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    Chemistry

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    Also known as: 151533-22-1, Calcium levomefolate, Bodyfolin, Metafolin, Nutrifolin, Levomefolinate calcium
    Molecular Formula
    C20H23CaN7O6
    Molecular Weight
    497.5  g/mol
    InChI Key
    VWBBRFHSPXRJQD-QNTKWALQSA-L
    FDA UNII
    A9R10K3F2F
    Levomefolate Calcium
    1 2D Structure

    Levomefolate Calcium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
    2.1.2 InChI
    InChI=1S/C20H25N7O6.Ca/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29;/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31);/q;+2/p-2/t12-,13-;/m0./s1
    2.1.3 InChI Key
    VWBBRFHSPXRJQD-QNTKWALQSA-L
    2.1.4 Canonical SMILES
    CN1C(CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Ca+2]
    2.1.5 Isomeric SMILES
    CN1[C@H](CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Ca+2]
    2.2 Other Identifiers
    2.2.1 UNII
    A9R10K3F2F
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Metafolin

    2. N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-l-glutamic Acid Calcium Salt

    3. Safyral

    2.3.2 Depositor-Supplied Synonyms

    1. 151533-22-1

    2. Calcium Levomefolate

    3. Bodyfolin

    4. Metafolin

    5. Nutrifolin

    6. Levomefolinate Calcium

    7. Lmca

    8. L-methylfolate Calcium

    9. Extrafolate-s

    10. Levomefolate (calcium)

    11. Deplin

    12. Levomefolate Calcium [usan]

    13. L-5-mthf-ca

    14. L-methylfolate-calcium

    15. Calcium L-5-methyltetrahydrofolate

    16. Lmc-a

    17. L-5-methyl Tetrahydrofolic

    18. Bay86-7660

    19. Bay 86-7660

    20. L-5-methyltetrahydrofolate Calcium

    21. A9r10k3f2f

    22. (s)-2-(4-((((s)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic Acid, Calcium Salt

    23. Metafolin (tn)

    24. (6s)-5-methyltetrahydrofolic Acid Calcium Salt

    25. Levomefolate Calcium (usan)

    26. Calcium;(2s)-2-[[4-[[(6s)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate

    27. L-5-methyletrahydrofolate Calcium

    28. Calcium N-(4-((((6s)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-l-glutamate

    29. Unii-a9r10k3f2f

    30. Calcium L-methylfolate

    31. Ndi 638 [fdms]

    32. Chembl1615371

    33. Ndi 638

    34. Chebi:189695

    35. Calcium;(2s)-2-[[4-[[(6s)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate

    36. Levomefolate Calcium [vandf]

    37. Calcium Levomefolate [mart.]

    38. Mfcd18642975

    39. Calcium Levomefolate [who-dd]

    40. Akos025117256

    41. Akos025402270

    42. Ac-7457

    43. Cs-1066

    44. Gs-6017

    45. Hy-17383

    46. Levomefolate Calcium [orange Book]

    47. N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-l-glutamic Acid Calcium Salt

    48. Beyaz Component Levomefolate Calcium

    49. Safyral Component Levomefolate Calcium

    50. Levomefolate Calcium Component Of Beyaz

    51. D09354

    52. Calcium L-5-methyltetrahydrofolate [dsc]

    53. Levomefolate Calcium Component Of Safyral

    54. L-5-methyltetrahydrofolic Acid, Calcium Salt

    55. Q27273818

    56. 6(s)-5-methyltetrahydrofolic Acid, Calcium Salt [ndi]

    57. (s)-2-(4-((((s)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioicacid,calciumsalt

    58. 129025-21-4

    59. Calcium (2s)-2-[4-({[(6s)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzamido]pentanedioate

    60. Calcium (2s)-2-{[4-({[(6s)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioate

    61. Calcium (4-((((s)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-l-glutamate

    62. L-glutamic Acid, N-(4-((((6s)-2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, Calcium Salt (1:1)

    2.3.3 Other Synonyms

    1. Deplin

    2. Prefolic A

    3. L-methyl Folate

    4. Methyl Folate

    2.4 Create Date
    2019-01-15
    3 Chemical and Physical Properties
    Molecular Weight 497.5 g/mol
    Molecular Formula C20H23CaN7O6
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count7
    Exact Mass497.1335723 g/mol
    Monoisotopic Mass497.1335723 g/mol
    Topological Polar Surface Area204 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity854
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2

    API Reference Price

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    PharmaCompass offers a list of Levomefolate Calcium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Levomefolate Calcium manufacturer or Levomefolate Calcium supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Levomefolate Calcium manufacturer or Levomefolate Calcium supplier.

    PharmaCompass also assists you with knowing the Levomefolate Calcium API Price utilized in the formulation of products. Levomefolate Calcium API Price is not always fixed or binding as the Levomefolate Calcium Price is obtained through a variety of data sources. The Levomefolate Calcium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Levomefolate Calcium

    Synonyms

    151533-22-1, Calcium levomefolate, Bodyfolin, Metafolin, Nutrifolin, Levomefolinate calcium

    Cas Number

    129025-21-4

    Unique Ingredient Identifier (UNII)

    A9R10K3F2F

    L-methylfolate Calcium Manufacturers

    A L-methylfolate Calcium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of L-methylfolate Calcium, including repackagers and relabelers. The FDA regulates L-methylfolate Calcium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. L-methylfolate Calcium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of L-methylfolate Calcium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    L-methylfolate Calcium Suppliers

    A L-methylfolate Calcium supplier is an individual or a company that provides L-methylfolate Calcium active pharmaceutical ingredient (API) or L-methylfolate Calcium finished formulations upon request. The L-methylfolate Calcium suppliers may include L-methylfolate Calcium API manufacturers, exporters, distributors and traders.

    click here to find a list of L-methylfolate Calcium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    L-methylfolate Calcium USDMF

    A L-methylfolate Calcium DMF (Drug Master File) is a document detailing the whole manufacturing process of L-methylfolate Calcium active pharmaceutical ingredient (API) in detail. Different forms of L-methylfolate Calcium DMFs exist exist since differing nations have different regulations, such as L-methylfolate Calcium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A L-methylfolate Calcium DMF submitted to regulatory agencies in the US is known as a USDMF. L-methylfolate Calcium USDMF includes data on L-methylfolate Calcium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The L-methylfolate Calcium USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of L-methylfolate Calcium suppliers with USDMF on PharmaCompass.

    L-methylfolate Calcium WC

    A L-methylfolate Calcium written confirmation (L-methylfolate Calcium WC) is an official document issued by a regulatory agency to a L-methylfolate Calcium manufacturer, verifying that the manufacturing facility of a L-methylfolate Calcium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting L-methylfolate Calcium APIs or L-methylfolate Calcium finished pharmaceutical products to another nation, regulatory agencies frequently require a L-methylfolate Calcium WC (written confirmation) as part of the regulatory process.

    click here to find a list of L-methylfolate Calcium suppliers with Written Confirmation (WC) on PharmaCompass.

    L-methylfolate Calcium NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing L-methylfolate Calcium as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for L-methylfolate Calcium API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture L-methylfolate Calcium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain L-methylfolate Calcium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a L-methylfolate Calcium NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of L-methylfolate Calcium suppliers with NDC on PharmaCompass.

    L-methylfolate Calcium GMP

    L-methylfolate Calcium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of L-methylfolate Calcium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right L-methylfolate Calcium GMP manufacturer or L-methylfolate Calcium GMP API supplier for your needs.

    L-methylfolate Calcium CoA

    A L-methylfolate Calcium CoA (Certificate of Analysis) is a formal document that attests to L-methylfolate Calcium's compliance with L-methylfolate Calcium specifications and serves as a tool for batch-level quality control.

    L-methylfolate Calcium CoA mostly includes findings from lab analyses of a specific batch. For each L-methylfolate Calcium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    L-methylfolate Calcium may be tested according to a variety of international standards, such as European Pharmacopoeia (L-methylfolate Calcium EP), L-methylfolate Calcium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (L-methylfolate Calcium USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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