyl Ester

    26. Travoprost [usan:usp:inn:ban]

    27. Travoprost In Bulk

    28. Travoprostintermediates

    29. Travoprost [mi]

    30. Travoprost [inn]

    31. Travoprost [jan]

    32. Travoprost [vandf]

    33. Travoprost [mart.]

    34. Travoprost [usp-rs]

    35. Travoprost [who-dd]

    36. Schembl93818

    37. Travoprost (jan/usp/inn)

    38. (1r-(1alpha(z),2beta(1e,3r*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic Acid, 1-methylethyl Ester

    39. (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((1e,3r)-3-hydroxy-4-((alpha,alpha,alpha-trifluoro-m-isopropyl-tolyl)oxy)-1-butenyl)cyclopentyl)-5-heptenoate

    40. 5-heptenoic Acid, 7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, 1-methylethyl Ester, (1r-(1alpha(z),2beta(1e,3r*),3alpha,5alpha))-

    41. Travoprost [ema Epar]

    42. Gtpl7102

    43. Chembl1200799

    44. Travoprost [orange Book]

    45. Dtxsid80896948

    46. Travoprost [usp Monograph]

    47. Duotrav Component Travoprost

    48. Ex-a1772

    49. Hy-b0584

    50. Zinc4474682

    51. Bdbm50248302

    52. S3738

    53. Akos024458039

    54. Travoprost Component Of Duotrav

    55. Ac-6103

    56. Am84515

    57. Ccg-269692

    58. Db00287

    59. Nsc 760366

    60. Ncgc00346741-02

    61. 5-heptenoic Acid, 7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((1e,3r)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, 1-methylethyl Ester, (5z)-

    62. Bs-15509

    63. Fluprostenol Isopropyl Ester;al6221;flu-ipr

    64. D01964

    65. 283t686

    66. Sr-01000942266

    67. Sr-01000946860

    68. J-502633

    69. Q2193376

    70. Sr-01000942266-1

    71. Sr-01000946860-1

    72. Fluprostenol Isopropyl Ester, >=98%, Ethanol Solution

    73. (1r-(1.alpha.(z),2.beta.(1e,3r*),3.alpha.,5.alpha.))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic Acid, 1-methylethyl Ester

    74. (5z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(1e,3r)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic Acid 1-methyethyl Ester

    75. (z)-isopropyl 7-((1r,2r)-3,5-dihydroxy-2-((s,e)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate

    76. (z)-isopropyl 7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((r,e)-3-hydroxy-4-(3-(trifluoromethyl) Phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate

    77. (z)-isopropyl7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((r,e)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate

    78. Isopropyl (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((1e,3r)-3-hydroxy-4-((.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)oxy)-1-butenyl)cyclopentyl)-5-heptenoate

    79. Isopropyl (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((3r,e)-3-hydroxy-4-(3-(trifluoromethyl)-phenoxy)-but-1-enyl)-cyclopentyl)-hept-5-enoate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 500.5 g/mol
    Molecular Formula C26H35F3O6
    XLogP34.1
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count13
    Exact Mass500.23857332 g/mol
    Monoisotopic Mass500.23857332 g/mol
    Topological Polar Surface Area96.2 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity693
    Isotope Atom Count0
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count2
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameTravatan z
    PubMed HealthTravoprost (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelTravoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[1(Z),2(1E,3R*),3,5]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid, 1-methylethylester. It has a molecular f...
    Active IngredientTravoprost
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength0.004%
    Market StatusPrescription
    CompanyAlcon Pharms

    2 of 4  
    Drug NameTravoprost
    PubMed HealthTravoprost (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelTravoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[1(Z),2(1E,3R*),3,5]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid, 1-methylethylester. It has a molecular f...
    Active IngredientTravoprost
    Dosage FormSolution/drops; Solution
    RouteOphthalmic; ophthalmic
    Strength0.004%
    Market StatusTentative Approval; Prescription
    CompanyPar Pharm

    3 of 4  
    Drug NameTravatan z
    PubMed HealthTravoprost (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelTravoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[1(Z),2(1E,3R*),3,5]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid, 1-methylethylester. It has a molecular f...
    Active IngredientTravoprost
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength0.004%
    Market StatusPrescription
    CompanyAlcon Pharms

    4 of 4  
    Drug NameTravoprost
    PubMed HealthTravoprost (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelTravoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[1(Z),2(1E,3R*),3,5]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid, 1-methylethylester. It has a molecular f...
    Active IngredientTravoprost
    Dosage FormSolution/drops; Solution
    RouteOphthalmic; ophthalmic
    Strength0.004%
    Market StatusTentative Approval; Prescription
    CompanyPar Pharm

    4.2 Drug Indication

    Travoprost ophthalmic solution is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Travoprost is also currently indicated for the decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma.

    FDA Label

    Decrease of elevated intraocular pressure in adult patients with ocular hypertension or open-angle glaucoma (see section 5. 1). Decrease of elevated intraocular pressure in paediatric patients aged 3 years to < 18 years with ocular hypertension or paediatric glaucoma.

    Decrease of elevated intraocular pressure in adult patients with ocular hypertension or open-angle glaucoma (see section 5. 1).

    Decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma (see section 5. 1).

    Treatment of glaucoma

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Travoprost, an isopropyl ester prodrug, is a synthetic prostaglandin F2 alpha analog that is rapidly hydrolyzed by esterases in the cornea to its biologically active free acid. The travoprost free acid is potent and highly selective for the FP prostanoid receptor.

    5.2 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    TRAVOPROST
    5.3.2 FDA UNII
    WJ68R08KX9
    5.3.3 Pharmacological Classes
    Prostaglandins [CS]; Prostaglandin Analog [EPC]
    5.4 ATC Code

    S01EE04

    S01EE04

    S - Sensory organs

    S01 - Ophthalmologicals

    S01E - Antiglaucoma preparations and miotics

    S01EE - Prostaglandin analogues

    S01EE04 - Travoprost

    5.5 Absorption, Distribution and Excretion

    Absorption

    Travoprost is systemically absorbed through the cornea. In humans, peak plasma concentrations of travoprost free acid were low (25 pg/mL or less) and occurred within 30 minutes following topical ocular administration of one drop of 0.004% travoprost ophthalmic solution.

    Route of Elimination

    Less than 2% of the topical ocular dose of travoprost was excreted in the urine within 4 hours as the travoprost free acid. Moreover, elimination from plasma is rapid, resulting in concentrations below the limit of quantitation (< 10 pg/mL) by one hour. Furthermore, in rats, 95% of a subcutaneous radiolabeled dose was eliminated within 24 hours. The major route of elimination was via the bile (61%) with the remainder excreted by the kidneys.

    Volume of Distribution

    Given the data currently available, it has been recorded that travoprost free acid is moderately distributed into body tissues with a volume of distribution of 2.6 L/kg in rats.

    Clearance

    Data regarding the clearance of travoprost is not readily available or accessible.

    5.6 Metabolism/Metabolites

    Travoprost, an isopropyl ester prodrug, is hydrolyzed by esterases in the cornea to its biologically active free acid. Systemically, travoprost free acid is rapidly and extensively metabolized in the kidney, liver, and lung to inactive metabolites via beta-oxidation of the α(carboxylic acid) chain to give the 1,2-dinor and 1,2,3,4-tetranor analogs, via oxidation of the 15-hydroxyl moiety, as well as via reduction of the 13,14 double bond.

    5.7 Biological Half-Life

    The terminal elimination half-life of travoprost free acid is determined to be approximately 45 minutes, although studies demonstrated half-life values that ranged from 17 to 86 minutes.

    5.8 Mechanism of Action

    Travoprost, a prostaglandin F2 analogue, is a highly selective full agonist which has a high affinity for the prostaglandin FP receptor, and facilitates reductions in intraocular pressure by increasing the outflow of aqueous humour via trabecular meshwork and uveoscleral pathways. Reduction of the intraocular pressure in man starts about 2 hours after administration and maximum effect is reached after 12 hours. Significant lowering of intraocular pressure can be maintained for periods exceeding 24 hours with a single dose.

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    DMF Number : 14890

    Submission : 2000-05-08

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    Registrant Name : Novartis Korea Ltd.

    Registration Date : 2012-11-08

    Registration Number : 20121108-208-I-101-01

    Manufacturer Name : Dr. Reddy's Laboratories (EU) Ltd

    Manufacturer Address : Steanard Lane, Mirfield, West Yorkshire, WF14 8HZ

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    Virtual BoothGentec Pharmaceutical Group is focused on manufacturing & developing APIs/HPAPIs, Advanced Intermediates & Fine Chemicals.

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    Virtual BoothCapital Farma, a leading European pharmaceutical company focusing on the development & distribution of niche APIs & Pharma Services.

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    GDUFA

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    DMF Number : 32964

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    API Reference Price

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INTERNATIONAL","supplierCountry":"TAIWAN","foreign_port":"NA","customer":"VIATRIS","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"0.05","unit":"KGS","unitRateFc":"2650000","totalValueFC":"134872.7","currency":"USD","unitRateINR":"203520000","date":"21-Apr-2022","totalValueINR":"10176000","totalValueInUsd":"134872.7","indian_port":"BANGALORE AIR","hs_no":"29420090","bill_no":"8356250","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"564\/A\/22, ROAD NO. 92,JUBILEE HILL S,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1658169000,"product":"TRAVOPROST (QTY : 22 GM)","address":"INDOCO HOUSE 166 CST ROAD","city":"SANTACRUZ EAST","supplier":"FLAVINE","supplierCountry":"CZECH REPUBLIC","foreign_port":"NA","customer":"INDOCO REMEDIES LIMITED","customerCountry":"INDIA","quantity":"22.00","actualQuantity":"22","unit":"GMS","unitRateFc":"2800","totalValueFC":"64610.1","currency":"USD","unitRateINR":"233525.9","date":"19-Jul-2022","totalValueINR":"5137570","totalValueInUsd":"64610.1","indian_port":"BOMBAY AIR","hs_no":"29189990","bill_no":"9621738","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"INDOCO HOUSE 166 CST ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1661538600,"product":"15-KETO-TRAVOPROST (AS PER INVOICE):-FOR EXAMINATION,TEST ORANALYSIS PURPOSE ONLY","address":"COMMERCE HOUSE V BESIDES VODAFONE HOUSE PRAHLADNAGAR CORPORATE RD Con","city":"AHMEDABAD GUJARAT INDIA","supplier":"CAYMAN PHARMA S.R.O","supplierCountry":"CZECH REPUBLIC","foreign_port":"NA","customer":"ACULIFE HEALTHCARE","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"0.05","unit":"GMS","unitRateFc":"69000","totalValueFC":"3730.6","currency":"EUR","unitRateINR":"5936720.8","date":"27-Aug-2022","totalValueINR":"296836.04","totalValueInUsd":"3730.6","indian_port":"AHMEDABAD AIR","hs_no":"29375000","bill_no":"2183012","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"COMMERCE HOUSE V BESIDES VODAFONE HOUSE PRAHLADNAGAR CORPORATE RD Con"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1661538600,"product":"5-TRANS-TRAVOPROST (AS PER INVOICE):-FOR EXAMINATION,TEST ORANALYSIS PURPOSE ONLY","address":"COMMERCE HOUSE V BESIDES VODAFONE HOUSE PRAHLADNAGAR CORPORATE RD Con","city":"AHMEDABAD GUJARAT INDIA","supplier":"CAYMAN PHARMA S.R.O","supplierCountry":"CZECH REPUBLIC","foreign_port":"NA","customer":"ACULIFE HEALTHCARE","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"0.05","unit":"GMS","unitRateFc":"69000","totalValueFC":"3730.6","currency":"EUR","unitRateINR":"5936720.8","date":"27-Aug-2022","totalValueINR":"296836.04","totalValueInUsd":"3730.6","indian_port":"AHMEDABAD AIR","hs_no":"29375000","bill_no":"2183012","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"COMMERCE HOUSE V BESIDES VODAFONE HOUSE PRAHLADNAGAR CORPORATE RD Con"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1676226600,"product":"TRAVOPROST IP","address":"NO 31, RACE COURSE ROAD BANGALORE Contact No: 919945641620","city":"BENGALURU","supplier":"CAYMAN PHARMA S.R.O","supplierCountry":"CZECH REPUBLIC","foreign_port":"NA","customer":"MICRO LABS LIMITED","customerCountry":"INDIA","quantity":"40.00","actualQuantity":"40","unit":"GMS","unitRateFc":"1200","totalValueFC":"48093","currency":"USD","unitRateINR":"99300","date":"13-Feb-2023","totalValueINR":"3972000","totalValueInUsd":"48093","indian_port":"MADRAS AIR","hs_no":"29189990","bill_no":"4617268","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"NO 31, RACE COURSE ROAD BANGALORE Contact No: 919945641620"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1678300200,"product":"TRAVOPROST (ISOMER FREE) USP (5 GRAM)","address":"HETERO CORPORATE, NO. 7-2-A2, INDUSTRIAL ESTATE,SANATHNAGAR Conta","city":"HYDERABAD","supplier":"CHIROGATE INTERNATIONAL","supplierCountry":"TAIWAN","foreign_port":"NA","customer":"HETERO DRUGS","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"0.005","unit":"KGS","unitRateFc":"2400000","totalValueFC":"12182.3","currency":"USD","unitRateINR":"200400000","date":"09-Mar-2023","totalValueINR":"1002000","totalValueInUsd":"12182.3","indian_port":"MADRAS AIR","hs_no":"29375000","bill_no":"4970200","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"HETERO CORPORATE, NO. 7-2-A2, INDUSTRIAL ESTATE,SANATHNAGAR Conta"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1681151400,"product":"TRAVOPROST - BATCH NO : T-50-2065 (QTY 50 G)","address":"564\/A\/22, ROAD NO. 92,JUBILEE HILL S,","city":"HYDERABAD,TELANGANA","supplier":"CHIROGATE INTERNATIONAL","supplierCountry":"TAIWAN","foreign_port":"NA","customer":"VIATRIS","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"0.05","unit":"KGS","unitRateFc":"2500000","totalValueFC":"126367","currency":"USD","unitRateINR":"207125000","date":"11-Apr-2023","totalValueINR":"10356250","totalValueInUsd":"126367","indian_port":"BANGALORE AIR","hs_no":"29420090","bill_no":"5465304","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"564\/A\/22, ROAD NO. 92,JUBILEE HILL S,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1699554600,"product":"TRAVOPROST (FOR R & D PURPOSE TEST LIC. TL\/WZ\/23\/003208)","address":"142-48 S.V.ROAD,","city":"MUMBAI, MAHARASHTRA","supplier":"CAYMAN PHARMA S.R.O","supplierCountry":"CZECH REPUBLIC","foreign_port":"PRAGUE - RUZYNE","customer":"FDC","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"GMS","unitRateFc":"2000","totalValueFC":"2158","currency":"EUR","unitRateINR":"179700","date":"10-Nov-2023","totalValueINR":"179700","totalValueInUsd":"2158","indian_port":"Bombay Air","hs_no":"29189990","bill_no":"8722589","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"UL. PRACE 657CZ-277 11NERATOVICESDNFSDNF CZECH REPUBLIC","customerAddress":"142-48 S.V.ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708281000,"product":"TRAVOPROST","address":"NO 31, RACE COURSE ROAD,BANGALORE","city":"BENGALURU,KARNATAKA","supplier":"CAYMAN PHARMA S.R.O","supplierCountry":"CZECH REPUBLIC","foreign_port":"PRAGUE - RUZYNE","customer":"MICRO LABS LIMITED","customerCountry":"INDIA","quantity":"65.00","actualQuantity":"65","unit":"GMS","unitRateFc":"1200","totalValueFC":"78870.7","currency":"USD","unitRateINR":"100680","date":"19-Feb-2024","totalValueINR":"6544200","totalValueInUsd":"78870.7","indian_port":"Madras Air","hs_no":"29189990","bill_no":"2198370","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"UL PRACE 65727711 NERATOVICESDNF CZECH REPUBLIC","customerAddress":"NO 31, RACE COURSE ROAD,BANGALORE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1710527400,"product":"TRAVOPROST","address":"MUMBAI CENTRAL,","city":"MUMBAI, MAHARASHTRA.","supplier":"CAYMAN PHARMA S.R.O","supplierCountry":"CZECH REPUBLIC","foreign_port":"PRAGUE - RUZYNE","customer":"CIPLA","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"GMS","unitRateFc":"1700","totalValueFC":"18814.8","currency":"EUR","unitRateINR":"156230","date":"16-Mar-2024","totalValueINR":"1562300","totalValueInUsd":"18814.8","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"2597618","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"UL. 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OFFICE: NO. 16\/2,","city":"BANGALORE, KARNATAKA","supplier":"CHIROGATE INTERNATIONAL","supplierCountry":"TAIWAN","foreign_port":"TAIPEI","customer":"SOMERSET THERAPEUTICS LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"GMS","unitRateFc":"1500","totalValueFC":"78089.5","currency":"USD","unitRateINR":"130420.9","date":"12-Apr-2024","totalValueINR":"6521045.31","totalValueInUsd":"78089.5","indian_port":"Bangalore Air","hs_no":"29379090","bill_no":"2994783","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TAIPEI","supplierAddress":"NO 2 SHIH 4TH RD YANGMEI DIST TAOYUAN CITY 326013 TAIWAN Taipei, , Taiwan Taiwan","customerAddress":"REGD. OFFICE: NO. 16\/2,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721068200,"product":"TRAVOPROST (QTY: 5GMS, VALUE USD: 15000)","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"YS LIFE SCIENCE ","supplierCountry":"KOREA, REPUBLIC OF","foreign_port":"SEOUL - INCHEON INT\\'","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"0.005","unit":"KGS","unitRateFc":"3000000","totalValueFC":"15418","currency":"USD","unitRateINR":"257761688","date":"16-Jul-2024","totalValueINR":"1288808.44","totalValueInUsd":"15418","indian_port":"Hyderabad Air","hs_no":"29189990","bill_no":"4536787","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"SEOUL - INCHEON INT\\'","supplierAddress":"207 SUJEONG-RO, JANGAN-MYEON, HWASEONG-SI, GYEONGGI-DO 18581 REPUBLICOF KOREA Korea, Republic of","customerAddress":"PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728239400,"product":"TRAVOPROST (FOR TESTING PURPOSE ONLY)","address":"INDOCO HOUSE,166 CST RD.VIDYANAGRI,","city":"MUMBAI.MAHARASHTRA","supplier":"FLAVINE","supplierCountry":"CZECH REPUBLIC","foreign_port":"PRAGUE - RUZYNE","customer":"INDOCO REMEDIES LIMITED","customerCountry":"INDIA","quantity":"35.00","actualQuantity":"35","unit":"GMS","unitRateFc":"2800","totalValueFC":"102191.7","currency":"USD","unitRateINR":"245337.7","date":"07-Oct-2024","totalValueINR":"8586820","totalValueInUsd":"102191.7","indian_port":"Bombay Air","hs_no":"29189990","bill_no":"5996548","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565 PA RAMUS , NEW JERSEY 07652 Closter\/Ne w Jersey, , United States United States","customerAddress":"INDOCO HOUSE,166 CST RD.VIDYANAGRI,"}]
    06-Jan-2021
    27-Jan-2025
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    ABOUT THIS PAGE

    Looking for 157283-68-6 / Travoprost API manufacturers, exporters & distributors?

    Travoprost manufacturers, exporters & distributors 1

    63

    PharmaCompass offers a list of Travoprost API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Travoprost manufacturer or Travoprost supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Travoprost manufacturer or Travoprost supplier.

    PharmaCompass also assists you with knowing the Travoprost API Price utilized in the formulation of products. Travoprost API Price is not always fixed or binding as the Travoprost Price is obtained through a variety of data sources. The Travoprost Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Travoprost

    Synonyms

    157283-68-6, Travatan, Travatan z, Izba, Al-6221, Travaprost

    Cas Number

    157283-68-6

    Unique Ingredient Identifier (UNII)

    WJ68R08KX9

    About Travoprost

    A cloprostenol derivative that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.

    IZBA Manufacturers

    A IZBA manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of IZBA, including repackagers and relabelers. The FDA regulates IZBA manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. IZBA API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of IZBA manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    IZBA Suppliers

    A IZBA supplier is an individual or a company that provides IZBA active pharmaceutical ingredient (API) or IZBA finished formulations upon request. The IZBA suppliers may include IZBA API manufacturers, exporters, distributors and traders.

    click here to find a list of IZBA suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    IZBA USDMF

    A IZBA DMF (Drug Master File) is a document detailing the whole manufacturing process of IZBA active pharmaceutical ingredient (API) in detail. Different forms of IZBA DMFs exist exist since differing nations have different regulations, such as IZBA USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A IZBA DMF submitted to regulatory agencies in the US is known as a USDMF. IZBA USDMF includes data on IZBA's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The IZBA USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of IZBA suppliers with USDMF on PharmaCompass.

    IZBA JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The IZBA Drug Master File in Japan (IZBA JDMF) empowers IZBA API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the IZBA JDMF during the approval evaluation for pharmaceutical products. At the time of IZBA JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of IZBA suppliers with JDMF on PharmaCompass.

    IZBA KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a IZBA Drug Master File in Korea (IZBA KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of IZBA. The MFDS reviews the IZBA KDMF as part of the drug registration process and uses the information provided in the IZBA KDMF to evaluate the safety and efficacy of the drug.

    After submitting a IZBA KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their IZBA API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of IZBA suppliers with KDMF on PharmaCompass.

    IZBA WC

    A IZBA written confirmation (IZBA WC) is an official document issued by a regulatory agency to a IZBA manufacturer, verifying that the manufacturing facility of a IZBA active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting IZBA APIs or IZBA finished pharmaceutical products to another nation, regulatory agencies frequently require a IZBA WC (written confirmation) as part of the regulatory process.

    click here to find a list of IZBA suppliers with Written Confirmation (WC) on PharmaCompass.

    IZBA GMP

    IZBA Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of IZBA GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right IZBA GMP manufacturer or IZBA GMP API supplier for your needs.

    IZBA CoA

    A IZBA CoA (Certificate of Analysis) is a formal document that attests to IZBA's compliance with IZBA specifications and serves as a tool for batch-level quality control.

    IZBA CoA mostly includes findings from lab analyses of a specific batch. For each IZBA CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    IZBA may be tested according to a variety of international standards, such as European Pharmacopoeia (IZBA EP), IZBA JP (Japanese Pharmacopeia) and the US Pharmacopoeia (IZBA USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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