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Chemistry

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Also known as: 849776-05-2, Ladarixin [inn], (r)-4-[1-(methylsulfonamido)-1-oxo-2-propyl]phenyl trifluoromethanesulfonate, 4-((2r)-1-oxo-1-(methanesulfonamido)propan-2-yl)phenyl trifluoromethanesulfonate, Deh7q6472o, 849776-05-2 (free)
Molecular Formula
C11H12F3NO6S2
Molecular Weight
375.3  g/mol
InChI Key
DDLPYOCJHQSVSZ-SSDOTTSWSA-N
FDA UNII
DEH7Q6472O

Ladarixin
Ladarixin is under investigation in clinical trial NCT04628481 (A Study of Oral Ladarixin in New-onset Type 1 Diabetes and a Low Residual -Cell Function).
1 2D Structure

Ladarixin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[4-[(2R)-1-(methanesulfonamido)-1-oxopropan-2-yl]phenyl] trifluoromethanesulfonate
2.1.2 InChI
InChI=1S/C11H12F3NO6S2/c1-7(10(16)15-22(2,17)18)8-3-5-9(6-4-8)21-23(19,20)11(12,13)14/h3-7H,1-2H3,(H,15,16)/t7-/m1/s1
2.1.3 InChI Key
DDLPYOCJHQSVSZ-SSDOTTSWSA-N
2.1.4 Canonical SMILES
CC(C1=CC=C(C=C1)OS(=O)(=O)C(F)(F)F)C(=O)NS(=O)(=O)C
2.1.5 Isomeric SMILES
C[C@H](C1=CC=C(C=C1)OS(=O)(=O)C(F)(F)F)C(=O)NS(=O)(=O)C
2.2 Other Identifiers
2.2.1 UNII
DEH7Q6472O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2'-((4'-trifluoromethanesulfonyloxy)phenyl)-n-methanesulfonylpropionamide

2. Df 2156a

3. Df 2156y

4. Df-2156a

5. Df-2156y

6. Df2156a

7. Df2156y

2.3.2 Depositor-Supplied Synonyms

1. 849776-05-2

2. Ladarixin [inn]

3. (r)-4-[1-(methylsulfonamido)-1-oxo-2-propyl]phenyl Trifluoromethanesulfonate

4. 4-((2r)-1-oxo-1-(methanesulfonamido)propan-2-yl)phenyl Trifluoromethanesulfonate

5. Deh7q6472o

6. 849776-05-2 (free)

7. Methanesulfonic Acid, 1,1,1-trifluoro-, 4-((1r)-1-methyl-2-((methylsulfonyl)amino)-2-oxoethyl)phenyl Ester

8. Methanesulfonic Acid, Trifluoro-, 4-((1r)-1-methyl-2-((methylsulfonyl)amino)-2-oxoethyl)phenyl Ester

9. Df2156a

10. Unii-deh7q6472o

11. Ladarixin [who-dd]

12. Schembl251618

13. Chembl189475

14. Dtxsid50234030

15. Df-2156a

16. Ac6925

17. Bdbm50475370

18. Akos037649625

19. Cs-12792

20. Hy-19519

21. Cs-0015618

22. A857904

23. Q27276351

24. (r)-(-)-n-(2-(4-(trifluoromethanesulfonyloxy)phenyl)propionyl)methanesulfonamide

25. [4-[(2r)-1-(methanesulfonamido)-1-oxopropan-2-yl]phenyl] Trifluoromethanesulfonate

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 375.3 g/mol
Molecular Formula C11H12F3NO6S2
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass375.00581394 g/mol
Monoisotopic Mass375.00581394 g/mol
Topological Polar Surface Area123 Ų
Heavy Atom Count23
Formal Charge0
Complexity624
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of type I diabetes mellitus


ABOUT THIS PAGE

Ladarixin Manufacturers

A Ladarixin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ladarixin, including repackagers and relabelers. The FDA regulates Ladarixin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ladarixin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ladarixin Suppliers

A Ladarixin supplier is an individual or a company that provides Ladarixin active pharmaceutical ingredient (API) or Ladarixin finished formulations upon request. The Ladarixin suppliers may include Ladarixin API manufacturers, exporters, distributors and traders.

Ladarixin GMP

Ladarixin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ladarixin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ladarixin GMP manufacturer or Ladarixin GMP API supplier for your needs.

Ladarixin CoA

A Ladarixin CoA (Certificate of Analysis) is a formal document that attests to Ladarixin's compliance with Ladarixin specifications and serves as a tool for batch-level quality control.

Ladarixin CoA mostly includes findings from lab analyses of a specific batch. For each Ladarixin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ladarixin may be tested according to a variety of international standards, such as European Pharmacopoeia (Ladarixin EP), Ladarixin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ladarixin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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