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1. 0431, Mk
2. 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
3. Anhydrous, Sitagliptin Phosphate
4. Januvia
5. Mk 0431
6. Mk-0431
7. Mk0431
8. Monohydrate, Sitagliptin Monophosphate
9. Monohydrate, Sitagliptin Phosphate
10. Monophosphate Monohydrate, Sitagliptin
11. Phosphate Anhydrous, Sitagliptin
12. Phosphate Monohydrate, Sitagliptin
13. Phosphate, Sitagliptin
14. Sitagliptin
15. Sitagliptin Monophosphate Monohydrate
16. Sitagliptin Phosphate Anhydrous
17. Sitagliptin Phosphate Monohydrate
1. 654671-78-0
2. Sitagliptin (phosphate)
3. Mk-0431
4. Chembl393336
5. 494p4635i6
6. Mk0431
7. (2r)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate Salt
8. (3r)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric Acid
9. (r)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one Phosphate
10. 1-butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8h)-yl]-4-(2,4,5-trifluorophenyl)-, (3r)-, Phosphate (1:1)
11. Sitagliptin Monophosphate
12. Sitagliptin Phosphate Anhydrous
13. (3r)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)-1-butanone; Phosphoric Acid
14. Mk 0431
15. Sr-05000001748
16. Unii-494p4635i6
17. (2r)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate Salt
18. Mk 431
19. Mk-0431 Phosphate
20. Schembl877069
21. Dtxsid10215789
22. Hy-13749a
23. Mfcd09952339
24. Akos015896098
25. Sitagliptin Phosphate [who-dd]
26. Ks-1214
27. 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate
28. Sitagliptin Monophosphate Anhydrous [mi]
29. 671s780
30. A835125
31. Sr-05000001748-2
32. Q27259224
33. Sitagliptin Phosphate Anhydrous Component Of Janumet
34. (3r)-3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8h)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone Phosphate
35. (3r)-3-azanyl-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-[2,4,5-tris(fluoranyl)phenyl]butan-1-one; Phosphoric Acid
36. 1,2,4-triazolo(4,3-a)pyrazine, 7-((3r)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, Phosphate (1:1)
37. 1269630-53-6
38. 7-((3r)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazinemonophosphate
39. 7-(3r)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Phosphate
| Molecular Weight | 505.31 g/mol |
|---|---|
| Molecular Formula | C16H18F6N5O5P |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 14 |
| Rotatable Bond Count | 4 |
| Exact Mass | 505.09497466 g/mol |
| Monoisotopic Mass | 505.09497466 g/mol |
| Topological Polar Surface Area | 155 Ų |
| Heavy Atom Count | 33 |
| Formal Charge | 0 |
| Complexity | 616 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
| 1 of 4 | |
|---|---|
| Drug Name | Januvia |
| PubMed Health | Sitagliptin (By mouth) |
| Drug Classes | Antidiabetic |
| Drug Label | JANUVIA Tablets contain sitagliptin phosphate, an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahy... |
| Active Ingredient | Sitagliptin phosphate |
| Dosage Form | Tablet |
| Route | Oral |
| Strength | eq 100mg base; eq 50mg base; eq 25mg base |
| Market Status | Prescription |
| Company | Merck Sharp Dohme |
| 2 of 4 | |
|---|---|
| Drug Name | Sitagliptin phosphate |
| Active Ingredient | Sitagliptin phosphate |
| Dosage Form | Tablet |
| Route | oral; Oral |
| Strength | eq 100mg base; 25mg; eq 50mg base; 100mg; 50mg; eq 25mg base |
| Market Status | Tentative Approval |
| Company | Mylan Pharms; Apotex; Sandoz; Sun Pharma Global; Watson Labs |
| 3 of 4 | |
|---|---|
| Drug Name | Januvia |
| PubMed Health | Sitagliptin (By mouth) |
| Drug Classes | Antidiabetic |
| Drug Label | JANUVIA Tablets contain sitagliptin phosphate, an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahy... |
| Active Ingredient | Sitagliptin phosphate |
| Dosage Form | Tablet |
| Route | Oral |
| Strength | eq 100mg base; eq 50mg base; eq 25mg base |
| Market Status | Prescription |
| Company | Merck Sharp Dohme |
| 4 of 4 | |
|---|---|
| Drug Name | Sitagliptin phosphate |
| Active Ingredient | Sitagliptin phosphate |
| Dosage Form | Tablet |
| Route | oral; Oral |
| Strength | eq 100mg base; 25mg; eq 50mg base; 100mg; 50mg; eq 25mg base |
| Market Status | Tentative Approval |
| Company | Mylan Pharms; Apotex; Sandoz; Sun Pharma Global; Watson Labs |
Hypoglycemic Agents
Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)
Incretins
Peptides which stimulate INSULIN release from the PANCREATIC BETA CELLS following oral nutrient ingestion, or postprandially. (See all compounds classified as Incretins.)
Dipeptidyl-Peptidase IV Inhibitors
Compounds that suppress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE IV. This helps to correct the defective INSULIN and GLUCAGON secretion characteristic of TYPE 2 DIABETES MELLITUS by stimulating insulin secretion and suppressing glucagon release. (See all compounds classified as Dipeptidyl-Peptidase IV Inhibitors.)
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GDUFA
DMF Review : Reviewed
Rev. Date : 2019-09-23
Pay. Date : 2019-09-13
DMF Number : 33551
Submission : 2019-01-31
Status : Active
Type : II
Certificate Number : R0-CEP 2021-155 - Rev 00
Issue Date : 2022-05-20
Type : Chemical
Substance Number : 2778
Status : Valid
Date of Issue : 2022-06-17
Valid Till : 2025-07-07
Written Confirmation Number : WC-0067
Address of the Firm :
NDC Package Code : 71796-035
Start Marketing Date : 2021-02-19
End Marketing Date : 2026-12-31
Dosage Form (Strength) : POWDER (1kg/kg)
Marketing Category : BULK INGREDIENT
| Available Reg Filing : BR, CA |
Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.
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Temad- We think of world-class quality.
GDUFA
DMF Review : Reviewed
Rev. Date : 2024-05-28
Pay. Date : 2024-01-22
DMF Number : 39377
Submission : 2024-02-02
Status : Active
Type : II
IOL Chemicals is an innovation-driven bulk drug, Intermediate and Specialty Chemicals company.
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 38931
Submission : 2024-01-31
Status : Active
Type : II
NDC Package Code : 49716-338
Start Marketing Date : 2023-10-25
End Marketing Date : 2025-12-31
Dosage Form (Strength) : POWDER (1kg/kg)
Marketing Category : BULK INGREDIENT
Moehs Group, a reference company in the production of pharmaceutical active ingredients.
GDUFA
DMF Review : Reviewed
Rev. Date : 2019-02-15
Pay. Date : 2018-09-20
DMF Number : 33206
Submission : 2018-09-28
Status : Active
Type : II
NDC Package Code : 71495-0004
Start Marketing Date : 2023-09-28
End Marketing Date : 2025-12-31
Dosage Form (Strength) : POWDER (1kg/kg)
Marketing Category : BULK INGREDIENT
Faran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.
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AMI Lifesciences is Driven by Chemistry. Powered by People.
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 37030
Submission : 2022-05-02
Status : Active
Type : II
Certificate Number : CEP 2022-340 - Rev 00
Issue Date : 2024-05-06
Type : Chemical
Substance Number : 2778
Status : Valid
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Delivering quality and niche Active Pharmaceutical Ingredients across the global from our USFDA-approved facility.
RLD :
TE Code :
Brand Name : SITAGLIPTIN
Dosage Form : TABLET; FILM COATED
Dosage Strength : 25MG
Approval Date :
Application Number : 216919
RX/OTC/DISCN :
RLD :
TE Code :
Delivering quality and niche Active Pharmaceutical Ingredients across the global from our USFDA-approved facility.
RLD :
TE Code :
Brand Name : SITAGLIPTIN
Dosage Form : TABLET; FILM COATED
Dosage Strength : 50MG
Approval Date :
Application Number : 216919
RX/OTC/DISCN :
RLD :
TE Code :
Delivering quality and niche Active Pharmaceutical Ingredients across the global from our USFDA-approved facility.
RLD :
TE Code :
Brand Name : SITAGLIPTIN
Dosage Form : TABLET; FILM COATED
Dosage Strength : 100MG
Approval Date :
Application Number : 216919
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
SITAGLIPTIN PHOSPHATE; METFORMIN HYDROCHLORIDE
Brand Name : SITAGLIPTIN PHOSPHATE; METFORMIN HYDROCHLORIDE
Dosage Form : TABLET;ORAL
Dosage Strength : 50MG;500MG
Approval Date :
Application Number : 202365
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE
Brand Name : METFORMIN HYDROCHLORIDE AND SITAGLIPTIN PHOSPHATE
Dosage Form : TABLET, EXTENDED RELEASE;ORAL
Dosage Strength : 500MG; EQ 50MG BASE
Approval Date :
Application Number : 204144
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE
Brand Name : METFORMIN HYDROCHLORIDE AND SITAGLIPTIN PHOSPHATE
Dosage Form : TABLET, EXTENDED RELEASE;ORAL
Dosage Strength : 1GM; EQ 50MG BASE
Approval Date :
Application Number : 204144
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : SITAGLIPTIN PHOSPHATE
Dosage Form : TABLET; ORAL
Dosage Strength : 50MG
Approval Date :
Application Number : 202425
RX/OTC/DISCN :
RLD :
TE Code :
RLD : Yes
TE Code :
METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE
Brand Name : JANUMET XR
Dosage Form : TABLET, EXTENDED RELEASE;ORAL
Dosage Strength : 1GM;EQ 50MG BASE
Approval Date : 2012-02-02
Application Number : 202270
RX/OTC/DISCN : RX
RLD : Yes
TE Code :
RLD : Yes
TE Code :
METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE
Brand Name : JANUMET XR
Dosage Form : TABLET, EXTENDED RELEASE;ORAL
Dosage Strength : 1GM;EQ 100MG BASE
Approval Date : 2012-02-02
Application Number : 202270
RX/OTC/DISCN : RX
RLD : Yes
TE Code :
RLD :
TE Code :
SITAGLIPTIN PHOSPHATE; METFORMIN HYDROCHLORIDE
Brand Name : SITAGLIPTIN PHOSPHATE; METFORMIN HYDROCHLORIDE
Dosage Form : TABLET, EXTENDED RELEASE;ORAL
Dosage Strength : 50MG;1000MG
Approval Date :
Application Number : 204591
RX/OTC/DISCN :
RLD :
TE Code :
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DOSAGE - TABLET;ORAL - EQ 100MG BASE
USFDA APPLICATION NUMBER - 21995
DOSAGE - TABLET;ORAL - EQ 25MG BASE
USFDA APPLICATION NUMBER - 21995
DOSAGE - TABLET;ORAL - EQ 50MG BASE
USFDA APPLICATION NUMBER - 21995
DOSAGE - TABLET;ORAL - 1GM;EQ 50MG BASE
USFDA APPLICATION NUMBER - 22044
DOSAGE - TABLET;ORAL - 500MG;EQ 50MG BASE
USFDA APPLICATION NUMBER - 22044
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PharmaCompass offers a list of Sitagliptin Phosphate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sitagliptin Phosphate manufacturer or Sitagliptin Phosphate supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sitagliptin Phosphate manufacturer or Sitagliptin Phosphate supplier.
PharmaCompass also assists you with knowing the Sitagliptin Phosphate API Price utilized in the formulation of products. Sitagliptin Phosphate API Price is not always fixed or binding as the Sitagliptin Phosphate Price is obtained through a variety of data sources. The Sitagliptin Phosphate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Januvia manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Januvia, including repackagers and relabelers. The FDA regulates Januvia manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Januvia API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Januvia manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Januvia supplier is an individual or a company that provides Januvia active pharmaceutical ingredient (API) or Januvia finished formulations upon request. The Januvia suppliers may include Januvia API manufacturers, exporters, distributors and traders.
click here to find a list of Januvia suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Januvia DMF (Drug Master File) is a document detailing the whole manufacturing process of Januvia active pharmaceutical ingredient (API) in detail. Different forms of Januvia DMFs exist exist since differing nations have different regulations, such as Januvia USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Januvia DMF submitted to regulatory agencies in the US is known as a USDMF. Januvia USDMF includes data on Januvia's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Januvia USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Januvia suppliers with USDMF on PharmaCompass.
The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.
The Januvia Drug Master File in Japan (Januvia JDMF) empowers Januvia API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).
PMDA reviews the Januvia JDMF during the approval evaluation for pharmaceutical products. At the time of Januvia JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.
click here to find a list of Januvia suppliers with JDMF on PharmaCompass.
In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.
Pharmaceutical companies submit a Januvia Drug Master File in Korea (Januvia KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Januvia. The MFDS reviews the Januvia KDMF as part of the drug registration process and uses the information provided in the Januvia KDMF to evaluate the safety and efficacy of the drug.
After submitting a Januvia KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Januvia API can apply through the Korea Drug Master File (KDMF).
click here to find a list of Januvia suppliers with KDMF on PharmaCompass.
A Januvia CEP of the European Pharmacopoeia monograph is often referred to as a Januvia Certificate of Suitability (COS). The purpose of a Januvia CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Januvia EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Januvia to their clients by showing that a Januvia CEP has been issued for it. The manufacturer submits a Januvia CEP (COS) as part of the market authorization procedure, and it takes on the role of a Januvia CEP holder for the record. Additionally, the data presented in the Januvia CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Januvia DMF.
A Januvia CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Januvia CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.
click here to find a list of Januvia suppliers with CEP (COS) on PharmaCompass.
A Januvia written confirmation (Januvia WC) is an official document issued by a regulatory agency to a Januvia manufacturer, verifying that the manufacturing facility of a Januvia active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Januvia APIs or Januvia finished pharmaceutical products to another nation, regulatory agencies frequently require a Januvia WC (written confirmation) as part of the regulatory process.
click here to find a list of Januvia suppliers with Written Confirmation (WC) on PharmaCompass.
National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Januvia as an active pharmaceutical ingredient (API).
The FDA updates the NDC directory daily. The NDC numbers for Januvia API and other APIs are published in this directory by the FDA.
The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.
Pharmaceutical companies that manufacture Januvia as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.
The NDC directory also contains data on finished compounded human drug products that contain Januvia and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Januvia NDC to their finished compounded human drug products, they may choose to do so.
click here to find a list of Januvia suppliers with NDC on PharmaCompass.
Januvia Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Januvia GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Januvia GMP manufacturer or Januvia GMP API supplier for your needs.
A Januvia CoA (Certificate of Analysis) is a formal document that attests to Januvia's compliance with Januvia specifications and serves as a tool for batch-level quality control.
Januvia CoA mostly includes findings from lab analyses of a specific batch. For each Januvia CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Januvia may be tested according to a variety of international standards, such as European Pharmacopoeia (Januvia EP), Januvia JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Januvia USP).
