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Also known as: 84057-84-1, 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, Lamictal, Lamictal cd, Lamictal xr, Lamotrigina
Molecular Formula
C9H7Cl2N5
Molecular Weight
256.09  g/mol
InChI Key
PYZRQGJRPPTADH-UHFFFAOYSA-N
FDA UNII
U3H27498KS

Lamotrigine
A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER.
Lamotrigine is an Anti-epileptic Agent and Mood Stabilizer. The mechanism of action of lamotrigine is as an Organic Cation Transporter 2 Inhibitor and Dihydrofolate Reductase Inhibitor. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
1 2D Structure

Lamotrigine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
2.1.2 InChI
InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
2.1.3 InChI Key
PYZRQGJRPPTADH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
2.2 Other Identifiers
2.2.1 UNII
U3H27498KS
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine

2. 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine

3. Bw 430c

4. Bw-430c

5. Bw430c

6. Crisomet

7. Labileno

8. Lamictal

9. Lamiktal

2.3.2 Depositor-Supplied Synonyms

1. 84057-84-1

2. 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

3. Lamictal

4. Lamictal Cd

5. Lamictal Xr

6. Lamotrigina

7. Lamotriginum

8. Bw 430c

9. Lamotriginum [latin]

10. Lamotrigina [spanish]

11. Bw-430c

12. Labileno

13. Lamitor

14. Lamictal Odt

15. 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine

16. 1,2,4-triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-

17. 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine

18. Bw430c

19. Ltg;bw430c

20. Chembl741

21. Nsc-759171

22. Mls000069685

23. Chebi:6367

24. U3h27498ks

25. Ncgc00015605-06

26. Smr000058464

27. Lamotrigine-13c-d3

28. Dsstox_cid_3195

29. Dsstox_rid_76918

30. Dsstox_gsid_23195

31. Lamictal (tn)

32. Ltg

33. Cas-84057-84-1

34. Sr-01000000187

35. Einecs 281-901-8

36. Mfcd00865333

37. Epilepax

38. Unii-u3h27498ks

39. Hsdb 7526

40. Eur-1048

41. Lamotrigine [usan:usp:inn:ban]

42. Zine-3,5-diamine

43. Lamotrigine- Bio-x

44. Opera_id_12

45. Tocris-1611

46. Hydroxymethyl Progesterone

47. Lamotrigine [mi]

48. Lamotrigine [inn]

49. Lamotrigine [jan]

50. Lopac-l-3791

51. Lamotrigine [hsdb]

52. Lamotrigine [usan]

53. L 3791

54. Lamotrigine [mart.]

55. Lopac0_000688

56. Schembl35439

57. Lamotrigine [usp-rs]

58. Lamotrigine [who-dd]

59. Mls000759486

60. Mls001077325

61. Mls001423991

62. Bidd:gt0794

63. Lamotrigine (jan/usp/inn)

64. Lamotrigine, >=98%, Powder

65. Gtpl2622

66. Dtxsid2023195

67. Zinc13156

68. Lamotrigine [ep Impurity]

69. Lamotrigine [orange Book]

70. Hms2051c10

71. Hms2089m08

72. Hms2093p21

73. Hms2230l04

74. Hms3262i17

75. Hms3268g17

76. Hms3371o16

77. Hms3393c10

78. Hms3657a17

79. Hms3715h21

80. Hms3885m03

81. Lamotrigine [ep Monograph]

82. Lamotrigine [usp Impurity]

83. Pharmakon1600-01505610

84. Lamotrigine [usp Monograph]

85. Amy40805

86. Bcp12156

87. Hy-b0495

88. Lamotrigine 1.0 Mg/ml In Methanol

89. Tox21_110179

90. Tox21_500688

91. Bdbm50031299

92. Nsc746307

93. Nsc759171

94. S3024

95. Stk628377

96. Akos005561147

97. Tox21_110179_1

98. 6-(2,2,4-triazine-3,5-diyldiamine

99. Ccg-100856

100. Db00555

101. Ks-1074

102. Lp00688

103. Nc00106

104. Nsc 746307

105. Nsc 759171

106. Nsc-746307

107. Sdccgsbi-0050666.p003

108. Smp2_000303

109. Ncgc00015605-01

110. Ncgc00015605-02

111. Ncgc00015605-03

112. Ncgc00015605-04

113. Ncgc00015605-05

114. Ncgc00015605-07

115. Ncgc00015605-08

116. Ncgc00015605-09

117. Ncgc00015605-10

118. Ncgc00015605-23

119. Ncgc00015605-24

120. Ncgc00022936-02

121. Ncgc00022936-04

122. Ncgc00022936-05

123. Ncgc00261373-01

124. Ac-10298

125. Ac-32483

126. Bl166799

127. Lamotrigine 100 Microg/ml In Acetonitrile

128. Sbi-0050666.p002

129. 6-(2,3-dichloro-phenyl)-[1,2,4]tria

130. Db-014839

131. B2249

132. Eu-0100688

133. Ft-0602546

134. Ft-0670713

135. Ft-0670714

136. L-205

137. L0241

138. Sw197486-3

139. 57l841

140. A11873

141. D00354

142. W13018

143. Ab00384359-16

144. Ab00384359_17

145. Ab00384359_18

146. A840709

147. Q410346

148. 3,5-diamino-(2,3-dichlorophenyl)-1,2,4-triazine

149. Q-201221

150. Sr-01000000187-2

151. Sr-01000000187-4

152. Sr-01000000187-7

153. Brd-k93460210-071-01-6

154. Sr-01000000187-10

155. 3,5-diamino-6-(2,3,-dichlorophenyl)-1,2,4-triazine

156. 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine.

157. F2173-0540

158. Z1550648755

159. 6-(2,3-dichloro-phenyl)-[1,2,4]triazine-3,5-diamine

160. 6-[2,3-bis(chloranyl)phenyl]-1,2,4-triazine-3,5-diamine

161. Lamotrigine, British Pharmacopoeia (bp) Reference Standard

162. Lamotrigine, European Pharmacopoeia (ep) Reference Standard

163. 1,2,4-triazine-3,5-diamine, 6-(2,3-dichlorophenyl)

164. 6-(2,3-dichloro-phenyl)-[1,2,4]triazine-3,5-diamine(lamotrigine)

165. Gi 267119x; 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

166. Lamotrigine, United States Pharmacopeia (usp) Reference Standard

167. Lamotrigine, Pharmaceutical Secondary Standard; Certified Reference Material

168. Lamotrigine For Peak Identification, European Pharmacopoeia (ep) Reference Standard

169. Lamotrigine For System Suitability, European Pharmacopoeia (ep) Reference Standard

170. Lamotrigine Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 256.09 g/mol
Molecular Formula C9H7Cl2N5
XLogP31.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass255.0078506 g/mol
Monoisotopic Mass255.0078506 g/mol
Topological Polar Surface Area90.7 Ų
Heavy Atom Count16
Formal Charge0
Complexity242
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 10  
Drug NameLamictal
PubMed HealthLamotrigine (By mouth)
Drug ClassesAnticonvulsant
Drug LabelLAMICTAL (lamotrigine), an AED of the phenyltriazine class, is chemically unrelated to existing AEDs. Its chemical name is 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine, its molecular formula is C9H7N5Cl2, and its molecular weight is 256.09. Lamotri...
Active IngredientLamotrigine
Dosage FormTablet
RouteOral
Strength200mg; 25mg; 150mg; 100mg
Market StatusPrescription
CompanyGlaxosmithkline

2 of 10  
Drug NameLamictal cd
PubMed HealthLamotrigine (By mouth)
Drug ClassesAnticonvulsant
Drug LabelLAMICTAL (lamotrigine), an AED of the phenyltriazine class, is chemically unrelated to existing AEDs. Its chemical name is 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine, its molecular formula is C9H7N5Cl2, and its molecular weight is 256.09. Lamotri...
Active IngredientLamotrigine
Dosage FormTablet, chewable
RouteOral
Strength25mg; 5mg; 2mg
Market StatusPrescription
CompanyGlaxosmithkline

3 of 10  
Drug NameLamictal odt
PubMed HealthLamotrigine (By mouth)
Drug ClassesAnticonvulsant
Drug LabelLAMICTALXR (lamotrigine), an AED of the phenyltriazine class, is chemically unrelated to existing AEDs. Its chemical name is 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine, its molecular formula is C9H7N5Cl2, and its molecular weight is 256.09. Lam...
Active IngredientLamotrigine
Dosage FormTablet, orally disintegrating
RouteOral
Strength200mg; 25mg; 100mg; 50mg
Market StatusPrescription
CompanyGlaxosmithkline

4 of 10  
Drug NameLamictal xr
Drug LabelLamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Its chemical name is 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine, its molecular formula is C9H7N5Cl2, and its molecular...
Active IngredientLamotrigine
Dosage FormTablet, extended release
Routeoral; Oral
Strength200mg; 250mg; 25mg; 300mg; 100mg; 50mg
Market StatusPrescription
CompanySmithkline Beecham; Glaxosmithkline

5 of 10  
Drug NameLamotrigine
Active IngredientLamotrigine
Dosage FormTablet, extended release; Tablet; Tablet, orally disintegrating; Tablet, chewable
Routeoral; Oral
Strength200mg; 250mg; 25mg; 150mg; 300mg; 5mg; 100mg; 2mg; 50mg
Market StatusTentative Approval; Prescription
CompanyWockhardt; Anchen Pharms; Teva; Apotex; Alkem Labs; Alembic Pharms; Aurobindo Pharma; Taro; Taro Pharm Inds; Torrent Pharms; Lupin; Sandoz; Cipla; Par Pharm; Hikma Pharms; Watson Labs; Glenmark Generics; Wilshire Pharms; Actavis Elizabeth; Caraco; Jubilan

6 of 10  
Drug NameLamictal
PubMed HealthLamotrigine (By mouth)
Drug ClassesAnticonvulsant
Drug LabelLAMICTAL (lamotrigine), an AED of the phenyltriazine class, is chemically unrelated to existing AEDs. Its chemical name is 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine, its molecular formula is C9H7N5Cl2, and its molecular weight is 256.09. Lamotri...
Active IngredientLamotrigine
Dosage FormTablet
RouteOral
Strength200mg; 25mg; 150mg; 100mg
Market StatusPrescription
CompanyGlaxosmithkline

7 of 10  
Drug NameLamictal cd
PubMed HealthLamotrigine (By mouth)
Drug ClassesAnticonvulsant
Drug LabelLAMICTAL (lamotrigine), an AED of the phenyltriazine class, is chemically unrelated to existing AEDs. Its chemical name is 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine, its molecular formula is C9H7N5Cl2, and its molecular weight is 256.09. Lamotri...
Active IngredientLamotrigine
Dosage FormTablet, chewable
RouteOral
Strength25mg; 5mg; 2mg
Market StatusPrescription
CompanyGlaxosmithkline

8 of 10  
Drug NameLamictal odt
PubMed HealthLamotrigine (By mouth)
Drug ClassesAnticonvulsant
Drug LabelLAMICTALXR (lamotrigine), an AED of the phenyltriazine class, is chemically unrelated to existing AEDs. Its chemical name is 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine, its molecular formula is C9H7N5Cl2, and its molecular weight is 256.09. Lam...
Active IngredientLamotrigine
Dosage FormTablet, orally disintegrating
RouteOral
Strength200mg; 25mg; 100mg; 50mg
Market StatusPrescription
CompanyGlaxosmithkline

9 of 10  
Drug NameLamictal xr
Drug LabelLamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Its chemical name is 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine, its molecular formula is C9H7N5Cl2, and its molecular...
Active IngredientLamotrigine
Dosage FormTablet, extended release
Routeoral; Oral
Strength200mg; 250mg; 25mg; 300mg; 100mg; 50mg
Market StatusPrescription
CompanySmithkline Beecham; Glaxosmithkline

10 of 10  
Drug NameLamotrigine
Active IngredientLamotrigine
Dosage FormTablet, extended release; Tablet; Tablet, orally disintegrating; Tablet, chewable
Routeoral; Oral
Strength200mg; 250mg; 25mg; 150mg; 300mg; 5mg; 100mg; 2mg; 50mg
Market StatusTentative Approval; Prescription
CompanyWockhardt; Anchen Pharms; Teva; Apotex; Alkem Labs; Alembic Pharms; Aurobindo Pharma; Taro; Taro Pharm Inds; Torrent Pharms; Lupin; Sandoz; Cipla; Par Pharm; Hikma Pharms; Watson Labs; Glenmark Generics; Wilshire Pharms; Actavis Elizabeth; Caraco; Jubilan

4.2 Therapeutic Uses

Anticonvulsants; Calcium Channel Blockers; Excitatory Amino Acid Antagonists; Voltage-Gated Sodium Channel Blockers

National Library of Medicine's Medical Subject Headings. Lamotrigine. Online file (MeSH, 2015). Available from, as of November 20, 2015: https://www.nlm.nih.gov/mesh/2015/mesh_browser/MBrowser.html


/CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Lamotrigine is included in the database.

NIH/NLM; ClinicalTrials.Gov. Available from, as of September 30, 2015: https://clinicaltrials.gov/search/intervention=lamotrigine


Lamictal is indicated as adjunctive therapy for the following seizure types in patients aged 2 years and older: partial-onset seizures, primary generalized tonic-clonic (PGTC) seizures, generalized seizures of Lennox-Gastaut syndrome. /Included in the US product label/

NIH; DailyMed. Current Medication Information for Lamictal (Lamotrigine Tablet), Lamictal (Lamotrigine Tablet, Chewable), Lamictal ODT (Lamotrigine Tablet, Orally Disintegrating), Lamictal (Lamotrigine), Lamictal ODT (Lamotrigine) (Updated: May 2015). Available from, as of November 24, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d7e3572d-56fe-4727-2bb4-013ccca22678


Lamcital is indicated for conversion to monotherapy in adults (aged 16 years and older) with partial-onset seizures who are receiving treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single antiepileptic drug (AED). /Included in US product label/

NIH; DailyMed. Current Medication Information for Lamictal (Lamotrigine Tablet), Lamictal (Lamotrigine Tablet, Chewable), Lamictal ODT (Lamotrigine Tablet, Orally Disintegrating), Lamictal (Lamotrigine), Lamictal ODT (Lamotrigine) (Updated: May 2015). Available from, as of November 24, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d7e3572d-56fe-4727-2bb4-013ccca22678


For more Therapeutic Uses (Complete) data for LAMOTRIGINE (6 total), please visit the HSDB record page.


4.3 Drug Warning

/BOXED WARNING/ WARNING: SERIOUS SKIN RASHES. Lamictal can cause serious rashes requiring hospitalization and discontinuation of treatment. The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0.3% to 0.8% in pediatric patients (aged 2 to 17 years) and 0.08% to 0.3% in adults receiving Lamictal. One rash-related death was reported in a prospectively followed cohort of 1,983 pediatric patients (aged 2 to 16 years) with epilepsy taking Lamictal as adjunctive therapy. In worldwide postmarketing experience, rare cases of toxic epidermal necrolysis and/or rash-related death have been reported in adult and pediatric patients, but their numbers are too few to permit a precise estimate of the rate. Other than age, there are as yet no factors identified that are known to predict the risk of occurrence or the severity of rash caused by Lamictal. There are suggestions, yet to be proven, that the risk of rash may also be increased by (1) coadministration of Lamictal with valproate (includes valproic acid and divalproex sodium), (2) exceeding the recommended initial dose of Lamictal, or (3) exceeding the recommended dose escalation for Lamictal. However, cases have occurred in the absence of these factors. Nearly all cases of life-threatening rashes caused by Lamictal have occurred within 2 to 8 weeks of treatment initiation. However, isolated cases have occurred after prolonged treatment (e.g., 6 months). Accordingly, duration of therapy cannot be relied upon as means to predict the potential risk heralded by the first appearance of a rash. Although benign rashes are also caused by Lamictal, it is not possible to predict reliably which rashes will prove to be serious or life threatening. Accordingly, Lamictal should ordinarily be discontinued at the first sign of rash, unless the rash is clearly not drug related. Discontinuation of treatment may not prevent a rash from becoming life threatening or permanently disabling or disfiguring

NIH; DailyMed. Current Medication Information for Lamictal (Lamotrigine Tablet), Lamictal (Lamotrigine Tablet, Chewable), Lamictal ODT (Lamotrigine Tablet, Orally Disintegrating), Lamictal (Lamotrigine), Lamictal ODT (Lamotrigine) (Updated: May 2015). Available from, as of November 24, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d7e3572d-56fe-4727-2bb4-013ccca22678


Dizziness, headache, and ataxia were the most frequent adverse nervous system effects, occurring in 38, 29, and 22% of adults, respectively, in controlled trials of lamotrigine adjunctive therapy. The frequency of dizziness and ataxia, and the rate of discontinuance of lamotrigine because of these adverse effects, were dose related in clinical trials; in a dose-response study, dizziness occurred in 54, 31, or 27% of patients receiving lamotrigine 500 mg/day, lamotrigine 300 mg/day, or placebo, respectively, while ataxia occurred in 28, 10, or 10% of those receiving these respective regimens.

American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 2235


Somnolence or insomnia occurred in 14 or 6%, respectively, of adults receiving lamotrigine as adjunctive therapy in controlled clinical trials. Incoordination or tremor was reported in 6 or 4%, respectively, of lamotrigine-treated adults ... Depression occurred in 4%, anxiety in 4%, irritability in 3%, speech disorder in 3%, and concentration disturbance in 2% of adults receiving lamotrigine as adjunctive therapy in controlled clinical trials. Seizure or seizure exacerbation has been reported in 3 or 2% of adults, respectively, receiving lamotrigine as adjunctive therapy in controlled trials; an increase in seizure frequency also has been reported with lamotrigine therapy. Treatment-emergent seizures diagnosed unequivocally as status epilepticus were reported in 7 of 2343 adults receiving adjunctive therapy with lamotrigine in clinical trials; however, the manufacturer states that valid estimates of the incidence of treatment-emergent status epilepticus are difficult to obtain because of variations in the definitions used by different investigators to identify such cases.

American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 2235


Coordination abnormality, dizziness, anxiety, and insomnia occurred in 7, 7, 5, and 5% respectively, of adults receiving lamotrigine as monotherapy in a controlled trial; amnesia, ataxia, asthenia, depression, hypesthesia, libido increase, decreased or increased reflexes, nystagmus, and irritability each occurred in 2% of such patients. Paresthesia or asthenia occurred in more than 1% of adults receiving lamotrigine as adjunctive therapy in controlled clinical trials but with equal or greater frequency in those receiving placebo.

American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 2235


For more Drug Warnings (Complete) data for LAMOTRIGINE (42 total), please visit the HSDB record page.


4.4 Drug Indication

Lamotrigine is indicated as adjunctive therapy for the following seizure types in patients 2 years of age: partial seizures, primary generalized tonic-clonic seizures, and generalized seizures due to Lennox-Gastaut syndrome. It is also indicated for the process of conversion to drug monotherapy for those at least 16 years of age or older with partial seizures and currently are receiving treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single antiepileptic drug (AED). In addition to the above, lamotrigine is also indicated for the maintenance treatment of bipolar I disorder, delaying the time to mood episodes (which may include mania, hypomania, depression, mixed episodes) in adults at least 18 years or older, who have been treated for acute mood symptoms with standard therapy. Limitations of use It is important to note that lamotirigine should not be used in the treatment of acute mood episodes, as efficacy has not been established in this context.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Lamotrigine likely prevents seizures and prevents mood symptoms via stabilizing presynaptic neuronal membranes and preventing the release of excitatory neurotransmitters such as glutamate, which contribute to seizure activity. A note on cardiovascular effects The metabolite of lamotrigine, 2-N-methyl metabolite (formed by glucuronidation), is reported to cause dose-dependent prolongations of the PR interval, widening of the QRS complex, and at higher doses, complete AV block. Although this harmful metabolite is only found in trace amounts in humans, plasma concentrations may increase in conditions that cause decreased drug glucuronidation, such as liver disease.


5.2 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)


Sodium Channel Blockers

A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity. (See all compounds classified as Sodium Channel Blockers.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
LAMOTRIGINE
5.3.2 FDA UNII
U3H27498KS
5.3.3 Pharmacological Classes
Decreased Central Nervous System Disorganized Electrical Activity [PE]; Dihydrofolate Reductase Inhibitors [MoA]; Mood Stabilizer [EPC]; Organic Cation Transporter 2 Inhibitors [MoA]; Anti-epileptic Agent [EPC]
5.4 ATC Code

N03AX09

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


N - Nervous system

N03 - Antiepileptics

N03A - Antiepileptics

N03AX - Other antiepileptics

N03AX09 - Lamotrigine


5.5 Absorption, Distribution and Excretion

Absorption

Lamotrigine is rapidly and entirely absorbed with minimal first-pass metabolism effects, with a bioavailability estimated at 98%. Cmax is reached in the range of 1.4 to 4.8 hours post-dose, but this depends on the dose administered, concomitant medications, and epileptic status. The rate and extent of lamictal absorption is considered equivalent between the compressed tablet form taken with water to that of the chewable dispersible tablets, taken with or without water.


Route of Elimination

Lamotrigine is excreted in both the urine and feces. Following oral administration of 240 mg radiolabelled lamotrigine, about 94% of total drug and its metabolites administered is recovered in the urine and 2% is recovered in the feces. One pharmacokinetic study recovered 43 to 87% of a lamotrigine dose in the urine mainly as glucuronidated metabolites. 2-N-glucuronide is mainly excreted in the urine.


Volume of Distribution

The mean apparent volume of distribution (Vd/F) of lamotrigine following oral administration ranges from 0.9 to 1.3 L/kg and is independent of dose administered. Lamotrigine accumulated in the kidney of the male rat, and likely behaves in a similar fashion in humans. Lamotrigine also binds to tissues containing melanin, such as the eyes and pigmented skin.


Clearance

The mean apparent plasma clearance (Cl/F) ranges from 0.18 to 1.21 mL/min/kg. The values vary depending on dosing regimen, concomitant antiepileptic medications, and disease state of the individual. In one study, healthy volunteers on lamictal monotherapy showed a clearance of about 0.44 mL/min/kg after a single dose.


/MILK/ Lamotrigine is distributed into milk. Because of the potential for serious adverse reactions to lamotrigine in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.

American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 2239


/MILK/ To investigate the pharmacokinetics of lamotrigine (LTG) during delivery, during the neonatal period, and lactation. High-performance liquid chromatography was used to determine plasma and milk levels of LTG in nine pregnant women with epilepsy treated with LTG, and plasma levels in their 10 infants. Samples were obtained at delivery, the first 3 days postpartum, and at breast-feeding 2-3 weeks after delivery. At delivery, maternal plasma LTG concentrations were similar to those from the umbilical cord, indicating extensive placental transfer of LTG. There was a slow decline in the LTG plasma concentration in the newborn. At 72 hr postpartum, median LTG plasma levels in the infants were 75% of the cord plasma levels (range, 50-100%). The median milk/maternal plasma concentration ratio was 0.61 (range, 0.47-0.77) 2-3 weeks after delivery, and the nursed infants maintained LTG plasma concentrations of approximately 30% (median, range 23-50%) of the mother's plasma levels. Maternal plasma LTG concentrations increased significantly during the first 2 weeks after parturition, the median increase in plasma concentration/dose ratio being 170%.

PMID:10840403 Ohman I et al; Epilepsia 41 (6): 709-13 (2000)


Lamotrigine binds to melanin-containing ocular tissue in pigmented rats and cynomolgus monkeys, but evidence of this manifestation has not been reported in humans ... prolonged administration of the drug could potentially result in its accumulation and possible toxic effects in melanin-rich tissues, including those of the eye, and that clinicians should be aware of possible adverse ophthalmologic effects occurring as a result of binding of the drug to melanin.

American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 2238


To determine the relative bioavailability of lamotrigine (LTG) chewable dispersible tablets after rectal administration. Two-period, crossover study with a 2-week washout between dosing periods. Twelve healthy adult volunteers. One hundred milligrams of a LTG chewable dispersible tablet was administered by oral and rectal routes. Plasma samples were collected before and up to 120 hours after drug administration. The samples were analyzed for LTG by high-performance liquid chromatography, and the relative bioavailability was determined. Drug concentrations were lower after rectal than after oral administration. The relative bioavailability (F = AUC(rectal)/AUC(oral)) was 0.52 +/- 0.23 (SD). Drug prepared from LTG chewable dispersible tablets is absorbed rectally, although not to the same extent as when given orally. Rectal administration of suspension of these tablets can be an acceptable route of administration.

PMID:11213851 Birnbaum A et al; Pharmacotherapy 21 (2): 158-62 (2001)


For more Absorption, Distribution and Excretion (Complete) data for LAMOTRIGINE (9 total), please visit the HSDB record page.


5.6 Metabolism/Metabolites

Lamotrigine is mainly glucuronidated, forming 2-N-glucuronide conjugate, a pharmacologically inactive metabolite. The total radioactivity detected after a 240mg radiolabeled dose of lamotrigine during clinical trials were as follows: lamotrigine as unchanged drug(10%), a 2-N-glucuronide (76%), a 5-N-glucuronide (10%), a 2-N-methyl metabolite (0.14%), as well as various other minor metabolites (4%).


The metabolites of [(14)C]lamotrigine (78 micromol/kg, iv) in adult male Wistar rats were characterized with particular reference to thioether derivatives of an epoxide intermediate. Biliary recovery of radioactivity from anesthetized and cannulated animals was 7.3 +/- 3.0% (mean +/- SD, n = 4) of the dose over 4 hr; 5.5 +/- 0.5% was recovered in bladder urine after 4 hr. Bile contained [(14)C]lamotrigine (1.4 +/- 0.3%), a glutathione adduct of [(14)C]dihydrohydroxylamotrigine (1.8 +/- 0.3%), i.e., an adduct of an arene oxide, and the glutathione (1.5 +/- 0.7%), cysteinylglycine (1.9 +/- 0.5%), and N-acetylcysteine (0.4 +/- 0.2%) adducts of [(14)C]lamotrigine. Formation of the thioether metabolites was partially blocked by the cytochrome P450 inhibitor, ketoconazole. Urine contained [(14)C]lamotrigine (4.5 +/- 0.5%) and [(14)C]lamotrigine N-oxide (0.9 +/- 0.2%). The radiolabeled material in skin (15.6 +/- 1.4%) was almost entirely [(14)C]lamotrigine. ...

PMID:11087428 Maggs J et al; Chem Res Toxicol 13 (11): 1075-81 (2000)


5.7 Biological Half-Life

The average elimination half-life of lamotrigine ranges from approximately 14-59 hours. The value is dependent on the dose administered, concomitant drug therapy, as well as disease status. One pharmacokinetic study revealed a half-life of 22.8 to 37.4 hours in healthy volunteers. It also reported that enzyme-inducing antiepileptic drugs such as pheobarbital, phenytoin, or carbamazepine decrease the half-life of lamotrigine. On the other hand, valproic acid increases the half-life of lamotrigine (in the range of 48-59 hours).


/Investigators/ describe the findings in a patient following the deliberate ingestion of a large amount of lamotrigine (stated 4.5 g, absorbed estimated 2.9 g) ... Peak measured concentration of lamotrigine was 35.8 mg/L and half-life 19.5 hours, suggesting linear kinetics in overdose.

PMID:11185974 O'Donnell J et al; J Toxicol Clin Toxicol 38 (6): 659-60 (2000)


The plasma half-life of a single dose is 24 to 35 hr. Administration of phenytoin, carbamazepine, phenobarbital, or primidone reduces the half-life of lamotrigine to approximately 15 hr and reduces plasma concentrations of lamotrigine.

Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 539


5.8 Mechanism of Action

The exact mechanism of action of lamotrigine is not fully elucidated, as it may exert cellular activities that contribute to its efficacy in a range of conditions. Although chemically unrelated, lamotrigine actions resemble those of phenytoin and carbamazepine, inhibiting voltage-sensitive sodium channels, stabilizing neuronal membranes, thereby modulating the release of presynaptic excitatory neurotransmitters. Lamotrigine likely acts by inhibiting sodium currents by selective binding to the inactive sodium channel, suppressing the release of the excitatory amino acid, glutamate. The mechanism of action of lamotrigine in reducing anticonvulsant activity is likely the same in managing bipolar disorder. Studies on lamotrigine have identified its binding to sodium channels in a fashion similar to local anesthetics, which could explain the demonstrated clinical benefit of lamotrigine in some neuropathic pain states. Lamotrigine displays binding properties to several different receptors. In laboratory binding assays, it demonstrates weak inhibitory effect on the serotonin 5-HT3 receptor. Lamotrigine also weakly binds to Adenosine A1/A2 receptors, 1/2/ adrenergic receptors, dopamine D1/D2 receptors, GABA A/B receptors, histamine H1 receptors, -opioid receptor (KOR), mACh receptors and serotonin 5-HT2 receptors with an IC50>100 M. Weak inhibitory effects were observed at sigma opioid receptors. An in vivo study revealed evidence that lamotrigine inhibits Cav2.3 (R-type) calcium currents, which may also contribute to its anticonvulsant effects.


Spectrophotometry with the Ca(++)-sensitive dye fura-2 was used to study the effect of lamotrigine (LAG) on the depolarization-evoked Ca++ influx in the acutely isolated basolateral amygdala neurons. Depolarization of the neurons with high K+ resulted in the elevation of intracellular Ca++ concentration [Ca++]i in a concentration-dependent manner. The K(+)-induced Ca++ influx was completely blocked in the Ca(++)-free solution or by Cd++, indicating that depolarization-induced increases in [Ca++]i were triggered largely, if not completely, by Ca++ entry from extracellular space and Ca++ entry occurred through voltage-dependent Ca++ channels. Application of LAG reduced the depolarization-evoked Ca++ influx in a concentration-dependent manner. The effect of LAG was markedly reduced in the presence of N-type Ca++ channel blocker omega-conotoxin-GVIA (omega-CgTX). These results suggest that the action of LAG is mediated, at least in part, by the modulation of N-type Ca++ channels.

PMID:9661253 Wang S et al; Synapse 29 (4): 355-62 (1998)


Lamotrigine (LAG) is an antiepileptic drug which is believed to suppress seizures by inhibiting the release of excitatory neurotransmitters. The present study was aimed at investigating the effect of LAG on the 4-aminopyridine (4AP)-evoked glutamate release in cerebrocortical nerve terminals (synaptosomes). LAG inhibited the release of glutamate evoked by 4AP in a concentration-dependent manner. This inhibitory effect was associated with a reduction in the depolarization-evoked increase in the cytoplasmic free Ca2+ concentration ([Ca2+]C). In addition, LAG did not alter the resting synaptosomal membrane potential or 4AP-evoked depolarization. Furthermore, ionomycin-evoked glutamate release was not affected by LAG. Based on these results, we suggest that presynaptic calcium influx blockade and inhibition of glutamate release may underlie the mechanism of action of LAG. These action may also contribute to their neuroprotective properties in excitotoxic injury.

PMID:11447345 Wang S et al; Neuroreport 12 (10): 2255-8 (2001)


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01-Jan-2021
31-Oct-2024
KGS
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Average Price (USD/KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 100MG

USFDA APPLICATION NUMBER - 20241

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DOSAGE - TABLET;ORAL - 150MG

USFDA APPLICATION NUMBER - 20241

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DOSAGE - TABLET;ORAL - 200MG

USFDA APPLICATION NUMBER - 20241

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DOSAGE - TABLET;ORAL - 250MG **Federal Regist...DOSAGE - TABLET;ORAL - 250MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20241

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DOSAGE - TABLET;ORAL - 25MG

USFDA APPLICATION NUMBER - 20241

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DOSAGE - TABLET;ORAL - 50MG **Federal Registe...DOSAGE - TABLET;ORAL - 50MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20241

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