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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

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$ 0

MARKET PLACE

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API

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FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

PATENTS & EXCLUSIVITIES

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US Patents

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DIGITAL CONTENT

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Data Compilation #PharmaFlow

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Stock Recap #PipelineProspector

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News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

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Annual Reports

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Finished Drug Prices

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0RELATED EXCIPIENT COMPANIES

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Chemistry

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Also known as: 1268524-70-4, (+)-jq1, (+)-jq-1, Jq1 compound, Jq1, Jq-1
Molecular Formula
C23H25ClN4O2S
Molecular Weight
457.0  g/mol
InChI Key
DNVXATUJJDPFDM-KRWDZBQOSA-N
FDA UNII
1MRH0IMX0W

JQ-1
1 2D Structure

JQ-1

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate
2.1.2 InChI
InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
2.1.3 InChI Key
DNVXATUJJDPFDM-KRWDZBQOSA-N
2.1.4 Canonical SMILES
CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
2.1.5 Isomeric SMILES
CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
2.2 Other Identifiers
2.2.1 UNII
1MRH0IMX0W
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (+)-jq1 Compound

2. Bet Inhibitor Jq1

3. Jq1 Compound

2.3.2 Depositor-Supplied Synonyms

1. 1268524-70-4

2. (+)-jq1

3. (+)-jq-1

4. Jq1 Compound

5. Jq1

6. Jq-1

7. (s)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

8. (s)-jq1

9. Bromodomain Inhibitor, (+)-jq1

10. 1mrh0imx0w

11. C23h25cln4o2s

12. Chembl1957266

13. 6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine-6-acetic Acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl Ester, (6s)-

14. Tert-butyl (s)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

15. Tert-butyl 2-((6s)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-6-yl)acetate

16. (s)-(+)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

17. 3mxf

18. 6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic Acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl Ester, (6s)-

19. Unii-1mrh0imx0w

20. 4flp

21. 4qzs

22. (6s)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic Acid 1,1-dimethylethyl Ester

23. Tert-butyl 2-((6s)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

24. Mls006011158

25. Schembl881227

26. Gtpl7511

27. Chebi:95080

28. Dtxsid20155309

29. Ex-a457

30. Chebi:137113

31. Bdbm50365262

32. Nsc760183

33. Nsc764043

34. S7110

35. Zinc57318556

36. Akos016344680

37. (+)jq-1

38. Ccg-269306

39. Cs-0581

40. Jq1 (+)

41. Jq1-(+)

42. Nsc-760183

43. Nsc-764043

44. Ncgc00250412-01

45. Ncgc00250412-15

46. Ncgc00250412-21

47. (s)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diaz

48. Ac-32617

49. As-16352

50. Bp-21590

51. Hy-13030

52. Smr004702930

53. Bb 0262647

54. (+)-jq1, >=98% (hplc)

55. A854208

56. Q3156953

57. (6s)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]di Azepine-6-acetic Acid 1,1-dimethylethyl Ester

58. Tert-butyl (s)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(s)-(+)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

59. Tert-butyl [(6s)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate

60. Tert-butyl 2-[(9s)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate

61. Tert-butyl[(s)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate

2.4 Create Date
2010-10-07
3 Chemical and Physical Properties
Molecular Weight 457.0 g/mol
Molecular Formula C23H25ClN4O2S
XLogP34.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass456.1386749 g/mol
Monoisotopic Mass456.1386749 g/mol
Topological Polar Surface Area97.6 Ų
Heavy Atom Count31
Formal Charge0
Complexity706
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

JQ 1 Manufacturers

A JQ 1 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of JQ 1, including repackagers and relabelers. The FDA regulates JQ 1 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. JQ 1 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

JQ 1 Suppliers

A JQ 1 supplier is an individual or a company that provides JQ 1 active pharmaceutical ingredient (API) or JQ 1 finished formulations upon request. The JQ 1 suppliers may include JQ 1 API manufacturers, exporters, distributors and traders.

JQ 1 GMP

JQ 1 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of JQ 1 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right JQ 1 GMP manufacturer or JQ 1 GMP API supplier for your needs.

JQ 1 CoA

A JQ 1 CoA (Certificate of Analysis) is a formal document that attests to JQ 1's compliance with JQ 1 specifications and serves as a tool for batch-level quality control.

JQ 1 CoA mostly includes findings from lab analyses of a specific batch. For each JQ 1 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

JQ 1 may be tested according to a variety of international standards, such as European Pharmacopoeia (JQ 1 EP), JQ 1 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (JQ 1 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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