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    Chemistry

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    Also known as: 175481-36-4, Erlosamide, Vimpat, (r)-2-acetamido-n-benzyl-3-methoxypropanamide, Harkoseride, Spm 927
    Molecular Formula
    C13H18N2O3
    Molecular Weight
    250.29  g/mol
    InChI Key
    VPPJLAIAVCUEMN-GFCCVEGCSA-N
    FDA UNII
    563KS2PQY5
    Lacosamide
    Lacosamide is a functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity.
    The physiologic effect of lacosamide is by means of Decreased Central Nervous System Disorganized Electrical Activity.
    1 2D Structure

    Lacosamide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2R)-2-acetamido-N-benzyl-3-methoxypropanamide
    2.1.2 InChI
    InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1
    2.1.3 InChI Key
    VPPJLAIAVCUEMN-GFCCVEGCSA-N
    2.1.4 Canonical SMILES
    CC(=O)NC(COC)C(=O)NCC1=CC=CC=C1
    2.1.5 Isomeric SMILES
    CC(=O)N[C@H](COC)C(=O)NCC1=CC=CC=C1
    2.2 Other Identifiers
    2.2.1 UNII
    563KS2PQY5
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-(acetylamino)-3-methoxy-n-(phenylmethyl)-, (2r)-

    2. Add-234037

    3. Ertosamide

    4. Harkoseride

    5. Spm-927

    2.3.2 Depositor-Supplied Synonyms

    1. 175481-36-4

    2. Erlosamide

    3. Vimpat

    4. (r)-2-acetamido-n-benzyl-3-methoxypropanamide

    5. Harkoseride

    6. Spm 927

    7. Spm-927

    8. (2r)-2-acetamido-n-benzyl-3-methoxypropanamide

    9. (r)-lacosamide 1

    10. Propanamide, 2-(acetylamino)-3-methoxy-n-(phenylmethyl)-, (2r)-

    11. Add 243037

    12. Add-234037

    13. Chembl58323

    14. 563ks2pqy5

    15. Add-243037

    16. Erlosamide [inn]

    17. Ncgc00253740-01

    18. (r)-2-acetamido-n-benzyl-3-methoxypropionamide.

    19. (r)-2-acetylamino-n-benzyl-3-methoxy-propionamide

    20. Lacosamide [usan]

    21. (+)-(2r)-2-(acetylamino)-n-benzyl-3-methoxypropanamide

    22. Ertosamide

    23. Add 234037

    24. Harkeroside

    25. Unii-563ks2pqy5

    26. Lacosamide [usan:inn:ban]

    27. Lacosamide Cv

    28. Spm-929

    29. Lacosamide Racemate

    30. Lacosamide- Bio-x

    31. (2r)-2-(acetylamino)-n-benzyl-3-methoxypropanamide

    32. Vimpat (tn)

    33. Lacosamide [mi]

    34. Lacosamide [inn]

    35. Lacosamide [jan]

    36. Lacosamide [vandf]

    37. Lacosamide [mart.]

    38. (r)-n-benzyl-2-acetamido-3-methoxypropionamide

    39. Dsstox_cid_31455

    40. Dsstox_rid_97341

    41. Lacosamide [who-dd]

    42. Dsstox_gsid_57666

    43. Schembl35330

    44. Lacosamide (jan/usan/inn)

    45. Lacosamide [ema Epar]

    46. Gtpl7472

    47. Zinc7673

    48. Dea No. 2746

    49. Lacosamide Cv [usp-rs]

    50. Dtxsid1057666

    51. Lacosamide [orange Book]

    52. Lacosamide [ep Monograph]

    53. Chebi:135939

    54. Lacosamide [usp Monograph]

    55. Bcp02197

    56. Tox21_113857

    57. Bdbm50300204

    58. Mfcd08272557

    59. Akos005146274

    60. Lacosamide 1.0 Mg/ml In Acetonitrile

    61. Cs-0529

    62. Db06218

    63. Ks-1227

    64. Ac-22750

    65. Am808141

    66. Bl164605

    67. Hy-13015

    68. A3897

    69. Bb 0260890

    70. Cas-175481-36-4

    71. (r)-n-benzyl-2-acetamido-3-methoxypropanamide

    72. D07299

    73. (2r)-n-benzyl-2-acetamido-3-methoxypropanamide

    74. (r)-2-acetamido-n-benzyl-3-methoxypropionamide

    75. (r)-n-benzyl 2-acetamido-3-methoxypropionamide

    76. (r)-n-benzyl 2-acetamido-3-methoxypropionamide,

    77. Ab01559947-01

    78. (2r)-2-acetylamino-n-benzyl-3-methoxypropanamide

    79. (r)-2-acetylamino-n-benzyl-3-methoxypropionamide

    80. 481l364

    81. Ar-270/11402703

    82. Q420077

    83. Sr-01000942286

    84. Sr-01000942286-1

    85. (2r)-2-acetamido-3-methoxy-n-(phenylmethyl)propanamide

    86. 2-(acetylamino)-3-methoxy-n-(phenylmethyl)-, (2r)-

    87. Z1550648754

    88. Lacosamide Solution, 1.0 Mg/ml In Acetonitrile, Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 250.29 g/mol
    Molecular Formula C13H18N2O3
    XLogP30.3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count6
    Exact Mass250.13174244 g/mol
    Monoisotopic Mass250.13174244 g/mol
    Topological Polar Surface Area67.4 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity275
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameVimpat
    PubMed HealthLacosamide
    Drug ClassesAnticonvulsant
    Active IngredientLacosamide
    Dosage FormTablet; Solution
    RouteOral; Intravenous
    Strength200mg/20ml (10mg/ml); 200mg; 150mg; 10mg/ml; 100mg; 50mg
    Market StatusPrescription
    CompanyUcb

    2 of 2  
    Drug NameVimpat
    PubMed HealthLacosamide
    Drug ClassesAnticonvulsant
    Active IngredientLacosamide
    Dosage FormTablet; Solution
    RouteOral; Intravenous
    Strength200mg/20ml (10mg/ml); 200mg; 150mg; 10mg/ml; 100mg; 50mg
    Market StatusPrescription
    CompanyUcb

    4.2 Drug Indication

    Lacosamide is indicated for adjunctive therapy for partial onset seizures in patients with epilepsy over 17 years old. Injection is indicated for short term use when oral therapy is not feasible.

    FDA Label

    Vimpat is indicated as monotherapy and adjunctive therapy in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 4 years of age with epilepsy.

    Lacosamide Accord is indicated as monotherapy in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 4 years of age with epilepsy.

    Lacosamide Accord is indicated as adjunctive therapy

    in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 4 years of age with epilepsy.

    in the treatment of primary generalised tonic-clonic seizures in adults, adolescents and children from 4 years of age with idiopathic generalised epilepsy.

    Lacosamide UCB is indicated as monotherapy and adjunctive therapy in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 4 years of age with epilepsy.

    Treatment of epilepsy with partial-onset seizures

    Treatment of generalised epilepsy and epileptic syndromes

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Lacosamide therapy is correlated with a decrease in seizure frequency. It should be noted that in group analyses, dosages above 400 mg/day do not appear to result in additional benefit.

    5.2 FDA Pharmacological Classification
    5.2.1 Active Moiety
    LACOSAMIDE
    5.2.2 FDA UNII
    563KS2PQY5
    5.2.3 Pharmacological Classes
    Decreased Central Nervous System Disorganized Electrical Activity [PE]; Anti-epileptic Agent [EPC]; Decreased Central Nervous System Disorganized Electrical Activity [PE]
    5.3 ATC Code

    N03AX18

    N03AX18

    N03AX18

    N03AX18

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N03 - Antiepileptics

    N03A - Antiepileptics

    N03AX - Other antiepileptics

    N03AX18 - Lacosamide

    5.4 Absorption, Distribution and Excretion

    Absorption

    Lacosamide has a negligible first pass effect with bioavailability of about 100%. The maximum Lacosamide plasma concentrations occur about 1-4 hours after oral administration, and the pharmacokinetics of Lacosamide are dose proportional. Food does not affect absorption.

    Route of Elimination

    Lacosamide is eliminated primarily from the systemic circulation by biotransformation and renal excretion.

    Volume of Distribution

    approximately 0.6 L/kg; thus close to the volume of total body water.

    Clearance

    95% recovered in the urine 0.5% in the feces

    5.5 Metabolism/Metabolites

    Lacosamide is a CYP2C19 substrate. The relative contribution of other CYP isoforms or non-CYP enzymes in the metabolism of lacosamide is not known. Primary compounds excreted were unchanged lacosamide (approximately 40% of the dose), its O-desmethyl metabolite (approximately 30%), and a structurally unknown polar fraction (~20%). The plasma exposure of the major human metabolite, O-desmethyl-lacosamide, is approximately 10% of that of lacosamide. This metabolite has no known pharmacological activity.

    5.6 Biological Half-Life

    13 Hours

    5.7 Mechanism of Action

    It is proposed that lacosamide's inhibition of sodium channels is responsible for analgesia. Lacosamide may be selective for inhibiting depolarized neurons rather than neurons with normal resting potentials. Pain and nociceptor hyperexcitability are associated with neural membrane depolarization. Lacosamide binds to collapsin response mediator protein-2 (CRMP-2), a phosphoprotein which is expressed primarily in the nervous system and is involved in neuronal differentiation and control of axonal outgrowth. The role CRMP-2 of binding in seizure control is hasn't been elucidated.

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TAMIL NADU.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725474600,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS(API)(PHARMACEUTICALS RAW MATERIAL FOR PHARMAINDUSTRIES)PRODUCT- LACOSAMIDE","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"TO THE ORDER OF","customerCountry":"REPUBLIC OF KOREA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"540","totalValueFC":"52814.6","currency":"USD","unitRateINR":44259.284400000004,"date":"05-Sep-2024","totalValueINR":"4425928.44","totalValueInUsd":"52814.6","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"3774814","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"ALEMBIC ROAD, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725820200,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS(API)(PHARMACEUTICALS RAW MATERIAL FOR PHARMAINDUSTRIES)PRODUCT- LACOSAMIDE","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"TO THE ORDER OF","customerCountry":"REPUBLIC OF KOREA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"405","totalValueFC":"39453.6","currency":"USD","unitRateINR":33062.601900000001,"date":"09-Sep-2024","totalValueINR":"3306260.19","totalValueInUsd":"39453.6","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"3871477","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"ALEMBIC ROAD, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725906600,"product":"(PROD CODE: 8411167001) - LACOSAMIDE","address":"717\/718, MAKER CHAMBER V,","city":"MUMBAI, MAHARASHTRA","supplier":"HIKAL","supplierCountry":"INDIA","foreign_port":"BUENOS AIRES, BA","customer":"M\/S","customerCountry":"ARGENTINA","quantity":"85.00","actualQuantity":"85","unit":"KGS","unitRateFc":"430","totalValueFC":"35175.7","currency":"USD","unitRateINR":34679.629411764705,"date":"10-Sep-2024","totalValueINR":"2947768.5","totalValueInUsd":"35175.7","indian_port":"Bangalore Air","hs_no":"29224990","bill_no":"3902369","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ARGENTINA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"717\/718, MAKER CHAMBER V,, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725906600,"product":"LACOSAMIDE","address":"404 VAIBHAV CHAMBERS, BANDRA-","city":"MUMBAI, MAHARASHTRA","supplier":"NAGASE EUROPA GMBH","supplierCountry":"INDIA","foreign_port":"OSAKA - KANSAI INT\\'L","customer":"NAGASE & CO., LTD. AMAGASAKI OFFICE","customerCountry":"JAPAN","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"853.5","totalValueFC":"4196.7","currency":"USD","unitRateINR":70337.388000000006,"date":"10-Sep-2024","totalValueINR":"351686.94","totalValueInUsd":"4196.7","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"3890591","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"404 VAIBHAV CHAMBERS, BANDRA-, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725906600,"product":"LACOSAMIDE","address":"404 VAIBHAV CHAMBERS, BANDRA-","city":"MUMBAI, MAHARASHTRA","supplier":"NAGASE EUROPA GMBH","supplierCountry":"INDIA","foreign_port":"OSAKA - KANSAI INT\\'L","customer":"NAGASE & CO., LTD. AMAGASAKI OFFICE","customerCountry":"JAPAN","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"853.5","totalValueFC":"8393.4","currency":"USD","unitRateINR":70337.334999999992,"date":"10-Sep-2024","totalValueINR":"703373.35","totalValueInUsd":"8393.4","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"3890591","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"404 VAIBHAV CHAMBERS, BANDRA-, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725906600,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS(API)(PHARMACEUTICALS RAW MATERIAL FOR PHARMAINDUSTRIES)PRODUCT- LACOSAMIDE ","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"BARCELONA","customer":"TO THE ORDER OF","customerCountry":"SPAIN","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"400","totalValueFC":"86087","currency":"EUR","unitRateINR":36070.983800000002,"date":"10-Sep-2024","totalValueINR":"7214196.76","totalValueInUsd":"86087","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"3902374","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"ALEMBIC ROAD, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725993000,"product":"LACOSAMIDE USP","address":"PLOT NO. C-24, INDUSTRIAL ESTATE,","city":"HYDERABAD. AP","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"PODOR","customer":"TABUK PHARMACEUTICALS","customerCountry":"SAUDI ARABIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"720","totalValueFC":"3452.4","currency":"USD","unitRateINR":57862.800000000003,"date":"11-Sep-2024","totalValueINR":"289314","totalValueInUsd":"3452.4","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"3937491","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SAUDI ARABIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO. C-24, INDUSTRIAL ESTATE,, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725993000,"product":"OTHER - LACOSAMIDE PH.EUR","address":"26, VANDALUR - KELAMBAKKAM ROAD,","city":"CHENNAI. TAMIL NADU.","supplier":"VENKATA NARAYANA ACTIVE INGREDIENTS","supplierCountry":"INDIA","foreign_port":"BAGDAD, METROPOLITAN","customer":"TO THE ORDER OF","customerCountry":"IRAQ","quantity":"400.00","actualQuantity":"400","unit":"KGS","unitRateFc":"250","totalValueFC":"96171.1","currency":"USD","unitRateINR":20148.1325,"date":"11-Sep-2024","totalValueINR":"8059253","totalValueInUsd":"96171.1","indian_port":"Madras Air","hs_no":"29420090","bill_no":"3932368","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"IRAQ","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"26, VANDALUR - KELAMBAKKAM ROAD,, CHENNAI. TAMIL NADU.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727289000,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS(API)(PHARMACEUTICALS RAW MATERIAL FOR PHARMAINDUSTRIES)PRODUCT- LACOSAMIDE","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"ALEMBIC PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"\\\"TO THE ORDER OF\\\"","customerCountry":"REPUBLIC OF KOREA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"468","totalValueFC":"91658.9","currency":"USD","unitRateINR":38405.630150000005,"date":"26-Sep-2024","totalValueINR":"7681126.03","totalValueInUsd":"91658.9","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"4359646","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"ALEMBIC ROAD, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"PROD CODE: 8411167001- LACOSAMIDE (LOT NO: F11670324\/006\/008\/010\/011\/012\/013\/014\/015\/016)","address":"717\/718, MAKER CHAMBER V,","city":"MUMBAI, MAHARASHTRA","supplier":"HIKAL","supplierCountry":"INDIA","foreign_port":"TOKYO - NARITA","customer":"M\/S","customerCountry":"JAPAN","quantity":"650.00","actualQuantity":"650","unit":"KGS","unitRateFc":"451","totalValueFC":"288744","currency":"USD","unitRateINR":37226.313846153847,"date":"27-Sep-2024","totalValueINR":"24197104","totalValueInUsd":"288744","indian_port":"Bangalore Air","hs_no":"29224990","bill_no":"4379864","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"717\/718, MAKER CHAMBER V,, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS (API)EXPORT INVOICE NUMBER : F32518002414 DT. 25.09.2024 LACOSAMIDE PH.EUR.","address":"PLOT 170-172, CHANDRAMOULI,INDUSTR","city":"SOLAPUR,MAHARASHTRA","supplier":"GLENMARK PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"BUENOS AIRES","customer":"TO THE ORDER","customerCountry":"ARGENTINA","quantity":"700.00","actualQuantity":"700","unit":"KGS","unitRateFc":"580","totalValueFC":"400792.9","currency":"USD","unitRateINR":47981.335714285713,"date":"27-Sep-2024","totalValueINR":"33586935","totalValueInUsd":"400792.9","indian_port":"JNPT","hs_no":"29242990","bill_no":"4377493","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ARGENTINA","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"PLOT 170-172, CHANDRAMOULI,INDUSTR, SOLAPUR,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727634600,"product":"(PORD. CODE:8411167001)LACOSAMIDE(LOT NO:F11670324\/007,F11670324\/019,F11670324\/020)","address":"717\/718, MAKER CHAMBER V,","city":"MUMBAI, MAHARASHTRA","supplier":"HIKAL","supplierCountry":"INDIA","foreign_port":"TOKYO - NARITA","customer":"M\/S","customerCountry":"JAPAN","quantity":"150.00","actualQuantity":"150","unit":"KGS","unitRateFc":"451","totalValueFC":"66564.5","currency":"USD","unitRateINR":37187.926666666666,"date":"30-Sep-2024","totalValueINR":"5578189","totalValueInUsd":"66564.5","indian_port":"Bangalore Air","hs_no":"29224990","bill_no":"4486377","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"717\/718, MAKER CHAMBER V,, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727634600,"product":"PROD CODE: 8411167001- LACOSAMIDE (LOT NO: F11670324\/005,F11670324\/007,F11670324\/017,F11670324\/018)","address":"717\/718, MAKER CHAMBER V,","city":"MUMBAI, MAHARASHTRA","supplier":"HIKAL","supplierCountry":"INDIA","foreign_port":"TOKYO - NARITA","customer":"M\/S","customerCountry":"JAPAN","quantity":"150.02","actualQuantity":"150.02","unit":"KGS","unitRateFc":"451","totalValueFC":"66565","currency":"USD","unitRateINR":37183.233968804154,"date":"30-Sep-2024","totalValueINR":"5578228.76","totalValueInUsd":"66565","indian_port":"Bangalore Air","hs_no":"29224990","bill_no":"4468909","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"717\/718, MAKER CHAMBER V,, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1626114600,"product":"REIMPORT OF LACOSAMIDE (BATCH NO. 801905016)","address":"PLOT 170-172, CHANDRAMOULI,INDUSTR IAL ESTATE, MOHOL BAZARPETH","city":"SOLAPUR,MAHARASHTRA","supplier":"MONTE VERDE S.A.","supplierCountry":"INDIA","foreign_port":"","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"125.98","actualQuantity":"125.98","unit":"KGS","unitRateFc":"560","totalValueFC":"74588.3","currency":"USD","unitRateINR":"44124.7","date":"13-Jul-2021","totalValueINR":"5558825.82","totalValueInUsd":"74588.3","indian_port":"BOMBAY AIR","hs_no":"29242990","bill_no":"4656111","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"PLOT 170-172, CHANDRAMOULI,INDUSTR IAL ESTATE, MOHOL BAZARPETH"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1627842600,"product":"LACOSAMIDE API -(QTY 1 PC - 10G)-( QUERY SAMPLE FROM EXPORTSHIPMENT )FOC","address":"ALEMBIC PHARMACEUTICALS LTD\\r\\nALEMBIC ROAD","city":"VADODARA","supplier":"KRKA","supplierCountry":"INDIA","foreign_port":"LJUBLJANA - BRNIK","customer":"ALEMBIC PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"0.01","unit":"KGS","unitRateFc":"1177","totalValueFC":"100.1","currency":"USD","unitRateINR":"742562","date":"02-Aug-2021","totalValueINR":"7425.62","totalValueInUsd":"100.1","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"4906807","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"LJUBLJANA - BRNIK","supplierAddress":"","customerAddress":"ALEMBIC PHARMACEUTICALS LTD\\r\\nALEMBIC ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1633113000,"product":"LACOSAMIDE (RE-IMP VIDE SB.NO:2084576 DT:12.03.2020)","address":"MSN HOUSE ,PLOT NO. C-24, INDUSTRIAL ESTATE,SANATHNAGAR,HYDER","city":"HYDERABAD","supplier":"NEOPHARMA","supplierCountry":"INDIA","foreign_port":"NA","customer":"MSN LABORATORIES","customerCountry":"INDIA","quantity":"223.50","actualQuantity":"223.502","unit":"KGS","unitRateFc":"800","totalValueFC":"180634.8","currency":"USD","unitRateINR":"60544","date":"02-Oct-2021","totalValueINR":"13531709.96","totalValueInUsd":"180634.8","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"5679271","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"MSN HOUSE ,PLOT NO. C-24, INDUSTRIAL ESTATE,SANATHNAGAR,HYDER"}]
    05-Jan-2021
    30-Sep-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    INTERMEDIATES SUPPLIERS

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    01

    PMC Isochem

    France
    SupplySide West 2024
    Not Confirmed
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    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothPMC Isochem is your partner for smart CDMOs of Intermediates, APIs, & excipients & a catalog of Intermediates & Generic APIs.

    Boc-D-Serine (anhydrous)

    CAS Number : 6368-20-3

    End Use API : Lacosamide

    About The Company : PMC Isochem is a CDMO company acquired by PMC International in 2017. It manufactures cGMP intermediates, active pharmaceutical ingredients and functional excipi...

    PMC Isochem

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    Digital Content

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    Corporate PDF

    02

    Aarti Pharmalabs

    India
    CPhI India 2024
    Booth #2.F08
    arrow
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothAarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

    (R)-N-Benzyl-2-(benzyloxy carbonyl)amino-3-hydroxy...

    CAS Number : 219835-31-1

    End Use API : Lacosamide

    About The Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, c...

    Aarti Industries Company Banner

    Portfolio PDF

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    Digital Content

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    Corporate PDF

    03

    Aarti Pharmalabs

    India
    CPhI India 2024
    Booth #2.F08
    arrow
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothAarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

    (R)-2-((t-butoxy) carbonylamino)-3-methoxy propano...

    CAS Number : 86123-95-7

    End Use API : Lacosamide

    About The Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, c...

    Aarti Industries Company Banner

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    04

    Hikal Ltd.

    India
    SupplySide West 2024
    Not Confirmed
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    Hikal Ltd.

    India
    SupplySide West 2024
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Boc-D-serine benzyl amide = (R)-N-benzyl-2-N-Boc-...

    CAS Number : 1253790-58-7

    End Use API : Lacosamide

    About The Company : Hikal is an established provider of research services, active ingredients, intermediates and regulatory starting materials under cGMP conditions to thePharmaceu...

    blank

    Portfolio PDF

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    Digital Content

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    Corporate PDF

    05

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Boc-D-Serine

    CAS Number : 6368-20-3

    End Use API : Lacosamide

    About The Company : Established in 2000, Shodhana Laboratories offers a wide range of APIs and intermediates and caters to the generic and custom requirements of some of the most p...

    blank

    Portfolio PDF

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    Digital Content

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    06

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Boc-O-Methyl-D-serine

    CAS Number : 86123-95-7

    End Use API : Lacosamide

    About The Company : Established in 2000, Shodhana Laboratories offers a wide range of APIs and intermediates and caters to the generic and custom requirements of some of the most p...

    blank

    Portfolio PDF

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    07

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
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    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxoprop...

    CAS Number : 880468-89-3

    End Use API : Lacosamide

    About The Company : Established in 2000, Shodhana Laboratories offers a wide range of APIs and intermediates and caters to the generic and custom requirements of some of the most p...

    blank

    Portfolio PDF

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    Digital Content

    Website

    Corporate PDF

    08

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    (R)-2-amino-N-benzyl-3-methoxypropanamide

    CAS Number : 196601-69-1

    End Use API : Lacosamide

    About The Company : Established in 2000, Shodhana Laboratories offers a wide range of APIs and intermediates and caters to the generic and custom requirements of some of the most p...

    blank

    Portfolio PDF

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    Digital Content

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    09

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    N-Cbz-D-Serine

    CAS Number : 6081-61-4

    End Use API : Lacosamide

    About The Company : Established in 2000, Shodhana Laboratories offers a wide range of APIs and intermediates and caters to the generic and custom requirements of some of the most p...

    blank

    Portfolio PDF

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    Digital Content

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    10

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow

    Shodhana Laboratories

    India
    SupplySide West 2024
    Not Confirmed
    arrow
    • fda
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    (R)-N-benzyl-2-(benzyloxycarbonylamino)-3-hydroxyp...

    CAS Number : 219835-31-1

    End Use API : Lacosamide

    About The Company : Established in 2000, Shodhana Laboratories offers a wide range of APIs and intermediates and caters to the generic and custom requirements of some of the most p...

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - 100MG

    USFDA APPLICATION NUMBER - 22253

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    DOSAGE - TABLET;ORAL - 150MG

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    DOSAGE - TABLET;ORAL - 200MG

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    DOSAGE - TABLET;ORAL - 50MG

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