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Ketamine

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ACTIVE PHARMA INGREDIENTS

15 API Suppliers, 8 USDMF, 6 CEP/COS, 1 JDMF, 1 EU WC, 18 NDC API, 1 VMF, 11 Listed Suppliers, $ API Reference Price

15 API Suppliers
8 USDMF
6 CEP/COS
1 JDMF
1 EU WC
18 NDC API
1 VMF
11 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

125 Drugs in Development

125 Drugs in Development

FINISHED DOSAGE FORMULATIONS

63 FDF Dossiers, 18 FDA Orange Book, 11 Europe, 8 Canada, 6 South Africa, 20 Listed Dossiers

63 FDF Dossiers
18 FDA Orange Book
11 Europe
8 Canada
6 South Africa
20 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - EQ 100MG BASE/ML, INJECTABLE;INJECTION - EQ 10MG BASE/ML, INJECTABLE;INJECTION - EQ 50MG BASE/ML

drugProductComposition
INJECTABLE;INJECTION - EQ 100MG BASE/ML
INJECTABLE;INJECTION - EQ 10MG BASE/ML
INJECTABLE;INJECTION - EQ 50MG BASE/ML

RELATED EXCIPIENT COMPANIES

2 Nanjing Well Pharmaceutical, 3 Actylis, 1 BASF, 1 Finar, 1 Kerry, 1 Valens Pharmachem

relatedExcipients
2 Nanjing Well Pharmaceutical
3 Actylis
1 BASF
1 Finar
1 Kerry
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

4 Parenteral, 4 Solubilizers, 3 Topical, 2 Emulsifying Agents, 2 Film Formers & Plasticizers, 1 Controlled & Modified Release, 1 Thickeners and Stabilizers, 1 Coating Systems & Additives

excipientsByApplications
4 Parenteral
4 Solubilizers
3 Topical
2 Emulsifying Agents
2 Film Formers & Plasticizers
1 Controlled & Modified Release
1 Thickeners and Stabilizers
1 Coating Systems & Additives

DIGITAL CONTENT

101 NEWS #PharmaBuzz

media
101 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

7 Finished Drug Prices

globalSalesInformation
7 Finished Drug Prices

MARKET PLACE

11 APIs, 7 FDF Dossiers

marketPlace
11 APIs
7 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 2 Others

otherSolutions
2 EDQM
2 USP
2 Others

ANALYTICAL

1 Analytical Methods

otherMethods
1 Analytical Methods

Seqens Ketamine Hydrochloride

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

101

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

18EXCIPIENTS BY APPLICATIONS

Chemistry

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Click the button for full data set

Also known as: 1867-66-9, Vetalar, Ketaset, Ketalar, Ketamine hcl, Ketanest

Molecular Formula

C₁₃H₁₇Cl₂NO

Molecular Weight

274.18 g/mol

InChI Key

VCMGMSHEPQENPE-UHFFFAOYSA-N

FDA UNII

O18YUO0I83

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.

1 2D Structure

Ketamine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;hydrochloride

2.1.2 InChI

InChI=1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H

2.1.3 InChI Key

VCMGMSHEPQENPE-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CNC1(CCCCC1=O)C2=CC=CC=C2Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

O18YUO0I83

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone

2. Calipsol

3. Calypsol

4. Ci 581

5. Ci-581

6. Ci581

7. Kalipsol

8. Ketalar

9. Ketamine

10. Ketanest

11. Ketaset

2.3.2 Depositor-Supplied Synonyms

1. 1867-66-9

2. Vetalar

3. Ketaset

4. Ketalar

5. Ketamine Hcl

6. Ketanest

7. Ketolar

8. 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride

9. Cl 369

10. Cn-52,372-2

11. (+-)-ketamine Hydrochloride

12. Ci-581

13. Ketamine Hydrochloride Ciii

14. Ketamine (as Hydrochloride)

15. O18yuo0i83

16. Calipsol

17. Kalipsol

18. Ketavet

19. (+-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride

20. Cl-369

21. Dea No. 7285

22. Cn-523722

23. 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;hydrochloride

24. Cn-52372-2

25. Ketamine Chloride

26. Ketavet 100

27. Ketavet (veterinary)

28. Ci 581

29. Chebi:650657

30. Einecs 217-484-6

31. Unii-o18yuo0i83

32. Ketalar (tn)

33. Ketamini Hydrochloridum

34. Ketamine Hydrochloride [usan:usp:jan]

35. Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, Hydrochloride

36. Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, Hydrochloride, (+-)-

37. Ec 217-484-6

38. Chembl1714

39. Schembl26999

40. Dtxsid4040137

41. Ketamine Hydrochloride [mi]

42. 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one Hydrochloride

43. Bcp25943

44. Ketamine Hydrochloride (jp17/usp)

45. Ketamine Hydrochloride [jan]

46. (+/-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride

47. Ketamine Hydrochloride [usan]

48. Nsc116131

49. (+/-)-ketamine Hydrochloride, Solid

50. Ketamine Hydrochloride [vandf]

51. Akos005287313

52. Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, Hydrochloride, (+-)-

53. Ketamine Hydrochloride [mart.]

54. Ab02117

55. Ketamine Hydrochloride [who-dd]

56. Ketamine Hydrochloride [who-ip]

57. Nsc-116131

58. Ketamine Hydrochloride [green Book]

59. Db-044614

60. Db-048467

61. Ketamine Hydrochloride [ep Impurity]

62. Ketamine Hydrochloride [orange Book]

63. Ketamine Hydrochloride [ep Monograph]

64. Ketamine Hydrochloride Ciii [usp-rs]

65. Ketamine Hydrochloride [usp Monograph]

66. Ketamini Hydrochloridum [who-ip Latin]

67. C07843

68. D00711

69. 867k669

70. A813079

71. Q-201266

72. Q27105184

73. Ketamine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

74. 2-(2-chlorophenyl)-2-(methylamino)-1-cyclohexanone Hydrochloride

75. Ketamine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

76. Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, Hydrochloride (1:1)

77. Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, Hydrochloride, (+/-)-

78. Ketamine (+-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanonehydrochloride

79. Ketamine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₇Cl₂NO
Molecular Weight	274.18 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	273.0687196 g/mol
Monoisotopic Mass	273.0687196 g/mol
Topological Polar Surface Area	29.1 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	269
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Ketalar
Drug Label	Ketalar is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injection in concentrat...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Par Sterile Products

2 of 4
Drug Name	Ketamine hydrochloride
PubMed Health	Ketamine (Injection)
Drug Label	Ketamine hydrochloride is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injectio...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Hospira; Mylan Institutional; Eurohlth Intl

3 of 4
Drug Name	Ketalar
Drug Label	Ketalar is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injection in concentrat...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Par Sterile Products

4 of 4
Drug Name	Ketamine hydrochloride
PubMed Health	Ketamine (Injection)
Drug Label	Ketamine hydrochloride is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injectio...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Hospira; Mylan Institutional; Eurohlth Intl

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anesthetics, Dissociative

Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) (See all compounds classified as Anesthetics, Dissociative.)

Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)

Excitatory Amino Acid Antagonists

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (See all compounds classified as Excitatory Amino Acid Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

General Anesthetic [EPC]; General Anesthesia [PE]

API SUPPLIERS

01

Seqens

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

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LGM Pharma

U.S.A

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Medlab Asia & Asia Health

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03

Suanfarma

Spain

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04

Supriya Lifescience

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

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CEP/COS

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05

Arevipharma

Germany

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Medlab Asia & Asia Health

Not Confirmed

06

GLAND PHARMA LIMITED

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

07

Maithri Drugs

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

08

Fine Organics

United Kingdom

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

09

Gedeon Richter

Hungary

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

10

KAMUD DRUGS PVT LTD

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

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USDMF

01

Cu Chemie Uetikon Gmbh

France

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Ketamine Hydrochloride

GDUFA

DMF Review : Complete

Rev. Date : 2019-11-05

Pay. Date : 2019-10-28

DMF Number : 7686

Submission : 1988-09-22

Status : Active

Type : II

02

Supriya Lifescience Ltd

India

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Supriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

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Ketamine Hydrochloride Usp

GDUFA

DMF Review : Complete

Rev. Date : 2022-12-22

Pay. Date : 2022-12-20

DMF Number : 27921

Submission : 2014-01-15

Status : Active

Type : II

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CEP/COS

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CU Chemie Uetikon GmbH Lahr DE

France

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Ketamine hydrochloride

Certificate Number : CEP 2005-281 - Rev 02

Status : Valid

Issue Date : 2024-03-11

Type : Chemical

Substance Number : 1020

02

SUPRIYA LIFESCIENCE LTD. Mumbai IN

India

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Ketamine hydrochloride

Certificate Number : CEP 2016-194 - Rev 01

Status : Valid

Issue Date : 2024-05-07

Type : Chemical

Substance Number : 1020

03

AREVIPHARMA GMBH Radebeul DE

Germany

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04

Fine Organics LIMITED Middlesbrough...

United Kingdom

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HARMAN FINOCHEM LIMITED Mumbai IN

India

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MAITHRI DRUGS PRIVATE LIMITED Bonth...

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JDMF

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CU CHEMIE UETIKON GMBH

France

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KETAMINE HYDROCHLORIDE

Registration Number : 218MF10980

Registrant's Address : Raiffeisenstrasse 4, D-77933 Lahr Germany

Initial Date of Registration : 2006-12-01

Latest Date of Registration : 2021-12-09

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EU WC

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Supriya Lifescience

India

CPHI Middle east

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Ketamine Hydrochloride (BP/EP/USP)

Date of Issue : 2022-06-29

Valid Till : 2025-07-02

Written Confirmation Number : WC-0218

Address of the Firm : A-5/2, Late Parshuram Industrial Area, MIDC, Tal-Khed, Dist. Ratnagiri-415 722, ...

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NDC API

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CU Chemie Uetikon GmbH (340717289)

France

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KETAMINE HYDROCHLORIDE

NDC Package Code : 54382-128

Start Marketing Date : 1989-08-02

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT FOR HUMAN P...

02

CU Chemie Uetikon GmbH

France

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KETAMINE HYDROCHLORIDE

NDC Package Code : 54382-114

Start Marketing Date : 1989-02-08

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

03

PCAS

France

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KETAMINE HYDROCHLORIDE

NDC Package Code : 49169-1041

Start Marketing Date : 2024-01-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

04

Supriya Lifescience Limited

India

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KETAMINE HYDROCHLORIDE

NDC Package Code : 61281-8000

Start Marketing Date : 2013-07-08

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

05

Arevipharma GmbH

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VMF

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Norchim

France

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France

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KETAMINE HYDROCHLORIDE

VMF Number : 5368

Submission : 1991-07-15

Status : Inactive

Type : II

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Listed Suppliers

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Seqens

France

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Ketamine Hydrochloride

About the Company : Since its inception in 2003, Seqens has grown to become a global leader in pharmaceutical solutions and specialty ingredients. Seqens supports its customers in developing, scaling ...

Since its inception in 2003, Seqens has grown to become a global leader in pharmaceutical solutions and specialty ingredients. Seqens supports its customers in developing, scaling up and manufacturing drug substances from the pre-clinical phase to the commercial phase. It offers a large portfolio of APIs and proprietary products. Seqens also develops custom solutions and ingredients for the most demanding industries, such as healthcare, electronics and cosmetics. Its unique range of technologies enables it to manufacture complex molecules for small- and large-scale demands. It operates 24 industrial plants and 10 R&D centres across the globe.

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LGM Pharma

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Ketamine

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

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Suanfarma

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Ketamine Hydrochloride

About the Company : Suanfarma founded in 1993, is a B2B life science partner committed to health & innovation by developing, manufacturing, & distributing high-quality APIs for the pharmaceutical indu...

Suanfarma founded in 1993, is a B2B life science partner committed to health & innovation by developing, manufacturing, & distributing high-quality APIs for the pharmaceutical industry innovatively & sustainably. Backed by a robust global network of 12 strategically located local offices, we cater to the needs of over 400 active customers in 70+ countries. At Suanfarma we offer our CDMO capacity for fermentation & chemical synthesis projects, offering a One Stop Shop service with a solid track record, & which allows us to achieve success in the development, scaling, manufacturing, & commercialization of an API, either innovative or generic.

04

Supriya Lifescience

India

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Ketamine Hydrochloride

About the Company : Supriya Lifescience Ltd. specializes in API manufacturing, focusing on therapeutic segments like antihistamines, anti-allergic drugs, vitamins, anaesthetics and anti-asthmatics. Su...

Supriya Lifescience Ltd. specializes in API manufacturing, focusing on therapeutic segments like antihistamines, anti-allergic drugs, vitamins, anaesthetics and anti-asthmatics. Supriya follows industry standards and constantly improves to deliver quality products. Its facility is 47,000 square meters with dedicated areas for warehouse, QA, QC, R&D, production and finished products. The current capacity is 550 KL, with plans to expand to over 1000 KL by 2024. Supriya has 14 active USDMFs, 8 active CEPs, strong R&D and compliant facilities worldwide. Supriya works with innovators, generic companies, and as a CMO.

05

Arevipharma

Germany

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Arevipharma

Germany

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07

Biotechnica DWC

Algeria

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08

Maithri Drugs

India

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09

SB Pharma

Germany

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UQUIFA

Spain

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

01 Douglas CDMO

New Zealand

DCAT Week

Attending

End-to-end drug development, specializing in high-potency softgels and liquids, providing global partners with a competitive advantage.

Lead Product(s) : Ketamine Hydrochloride

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

DEALS_DEV

R-107 Depression Study Results Published in Nature Medicine

Details : R-107 (ketamine) is an oral NMDA receptor negative allosteric modulator, small molecule drug candidate, which is being evaluated for the treatment of treatment-resistant depression.

Brand Name : R-107

Molecule Type : Small molecule

Upfront Cash : Not Applicable

June 25, 2024

Stock Recap
#PipelineProspector

Data Compilation
#PharmaFlow

Virtual Booth

02 Douglas CDMO

New Zealand

DCAT Week

Attending

End-to-end drug development, specializing in high-potency softgels and liquids, providing global partners with a competitive advantage.

Lead Product(s) : Ketamine Hydrochloride

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

DEALS_DEV

Douglas Pharmaceuticals Announces Formation of Clinical Advisory Board for Lead Program R-107

Details : R-107, an oral extended-release dose of racemic ketamine being developed as add-on or monotherapy for treatment resistant depression (TRD). It has demonstrated a significant antidepressant effect with maintenance of response at 3 months, high compliance ...

Brand Name : R-107

Molecule Type : Small molecule

Upfront Cash : Not Applicable

January 26, 2023

Stock Recap
#PipelineProspector

Data Compilation
#PharmaFlow

Virtual Booth

03 Douglas CDMO

New Zealand

DCAT Week

Attending

End-to-end drug development, specializing in high-potency softgels and liquids, providing global partners with a competitive advantage.

Lead Product(s) : Ketamine Hydrochloride

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

DEALS_DEV

Trial Data Suggests Major Breakthrough in Treatment Resistant Depression

Details : R-107 (extended-release oral dose of ketamine) act as a blocks the NMDA receptor and it is investigated for the treatment of treatment resistant depression.

Brand Name : R-107

Molecule Type : Small molecule

Upfront Cash : Not Applicable

June 15, 2021