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    Chemistry

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    Also known as: 654671-78-0, Sitagliptin (phosphate), Mk-0431, Chembl393336, 494p4635i6, Mk0431
    Molecular Formula
    C16H18F6N5O5P
    Molecular Weight
    505.31  g/mol
    InChI Key
    IQFYVLUXQXSJJN-SBSPUUFOSA-N
    FDA UNII
    494P4635I6
    Sitagliptin Phosphate
    A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.
    1 2D Structure

    Sitagliptin Phosphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric acid
    2.1.2 InChI
    InChI=1S/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)/t9-;/m1./s1
    2.1.3 InChI Key
    IQFYVLUXQXSJJN-SBSPUUFOSA-N
    2.1.4 Canonical SMILES
    C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O
    2.1.5 Isomeric SMILES
    C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O
    2.2 Other Identifiers
    2.2.1 UNII
    494P4635I6
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 0431, Mk

    2. 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine

    3. Anhydrous, Sitagliptin Phosphate

    4. Januvia

    5. Mk 0431

    6. Mk-0431

    7. Mk0431

    8. Monohydrate, Sitagliptin Monophosphate

    9. Monohydrate, Sitagliptin Phosphate

    10. Monophosphate Monohydrate, Sitagliptin

    11. Phosphate Anhydrous, Sitagliptin

    12. Phosphate Monohydrate, Sitagliptin

    13. Phosphate, Sitagliptin

    14. Sitagliptin

    15. Sitagliptin Monophosphate Monohydrate

    16. Sitagliptin Phosphate Anhydrous

    17. Sitagliptin Phosphate Monohydrate

    2.3.2 Depositor-Supplied Synonyms

    1. 654671-78-0

    2. Sitagliptin (phosphate)

    3. Mk-0431

    4. Chembl393336

    5. 494p4635i6

    6. Mk0431

    7. (2r)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate Salt

    8. (3r)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric Acid

    9. (r)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one Phosphate

    10. 1-butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8h)-yl]-4-(2,4,5-trifluorophenyl)-, (3r)-, Phosphate (1:1)

    11. Sitagliptin Monophosphate

    12. Sitagliptin Phosphate Anhydrous

    13. (3r)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)-1-butanone; Phosphoric Acid

    14. Mk 0431

    15. Sr-05000001748

    16. Unii-494p4635i6

    17. (2r)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate Salt

    18. Mk 431

    19. Mk-0431 Phosphate

    20. Schembl877069

    21. Dtxsid10215789

    22. Hy-13749a

    23. Mfcd09952339

    24. Akos015896098

    25. Sitagliptin Phosphate [who-dd]

    26. Ks-1214

    27. 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate

    28. Sitagliptin Monophosphate Anhydrous [mi]

    29. 671s780

    30. A835125

    31. Sr-05000001748-2

    32. Q27259224

    33. Sitagliptin Phosphate Anhydrous Component Of Janumet

    34. (3r)-3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8h)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone Phosphate

    35. (3r)-3-azanyl-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-[2,4,5-tris(fluoranyl)phenyl]butan-1-one; Phosphoric Acid

    36. 1,2,4-triazolo(4,3-a)pyrazine, 7-((3r)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, Phosphate (1:1)

    37. 1269630-53-6

    38. 7-((3r)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazinemonophosphate

    39. 7-(3r)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Phosphate

    2.4 Create Date
    2006-04-29
    3 Chemical and Physical Properties
    Molecular Weight 505.31 g/mol
    Molecular Formula C16H18F6N5O5P
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count4
    Exact Mass505.09497466 g/mol
    Monoisotopic Mass505.09497466 g/mol
    Topological Polar Surface Area155 Ų
    Heavy Atom Count33
    Formal Charge0
    Complexity616
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameJanuvia
    PubMed HealthSitagliptin (By mouth)
    Drug ClassesAntidiabetic
    Drug LabelJANUVIA Tablets contain sitagliptin phosphate, an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahy...
    Active IngredientSitagliptin phosphate
    Dosage FormTablet
    RouteOral
    Strengtheq 100mg base; eq 50mg base; eq 25mg base
    Market StatusPrescription
    CompanyMerck Sharp Dohme

    2 of 4  
    Drug NameSitagliptin phosphate
    Active IngredientSitagliptin phosphate
    Dosage FormTablet
    Routeoral; Oral
    Strengtheq 100mg base; 25mg; eq 50mg base; 100mg; 50mg; eq 25mg base
    Market StatusTentative Approval
    CompanyMylan Pharms; Apotex; Sandoz; Sun Pharma Global; Watson Labs

    3 of 4  
    Drug NameJanuvia
    PubMed HealthSitagliptin (By mouth)
    Drug ClassesAntidiabetic
    Drug LabelJANUVIA Tablets contain sitagliptin phosphate, an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahy...
    Active IngredientSitagliptin phosphate
    Dosage FormTablet
    RouteOral
    Strengtheq 100mg base; eq 50mg base; eq 25mg base
    Market StatusPrescription
    CompanyMerck Sharp Dohme

    4 of 4  
    Drug NameSitagliptin phosphate
    Active IngredientSitagliptin phosphate
    Dosage FormTablet
    Routeoral; Oral
    Strengtheq 100mg base; 25mg; eq 50mg base; 100mg; 50mg; eq 25mg base
    Market StatusTentative Approval
    CompanyMylan Pharms; Apotex; Sandoz; Sun Pharma Global; Watson Labs

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Hypoglycemic Agents

    Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)

    Incretins

    Peptides which stimulate INSULIN release from the PANCREATIC BETA CELLS following oral nutrient ingestion, or postprandially. (See all compounds classified as Incretins.)

    Dipeptidyl-Peptidase IV Inhibitors

    Compounds that suppress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE IV. This helps to correct the defective INSULIN and GLUCAGON secretion characteristic of TYPE 2 DIABETES MELLITUS by stimulating insulin secretion and suppressing glucagon release. (See all compounds classified as Dipeptidyl-Peptidase IV Inhibitors.)

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E\/1466\/C23003SITAGLIPTIN PHOSPHATE MONOHYDRATE (USP+IH)D50 NLT 40, D90 BE","address":"304,ATLANTA ARCADE,","city":"MUMBAI MAHARASHTRA","supplier":"MACLEODS PHARMACEUTICAL LTD.","supplierCountry":"INDIA","foreign_port":"INDORE","customer":"MACLEODS PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"6.04","actualQuantity":"6.041","unit":"KGS","unitRateFc":"502.1","totalValueFC":"3066","currency":"USD","unitRateINR":"42830.1","date":"19-Nov-2024","totalValueINR":"258736.46","totalValueInUsd":"3066","indian_port":"Indore-EPZ\/SEZ","hs_no":"29339100","bill_no":"6753636","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"INDORE","supplierAddress":"PLOT NO. M-50 TO 54&54A, PHASE-II, INDORE SPECIAL ECONOMIC ZONE, PITHAMPUR, DIST. DHAR, INDIA","customerAddress":"304,ATLANTA ARCADE,"}]
    05-Jan-2021
    27-Jan-2025
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    india-flag.png
    Sitagliptin API needed in India [ENA21849]
    A company that focuses on research, development & manufacturing of pellets, micro-pellets and granules is looking for suppliers of Sitagliptin API for development purposes. The suppliers must support this enquiry with USDMF & CoA.
    24 Jan 2025

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    24 Jan 2025

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    24 Jan 2025

    Egypt.png
    Sitagliptin (5 kg) API needed in Egypt [ENA21249]
    A company that focuses on manufacturing of various finished formulations is looking for suppliers of USP/ BP Grade Sitagliptin (5 kg) API for development purposes. The suppliers must support this enquiry with DMF, GMP & CoA.
    28 Nov 2024

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    28 Nov 2024

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    28 Nov 2024

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    Sitagliptin (5 kg) needed in India [ENA18138]
    A pharmaceutical manufacturing company that deals in beta-lactam, non beta-lactam and food supplements for both tablets and capsules is looking for suppliers of Sitagliptin (5 kg) for commercial/R&D Purposes. The suppliers must support this enquiry with CoA.
    25 Sep 2023

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    25 Sep 2023

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    25 Sep 2023

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    Sitagliptin (5 kg) API needed in India [ENA17693]
    A pharmaceutical manufacturing company that deals in beta-lactam, non-beta-lactam and food supplements for both tablets and capsules is looking for suppliers of Sitagliptin (5 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    28 Jul 2023

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    28 Jul 2023

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    Reply Comment (5)

    28 Jul 2023

    india-flag.png
    Sitagliptin Phosphate (1 MT) API needed in India [ENA17515]
    A company that focuses on research, development and manufacturing of OSDs & injectables is looking for suppliers of Sitagliptin Phosphate (1 MT) API for commercial purposes. The suppliers must support this enquiry with USFDA and CoA.
    11 Jul 2023

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    11 Jul 2023

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    Reply Comment (9)

    11 Jul 2023

    india-flag.png
    Various APIs needed in India [ENA17110]
    A company that deals in various pharmaceutical products is looking for suppliers of Various APIs for commercial purposes. The suppliers must support this enquiry with CoA. 1. Vildagliptin API 2. Sitagliptin API 3. Ranolazine API 4. Telmisartan API 5. Losartan API
    16 May 2023

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    16 May 2023

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    Reply Comment (6)

    16 May 2023

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    USP Grade Sitagliptin Phosphate (25 kg) API needed in India [ENA16924]
    A CMO that focuses on solid & liquid finished formulations in various therapeutic areas is looking for suppliers of USP Grade Sitagliptin Phosphate (25 kg) API for commercial purposes. The suppliers must support this enquiry with CEP & CoA.
    19 Apr 2023

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    19 Apr 2023

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    Reply Comment (4)

    19 Apr 2023

    india-flag.png
    Various APIs needed in India [ENA16563]
    A company that focuses on research, development and manufacturing of tablets, capsules, lozenges, injectables, oral liquids, ointment and gels is looking for suppliers of Various APIs. The suppliers must support this enquiry with CoA. 1. Ezetimibe (5 kg) API 2. Sitagliptin Phosphate (120 kg) API
    09 Mar 2023

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    09 Mar 2023

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    Reply Comment (9)

    09 Mar 2023

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    Sitagliptin (10 kg) API needed in India [ENA16541]
    A company that deals in the distribution of various pharmaceutical products is looking for suppliers of Sitagliptin (10 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    06 Mar 2023

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    06 Mar 2023

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    Reply Comment (8)

    06 Mar 2023

    india-flag.png
    Sitagliptin API needed in India [ENA16422]
    A company that deals in the export and supply of various pharmaceutical products is looking for suppliers of Sitagliptin API for development purposes. The suppliers must support this enquiry with CoA.
    18 Feb 2023

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    18 Feb 2023

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    Reply Comment (12)

    18 Feb 2023

    Only 10 entries up to this point, click to access all click full view read-more
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    Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

    Patents & EXCLUSIVITIES

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    US Patents

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    01

    MERCK SHARP DOHME

    SIMVASTATIN; SITAGLIPTIN PHOSPHATE

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    ASPEN
    Not Confirmed

    MERCK SHARP DOHME

    U.S.A
    arrow
    ASPEN
    Not Confirmed

    Patent Expiration Date : 2026-10-11

    SIMVASTATIN; SITAGLIPTIN PHOSPHATE

    US Patent Number : 7326708*PED

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 202343

    Patent Use Code :

    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2026-10-11

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    02

    MERCK SHARP DOHME

    SITAGLIPTIN PHOSPHATE

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    ASPEN
    Not Confirmed

    MERCK SHARP DOHME

    U.S.A
    arrow
    ASPEN
    Not Confirmed

    Patent Expiration Date : 2026-11-24

    SITAGLIPTIN PHOSPHATE

    US Patent Number : 7326708

    Drug Substance Claim : Y

    Drug Product Claim : Y

    Application Number : 21995

    Patent Use Code : U-802

    Delist Requested :

    Patent Use Description : METHOD OF TREATING TYP...

    Patent Expiration Date : 2026-11-24

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    03

    MERCK SHARP DOHME

    SIMVASTATIN; SITAGLIPTIN PHOSPHATE

    arrow
    ASPEN
    Not Confirmed

    MERCK SHARP DOHME

    U.S.A
    arrow
    ASPEN
    Not Confirmed

    Patent Expiration Date : 2026-10-11

    SIMVASTATIN; SITAGLIPTIN PHOSPHATE

    US Patent Number : 7326708*PED

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 202343

    Patent Use Code :

    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2026-10-11

    blank

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    04

    MSD SUB MERCK

    METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE

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    ASPEN
    Not Confirmed

    MSD SUB MERCK

    India
    arrow
    ASPEN
    Not Confirmed

    Patent Expiration Date : 2029-01-21

    METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE

    US Patent Number : 8414921*PED

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 22044

    Patent Use Code :

    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2029-01-21

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    05

    MSD SUB MERCK

    ERTUGLIFLOZIN; SITAGLIPTIN PHOSPHATE

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    ASPEN
    Not Confirmed

    MSD SUB MERCK

    India
    arrow
    ASPEN
    Not Confirmed

    Patent Expiration Date : 2030-10-21

    ERTUGLIFLOZIN; SITAGLIPTIN PHOSPHATE

    US Patent Number : 9439901

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 209805

    Patent Use Code : U-2214

    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2030-10-21

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    06

    MSD SUB MERCK

    METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE

    arrow
    ASPEN
    Not Confirmed

    MSD SUB MERCK

    India
    arrow
    ASPEN
    Not Confirmed

    Patent Expiration Date : 2026-11-24

    METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE

    US Patent Number : 7326708

    Drug Substance Claim : Y

    Drug Product Claim : Y

    Application Number : 202270

    Patent Use Code : U-1227

    Delist Requested :

    Patent Use Description : METHOD OF TREATING TYP...

    Patent Expiration Date : 2026-11-24

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    07

    MSD SUB MERCK

    METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE

    arrow
    ASPEN
    Not Confirmed

    MSD SUB MERCK

    India
    arrow
    ASPEN
    Not Confirmed

    Patent Expiration Date : 2027-05-24

    METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE

    US Patent Number : 7326708*PED

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 22044

    Patent Use Code :

    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2027-05-24

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    08

    MSD SUB MERCK

    ERTUGLIFLOZIN; SITAGLIPTIN PHOSPHATE

    arrow
    ASPEN
    Not Confirmed

    MSD SUB MERCK

    India
    arrow
    ASPEN
    Not Confirmed

    Patent Expiration Date : 2030-10-21

    ERTUGLIFLOZIN; SITAGLIPTIN PHOSPHATE

    US Patent Number : 9439901

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 209805

    Patent Use Code : U-2214

    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2030-10-21

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    09

    MSD SUB MERCK

    METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE

    arrow
    ASPEN
    Not Confirmed

    MSD SUB MERCK

    India
    arrow
    ASPEN
    Not Confirmed

    Patent Expiration Date : 2027-05-24

    METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE

    US Patent Number : 7326708*PED

    Drug Substance Claim :

    Drug Product Claim :

    Application Number : 22044

    Patent Use Code :

    Delist Requested :

    Patent Use Description :

    Patent Expiration Date : 2027-05-24

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    10

    MSD SUB MERCK

    METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE

    arrow
    ASPEN
    Not Confirmed

    MSD SUB MERCK

    India
    arrow
    ASPEN
    Not Confirmed

    Patent Expiration Date : 2028-07-21

    METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE

    US Patent Number : 8414921

    Drug Substance Claim :

    Drug Product Claim : Y

    Application Number : 22044

    Patent Use Code : U-1036

    Delist Requested :

    Patent Use Description : METHOD OF TREATING TYP...

    Patent Expiration Date : 2028-07-21

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    Portfolio PDF

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    ABOUT THIS PAGE

    Looking for 1269630-53-6 / Sitagliptin Phosphate API manufacturers, exporters & distributors?

    Sitagliptin Phosphate manufacturers, exporters & distributors 1

    22

    PharmaCompass offers a list of Sitagliptin Phosphate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sitagliptin Phosphate manufacturer or Sitagliptin Phosphate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sitagliptin Phosphate manufacturer or Sitagliptin Phosphate supplier.

    PharmaCompass also assists you with knowing the Sitagliptin Phosphate API Price utilized in the formulation of products. Sitagliptin Phosphate API Price is not always fixed or binding as the Sitagliptin Phosphate Price is obtained through a variety of data sources. The Sitagliptin Phosphate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Sitagliptin Phosphate

    Synonyms

    654671-78-0, Sitagliptin (phosphate), Mk-0431, Chembl393336, 494p4635i6, Mk0431

    Cas Number

    1269630-53-6

    Unique Ingredient Identifier (UNII)

    494P4635I6

    About Sitagliptin Phosphate

    A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.

    Janumet Manufacturers

    A Janumet manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Janumet, including repackagers and relabelers. The FDA regulates Janumet manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Janumet API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Janumet manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Janumet Suppliers

    A Janumet supplier is an individual or a company that provides Janumet active pharmaceutical ingredient (API) or Janumet finished formulations upon request. The Janumet suppliers may include Janumet API manufacturers, exporters, distributors and traders.

    click here to find a list of Janumet suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Janumet USDMF

    A Janumet DMF (Drug Master File) is a document detailing the whole manufacturing process of Janumet active pharmaceutical ingredient (API) in detail. Different forms of Janumet DMFs exist exist since differing nations have different regulations, such as Janumet USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Janumet DMF submitted to regulatory agencies in the US is known as a USDMF. Janumet USDMF includes data on Janumet's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Janumet USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Janumet suppliers with USDMF on PharmaCompass.

    Janumet JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Janumet Drug Master File in Japan (Janumet JDMF) empowers Janumet API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Janumet JDMF during the approval evaluation for pharmaceutical products. At the time of Janumet JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Janumet suppliers with JDMF on PharmaCompass.

    Janumet KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Janumet Drug Master File in Korea (Janumet KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Janumet. The MFDS reviews the Janumet KDMF as part of the drug registration process and uses the information provided in the Janumet KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Janumet KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Janumet API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Janumet suppliers with KDMF on PharmaCompass.

    Janumet CEP

    A Janumet CEP of the European Pharmacopoeia monograph is often referred to as a Janumet Certificate of Suitability (COS). The purpose of a Janumet CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Janumet EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Janumet to their clients by showing that a Janumet CEP has been issued for it. The manufacturer submits a Janumet CEP (COS) as part of the market authorization procedure, and it takes on the role of a Janumet CEP holder for the record. Additionally, the data presented in the Janumet CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Janumet DMF.

    A Janumet CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Janumet CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Janumet suppliers with CEP (COS) on PharmaCompass.

    Janumet WC

    A Janumet written confirmation (Janumet WC) is an official document issued by a regulatory agency to a Janumet manufacturer, verifying that the manufacturing facility of a Janumet active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Janumet APIs or Janumet finished pharmaceutical products to another nation, regulatory agencies frequently require a Janumet WC (written confirmation) as part of the regulatory process.

    click here to find a list of Janumet suppliers with Written Confirmation (WC) on PharmaCompass.

    Janumet NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Janumet as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Janumet API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Janumet as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Janumet and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Janumet NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Janumet suppliers with NDC on PharmaCompass.

    Janumet GMP

    Janumet Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Janumet GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Janumet GMP manufacturer or Janumet GMP API supplier for your needs.

    Janumet CoA

    A Janumet CoA (Certificate of Analysis) is a formal document that attests to Janumet's compliance with Janumet specifications and serves as a tool for batch-level quality control.

    Janumet CoA mostly includes findings from lab analyses of a specific batch. For each Janumet CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Janumet may be tested according to a variety of international standards, such as European Pharmacopoeia (Janumet EP), Janumet JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Janumet USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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